AIM: To perform a meta-analysis to quantitatively summarize the evidence for the association between the Notch signaling pathway and gastric cancer ( GC). METHODS: An electronic search of the MEDLINE, EMBASE and Chine...AIM: To perform a meta-analysis to quantitatively summarize the evidence for the association between the Notch signaling pathway and gastric cancer ( GC). METHODS: An electronic search of the MEDLINE, EMBASE and Chinese National Knowledge Infrastructure, which contain articles published from 1966 onwards, was conducted to select studies for this meta-analysis. RESULTS: Fifteen studies with a total of 1547 gastric cancer cases and 450 controls were included in this meta-analysis. Overall, the expression of Notch1, Notch2, Delta-like 4 and Hes1 was significantly higher in tumor tissues of GC compared to normal tissues. Specifically, stratified analyses showed that significantly increased expression of Notch1 was associated with non-cardia location, > 5 cm size, diffuse type, positive lymphovascular invasion and distal metastasis. Statistically significant higher expression of Notch3 was found in diffuse type GC. Jagged1 was also significantly over-expressed in diffuse type and poor differentiation type of GC. DLL4 was significantly over-expressed in advanced T stage, N stage and TNM stage in GC patients. However, the stratified analysis showed that there was no statistically significant difference in Hes1 expression between different subgroups. Sporadic reports showed that Notch1 and Jagged1 were independent poor prognostic predictors in GC. CONCLUSION: The Notch signaling pathway plays an important role in tumor progression of gastric cancer. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.展开更多
AIM:To investigate the efficacy of the anal fistula plug(AFP) compared to the mucosa advancement flap(MAF),considered the best procedure for patients with a complex anal fistula.METHODS:The literature search included ...AIM:To investigate the efficacy of the anal fistula plug(AFP) compared to the mucosa advancement flap(MAF),considered the best procedure for patients with a complex anal fistula.METHODS:The literature search included PubMed,EMBASE,Cochrane Library and OVID original studies on the topic of AFP compared to MAF for complex fistula-in-ano that had a deadline for publication by April 2011.Randomized controlled trials,controlled clinical trials and prospective cohort studies were included in the review.After information collection,a meta-analysis was performed using data on overall success rates as well as incidence of incontinence and morbidity.The quality of postoperative life was also included with the clinical results.RESULTS:Six studies involving 408 patients(AFP = 167,MAF = 241) were included in the meta-analysis.The differences in the overall success rates and incidence of fistula recurrence were not statistically significant between the AFP and MAF [risk difference(RD) =-0.12,95%CI:-0.39-0.14;RD = 0.13;95%CI:-0.18-0.43,respectively].However,for the AFP,the risk of postoperative impaired continence was lower(RD =-0.08,95%CI:-0.15--0.02) as was the incidence of other complications(RD =-0.06,95%CI:-0.11-0.00).The postoperative quality of life,for patients treated using the AFP was superior to that of the MAF patients.Patients treated with the AFP had less persistent pain of a shorter duration and the healing time of the fistula and hospital stay were also reduced.CONCLUSION:The AFP is an effective procedure for patients with a complex anal fistula;it has the same success rate but a lower risk of complications than the MAF and may also be associated with an improved postoperative quality of life.Additional evidence is needed to confirm these findings.展开更多
目的评价纵切横缝术和肛裂切除术治疗肛裂的疗效及安全性差异。方法计算机检索中国知网、万方数据库、维普中文期刊、PubMed、Web of Science中关于纵切横缝术和肛裂切除术治疗肛裂的临床随机对照试验,检索时间为建库至2024年7月30日,应...目的评价纵切横缝术和肛裂切除术治疗肛裂的疗效及安全性差异。方法计算机检索中国知网、万方数据库、维普中文期刊、PubMed、Web of Science中关于纵切横缝术和肛裂切除术治疗肛裂的临床随机对照试验,检索时间为建库至2024年7月30日,应用RevMan5.3进行Meta分析。结果共纳入12项研究952例患者。Meta分析显示在有效率和治疗前后肛管直径变化方面,纵切横缝术和肛裂切除术无明显差异;纵切横缝术在缩短创面愈合时间、减轻术后疼痛、减少并发症发生、降低复发率等方面均优于肛裂切除术。结论纵切横缝术和肛裂切除术均能有效治疗肛裂,扩大肛管直径,但纵切横缝术相比于肛裂切除术更能有效缩短创面愈合时间,减轻创面疼痛,减少术后并发症的发生,降低复发率。展开更多
目的:基于网状Meta分析方法系统评价7种中药软膏修复肛瘘术后创面的临床疗效。方法:通过计算机检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库、PubMed、Embase、Web of Science及Cochrane Library数据库,搜集中药软膏...目的:基于网状Meta分析方法系统评价7种中药软膏修复肛瘘术后创面的临床疗效。方法:通过计算机检索中国知网、万方数据库、维普数据库、中国生物医学文献数据库、PubMed、Embase、Web of Science及Cochrane Library数据库,搜集中药软膏修复肛瘘术后创面随机对照试验研究,检索时限均为建库至2023年7月。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险,然后采用Stata 17.0和RevMan 5.3软件进行网状Meta分析。结果:本研究共纳入28项随机对照试验研究,包括2 762例患者,涉及7种中药软膏干预措施。网状Meta分析结果显示,在缩短创面愈合时间方面,疗效居前3位的干预措施依次为三黄珍珠膏、九华膏、紫草生肌膏;在提高治愈率方面,疗效居前3位的软膏为九华膏、生肌创愈膏、三黄珍珠膏;在改善疼痛积分方面,疗效居前3位的软膏为三黄珍珠膏、当白生肌膏、九华膏;在改善分泌物积分方面,疗效居前3位的干预措施依次为紫草生肌膏、当白生肌膏、象皮生肌膏。结论:现有证据表明,相较于常规换药处理,中药软膏能够减少创面分泌物,有效改善术后疼痛等临床症状,不同程度地缩短肛瘘术后创面愈合时间,提高临床治愈率。但是受纳入研究数量和文献质量的限制,上述结论尚需更多高质量研究予以验证。展开更多
目的探讨人乳头状瘤病毒(HPV)与鼻腔鼻窦内翻性乳头状瘤(SNIP)发生、复发及恶变的关系。方法检索Pubmed、Web of science、Embase、Cochrane Library、CNKI、维普、中国知网及万方等数据库,查找2000~2017年国内外公开发表的HPV与SNIP发...目的探讨人乳头状瘤病毒(HPV)与鼻腔鼻窦内翻性乳头状瘤(SNIP)发生、复发及恶变的关系。方法检索Pubmed、Web of science、Embase、Cochrane Library、CNKI、维普、中国知网及万方等数据库,查找2000~2017年国内外公开发表的HPV与SNIP发生、复发及恶变相关的所有病例对照研究文献,应用RevMan 5.3统计软件对各研究原始数据进行统计分析。结果 Meta分析示SNIP组HPV感染率明显高于对照组(P<0.01,OR=19.72,95%CI为7.91~49.18);复发组HPV感染率明显高于对照组(P<0.01,OR=3.10,95%CI为1.90~5.08);恶变组HPV感染率明显高于对照组(P<0.01,OR=2.09,95%CI为1.41~3.09)。结论 HPV感染与SNIP的发生、复发及恶变密切相关。展开更多
目的系统评价脉血康胶囊治疗冠心病心绞痛的疗效。方法检索Cochrane Central Register of Controlled Trials(CENTRAL,2012年2月第二期)、PUBMED、中国生物医学文献数据库、万方期刊论文数据库、维普期刊资源整合服务平台、中国学术期...目的系统评价脉血康胶囊治疗冠心病心绞痛的疗效。方法检索Cochrane Central Register of Controlled Trials(CENTRAL,2012年2月第二期)、PUBMED、中国生物医学文献数据库、万方期刊论文数据库、维普期刊资源整合服务平台、中国学术期刊网络出版总库,时间均为建库至2013年12月,纳入符合标准的临床随机对照试验,并进行纳入研究的参考文献以及心血管相关杂志及会议报告的人工检索。经过文献筛选,对符合标准的临床随机对照试验进行Meta分析。结果最终纳入9项研究,包括577例冠心病患者。9项研究都对脉血康胶囊治疗冠心病进行了临床疗效分析,其总OR值为4.69,95%CI为(3.27,6.72),P<0.000 01;3项对心电图有效改变进行了分析,其总OR值为1.83,95%CI为(1.15,2.92),P=0.01。结论脉血康胶囊对冠心病能产生较好的临床疗效,并且能有效改善心电图。展开更多
目的系统整合中国MSM发生无保护性肛交影响因素的质性研究,为实施有效干预,减少艾滋病传播提供循证依据。方法计算机检索PubMed、Web of Science、CINHAL、Embase、Cochrane Library、中国知网、万方数据库等数据库中关于中国MSM发生无...目的系统整合中国MSM发生无保护性肛交影响因素的质性研究,为实施有效干预,减少艾滋病传播提供循证依据。方法计算机检索PubMed、Web of Science、CINHAL、Embase、Cochrane Library、中国知网、万方数据库等数据库中关于中国MSM发生无保护性肛交影响因素的质性研究,检索时限为建库至2024年7月,根据JBI循证卫生保健中心质性研究质量评价标准对所筛选的文献进行质量评价,使用汇集性整合法进行结果整合。结果共纳入13篇文献,提取出45个研究结果,归纳为12个类别,对中国MSM发生无保护性肛交的影响因素可以整合为5个结果:MSM对安全套的态度和认知、MSM对艾滋病的态度和认知、MSM发生无保护性肛交的个体因素、MSM发生无保护性肛交的群体因素、MSM在无保护性肛交前的物质和药物使用。结论中国MSM发生无保护性肛交的行为受多方面因素影响,应采取综合及个性化措施对其进行干预,提高安全套的使用率,普及相关知识,减少HIV的传播。展开更多
基金Supported by National Natural Science Foundation of China,No.81071777Sichuan Province Science and Technology Support Program,No.2011SZ0293 and No.2011SZ0087
文摘AIM: To perform a meta-analysis to quantitatively summarize the evidence for the association between the Notch signaling pathway and gastric cancer ( GC). METHODS: An electronic search of the MEDLINE, EMBASE and Chinese National Knowledge Infrastructure, which contain articles published from 1966 onwards, was conducted to select studies for this meta-analysis. RESULTS: Fifteen studies with a total of 1547 gastric cancer cases and 450 controls were included in this meta-analysis. Overall, the expression of Notch1, Notch2, Delta-like 4 and Hes1 was significantly higher in tumor tissues of GC compared to normal tissues. Specifically, stratified analyses showed that significantly increased expression of Notch1 was associated with non-cardia location, > 5 cm size, diffuse type, positive lymphovascular invasion and distal metastasis. Statistically significant higher expression of Notch3 was found in diffuse type GC. Jagged1 was also significantly over-expressed in diffuse type and poor differentiation type of GC. DLL4 was significantly over-expressed in advanced T stage, N stage and TNM stage in GC patients. However, the stratified analysis showed that there was no statistically significant difference in Hes1 expression between different subgroups. Sporadic reports showed that Notch1 and Jagged1 were independent poor prognostic predictors in GC. CONCLUSION: The Notch signaling pathway plays an important role in tumor progression of gastric cancer. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
文摘AIM:To investigate the efficacy of the anal fistula plug(AFP) compared to the mucosa advancement flap(MAF),considered the best procedure for patients with a complex anal fistula.METHODS:The literature search included PubMed,EMBASE,Cochrane Library and OVID original studies on the topic of AFP compared to MAF for complex fistula-in-ano that had a deadline for publication by April 2011.Randomized controlled trials,controlled clinical trials and prospective cohort studies were included in the review.After information collection,a meta-analysis was performed using data on overall success rates as well as incidence of incontinence and morbidity.The quality of postoperative life was also included with the clinical results.RESULTS:Six studies involving 408 patients(AFP = 167,MAF = 241) were included in the meta-analysis.The differences in the overall success rates and incidence of fistula recurrence were not statistically significant between the AFP and MAF [risk difference(RD) =-0.12,95%CI:-0.39-0.14;RD = 0.13;95%CI:-0.18-0.43,respectively].However,for the AFP,the risk of postoperative impaired continence was lower(RD =-0.08,95%CI:-0.15--0.02) as was the incidence of other complications(RD =-0.06,95%CI:-0.11-0.00).The postoperative quality of life,for patients treated using the AFP was superior to that of the MAF patients.Patients treated with the AFP had less persistent pain of a shorter duration and the healing time of the fistula and hospital stay were also reduced.CONCLUSION:The AFP is an effective procedure for patients with a complex anal fistula;it has the same success rate but a lower risk of complications than the MAF and may also be associated with an improved postoperative quality of life.Additional evidence is needed to confirm these findings.
文摘目的评价纵切横缝术和肛裂切除术治疗肛裂的疗效及安全性差异。方法计算机检索中国知网、万方数据库、维普中文期刊、PubMed、Web of Science中关于纵切横缝术和肛裂切除术治疗肛裂的临床随机对照试验,检索时间为建库至2024年7月30日,应用RevMan5.3进行Meta分析。结果共纳入12项研究952例患者。Meta分析显示在有效率和治疗前后肛管直径变化方面,纵切横缝术和肛裂切除术无明显差异;纵切横缝术在缩短创面愈合时间、减轻术后疼痛、减少并发症发生、降低复发率等方面均优于肛裂切除术。结论纵切横缝术和肛裂切除术均能有效治疗肛裂,扩大肛管直径,但纵切横缝术相比于肛裂切除术更能有效缩短创面愈合时间,减轻创面疼痛,减少术后并发症的发生,降低复发率。
文摘目的系统评价脉血康胶囊治疗冠心病心绞痛的疗效。方法检索Cochrane Central Register of Controlled Trials(CENTRAL,2012年2月第二期)、PUBMED、中国生物医学文献数据库、万方期刊论文数据库、维普期刊资源整合服务平台、中国学术期刊网络出版总库,时间均为建库至2013年12月,纳入符合标准的临床随机对照试验,并进行纳入研究的参考文献以及心血管相关杂志及会议报告的人工检索。经过文献筛选,对符合标准的临床随机对照试验进行Meta分析。结果最终纳入9项研究,包括577例冠心病患者。9项研究都对脉血康胶囊治疗冠心病进行了临床疗效分析,其总OR值为4.69,95%CI为(3.27,6.72),P<0.000 01;3项对心电图有效改变进行了分析,其总OR值为1.83,95%CI为(1.15,2.92),P=0.01。结论脉血康胶囊对冠心病能产生较好的临床疗效,并且能有效改善心电图。
文摘目的系统整合中国MSM发生无保护性肛交影响因素的质性研究,为实施有效干预,减少艾滋病传播提供循证依据。方法计算机检索PubMed、Web of Science、CINHAL、Embase、Cochrane Library、中国知网、万方数据库等数据库中关于中国MSM发生无保护性肛交影响因素的质性研究,检索时限为建库至2024年7月,根据JBI循证卫生保健中心质性研究质量评价标准对所筛选的文献进行质量评价,使用汇集性整合法进行结果整合。结果共纳入13篇文献,提取出45个研究结果,归纳为12个类别,对中国MSM发生无保护性肛交的影响因素可以整合为5个结果:MSM对安全套的态度和认知、MSM对艾滋病的态度和认知、MSM发生无保护性肛交的个体因素、MSM发生无保护性肛交的群体因素、MSM在无保护性肛交前的物质和药物使用。结论中国MSM发生无保护性肛交的行为受多方面因素影响,应采取综合及个性化措施对其进行干预,提高安全套的使用率,普及相关知识,减少HIV的传播。
