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Research Progress and Prospect of Biofeedback Technology Combined with Occupational Therapy in Hand Function Rehabilitation after Stroke
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作者 Guokai Gu Guodi Wen +4 位作者 Yuhao Li Ya Kong Kun Chen Debin Li Xiao Chen 《Journal of Clinical and Nursing Research》 2025年第12期146-151,共6页
Hand function impairment after stroke has become a key and difficult issue in clinical rehabilitation due to complex neural innervation and a long recovery cycle.Biofeedback technology combined with occupational thera... Hand function impairment after stroke has become a key and difficult issue in clinical rehabilitation due to complex neural innervation and a long recovery cycle.Biofeedback technology combined with occupational therapy can make up for the limitations of single therapy and provide a new solution for hand function rehabilitation after stroke.This paper systematically sorts out the theoretical basis and clinical research progress of biofeedback technology combined with occupational therapy in hand function rehabilitation after stroke,and looks forward to the future development direction,aiming to provide reference for clinical rehabilitation practice and scientific research. 展开更多
关键词 STROKE hand function rehabilitation Biofeedback technology Occupational therapy NEUROPLASTICITY
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Occupational therapy with or without combined acupuncture on upper limb pain and hand functions in children with spastic hemiplegic cerebral palsy:A three-arm randomized,placebo-controlled trial 被引量:3
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作者 Fei-yi ZHAO Yan XU +4 位作者 Li-ping YUE Si-han CHEN Xiao-jie XIA Ci HAN Qiang-qiang FU 《World Journal of Acupuncture-Moxibustion》 CSCD 2022年第1期1-8,共8页
Objective:This study is conducted to investigate the effects of occupational therapy(OT) with or without combined acupuncture for upper limb pain and hand functions among children with spastic hemiplegic cerebral pals... Objective:This study is conducted to investigate the effects of occupational therapy(OT) with or without combined acupuncture for upper limb pain and hand functions among children with spastic hemiplegic cerebral palsy.Methods:A total of 90 patients who met the inclusion criteria were enrolled in a three-arm randomized,placebo-controlled trial,and were allocated to mono-occupational therapy(OT) group(patients=30),OT combined with real-acupuncture(ORA) group(patients=30),and OT combined with placeboacupuncture(OPA) group(patients=30),respectively.In addition to receiving the conventional OT program as the basic treatment for total 8 weeks,patients in ORA and OPA group also received corresponding acupuncture treatment 5 days per week for the first two weeks,3 days per week for the next two weeks,2 days per week for another two weeks,and 1 day per week for the last two weeks.Non-communicating children’s pain checklist-revised scale(NCCPC-R) was used for assessing the upper limb pain among patients.Squeeze dynamometry,modified Ashworth scale(MAS),manual muscle testing(MMT),JebsenTaylor hand function test(JTHFT) and box and block test(BBT) were used for assessing various aspects of upper limb and hand functions among patients.Meanwhile,adverse effects were monitored and recorded.Results:After 8-week treatment,NCCPC-R global scores witnessed a dramatic decline in ORA group(P<0.05),but not in either OPA(P> 0.05) or OT group(P> 0.05).Dramatic increases were identified in both squeeze dynamometry scores and MMT scores in all three groups(all P <0.05).Furthermore,the increases of ORA group were more significant than those of another two groups(both P <0.05).There were no significant changes in MAS global scores in each group(all P> 0.05).The BBT global scores of all three groups significantly increased(all P <0.05) after treatment.Among them,the increase of the ORA group was more than that of the other two groups(P <0.05).The 8-week treatment also had a significant impact on several sub-tests of JTFHT in each group.No significant adverse event was reported.Conclusion:ORA is a potential and promising alternative therapy for mitigating upper limb pain as well as improving both upper limb and hand functions among children with spastic hemiplegic cerebral palsy. 展开更多
关键词 Occupational therapy ACUPUNCTURE Placebo-acupuncture PAIN hand functions Spastic hemiplegic cerebral palsy
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Research on Key Technologies of Hand Function Rehabilitation Training Evaluation System Based on Leap Motion 被引量:1
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作者 Zhiguo Xiao Yifei Zhao +2 位作者 Nianfeng Li Shang Zhou Hu Xu 《Journal of Computer and Communications》 2021年第1期19-35,共17页
This paper proposes an immersive training system for patients with hand dysfunction who can perform rehabilitation training independently. The system uses Leap Motion binocular vision sensors to collect human hand inf... This paper proposes an immersive training system for patients with hand dysfunction who can perform rehabilitation training independently. The system uses Leap Motion binocular vision sensors to collect human hand information, and uses the improved PCA<sub><img src="Edit_d6662636-9073-4fbd-855f-9a36e871d5a4.png" width="10" height="15" alt="" /></sub> (Principal Component Analysis) to perform data fusion on the real-time data collected by the sensor to obtain more hands with fewer principal components, and improve the stability and accuracy of the data. Immediately, the use of improved SVM<sub><img src="Edit_10c78725-e09e-4dcf-ae05-e21205df4acc.png" width="10" height="15" alt="" /></sub> (Support Vector Machine) and KNN<sub><img src="Edit_0ee97f55-2773-4b48-93b3-93f61aa25577.png" width="10" height="15" alt="" /></sub> (K-Nearest Neighbor Algorithm) for gesture recognition and classification is proposed to enable patients to perform rehabilitation training more effectively. Finally, the effective evaluation results of the rehabilitation effect of patients by the idea of AHP<sub><img src="Edit_70dd1964-28be-4137-afa5-9a184704f08e.png" width="10" height="15" alt="" /></sub> (Analytic Hierarchy Process) are taken as necessary reference factors for doctors to follow up treatment. Various experimental results show that the system has achieved the expected results and has a good application prospect. 展开更多
关键词 Leap Motion IMMERSIVE AHP PCA SVM KNN hand function Rehabilitation Evaluation System
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Supplementary motor area deactivation impacts the recovery of hand function from severe peripheral nerve injury 被引量:2
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作者 Ye-chen Lu Han-qiu Liu +4 位作者 Xu-yun Hua Yun-dong Shen Wen-dong Xu Jian-guang Xu Yu-dong Gu 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第4期670-675,共6页
Although some patients have successful peripheral nerve regeneration,a poor recovery of hand function often occurs after peripheral nerve injury.It is believed that the capability of brain plasticity is crucial for th... Although some patients have successful peripheral nerve regeneration,a poor recovery of hand function often occurs after peripheral nerve injury.It is believed that the capability of brain plasticity is crucial for the recovery of hand function.The supplementary motor area may play a key role in brain remodeling after peripheral nerve injury.In this study,we explored the activation mode of the supplementary motor area during a motor imagery task.We investigated the plasticity of the central nervous system after brachial plexus injury,using the motor imagery task.Results from functional magnetic resonance imaging showed that after brachial plexus injury,the motor imagery task for the affected limbs of the patients triggered no obvious activation of bilateral supplementary motor areas.This result indicates that it is difficult to excite the supplementary motor areas of brachial plexus injury patients during a motor imagery task,thereby impacting brain remodeling.Deactivation of the supplementary motor area is likely to be a serious problem for brachial plexus injury patients in terms of preparing,initiating and executing certain movements,which may be partly responsible for the unsatisfactory clinical recovery of hand function. 展开更多
关键词 nerve regeneration peripheral nerve injury brachial plexus injury neuronal plasticity supplementary motor area premotor area magnetic resonance imaging motor preparation motor imagery clinical restoration of hand function cortical remodeling block design neural regeneration
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Hand Function among Patients with Carpal Tunnel Syndrome
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作者 Israa Anwar Afshan Ameer +2 位作者 Shehryar Azam Mehwish Khalid Hafiz Muhammad Asim 《Open Journal of Therapy and Rehabilitation》 2019年第4期170-177,共8页
Background: Carpal Tunnel Syndrome (CTS) is the compression of the median nerve in carpal tunnel of wrist which leads to the typical symptoms of numbness, paresthesia and sometimes pain in the patient’s hand. The sym... Background: Carpal Tunnel Syndrome (CTS) is the compression of the median nerve in carpal tunnel of wrist which leads to the typical symptoms of numbness, paresthesia and sometimes pain in the patient’s hand. The symptoms are usually sensed in the first three radial fingers and the lateral side of the ring finger because these areas are innervated by the median nerve. Objective: To assess hand function among patient with Carpal Tunnel Syndrome (CTS). Methods: This was a descriptive study in which 41 subjects (27 females and 14 males) were included from Ghurki trust teaching hospital, Lahore and Shalamar hospital, Lahore (from August 2018 to October 2018) according to inclusion criteria. Samples were collected according to WHO (World Health Organization) calculator. Hand function was measured with Boston Carpal Tunnel Questionnaire (BCTQ). Results: Majority of the patients with CTS fell into mild functional severity and mild symptom severity. The mean score for functional severity was 2.34 and for symptom severity it was 2.97. Conclusion: Activities of daily living such as grasping, writing, gripping and carrying objects were affected by the symptoms of pain, numbness, tingling and weakness in the patients suffering from CTS. 展开更多
关键词 CARPAL TUNNEL SYNDROME BOSTON CARPAL TUNNEL QUESTIONNAIRE hand function
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Changes in motor function in the unaffected hand of stroke patients should not be ignored
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作者 Lingli Zhang Peihong Li +3 位作者 Zhibang Mao Xiang Qi Jun Zou Zhusheng Yu 《Neural Regeneration Research》 SCIE CAS CSCD 2014年第13期1323-1328,共6页
Motor function changes in the unaffected hand of stroke patients with hemiplegia. These changes are often ignored by clinicians owing to the extent of motor disability of the affected hand. Finger tapping frequency an... Motor function changes in the unaffected hand of stroke patients with hemiplegia. These changes are often ignored by clinicians owing to the extent of motor disability of the affected hand. Finger tapping frequency and Lind-mark hand function score showed that the motor function of unaffected hands in stroke patients was poorer than that of a healthy control hand. After 2 weeks of rehabilitation treatment, motor function of the unaffected hand of stroke patients was obviously improved. Therefore, attention should also be paid to motor function in the unaffected hand of stroke patients with hemiplegia during rehabilitation. 展开更多
关键词 nerve regeneration STROKE unaffected hand dominant hand right hand finger tapping Lind-mark hand function assessment rehabilitation training neural regeneration
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Difference in cortical activation during use of volar and dorsal hand splints:a functional magnetic resonance imaging study
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作者 Sung Ho Jang Woo Hyuk Jang 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第8期1274-1277,共4页
There have been no studies reported on the difference in cortical activation during use of volar and dorsal hand splints.We attempted to investigate the difference in cortical activation in the somatosensory cortical ... There have been no studies reported on the difference in cortical activation during use of volar and dorsal hand splints.We attempted to investigate the difference in cortical activation in the somatosensory cortical area during use of volar and dorsal hand splints by functional magnetic resonance imaging(f MRI).We recruited eight healthy volunteers.f MRI was performed while subjects who were fitted with volar or dorsal hand splints performed grasp-release movements.Regions of interest were placed on the primary motor cortex(M1),primary somatosensory cortex(S1),posterior parietal cortex(PPC),and secondary somatosensory cortex(S2).Results of group analysis of f MRI data showed that the total numbers of activated voxels in all ROIs were significantly higher during use of volar hand splint(3,376) compared with that(1,416) during use of dorsal hand splint.In each ROI,use of volar hand splint induced greater activation in all ROIs(M1:1,748,S1 :1,455,PPC:23,and S2:150) compared with use of dorsal hand splint(M1:783,S1:625,PPC:0,and S2:8).The peak activated value was also higher during use of volar hand splint(t-value:17.29) compared with that during use of dorsal hand splint(t-value:13.11).Taken together,use of volar hand splint induced greater cortical activation relevant to somatosensory function than use of dorsal hand splint.This result would be important for the physiatrist and therapist to apply appropriate somatosensory input in patients with brain injury. 展开更多
关键词 nerve regeneration functional MRI hand splint somatosensory function dorsal hand splint volar hand splint neural regeneration
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Evaluation of the Curative Effect of "Xingnao Kaiqiao" Acupuncture Based on Brunnstrom Staging on Upper Limb and Hand Motor Function in the Recovery Period after Stroke 被引量:1
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作者 CHEN Zeng-li WANG Xin-min +3 位作者 CAO Ying-ying LIU Long-long LI Xin-ying GONG Fa-tao 《World Journal of Integrated Traditional and Western Medicine》 2020年第9期1-6,共6页
Objective: To observe the effects of Xingnao Kaiqiao acupuncture(醒脑开窍针) on the motor function of upper limb and hand in the recovery period after stroke. Methods: Seventy-six cases of hemiplegia patients with isc... Objective: To observe the effects of Xingnao Kaiqiao acupuncture(醒脑开窍针) on the motor function of upper limb and hand in the recovery period after stroke. Methods: Seventy-six cases of hemiplegia patients with ischemic stroke were divided into the treatment group and the control group(n=38 in each). Based on the Brunnstrom's stage of Xingnao Kaiqiao acupuncture combined with rehabilitation training was used in the treatment group, and the control group was given rehabilitation training. FuglMeyer Assessment of the upper extremity(FMA-UE), Action Research Arm Test(ARAT) and Simple Test for Evaluating hand Function(STEF) were adopted separately to compare scores before treatment and 8 weeks after treatment. Results: The difference was not statistically significant in the two groups of patients for comparison of FMA-UE, ARAT and STEF scores before treatment(P>0.05). The difference was statistically significant in the two groups of score comparison of FMA-UE, ARAT and STEF after treatment(P<0.05). Conclusion: The Xingnao Kaiqiao acupuncture has its unique advantages in improving recovery of motor function of upper limb and hand in recovery period after stroke. 展开更多
关键词 Brunnstrom stage Xingnao Kaiqiao acupuncture Recovery period of cerebral ischemic stroke Motor function of upper limb and hand
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Processing Chinese hand-radicals activates the medial frontal gyrus A functional MRI investigation
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作者 Qing-Lin Wu Yu-Chen Chan +3 位作者 Joseph P.Lavallee Hsueh-Chin Chen Kuo-En Chang Yao-Ting Sung 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第20期1837-1843,共7页
Embodied semantics theory asserts that the meaning of action-related words is neurally represented through networks that overlap with or are identical to networks involved in sensory-motor processing. While some studi... Embodied semantics theory asserts that the meaning of action-related words is neurally represented through networks that overlap with or are identical to networks involved in sensory-motor processing. While some studies supporting this theory have focused on Chinese characters, less attention has been paid to their semantic radicals. Indeed, there is still disagreement about whether these radicals are processed independently. The present study investigated whether radicals are processed separately and, if so, whether this processing occurs in sensory-motor regions. Materials consisted of 72 high-frequency Chinese characters, with 18 in each of four categories: hand-action verbs with and without hand-radicals, and verbs not related to hand actions, with and without hand-radicals. Twenty-eight participants underwent functional MRI scans while reading the characters. Compared to characters without hand-radicals, reading characters with hand-radicals activated the right medial frontal gyrus. Verbs involving hand-action activated the left inferior parietal lobule, possibly reflecting integration of information in the radical with the semantic meaning of the verb. The findings may be consistent with embodied semantics theory and suggest that neural representation of radicals is indispensable in processing Chinese characters. 展开更多
关键词 neural regeneration NEUROIMAGING functional MRI hand-radical radical representation Chinese character recognition embodied semantics semantic function Chinese learning grants-supported paper NEUROREGENERATION
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Post-stroke hand motor impairment treated with acupuncture at Zhōngzhǔ(中渚 TE 3) and Wàiguān(外关 TE 5) 被引量:4
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作者 程先宽 王征美 +1 位作者 孙岚 李玉华 《World Journal of Acupuncture-Moxibustion》 2011年第3期15-19,共5页
Objective To observe the therapeutic effects of post-stroke hand motor impairment treated with acupuncture at Zhongzhu (中渚 TE 3) and Waiguan (外关TE 5). Methods Sixty cases of post-stroke hand motor impairment w... Objective To observe the therapeutic effects of post-stroke hand motor impairment treated with acupuncture at Zhongzhu (中渚 TE 3) and Waiguan (外关TE 5). Methods Sixty cases of post-stroke hand motor impairment were randomly divided into an observation group and a control group, 30 cases in each one. The conventional medication, physical therapy, occupational therapy and other rehabilitation trainings were applied in both groups. In observation group, Zhongzhu (中渚 TE 3) and Waiguan (外关TE 5) were punctured. The assessment was performed with neurologie deficit scoring of the National Institutes of Health Stroke Scale (NIHSS), hand motor function, walking ability and the modified Barthel index scale of the Activities of Daily Living (ADL) in both groups before and after treatment. Results After treatment, the scores of hand function, walking ability, ADL and NIHSS were improved in both groups as compared with those before treatment (all P〈0.01). The improvements of hand function, walking ability and ADL :in observation group were superior to those in control group (all P〈0.05). Conclusion The conventional medication and rehabilitation trainings combined with acupuncture at Zhongzhu (中渚 TE 3) and Waiguan (外关TE 5) ean obviously improve hand motor function, walking ability, the activities of daily living and rehabilitation efficacy in the patients with post-stroke hand motor impairment. 展开更多
关键词 Stroke functional Impairment of hand Acupuncture Therapy Point Zhongzhu (中渚 TE 3) Point Waiguan (外关TE 5)
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镜像疗法联合手部康复矫正器对脑卒中后手功能障碍患者手功能恢复的影响
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作者 李慧君 陈和木 +3 位作者 吴江玲 严奇才 王泽慧 李皖玉 《右江民族医学院学报》 2026年第1期35-41,共7页
目的探讨镜像疗法联合手部康复矫正器对脑卒中后手功能障碍患者手功能恢复的影响。方法选取2023年11月至2024年5月安庆医药高等专科学校临床研究中心康复医学科收治的脑卒中后手功能障碍患者60例,随机分为对照组、观察组与研究组,每组2... 目的探讨镜像疗法联合手部康复矫正器对脑卒中后手功能障碍患者手功能恢复的影响。方法选取2023年11月至2024年5月安庆医药高等专科学校临床研究中心康复医学科收治的脑卒中后手功能障碍患者60例,随机分为对照组、观察组与研究组,每组20例。对照组接受常规康复训练,观察组在常规训练基础上增加镜像疗法,研究组则在常规训练基础上联合应用镜像疗法与手部康复矫正器。治疗4周后,比较3组患者的上肢及手部运动功能、手握力与捏力、日常生活活动能力等指标。结果治疗后,研究组在各项评估中改善最为显著:Fugl-Meyer评分(59.25±7.43)分显著高于观察组(45.50±5.36)分,t=6.716,P<0.001;Brunnstrom分期达(5.00±1.03)分(接近分离运动阶段),高于观察组的(3.55±0.76)分;日常生活能力(MBI)评分(69.95±12.28)分显著高于对照组(54.15±10.31)分,t=5.098,P<0.001;手握力与捏力提升幅度最大(与观察组比较,t=6.131,P<0.001;t=5.363,P<0.001);Ashworth肌张力评分从(3.85±1.13)分降至(1.70±0.57)分,t=7.583,P<0.001;WMFT评分达(40.10±4.34)分,显著高于观察组的(28.70±3.65)分,t=8.983,P<0.001;SF-36量表在社交功能、生理功能等维度亦有明显改善。结论镜像疗法联合手部康复矫正器可显著改善脑卒中后手功能障碍患者的运动功能、肌张力、日常生活活动能力及生活质量,其疗效优于单一康复手段。 展开更多
关键词 卒中 手功能 镜像疗法 手部康复矫正器
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佩戴腕手矫形器对脑卒中患者手功能障碍作用的Meta分析
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作者 高峰 张俊 +5 位作者 余文君 单于玉婧 赵乐 胡雨婷 王俊华 刘永富 《中国组织工程研究》 北大核心 2026年第8期2124-2131,共8页
目的:腕手矫形器是一种常见的上肢功能障碍康复辅具,对脑卒中后手功能障碍患者的疗效存在争议。该文系统评价腕手矫形器对脑卒中患者手功能障碍的康复效果。方法:系统检索中国知网、万方、维普、SinoMed、PubMed、Embase、Web of Scienc... 目的:腕手矫形器是一种常见的上肢功能障碍康复辅具,对脑卒中后手功能障碍患者的疗效存在争议。该文系统评价腕手矫形器对脑卒中患者手功能障碍的康复效果。方法:系统检索中国知网、万方、维普、SinoMed、PubMed、Embase、Web of Science、Cochrane Library等数据库公开发表的腕手矫形器在脑卒中患者手功能康复中应用的随机对照试验,其中试验组采用腕手矫形器和常规康复治疗,对照组采用常规康复治疗,检索时限为各数据库建库到2024年7月。由2位研究者独立开展文献筛选、提取资料,并依据Cochrane风险偏倚评估工具评价文献质量,使用RevMan 5.4软件进行Meta分析。结果:最终纳入8篇文献,共305例患者。Meta分析结果显示:试验组改良Ashworth评分低于对照组[MD=-0.24,95%CI(-0.36,-0.12),P<0.0001],Fugl-Meyer上肢运动功能评分和改良Barthel评分[SMD=0.97,95%CI(0.51,1.43),P<0.0001;SMD=1.00,95%CI(0.05,1.94),P=0.04]均高于对照组,两组握力比较差异无显著性意义[MD=-0.89,95%CI(-5.37,3.58),P=0.70]。结论:腕手矫形器能够降低脑卒中患者腕手关节肌张力,提高患者手运动功能与日常生活活动能力,但对患者握力无明显改善。需注意的是,研究总样本量仅305例,且部分指标(如握力)仅纳入2篇文献,统计效力不足,未来需更多大样本、高质量的随机对照试验进行验证。 展开更多
关键词 脑卒中 手功能 手功能障碍 腕手矫形器 META分析
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基于功能性电刺激技术的脑卒中后手功能康复训练系统设计
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作者 雷佳琪 曹瑞娟 梁杨 《医疗卫生装备》 2026年第1期21-27,共7页
目的:针对传统脑卒中后手功能康复训练系统存在运动模式单一、控制系统缺乏实时性和精准性等问题,设计一种基于功能性电刺激(functional electrical stimulation,FES)技术的手功能康复训练系统。方法:手功能康复训练系统的硬件以Arduino... 目的:针对传统脑卒中后手功能康复训练系统存在运动模式单一、控制系统缺乏实时性和精准性等问题,设计一种基于功能性电刺激(functional electrical stimulation,FES)技术的手功能康复训练系统。方法:手功能康复训练系统的硬件以Arduino UNO R3开发板作为核心控制器,主要由可穿戴设备、被动运动训练模块、电刺激装置组成。其中,可穿戴设备内部配备Flex Sensor弯曲度传感器、MPU6050角度传感器、Flexiforce薄膜压力力敏传感器、SHT30温湿度传感器以及ST021加热片;被动运动训练模块由SG90舵机和连接机构组成;电刺激装置采用三轴独立调节机制,以自适应调控模块为核心,配备2套独立的刺激单元。该系统的软件依托Android Studio平台,采用Java语言开发。基于开源仿真平台(OpenSim)构建手部肌肉骨骼模型,将虚拟康复仿真平台(RCareWorld)的标准康复系统和比例-积分-微分(proportional-integral-derivative,PID)控制外骨骼系统作为对比对象,验证手功能康复训练系统的有效性与可靠性。结果:该系统具有被动运动和自主运动模式,可通过电刺激激活脑卒中后患者的手部肌肉并促进血液循环,还可自动记录单次运动的详细数据并形成训练报告,生成个性化的康复方案。验证结果显示,与RCareWorld的标准康复系统和PID控制外骨骼系统相比,该系统通过动态参数调节有效延缓了患者的疲劳进程,实现了更优的肌力维持和运动表现。结论:该系统具有多模式、精准个性化适配等优势,可为脑卒中后患者的手功能康复提供高效、可行的康复方案。 展开更多
关键词 FES 脑卒中 手功能康复 智能康复设备 可穿戴设备
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透明质酸与脂肪胶填充对断指再植术后指体萎缩患者手功能及生活质量的影响对比
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作者 杜康 薛士辉 杨传进 《中国美容医学》 2026年第1期29-32,共4页
目的:探讨透明质酸和脂肪胶填充对断指再植术后指体萎缩患者手功能及生活质量的影响。方法:选取2020年1月-2024年1月笔者科室收治的102例断指再植术后出现指体萎缩的患者作为研究对象,采用随机数字表法分为脂肪移植组和透明质酸组,每组5... 目的:探讨透明质酸和脂肪胶填充对断指再植术后指体萎缩患者手功能及生活质量的影响。方法:选取2020年1月-2024年1月笔者科室收治的102例断指再植术后出现指体萎缩的患者作为研究对象,采用随机数字表法分为脂肪移植组和透明质酸组,每组51例,两组萎缩指体皮下分别填充脂肪胶和透明质酸。填充后随访1个月,对两组患者手功能[密歇根州手功能评估量表(Michigan Hand Outcomes Questionnaire,MHQ)]、两点辨别觉、生活质量(Barthel指数)、手功能优良率(中华医学会外科学会断指再植功能评定标准)及并发症进行评定,并进行统计比较。结果:填充1个月后,脂肪移植组患者疼痛评分低于透明质酸组,但外观、日常活动、工作情况、手功能满意度以及手整体功能评分均高于透明质酸组(P<0.05);脂肪移植组患者Barthel指数高于透明质酸组(P<0.05),两点辨别觉距离短于透明质酸组(P<0.05);两组患者手功能恢复优良率及并发症发生情况比较差异无统计学意义(P>0.05)。结论:脂肪胶填充对断指再植术后指体萎缩患者手功能和生活质量的改善作用优于透明质酸,且安全性好,值得临床推荐。 展开更多
关键词 断指再植术 透明质酸 自体脂肪 脂肪胶 手功能 生活质量
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神经镜像激活康复理念对脑卒中后肩手综合征患者的效果
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作者 温瑞丽 古丽红 +2 位作者 梁万仟 梁洪铨 巫李雄 《中外医学研究》 2026年第2期95-98,102,共5页
目的:分析神经镜像激活康复理念对脑卒中后肩手综合征患者的效果。方法:选取2022年10月—2023年11月于广西壮族自治区荣誉军人康复医院就诊的80例SHSⅠ期患者为研究对象。根据简单随机化法将其分为经典组和分析组,每组各40例。经典组接... 目的:分析神经镜像激活康复理念对脑卒中后肩手综合征患者的效果。方法:选取2022年10月—2023年11月于广西壮族自治区荣誉军人康复医院就诊的80例SHSⅠ期患者为研究对象。根据简单随机化法将其分为经典组和分析组,每组各40例。经典组接受常规康复训练,分析组接受经镜像激活康复理念支持的康复训练。对最终汇总结果进行分析。结果:康复效应层级分布数据结果显示,分析组神经-运动整合康复水平较经典组佳,差异有统计学意义(P<0.05)。对神经源性疼痛指数变化情况研究,分析组干预后视觉模拟评分法(VAS)评分较经典组低,差异有统计学意义(P<0.05)。分析组多模态舒适感知在环境、生理、社会及心理方面的神经可塑性诱导智能康复后多模态舒适情况高于经典组,差异有统计学意义(P<0.05)。结论:针对肩手综合征患者,引入神经镜像激活康复理念支持利于其神经-运动康复水平改善,并降低其疼痛评分,提升其在多维度的舒适感知。 展开更多
关键词 神经功能 肩手功能 运动康复水平 疼痛评分 舒适感知 神经镜像
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双层人工真皮联合外用rh-bFGF在手指端皮肤缺损修复中的应用
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作者 黄静 林木良 +3 位作者 王婷婷 胡小峰 郑晓飞 冷楠楠 《中国美容医学》 2026年第1期58-62,共5页
目的:探究双层人工真皮联合外用重组人碱性成纤维细胞生长因子(Recombinant Human Basic Fibroblast Growth Factor,rh-bFGF)在手指端皮肤缺损修复中的应用效果。方法:选取2018年8月-2023年12月笔者医院收治的手指端创伤并进行皮肤缺损... 目的:探究双层人工真皮联合外用重组人碱性成纤维细胞生长因子(Recombinant Human Basic Fibroblast Growth Factor,rh-bFGF)在手指端皮肤缺损修复中的应用效果。方法:选取2018年8月-2023年12月笔者医院收治的手指端创伤并进行皮肤缺损修复的70例(96指)患者为研究对象,根据是否采用外用rh-bFGF分为两组。对照组31例(40指)患者彻底清创后,采用双层人工真皮覆盖创面,观察组39例(56指)患者在双层人工真皮覆盖创面基础上采用外用rh-bFGF治疗。记录两组一期愈合情况、愈合时间、温哥华瘢痕量表(VSS)评分及手部功能评分情况。结果:观察组一期愈合率达87.18%,高于对照组的64.52%(P<0.05)。对照组11例患者与观察组5例患者拆除人工真皮硅胶膜后有少量创面残留,均进行植皮手术治疗,两组植皮区成活率均为100%。两组感染率(对照组6.45%,观察组0.00%)比较,差异无统计学意义(P>0.05)。观察组愈合时间为(31.36±3.15)d,短于对照组愈合时间(38.94±3.87)d。术后6个月,观察组VSS各评分均低于对照组(P<0.05);两组手部功能各维度评分比较差异无统计学意义(P>0.05)。结论:双层人工真皮联合外用rh-bFGF可提高手指端创伤后皮肤缺损修复患者一期愈合率,降低植皮手术率,缩短修复部位愈合时间,术后瘢痕较轻,值得临床推荐。 展开更多
关键词 重组人碱性成纤维细胞生长因子(rh-bFGF) 双层人工真皮 指端缺损 瘢痕 手功能
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针刺对脑卒中后偏瘫患者抑郁相关脑区静息态fMRI特征的影响
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作者 许天骄 陆梦馨 +3 位作者 李媛媛 张慕昭 邹忆怀 方继良 《中国中西医结合影像学杂志》 2026年第1期29-34,共6页
目的:运用静息态fMRI探索单侧基底节和/或放射冠区域急性缺血性脑卒中(AIS)抑郁相关脑区静息态fMRI特征。方法:纳入43例AIS患者,运用随机数字表法随机分为真穴组23例和假穴组20例。真穴组行手足十二针针刺,假穴组行经穴旁开1寸针刺,针... 目的:运用静息态fMRI探索单侧基底节和/或放射冠区域急性缺血性脑卒中(AIS)抑郁相关脑区静息态fMRI特征。方法:纳入43例AIS患者,运用随机数字表法随机分为真穴组23例和假穴组20例。真穴组行手足十二针针刺,假穴组行经穴旁开1寸针刺,针刺干预2周,针刺5 d,休息2 d,共10次。2组针刺前后分别行Fugl-Meyer运动功能评定量表(FMA)、汉密尔顿抑郁量表(HAMD)评分和静息态fMRI扫描。分析2组针刺前后局部一致性(ReHo)值存在显著差异的脑区。结果:针刺后,真穴组FMA评分升高,HAMD评分降低(均P<0.05);假穴组FMA评分和HAMD评分与针刺前差异均无统计学意义(均P>0.05)。针刺后,真穴组左颞中回、左颞上回、右颞上回的ReHo值升高,右额上回、右角回、左额上回的ReHo值降低,差异均有统计学意义(均P<0.05,FWE校正);假穴组右额上回、右额中回、左额中回、左中央后回的ReHo值升高,右顶下回、右角回的ReHo值降低,差异均有统计学意义(均P<0.05,FWE校正)。与假穴组相比,真穴组针刺后左额中回、右额中回、左楔前叶、左顶下回的ReHo值升高,右楔前叶、右角回的ReHo值降低,差异均有统计学意义(均P<0.05,FWE校正)。结论:手足十二针主要通过激活AIS患者双侧颞中回、颞上回、额上回、角回、楔前叶、顶下回发挥情绪调控作用,左侧半球相关脑区在康复过程中存在优先激活,ReHo变化是卒中后抑郁临床诊断和疗效评估的影像学特征。 展开更多
关键词 卒中 抑郁 手足十二针 局部一致性 静息态功能磁共振
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微小隐孢子虫含EF-hand结构域蛋白家族的生物信息学研究 被引量:1
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作者 郭志云 杨光 +5 位作者 荆春霞 付芹芹 孙小会 王穗湘 李月琴 周天鸿 《中国人兽共患病学报》 CAS CSCD 北大核心 2012年第7期653-658,663,共7页
目的对微小隐孢子虫(Cryptosporidium parvum,Cp)含EF-hand结构域家族蛋白进行生物信息学研究,探讨该家族蛋白的EF-hand结构域与Ca2+信号的关系以预测该家族蛋白的功能,为隐孢子虫病的诊断和治疗提供新的方向。方法首先通过数据收集,获... 目的对微小隐孢子虫(Cryptosporidium parvum,Cp)含EF-hand结构域家族蛋白进行生物信息学研究,探讨该家族蛋白的EF-hand结构域与Ca2+信号的关系以预测该家族蛋白的功能,为隐孢子虫病的诊断和治疗提供新的方向。方法首先通过数据收集,获得EF-hand结构域家族蛋白的序列信息,接着对每个蛋白进行CDD结构域搜索和NCBI BLAST的比对分析,确证为EF-hand结构域家族蛋白,最后进行结构域分析和功能预测。结果搜索到了C.parvumIowa II中18个含有EF-hand结构域的蛋白,它们之间的氨基酸长度,分子量大小以及等电点等都有很大的区别,通过结构域分析把EF-hand家族分成了含一个EF-hand结构域、二个EF-hand结构域、同时含EF-hand和STKc-AGC两种结构域和同时含EF-hand和PKC两种结构域四大类。结论 EF-hand结构域蛋白家族与重要的钙离子信号作用有着密切的关系,而C.parvum对宿主细胞的侵袭能力与胞内的Ca2+水平密切相关,所以EF-hand蛋白家族很有可能成为隐孢子虫病治疗的一个新的突破点。 展开更多
关键词 微小隐孢子虫 EF—hand结构域 CA2+ 生物信息学分析 功能预测
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Granger因果分析手足十二针治疗中风偏瘫患者的中枢效应机制
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作者 徐梦方 邹忆怀 +5 位作者 许天骄 李媛媛 武琳璐 史昕玥 申艳 韩笑 《中国中医药信息杂志》 2026年第1期122-128,共7页
目的探讨手足十二针治疗中风偏瘫患者脑区间效应连接的变化特征,揭示针刺治疗中风偏瘫的中枢调控机制、穴位特异性疗效机制。方法纳入2018年5月-2023年9月北京中医药大学东直门医院住院中风偏瘫患者60例,发病时间均在1.5个月内。采用随... 目的探讨手足十二针治疗中风偏瘫患者脑区间效应连接的变化特征,揭示针刺治疗中风偏瘫的中枢调控机制、穴位特异性疗效机制。方法纳入2018年5月-2023年9月北京中医药大学东直门医院住院中风偏瘫患者60例,发病时间均在1.5个月内。采用随机数字表法分为真穴组、假穴组各30例。真穴组予手足十二针组穴针刺,假穴组予真穴旁开1寸针刺。比较2组组内与组间大脑双侧齿状核(DN)、丘脑(THA)、初级运动皮层(M1)、腹侧前运动皮层(PMv)、小脑(Cb)的Granger因果(GC)关系变化。结果研究过程中脱落8例,因核磁数据质量不佳剔除17例,最终纳入35例,其中真穴组20例、假穴组15例。真穴组针刺干预前DN.L→M1.L、THA.R→M1.R、DN.L→PMv.L、PMv.R→PMv.L、Cb.L→Cb.R的GC弱于假穴组,PMv.R→Cb.L的GC强于假穴组(P<0.05);真穴组针刺干预后DN.L→THA.L、DN.R→THA.L、M1.L→THA.L、PMv.L→THA.L、PMv.R→THA.L、Cb.L→THA.L、DN.L→M1.L、PMv.R→M1.L、DN.L→PMv.L的GC值均较针刺干预前增加(P<0.05);假穴组针刺干预后Cb.L→DN.R的GC值较针刺干预前增加(P<0.05);真穴组针刺干预后M1.L→PMv.L、Cb.L→PMv.L的GC强于假穴组,PMv.R→THA.L的GC弱于假穴组(P<0.05)。结论齿状核-丘脑-皮质-小脑环路间GC改变或为手足十二针治疗中风偏瘫的中枢调控机制;丘脑作为环路的中继站,或可作为针刺干预的靶点;针刺腧穴较非经非穴处激活脑区的范围更广、活性更强,揭示经穴的特异性疗效。 展开更多
关键词 中风偏瘫 手足十二针 GRANGER因果分析 功能磁共振成像 中枢效应 穴位特异性
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