Aim To compare lipophilicity measuring scale stemmed from immobilized artificial membrane chromatography and n octanol/buffer systems. Methods A test set consisted of 27 structurally diverse compounds. The lipophilici...Aim To compare lipophilicity measuring scale stemmed from immobilized artificial membrane chromatography and n octanol/buffer systems. Methods A test set consisted of 27 structurally diverse compounds. The lipophilicity of these were evaluated by both immobilized artificial memberane chromatography (IAMC) and n octanol/buffer systems, which were expressed as lg k IAM and lg D O/W,7 4 , respectively. Results With regard to each individual group, good correlation coefficient ( r 2) over 0 81 was obtained (0 82 for acid, 0 88 for neutral, 0 81 for base and 0 92 for ampholyte, respectively). However, a smaller r 2 (0 62) was acquired for all compounds studied than that of each individual group. Conclusion IAMC and n octanol/buffer systems were shown to be different in lipophilicity.展开更多
文摘Aim To compare lipophilicity measuring scale stemmed from immobilized artificial membrane chromatography and n octanol/buffer systems. Methods A test set consisted of 27 structurally diverse compounds. The lipophilicity of these were evaluated by both immobilized artificial memberane chromatography (IAMC) and n octanol/buffer systems, which were expressed as lg k IAM and lg D O/W,7 4 , respectively. Results With regard to each individual group, good correlation coefficient ( r 2) over 0 81 was obtained (0 82 for acid, 0 88 for neutral, 0 81 for base and 0 92 for ampholyte, respectively). However, a smaller r 2 (0 62) was acquired for all compounds studied than that of each individual group. Conclusion IAMC and n octanol/buffer systems were shown to be different in lipophilicity.
