Layered oxides have attracted significant attention as cathodes for sodium-ion batteries(SIBs)due to their compositional versatility and tuneable electrochemical performance.However,these materials still face challeng...Layered oxides have attracted significant attention as cathodes for sodium-ion batteries(SIBs)due to their compositional versatility and tuneable electrochemical performance.However,these materials still face challenges such as structural phase transitions,Na^(+)/vacancy ordering,and Jahn–Teller distortion effect,resulting in severe capacity decay and sluggish ion kinetics.We develop a novel Cu/Y dual-doping strategy that leads to the formation of"Na–Y"interlayer aggregates,which act as structural pillars within alkali metal layers,enhancing structural stability and disrupting the ordered arrangement of Na^(+)/vacancies.This disruption leads to a unique coexistence of ordered and disordered Na^(+)/vacancy states with near-zero strain,which significantly improves Na^(+)diffusion kinetics.This structural innovation not only mitigates the unfavorable P2–O2 phase transition but also facilitates rapid ion transport.As a result,the doped material demonstrates exceptional electrochemical performance,including an ultra-long cycle life of 3000 cycles at 10 C and an outstanding high-rate capability of~70 mAh g^(−1)at 50 C.The discovery of this novel interlayer pillar,along with its role in modulating Na^(+)/vacancy arrangements,provides a fresh perspective on engineering layered oxides.It opens up promising new pathways for the structural design of advanced cathode materials toward efficient,stable,and high-rate SIBs.展开更多
Objectives:Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia and Philadelphia-like B-cell acute lymphoblastic leukemia(Ph+/Ph-like ALL)constitute the majority of relapsed/refractory B-ALL(R/R B-ALL)...Objectives:Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia and Philadelphia-like B-cell acute lymphoblastic leukemia(Ph+/Ph-like ALL)constitute the majority of relapsed/refractory B-ALL(R/R B-ALL)cases,highlighting an urgent need to discover new therapeutic targets.This study aims to elucidate the mechanisms underlying poor prognosis in Ph+/Ph-like ALL through transcriptome sequencing and functional cytological assays,with the goal of informing new clinical treatment strategies.Results:Transcriptomic analysis of Ph+/Ph-like ALL patients revealed that low expression of P2X Purinoceptor 1(P2RX1)was associated with unfavorable outcomes.Specifically,patients with poor prognosis and low P2RX1 expression exhibited downregulation of genes involved in energy and calcium metabolism pathways,along with upregulation of genes governing key cellular processes such as cell proliferation(e.g.,MYC),cell cycle progression(e.g.,CCND2),and apoptosis inhibition(e.g.,DASP6).Cellular experiments demonstrated that SUP-B15 cells overexpressing P2RX1 displayed elevated intracellular levels of ATP,calcium,and glucose,together with enhanced glycolytic capacity,compared to empty vector controls.Treatment of SUP-B15 cells with dexamethasone(Dex),Imatinib,or their combination significantly suppressed proliferation and promoted apoptosis,which was accompanied by increases in intracellular ATP,calcium,and glucose.Moreover,exogenous ATP administration(a P2RX1 agonist)enhanced apoptosis and inhibited proliferation in control cells.Conversely,treatment with NF449(a P2RX1 inhibitor)increased proliferation in both P2RX1-overexpressing and control SUP-B15 cells.Conclusion:Our findings indicate that P2RX1 may exert this function through modulating energy metabolism and calcium homeostasis,resulting in elevated intracellular calcium levels.Sustained elevation of calcium promotes apoptosis,whereas exogenous ATP activates P2RX1,enhances calcium influx,and attenuates the suppression of apoptosis associated with P2RX1 underexpression,ultimately correlating with improved treatment response.展开更多
P2P2B模式下云服务投入是工业互联网(industrial internet of things,IIoT)平台的关键战略决策之一.构建由IIoT平台、龙头企业、潜在客户构成的演化博弈模型,研究IIoT平台在公有云研发投入和私有云研发投入中的策略选择,及其与龙头企业...P2P2B模式下云服务投入是工业互联网(industrial internet of things,IIoT)平台的关键战略决策之一.构建由IIoT平台、龙头企业、潜在客户构成的演化博弈模型,研究IIoT平台在公有云研发投入和私有云研发投入中的策略选择,及其与龙头企业的生态合作问题.结果表明:虽然公有云存在数据泄露隐患,但较高的规模收益仍会吸引IIoT平台投入公有云研发,而平台搭建期内龙头企业的高合作意愿会促使平台投入私有云,随着龙头企业合作研发的比例增加,平台又将改变其投入策略.驱动龙头企业合作的因素可以是成本收益、技术提升等直接因素,也可以是规模收益、数据泄露概率等间接因素.最后,基于平台生命周期探讨了初创期、平台搭建期与生态系统期IIoT平台的系统稳定策略,并得到相应的管理启示.展开更多
Pain is unfortunately a quite common symptom for cancer patients. Normally pain starts as an episodic experience at early cancer phases to become chronic in later stages. In order to improve the quality of life of onc...Pain is unfortunately a quite common symptom for cancer patients. Normally pain starts as an episodic experience at early cancer phases to become chronic in later stages. In order to improve the quality of life of oncological patients, anti-cancer treatments are often accompanied by analgesic therapies. The P2 X receptor are adenosine triphosphate(ATP) gated ion channels expressed by several cells including neurons, cancer and immune cells. Purinergic signaling through P2 X receptors recently emerged as possible common pathway for cancer onset/growth and pain sensitivity. Indeed, tumor microenvironment is rich in extracellular ATP, which has a role in both tumor development and pain sensation. The study of the different mechanisms by which P2 X receptors favor cancer progression and relative pain, represents an interesting challenge to design integrated therapeutic strategies for oncological patients. This review summarizes recent findings linking P2 X receptors and ATP to cancer growth, progression and related pain. Special attention has been paid to the role of P2X2, P2X3, P2X4 and P2X7 in the genesisof cancer pain and to the function of P2X7 in tumor growth and metastasis. Therapeutic implications of the administration of different P2 X receptor blockers to alleviate cancer-associated pain sensations contemporarily reducing tumor progression are also discussed.展开更多
电转气(power to gas, P2G)技术可将电能转化为天然气,在实现综合能源系统低碳经济调度方面发挥着重要作用。为解决P2G过程中O_(2)未充分利用的问题并进一步降低碳排放,文中提出一种考虑P2G富氧改进和混合光能利用的低碳综合能源系统。...电转气(power to gas, P2G)技术可将电能转化为天然气,在实现综合能源系统低碳经济调度方面发挥着重要作用。为解决P2G过程中O_(2)未充分利用的问题并进一步降低碳排放,文中提出一种考虑P2G富氧改进和混合光能利用的低碳综合能源系统。首先,利用P2G生产的O_(2)与CO_(2)混合作为助燃气体,P2G利用碳捕集的CO_(2)制造天然气供给燃气机组使用;然后,因锅炉效率受O_(2)浓度影响,通过遗传算法和Gurobi求解器的联合算法得出耗氧设备各时段的最优供氧状态;最后,通过混合光能利用提升光能效率,以减少化石能源使用。将富氧燃烧和混合光能利用引入综合能源系统,构建考虑P2G富氧改进和混合光能利用的综合能源系统低碳经济运行模型,并设置场景进行对比验证。仿真结果显示,对比富氧改进前CO_(2)排放量降低75.83%,对比无混合光能场景光能总出力增加9.79%,表明所提模型可有效降低碳排放和运行成本。展开更多
随着能源系统互联化和能源交易市场化的高度发展,通过多综合能源系统(Multi-Integrated Energy System,MIES)的区域互联使综合能源系统(Integrated Energy System,IES)的能源利用率更高效、经济收益更可观。首先,文中构建多能源市场背...随着能源系统互联化和能源交易市场化的高度发展,通过多综合能源系统(Multi-Integrated Energy System,MIES)的区域互联使综合能源系统(Integrated Energy System,IES)的能源利用率更高效、经济收益更可观。首先,文中构建多能源市场背景下的MIES合作联盟的能量共享架构,建立MIES之间的电能和备用点对点(Point To Point,P2P)交易模型;其次,对新能源出力的不确定性,电价及备用价格波动风险进行分析,文中采用条件风险价值(Conditional Value-at-Risk,CVaR)理论,构建风险成本函数,并将其纳入综合运行成本模型;最后,选择交替方向乘子法(Alternating Direction Method Of Multipliers,ADMM)进行分布式求解,并通过算例分析验证模型的正确性与合理性,实现MIES运行成本的最小化和支付收益最大化,体现不同条件风险厌恶系数对MIES的影响。展开更多
基金supported by the“Pioneer”and“Leading Goose”R&D Program of Zhejiang Province of China(No.2024C01056)。
文摘Layered oxides have attracted significant attention as cathodes for sodium-ion batteries(SIBs)due to their compositional versatility and tuneable electrochemical performance.However,these materials still face challenges such as structural phase transitions,Na^(+)/vacancy ordering,and Jahn–Teller distortion effect,resulting in severe capacity decay and sluggish ion kinetics.We develop a novel Cu/Y dual-doping strategy that leads to the formation of"Na–Y"interlayer aggregates,which act as structural pillars within alkali metal layers,enhancing structural stability and disrupting the ordered arrangement of Na^(+)/vacancies.This disruption leads to a unique coexistence of ordered and disordered Na^(+)/vacancy states with near-zero strain,which significantly improves Na^(+)diffusion kinetics.This structural innovation not only mitigates the unfavorable P2–O2 phase transition but also facilitates rapid ion transport.As a result,the doped material demonstrates exceptional electrochemical performance,including an ultra-long cycle life of 3000 cycles at 10 C and an outstanding high-rate capability of~70 mAh g^(−1)at 50 C.The discovery of this novel interlayer pillar,along with its role in modulating Na^(+)/vacancy arrangements,provides a fresh perspective on engineering layered oxides.It opens up promising new pathways for the structural design of advanced cathode materials toward efficient,stable,and high-rate SIBs.
基金supported by Guangdong Province Basic and Applied Basic Research Fund Project(2023A1515220104)Open Fund of Key Laboratory of Hepatoaplenic Surgery,Ministry of Education(Award Number:GPKF202407).
文摘Objectives:Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia and Philadelphia-like B-cell acute lymphoblastic leukemia(Ph+/Ph-like ALL)constitute the majority of relapsed/refractory B-ALL(R/R B-ALL)cases,highlighting an urgent need to discover new therapeutic targets.This study aims to elucidate the mechanisms underlying poor prognosis in Ph+/Ph-like ALL through transcriptome sequencing and functional cytological assays,with the goal of informing new clinical treatment strategies.Results:Transcriptomic analysis of Ph+/Ph-like ALL patients revealed that low expression of P2X Purinoceptor 1(P2RX1)was associated with unfavorable outcomes.Specifically,patients with poor prognosis and low P2RX1 expression exhibited downregulation of genes involved in energy and calcium metabolism pathways,along with upregulation of genes governing key cellular processes such as cell proliferation(e.g.,MYC),cell cycle progression(e.g.,CCND2),and apoptosis inhibition(e.g.,DASP6).Cellular experiments demonstrated that SUP-B15 cells overexpressing P2RX1 displayed elevated intracellular levels of ATP,calcium,and glucose,together with enhanced glycolytic capacity,compared to empty vector controls.Treatment of SUP-B15 cells with dexamethasone(Dex),Imatinib,or their combination significantly suppressed proliferation and promoted apoptosis,which was accompanied by increases in intracellular ATP,calcium,and glucose.Moreover,exogenous ATP administration(a P2RX1 agonist)enhanced apoptosis and inhibited proliferation in control cells.Conversely,treatment with NF449(a P2RX1 inhibitor)increased proliferation in both P2RX1-overexpressing and control SUP-B15 cells.Conclusion:Our findings indicate that P2RX1 may exert this function through modulating energy metabolism and calcium homeostasis,resulting in elevated intracellular calcium levels.Sustained elevation of calcium promotes apoptosis,whereas exogenous ATP activates P2RX1,enhances calcium influx,and attenuates the suppression of apoptosis associated with P2RX1 underexpression,ultimately correlating with improved treatment response.
文摘P2P2B模式下云服务投入是工业互联网(industrial internet of things,IIoT)平台的关键战略决策之一.构建由IIoT平台、龙头企业、潜在客户构成的演化博弈模型,研究IIoT平台在公有云研发投入和私有云研发投入中的策略选择,及其与龙头企业的生态合作问题.结果表明:虽然公有云存在数据泄露隐患,但较高的规模收益仍会吸引IIoT平台投入公有云研发,而平台搭建期内龙头企业的高合作意愿会促使平台投入私有云,随着龙头企业合作研发的比例增加,平台又将改变其投入策略.驱动龙头企业合作的因素可以是成本收益、技术提升等直接因素,也可以是规模收益、数据泄露概率等间接因素.最后,基于平台生命周期探讨了初创期、平台搭建期与生态系统期IIoT平台的系统稳定策略,并得到相应的管理启示.
基金Supported by Grants to Elena Adinolfi from the Italian association for Cancer research(MFAG11630)from the Region Emilia Romagna(Young researchers funds,Bando Alessandro Liberati)
文摘Pain is unfortunately a quite common symptom for cancer patients. Normally pain starts as an episodic experience at early cancer phases to become chronic in later stages. In order to improve the quality of life of oncological patients, anti-cancer treatments are often accompanied by analgesic therapies. The P2 X receptor are adenosine triphosphate(ATP) gated ion channels expressed by several cells including neurons, cancer and immune cells. Purinergic signaling through P2 X receptors recently emerged as possible common pathway for cancer onset/growth and pain sensitivity. Indeed, tumor microenvironment is rich in extracellular ATP, which has a role in both tumor development and pain sensation. The study of the different mechanisms by which P2 X receptors favor cancer progression and relative pain, represents an interesting challenge to design integrated therapeutic strategies for oncological patients. This review summarizes recent findings linking P2 X receptors and ATP to cancer growth, progression and related pain. Special attention has been paid to the role of P2X2, P2X3, P2X4 and P2X7 in the genesisof cancer pain and to the function of P2X7 in tumor growth and metastasis. Therapeutic implications of the administration of different P2 X receptor blockers to alleviate cancer-associated pain sensations contemporarily reducing tumor progression are also discussed.
文摘电转气(power to gas, P2G)技术可将电能转化为天然气,在实现综合能源系统低碳经济调度方面发挥着重要作用。为解决P2G过程中O_(2)未充分利用的问题并进一步降低碳排放,文中提出一种考虑P2G富氧改进和混合光能利用的低碳综合能源系统。首先,利用P2G生产的O_(2)与CO_(2)混合作为助燃气体,P2G利用碳捕集的CO_(2)制造天然气供给燃气机组使用;然后,因锅炉效率受O_(2)浓度影响,通过遗传算法和Gurobi求解器的联合算法得出耗氧设备各时段的最优供氧状态;最后,通过混合光能利用提升光能效率,以减少化石能源使用。将富氧燃烧和混合光能利用引入综合能源系统,构建考虑P2G富氧改进和混合光能利用的综合能源系统低碳经济运行模型,并设置场景进行对比验证。仿真结果显示,对比富氧改进前CO_(2)排放量降低75.83%,对比无混合光能场景光能总出力增加9.79%,表明所提模型可有效降低碳排放和运行成本。
文摘随着能源系统互联化和能源交易市场化的高度发展,通过多综合能源系统(Multi-Integrated Energy System,MIES)的区域互联使综合能源系统(Integrated Energy System,IES)的能源利用率更高效、经济收益更可观。首先,文中构建多能源市场背景下的MIES合作联盟的能量共享架构,建立MIES之间的电能和备用点对点(Point To Point,P2P)交易模型;其次,对新能源出力的不确定性,电价及备用价格波动风险进行分析,文中采用条件风险价值(Conditional Value-at-Risk,CVaR)理论,构建风险成本函数,并将其纳入综合运行成本模型;最后,选择交替方向乘子法(Alternating Direction Method Of Multipliers,ADMM)进行分布式求解,并通过算例分析验证模型的正确性与合理性,实现MIES运行成本的最小化和支付收益最大化,体现不同条件风险厌恶系数对MIES的影响。
