Objective:To analyze factors affecting the utilization of human immunodeficiency virus counseling and testing(HCT)service among human immunodeficiency virus risk groups at Hessa Air Genting Health Center,Asahan Regenc...Objective:To analyze factors affecting the utilization of human immunodeficiency virus counseling and testing(HCT)service among human immunodeficiency virus risk groups at Hessa Air Genting Health Center,Asahan Regency,North Sumatera,Indonesia.Methods:This quantitative unmatched case-control study was conducted from April 2024 to April 2025 at Hessa Air Genting Health Center,Asahan Regency,North Sumatra Province,Indonesia.Female sex workers and men who have sex with men were selected using purposive sampling based on predefined inclusion and exclusion criteria.Data were collected via questionnaires and analyzed using SPSS version 18.0,with univariate analysis,bivariate analysis(Chi-square test),and multivariate analysis(logistic regression analysis).Results:Comprehensive analysis of 75 cases and 75 controls was conducted to identify factors affecting the utilization of HCT services.Specifically,this study identified significant effects of knowledge(OR 3.2,95%CI 1.5-7.0,P=0.003),perception(OR 5.6,95%CI 2.5-12.5,P<0.001),information media(OR 3.1,95%CI 1.4-6.8,P=0.005),and health workers encouragement(OR 4.0,95%CI 1.5-10.4,P=0.005).In contrast,access to health services did not have a significant effect.Conclusions:Knowledge,perception,information media,and health worker encouragement had significant effects on HCT service utilization,with perception identified as the dominant factor.To improve utilization,strengthening positive perceptions,targeted training for healthcare workers,strengthened partnerships with local non-governmental organizations,and the use of social media for health promotion are recommended.展开更多
【目的】针对风电法兰分类细、规格多、直径大、孔数多,导致多孔加工坐标计算量大、输入效率低,且极坐标、旋转坐标及宏程序、二次开发等加工方案难以满足法兰生产企业实际生产需求的问题,提出一种高效解决方案。【方法】基于Visual Stu...【目的】针对风电法兰分类细、规格多、直径大、孔数多,导致多孔加工坐标计算量大、输入效率低,且极坐标、旋转坐标及宏程序、二次开发等加工方案难以满足法兰生产企业实际生产需求的问题,提出一种高效解决方案。【方法】基于Visual Studio 2022开发平台,开发了一款高效实用、能灵活快速生成螺栓孔加工程序的专用CAM系统。该系统应用了模块化设计思路,把零件信息、加工参数等按相应模块独立处理,有利于系统根据法兰设计标准的变化而及时调整,自动生成不同规格的风电法兰螺栓孔加工程序。【结果】所开发的风电法兰螺栓孔加工CAM系统,实现了多孔加工程序的快速自动生成,显著降低了数控编程员的劳动强度,提高了法兰孔加工生产效率。【结论】未来可进一步对AutoCAD、NX平台进行二次开发,借助平台强大的二维三维图形设计基础,开发基于法兰零件的集设计制造为一体的中小型CAD/CAM系统,以满足企业不断发展的生产管理需求。展开更多
BACKGROUND Proton pump inhibitors(PPIs)are among the most commonly prescribed medications globally.While concerns exist regarding their association with adverse infection-related outcomes,their impact on coronavirus d...BACKGROUND Proton pump inhibitors(PPIs)are among the most commonly prescribed medications globally.While concerns exist regarding their association with adverse infection-related outcomes,their impact on coronavirus disease 2019(COVID-19)severity remains uncertain.Emerging preclinical data suggest immunomodulatory and antiviral properties of PPIs,yet clinical evidence is conflicting.AIM To investigate whether chronic pre-hospital PPI use is associated with improved outcomes in patients hospitalized with COVID-19.METHODS We conducted a retrospective case-control study of adult inpatients with severe acute respiratory syndrome coronavirus 2 infection admitted to a racially and ethnically diverse communityhospital in Massachusetts from July 2021 to March 2022. Patients were stratified by documented pre-hospital PPIuse. The primary outcomes were intensive care unit (ICU) admission, need for invasive mechanical ventilation, andin-hospital mortality. Multivariable logistic regression was used to adjust for demographics, comorbidities, andtreatment variables. Significance was set at P < 0.05.RESULTSAmong 248 patients, 83 (33.4%) were on PPIs prior to hospitalization. Compared to non-users, PPI users hadsignificantly lower rates of ICU admission (13.3% vs 24.8%, P = 0.034), mechanical ventilation (13.3% vs 25.5%, P =0.027), and in-hospital mortality (6.0% vs 17.6%, P = 0.013). Multivariable analysis confirmed these associations:ICU admission [adjusted odds ratios (aOR): 0.462, 95%CI: 0.223–0.955], mechanical ventilation (aOR: 0.447, 95%CI:0.216–0.923), and mortality (aOR: 0.144, 95%CI: 0.031–0.677). Findings were consistent across demographic andcomorbidity strata.CONCLUSIONIn this diverse, real-world United States cohort, chronic pre-hospital PPI use was independently associated withlower odds of intensive care unit admission, mechanical ventilation, and mortality among COVID-19 inpatients.These findings highlight a potentially protective role of PPIs and support continued therapy in eligible patients.展开更多
This case-control study evaluated the frequency of Glutathione S-transferase Mu 1(GSTM1)deletion and Glutathione S-transferase Alpha 1(GSTA1)mutation in chronic obstructive pulmonary disease(COPD)patients,whether they...This case-control study evaluated the frequency of Glutathione S-transferase Mu 1(GSTM1)deletion and Glutathione S-transferase Alpha 1(GSTA1)mutation in chronic obstructive pulmonary disease(COPD)patients,whether they had concomitant lung squamous cell carcinoma(LSCC)or not,to assess their connection with cancer susceptibility.By means of multivariate logistic regression analysis,the GSTM1 null genotype serves as a significant standalone risk factor for LSCC,in addition to variables like age,smoking history,emphysema,body mass index(BMI),albumin level,and neutrophil-to-lymphocyte ratio(NLR).A predictive model incorporating these factors demonstrated superior discriminative ability compared to the established COPD Lung Cancer Screening Score(COPD-LUCSS).展开更多
Studio Xin是由设计师辛华琛创立于上海的设计工作室。辛华琛毕业于英国皇家艺术学院,主修产品设计。工作室的设计涵盖家具、灯具、家居饰品及室内空间等多个领域。在他的设计中,功能与情感并重。辛华琛善于以细腻的方式,引导人们用一...Studio Xin是由设计师辛华琛创立于上海的设计工作室。辛华琛毕业于英国皇家艺术学院,主修产品设计。工作室的设计涵盖家具、灯具、家居饰品及室内空间等多个领域。在他的设计中,功能与情感并重。辛华琛善于以细腻的方式,引导人们用一种既直觉又新鲜的角度重新看待日常物件,让设计在熟悉与深刻之间,悄然建立起共鸣。展开更多
The regional master teacher studio is a growth community that nurtures regional teachers.It has the characteristics of being interdisciplinary and leading,which is conducive to building a high-quality and professional...The regional master teacher studio is a growth community that nurtures regional teachers.It has the characteristics of being interdisciplinary and leading,which is conducive to building a high-quality and professional teaching staff.As the vanguard of educational innovation,it shoulders the mission of exploring new teaching models and promoting high-quality development of education.It should be rooted in local characteristics,break down disciplinary barriers,and take innovative collaboration mechanisms as the key point to carry out in-depth practical exploration of interdisciplinary integration.Based on this,this paper conducts research on the cross-disciplinary integration and innovation practice of the regional master teacher studio,systematically sorts out the practice path,explores the deep value and development path behind it,and provides useful references for educational reform in the new era.展开更多
文摘Objective:To analyze factors affecting the utilization of human immunodeficiency virus counseling and testing(HCT)service among human immunodeficiency virus risk groups at Hessa Air Genting Health Center,Asahan Regency,North Sumatera,Indonesia.Methods:This quantitative unmatched case-control study was conducted from April 2024 to April 2025 at Hessa Air Genting Health Center,Asahan Regency,North Sumatra Province,Indonesia.Female sex workers and men who have sex with men were selected using purposive sampling based on predefined inclusion and exclusion criteria.Data were collected via questionnaires and analyzed using SPSS version 18.0,with univariate analysis,bivariate analysis(Chi-square test),and multivariate analysis(logistic regression analysis).Results:Comprehensive analysis of 75 cases and 75 controls was conducted to identify factors affecting the utilization of HCT services.Specifically,this study identified significant effects of knowledge(OR 3.2,95%CI 1.5-7.0,P=0.003),perception(OR 5.6,95%CI 2.5-12.5,P<0.001),information media(OR 3.1,95%CI 1.4-6.8,P=0.005),and health workers encouragement(OR 4.0,95%CI 1.5-10.4,P=0.005).In contrast,access to health services did not have a significant effect.Conclusions:Knowledge,perception,information media,and health worker encouragement had significant effects on HCT service utilization,with perception identified as the dominant factor.To improve utilization,strengthening positive perceptions,targeted training for healthcare workers,strengthened partnerships with local non-governmental organizations,and the use of social media for health promotion are recommended.
文摘【目的】针对风电法兰分类细、规格多、直径大、孔数多,导致多孔加工坐标计算量大、输入效率低,且极坐标、旋转坐标及宏程序、二次开发等加工方案难以满足法兰生产企业实际生产需求的问题,提出一种高效解决方案。【方法】基于Visual Studio 2022开发平台,开发了一款高效实用、能灵活快速生成螺栓孔加工程序的专用CAM系统。该系统应用了模块化设计思路,把零件信息、加工参数等按相应模块独立处理,有利于系统根据法兰设计标准的变化而及时调整,自动生成不同规格的风电法兰螺栓孔加工程序。【结果】所开发的风电法兰螺栓孔加工CAM系统,实现了多孔加工程序的快速自动生成,显著降低了数控编程员的劳动强度,提高了法兰孔加工生产效率。【结论】未来可进一步对AutoCAD、NX平台进行二次开发,借助平台强大的二维三维图形设计基础,开发基于法兰零件的集设计制造为一体的中小型CAD/CAM系统,以满足企业不断发展的生产管理需求。
文摘BACKGROUND Proton pump inhibitors(PPIs)are among the most commonly prescribed medications globally.While concerns exist regarding their association with adverse infection-related outcomes,their impact on coronavirus disease 2019(COVID-19)severity remains uncertain.Emerging preclinical data suggest immunomodulatory and antiviral properties of PPIs,yet clinical evidence is conflicting.AIM To investigate whether chronic pre-hospital PPI use is associated with improved outcomes in patients hospitalized with COVID-19.METHODS We conducted a retrospective case-control study of adult inpatients with severe acute respiratory syndrome coronavirus 2 infection admitted to a racially and ethnically diverse communityhospital in Massachusetts from July 2021 to March 2022. Patients were stratified by documented pre-hospital PPIuse. The primary outcomes were intensive care unit (ICU) admission, need for invasive mechanical ventilation, andin-hospital mortality. Multivariable logistic regression was used to adjust for demographics, comorbidities, andtreatment variables. Significance was set at P < 0.05.RESULTSAmong 248 patients, 83 (33.4%) were on PPIs prior to hospitalization. Compared to non-users, PPI users hadsignificantly lower rates of ICU admission (13.3% vs 24.8%, P = 0.034), mechanical ventilation (13.3% vs 25.5%, P =0.027), and in-hospital mortality (6.0% vs 17.6%, P = 0.013). Multivariable analysis confirmed these associations:ICU admission [adjusted odds ratios (aOR): 0.462, 95%CI: 0.223–0.955], mechanical ventilation (aOR: 0.447, 95%CI:0.216–0.923), and mortality (aOR: 0.144, 95%CI: 0.031–0.677). Findings were consistent across demographic andcomorbidity strata.CONCLUSIONIn this diverse, real-world United States cohort, chronic pre-hospital PPI use was independently associated withlower odds of intensive care unit admission, mechanical ventilation, and mortality among COVID-19 inpatients.These findings highlight a potentially protective role of PPIs and support continued therapy in eligible patients.
基金Anhui Province’s Clinical Medical Research Transformation Special Initiative(Project No.:202204295107020016)。
文摘This case-control study evaluated the frequency of Glutathione S-transferase Mu 1(GSTM1)deletion and Glutathione S-transferase Alpha 1(GSTA1)mutation in chronic obstructive pulmonary disease(COPD)patients,whether they had concomitant lung squamous cell carcinoma(LSCC)or not,to assess their connection with cancer susceptibility.By means of multivariate logistic regression analysis,the GSTM1 null genotype serves as a significant standalone risk factor for LSCC,in addition to variables like age,smoking history,emphysema,body mass index(BMI),albumin level,and neutrophil-to-lymphocyte ratio(NLR).A predictive model incorporating these factors demonstrated superior discriminative ability compared to the established COPD Lung Cancer Screening Score(COPD-LUCSS).
文摘The regional master teacher studio is a growth community that nurtures regional teachers.It has the characteristics of being interdisciplinary and leading,which is conducive to building a high-quality and professional teaching staff.As the vanguard of educational innovation,it shoulders the mission of exploring new teaching models and promoting high-quality development of education.It should be rooted in local characteristics,break down disciplinary barriers,and take innovative collaboration mechanisms as the key point to carry out in-depth practical exploration of interdisciplinary integration.Based on this,this paper conducts research on the cross-disciplinary integration and innovation practice of the regional master teacher studio,systematically sorts out the practice path,explores the deep value and development path behind it,and provides useful references for educational reform in the new era.
