Objective: to analyze the application and clinical significance of early burn plastic surgery. Methods: Methods: 156 cases of burn and plastic surgery patients in my hospital who received early plastic surgery after 1...Objective: to analyze the application and clinical significance of early burn plastic surgery. Methods: Methods: 156 cases of burn and plastic surgery patients in my hospital who received early plastic surgery after 10 days were compared. The cases of two groups of patients who received early plastic surgery after 10 days were compared, and 102 cases of two groups of patients who received early plastic surgery after 10 days were compared. Results: The excellent and good rates of the short-term therapeutic effects in the experimental group after the operation reached 93.99% respectively;However, in the control group, the excellent and good rate of the recent treatment after the recent treatment reached 79.29% respectively, and the comparative difference between the two was statistically significant (P<0.05). During the long-term follow-up of the patients, no case in the experimental group may have significant scar and scar hyperplasia in the operation area, so it is required to complete the secondary operation, which is equivalent to the control group. Only 19 hands may have significant scar and scar, and need to undergo the secondary operation again. The occurrence rate has reached 13.57%. The difference between the two groups has certain data and statistical significance (P<0.05). Conclusion: For patients with severe hand burn and inflammation, early reconstructive surgery should be adopted. In principle, the necessary surgical treatment should be completed. Effective surgical treatment or ideal recovery of body function should be given accordingly, which can be popularized and applied in clinical practice.展开更多
The loss of cardiomyocytes during injury and disease can result in heart failure and sudden death, while the adult heart has a limited capacity for endogenous regeneration and repair. Current stem cell-based regenerat...The loss of cardiomyocytes during injury and disease can result in heart failure and sudden death, while the adult heart has a limited capacity for endogenous regeneration and repair. Current stem cell-based regenerative medicine approaches modestly improve cardiomyocyte survival, but offer neglectable cardiomyogenesis. This has prompted the need for methodological developments that crease de novo cardiomyocytes. Current insights in cardiac development on the processes and regulatory mechanisms in embryonic cardiomyocyte differentiation provide a basis to therapeutically induce these pathways to generate new cardiomyocytes. Here, we discuss the current knowledge on embryonic cardiomyocyte differentiation and the implementation of this knowledge in state-ofthe-art protocols to the direct reprogramming of cardiac fibroblasts into de novo cardiomyocytes in vitro and in vivo with an emphasis on micro RNA-mediated reprogramming. Additionally, we discuss current advances on state-of-theart targeted drug delivery systems that can be employed to deliver these micro RNAs to the damaged cardiac tissue. Together, the advances in our understanding of cardiac development, recent advances in micro RNAbased therapeutics, and innovative drug delivery systems, highlight exciting opportunities for effective therapies for myocardial infarction and heart failure.展开更多
The precise role of neural plasticity under pathological conditions remains not well understood. It appears to be well accepted, however, that changes in the ability of neurons to express plasticity accompany neurolog...The precise role of neural plasticity under pathological conditions remains not well understood. It appears to be well accepted, however, that changes in the ability of neurons to express plasticity accompany neurological diseases. Here, we discuss recent experimental evidence, which suggests that synaptic plasticity induced by a pathological stimulus, i.e., ischemic long-term-potentiation（i LTP） of excitatory synapses, could play an important role for post-stroke recovery by influencing the post-lesional reorganization of surviving neuronal networks.展开更多
文摘Objective: to analyze the application and clinical significance of early burn plastic surgery. Methods: Methods: 156 cases of burn and plastic surgery patients in my hospital who received early plastic surgery after 10 days were compared. The cases of two groups of patients who received early plastic surgery after 10 days were compared, and 102 cases of two groups of patients who received early plastic surgery after 10 days were compared. Results: The excellent and good rates of the short-term therapeutic effects in the experimental group after the operation reached 93.99% respectively;However, in the control group, the excellent and good rate of the recent treatment after the recent treatment reached 79.29% respectively, and the comparative difference between the two was statistically significant (P<0.05). During the long-term follow-up of the patients, no case in the experimental group may have significant scar and scar hyperplasia in the operation area, so it is required to complete the secondary operation, which is equivalent to the control group. Only 19 hands may have significant scar and scar, and need to undergo the secondary operation again. The occurrence rate has reached 13.57%. The difference between the two groups has certain data and statistical significance (P<0.05). Conclusion: For patients with severe hand burn and inflammation, early reconstructive surgery should be adopted. In principle, the necessary surgical treatment should be completed. Effective surgical treatment or ideal recovery of body function should be given accordingly, which can be popularized and applied in clinical practice.
文摘The loss of cardiomyocytes during injury and disease can result in heart failure and sudden death, while the adult heart has a limited capacity for endogenous regeneration and repair. Current stem cell-based regenerative medicine approaches modestly improve cardiomyocyte survival, but offer neglectable cardiomyogenesis. This has prompted the need for methodological developments that crease de novo cardiomyocytes. Current insights in cardiac development on the processes and regulatory mechanisms in embryonic cardiomyocyte differentiation provide a basis to therapeutically induce these pathways to generate new cardiomyocytes. Here, we discuss the current knowledge on embryonic cardiomyocyte differentiation and the implementation of this knowledge in state-ofthe-art protocols to the direct reprogramming of cardiac fibroblasts into de novo cardiomyocytes in vitro and in vivo with an emphasis on micro RNA-mediated reprogramming. Additionally, we discuss current advances on state-of-theart targeted drug delivery systems that can be employed to deliver these micro RNAs to the damaged cardiac tissue. Together, the advances in our understanding of cardiac development, recent advances in micro RNAbased therapeutics, and innovative drug delivery systems, highlight exciting opportunities for effective therapies for myocardial infarction and heart failure.
基金supported by German Israeli Foundation(G-1317-418.13/2015 to AV and NM)
文摘The precise role of neural plasticity under pathological conditions remains not well understood. It appears to be well accepted, however, that changes in the ability of neurons to express plasticity accompany neurological diseases. Here, we discuss recent experimental evidence, which suggests that synaptic plasticity induced by a pathological stimulus, i.e., ischemic long-term-potentiation（i LTP） of excitatory synapses, could play an important role for post-stroke recovery by influencing the post-lesional reorganization of surviving neuronal networks.
