Objective:To observe and study the practical value of adopting nest nursing in neonatal nursing.Methods:From January 2023 to January 2024,a total of 382 newborns that were admitted to the hospital were selected to car...Objective:To observe and study the practical value of adopting nest nursing in neonatal nursing.Methods:From January 2023 to January 2024,a total of 382 newborns that were admitted to the hospital were selected to carry out this study.They were divided into two groups,the routine group and the observation group,with 191 cases in each group.Newborns in the routine group were given basic nursing intervention,while those in the observation group were given bird’s nest nursing intervention.The growth and development indexes,the occurrence of adverse reactions,the improvement of gastrointestinal function,and the nursing satisfaction rate of their families were analyzed and studied.Results:The growth and development indexes of newborns in the observation group were significantly better than those in the routine group(P<0.05).The incidence of adverse neonatal reactions in the observation group was significantly lower than that in the routine group(P<0.05).The improvement of gastrointestinal function of newborns in the observation group was significantly better than that in the routine group(P<0.05).The nursing satisfaction rate of newborns’families in the observation group was significantly higher than that in the routine group(P<0.05).Conclusion:As for the key points of clinical newborn care,the actual effect of adopting the bird’s nest nursing intervention is more prominent,and its main function is to promote the growth and development of newborns.It can not only avoid the risk of adverse reactions in many aspects but also improve the gastrointestinal function of newborns,so that the nursing satisfaction rate of family members is obviously improved.It is recommended to be applied and popularized in clinical practice.展开更多
Aqueous zinc-based energy storage devices(ZESDs)have garnered considerable interest because of their high specific capacity,abundant zinc reserves,excellent safety,and environmental friendliness.In recent years,variou...Aqueous zinc-based energy storage devices(ZESDs)have garnered considerable interest because of their high specific capacity,abundant zinc reserves,excellent safety,and environmental friendliness.In recent years,various types of boron,nitrogen co-doped carbon(BNC)materials have been developed to improve electrochemical performance of ZESDs.To promote the advancement of these technologies,we herein give a comprehensive review of the progress in BNC materials for ZESDs.The different synthetic methods employed in the preparation of BNC materials,including direct carbonization,template method,chemical vapor deposition,hydrothermal method,etc.,are summarized.These methods play a vital role in tailoring the structure,composition,and properties of BNC materials to optimize their performance in energy storage applications.Furthermore,some key achievements of BNC materials in zinc-air batteries and zinc-ion hybrid supercapacitors are elaborated.Lastly,future challenges and development directions of BNC materials in ZESDs are prospected.This comprehensive review could serve as a valuable resource in the energy storage field,providing insights into the potential of BNC materials in zinc-based energy storage technologies.展开更多
Using the“Civil Aviation Oral English”course as a case study,we operationalize the ideological and political education(IPE)integrated evaluation system for oral English courses in higher vocational education,which i...Using the“Civil Aviation Oral English”course as a case study,we operationalize the ideological and political education(IPE)integrated evaluation system for oral English courses in higher vocational education,which is based on Kirkpatrick’s Model,into a tripartite teaching evaluation system.The system encompasses three components such as learning objective attainment,individual developmental progress,and value-added competency assessment.The proposed system facilitates three-dimensional,multi-level,and scientifically validated teaching evaluation.This approach aligns with the holistic development of students’knowledge structures,professional competencies,moral qualities,and emotional intelligence.The study provides novel methodological perspectives for IPE evaluation in vocational oral English instruction,particularly in:curriculum-based ideological mapping,competency growth metrics,and value internalization assessment.展开更多
The peripheral immune system has emerged as a regulator of neurodegenerative diseases such as Alzheimer’s disease.Microglia are resident immune cells in the brain that may orchestrate communication between the centra...The peripheral immune system has emerged as a regulator of neurodegenerative diseases such as Alzheimer’s disease.Microglia are resident immune cells in the brain that may orchestrate communication between the central nervous system and peripheral immune system,though the mechanisms are unclear.Here,we found that gamma-type immunoglobulin,a product originating from peripheral blood B cells,localized in the brain parenchyma of multiple mouse models with amyloid pathology,and was enriched on microglia but not on other brain cell types.Further experiments showed that gamma-type immunoglobulin bound to microglial cell membranes and led to diverse transcriptomic changes,including upregulation of pathways related to phagocytosis and immunity.Functional assays demonstrated that gamma-type immunoglobulin enhanced microglial phagocytic capacity for amyloid-beta fibrils via its Fc fragment,but not Fab fragment,fragment.Our data indicate that microglia,when exposed to gamma-type immunoglobulin,exhibit an enhanced capacity for clearing amyloid-beta fibrils,potentially via the gamma-type immunoglobulin Fc fragment signaling pathway.This suggests that parenchymal gamma-type immunoglobulin should be further investigated to determine whether it may play a beneficial role against Alzheimer’s disease by enhancing microglial function.展开更多
Hepatitis C virus(HCV)and hepatitis B virus(HBV)infections are increasingly recognized as significant etiological factors in the pathogenesis of B-cell non-Hodgkin’s lymphomas(B-NHLs).Epidemiological and molecular st...Hepatitis C virus(HCV)and hepatitis B virus(HBV)infections are increasingly recognized as significant etiological factors in the pathogenesis of B-cell non-Hodgkin’s lymphomas(B-NHLs).Epidemiological and molecular studies have demonstrated a consistent association between chronic viral infection and B-NHLs.Multiple pathogenic mechanisms have been implicated in lymphomagenesis,both direct and indirect,including chronic antigenic stimulation,direct infection of B cells,and viral protein-mediated oncogenic signaling,It is likely that a combination of several pathogenic conditions is required to eventually lead to the development of lymphoma.The prevalence of B-cell lymphomas among individuals with chronic HCV or HBV infection presents a complex pathogenetic scenario,given the tumor heterogeneity and variable clinical behavior,and poses therapeutic challenges,due to the partial efficacy of current treatment options.The advent of direct-acting antivirals(DAAs)for HCV and high-genetic barrier nucleos(t)ide analogues(NAs)for HBV has improved patient outcomes.In indolent HCV-associated B-NHLs,antiviral therapy with DAAs alone often achieves sustained virologic response and may lead to lymphoma regression.Conversely,aggressive subtypes like diffuse large B-cell lymphomas require combination treatment with immunochemotherapy.In the setting of HBV-associated lymphomas,antiviral prophylaxis with potent NAs(e.g.,entecavir or tenofovir)is essential to prevent HBV reactivation during rituximab-containing chemotherapy regimen.The integration of antiviral and anticancer therapies has been shown to enhance survival outcomes while mitigating hepatic toxicity.A comprehensive understanding of the biological interplay between chronic viral infection and B-cell transformation is critical for optimizing diagnostic and therapeutic strategies.Aim of this viewpoint is to provide evidence that early viral detection and prompt management remain the most effective strategies to improve survival rates and to reduce treatment-related morbidity in these patients.展开更多
文摘Objective:To observe and study the practical value of adopting nest nursing in neonatal nursing.Methods:From January 2023 to January 2024,a total of 382 newborns that were admitted to the hospital were selected to carry out this study.They were divided into two groups,the routine group and the observation group,with 191 cases in each group.Newborns in the routine group were given basic nursing intervention,while those in the observation group were given bird’s nest nursing intervention.The growth and development indexes,the occurrence of adverse reactions,the improvement of gastrointestinal function,and the nursing satisfaction rate of their families were analyzed and studied.Results:The growth and development indexes of newborns in the observation group were significantly better than those in the routine group(P<0.05).The incidence of adverse neonatal reactions in the observation group was significantly lower than that in the routine group(P<0.05).The improvement of gastrointestinal function of newborns in the observation group was significantly better than that in the routine group(P<0.05).The nursing satisfaction rate of newborns’families in the observation group was significantly higher than that in the routine group(P<0.05).Conclusion:As for the key points of clinical newborn care,the actual effect of adopting the bird’s nest nursing intervention is more prominent,and its main function is to promote the growth and development of newborns.It can not only avoid the risk of adverse reactions in many aspects but also improve the gastrointestinal function of newborns,so that the nursing satisfaction rate of family members is obviously improved.It is recommended to be applied and popularized in clinical practice.
基金financially supported by the National Natural Science Foundation of China(No.22302177)the Public Technology Application Project of Jinhua City(No.2022–4-067)the Self Designed Scientific Research of Zhejiang Normal University(No.2021ZS0604)。
文摘Aqueous zinc-based energy storage devices(ZESDs)have garnered considerable interest because of their high specific capacity,abundant zinc reserves,excellent safety,and environmental friendliness.In recent years,various types of boron,nitrogen co-doped carbon(BNC)materials have been developed to improve electrochemical performance of ZESDs.To promote the advancement of these technologies,we herein give a comprehensive review of the progress in BNC materials for ZESDs.The different synthetic methods employed in the preparation of BNC materials,including direct carbonization,template method,chemical vapor deposition,hydrothermal method,etc.,are summarized.These methods play a vital role in tailoring the structure,composition,and properties of BNC materials to optimize their performance in energy storage applications.Furthermore,some key achievements of BNC materials in zinc-air batteries and zinc-ion hybrid supercapacitors are elaborated.Lastly,future challenges and development directions of BNC materials in ZESDs are prospected.This comprehensive review could serve as a valuable resource in the energy storage field,providing insights into the potential of BNC materials in zinc-based energy storage technologies.
基金supported by grants from“2023 Research on Vocational English Curriculum Reform:‘Implementation Path of Ideological and Political Education in Vocational English Courses for Higher Vocational Education Under the New Curriculum Standards’(Grant No.WYJZW-2023GD0029)”“The Special Project of 2024 on‘Reading and Teacher Development’Under the 14th Five-Year Plan of the China Tao Xingzhi Research Association(Grant No.CTXZRA202411937GD)”.
文摘Using the“Civil Aviation Oral English”course as a case study,we operationalize the ideological and political education(IPE)integrated evaluation system for oral English courses in higher vocational education,which is based on Kirkpatrick’s Model,into a tripartite teaching evaluation system.The system encompasses three components such as learning objective attainment,individual developmental progress,and value-added competency assessment.The proposed system facilitates three-dimensional,multi-level,and scientifically validated teaching evaluation.This approach aligns with the holistic development of students’knowledge structures,professional competencies,moral qualities,and emotional intelligence.The study provides novel methodological perspectives for IPE evaluation in vocational oral English instruction,particularly in:curriculum-based ideological mapping,competency growth metrics,and value internalization assessment.
基金supported by the National Natural Science Foundation of China,Nos.82171082(to ZX),32000727(to TZ),32370731(to YZ)Guangdong Basic and Applied Basic Research Foundation,No.2024A151501069(to ZX)+1 种基金Shenzhen Science and Technology Program,Nos.JCYJ20210324101603009(to ZX),GJHZ20220913142807015(to TZ),JCYJ20220531100204010(to TZ),JCYJ20230807091308018(to YZ)Shenzhen Medical Research Funds,No.A2303068(to TZ).
文摘The peripheral immune system has emerged as a regulator of neurodegenerative diseases such as Alzheimer’s disease.Microglia are resident immune cells in the brain that may orchestrate communication between the central nervous system and peripheral immune system,though the mechanisms are unclear.Here,we found that gamma-type immunoglobulin,a product originating from peripheral blood B cells,localized in the brain parenchyma of multiple mouse models with amyloid pathology,and was enriched on microglia but not on other brain cell types.Further experiments showed that gamma-type immunoglobulin bound to microglial cell membranes and led to diverse transcriptomic changes,including upregulation of pathways related to phagocytosis and immunity.Functional assays demonstrated that gamma-type immunoglobulin enhanced microglial phagocytic capacity for amyloid-beta fibrils via its Fc fragment,but not Fab fragment,fragment.Our data indicate that microglia,when exposed to gamma-type immunoglobulin,exhibit an enhanced capacity for clearing amyloid-beta fibrils,potentially via the gamma-type immunoglobulin Fc fragment signaling pathway.This suggests that parenchymal gamma-type immunoglobulin should be further investigated to determine whether it may play a beneficial role against Alzheimer’s disease by enhancing microglial function.
基金supported by the National Italian Research Council(CNR)“Progetto DSB.AD007.305.001”to Monica Rinaldi。
文摘Hepatitis C virus(HCV)and hepatitis B virus(HBV)infections are increasingly recognized as significant etiological factors in the pathogenesis of B-cell non-Hodgkin’s lymphomas(B-NHLs).Epidemiological and molecular studies have demonstrated a consistent association between chronic viral infection and B-NHLs.Multiple pathogenic mechanisms have been implicated in lymphomagenesis,both direct and indirect,including chronic antigenic stimulation,direct infection of B cells,and viral protein-mediated oncogenic signaling,It is likely that a combination of several pathogenic conditions is required to eventually lead to the development of lymphoma.The prevalence of B-cell lymphomas among individuals with chronic HCV or HBV infection presents a complex pathogenetic scenario,given the tumor heterogeneity and variable clinical behavior,and poses therapeutic challenges,due to the partial efficacy of current treatment options.The advent of direct-acting antivirals(DAAs)for HCV and high-genetic barrier nucleos(t)ide analogues(NAs)for HBV has improved patient outcomes.In indolent HCV-associated B-NHLs,antiviral therapy with DAAs alone often achieves sustained virologic response and may lead to lymphoma regression.Conversely,aggressive subtypes like diffuse large B-cell lymphomas require combination treatment with immunochemotherapy.In the setting of HBV-associated lymphomas,antiviral prophylaxis with potent NAs(e.g.,entecavir or tenofovir)is essential to prevent HBV reactivation during rituximab-containing chemotherapy regimen.The integration of antiviral and anticancer therapies has been shown to enhance survival outcomes while mitigating hepatic toxicity.A comprehensive understanding of the biological interplay between chronic viral infection and B-cell transformation is critical for optimizing diagnostic and therapeutic strategies.Aim of this viewpoint is to provide evidence that early viral detection and prompt management remain the most effective strategies to improve survival rates and to reduce treatment-related morbidity in these patients.
