目的 分析创伤性颅脑损伤血清miR-31-5p、miR-129-5p水平及其与神经功能的关系。方法 回顾性选取2022年8月—2025年8月东南大学附属徐州市中心医院收治的创伤性颅脑损伤患者169例,根据格拉斯哥昏迷量表(Glasgow coma scale,GCS)评分将...目的 分析创伤性颅脑损伤血清miR-31-5p、miR-129-5p水平及其与神经功能的关系。方法 回顾性选取2022年8月—2025年8月东南大学附属徐州市中心医院收治的创伤性颅脑损伤患者169例,根据格拉斯哥昏迷量表(Glasgow coma scale,GCS)评分将患者分为轻型组(n=64)、中型组(n=54)、重型组(n=51)。另选同期东南大学附属徐州市中心医院体检的健康者100例为对照组。比较所有受试者血清miR-31-5p、miR-129-5p水平、美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分。采用Pearson相关分析血清miR-31-5p、miR-129-5p水平与NIHSS评分的相关性,采用受试者工作特征(receiver operating characteristic,ROC)曲线分析血清miR-31-5p、miR-129-5p水平对创伤性颅脑损伤患者发生神经功能缺损的诊断价值。结果 重型组、中型组、轻型组血清miR-31-5p水平、NIHSS评分均高于对照组,血清miR-129-5p水平均低于对照组,重型组、中型组血清miR-31-5p水平、NIHSS评分均高于轻型组,血清miR-129-5p水平均低于轻型组,重型组血清miR-31-5p水平、NIHSS评分均高于中型组,血清miR-129-5p水平低于中型组(P<0.05)。血清miR-31-5p水平与NIHSS评分呈正相关(r=0.666,P<0.05),血清miR-129-5p水平与NIHSS评分呈负相关(r=-0.715,P<0.05)。ROC结果显示,血清miR-31-5p、miR-129-5p水平联合诊断创伤性颅脑损伤患者神经功能缺损的敏感度为99.3%,特异度为92.9%,AUC为0.951,预测价值较高。结论 血清miR-31-5p水平升高、miR-129-5p水平降低与创伤性颅脑损伤患者神经功能缺损程度密切相关,二者联合检测对评估神经功能缺损具有较高预测价值。展开更多
Investigating effect of recrystallization mechanism on deformation mode and texture evolution is conducive to controlling deformation mechanism and texture in magnesium alloys under medium-high temperature impact load...Investigating effect of recrystallization mechanism on deformation mode and texture evolution is conducive to controlling deformation mechanism and texture in magnesium alloys under medium-high temperature impact loading.In the present study,a Johnson-Cook model incorporating twin strengthening was established to simulate macro-deformation,and a twinning induced recrystallization(TDRX)model and bulging recrystallization(GBBDRX)model are introduced into visco-plastic self consistant(VPSC)framework to quantitatively study the deformation mechanism of pre-twinned AZ31 magnesium alloy during medium-high temperature impact loading.Both TDRX and GBBDRX occur,with basal slip as the dominant slip system,followed by pyramidal〈c+a〉slip and prismatic slip.The dynamic recrystallization(DRX)significantly influences basal and pyramidal〈c+a〉slip systems,with minimal impact on secondary deformation mechanism.In addition,the recrystallization mechanism of grain boundary bowing increases the activity of basal slip and decreases the activity of pyramidal〈c+a〉slip.The nucleation and growth of recrystallized grains enhance basal slip activity and suppress pyramidal〈c+a〉slip,leading to the formation of a strong basal texture.As dynamic recrystallization progresses,a bimodal texture develops,characterized by a reduction in basal component pole density and a more pronounced basal slip.展开更多
This study produced wide(900-1200 mm)AZ31 alloy sheets with varying thicknesses via continuous casting direct rolling(7 mm,6 mm)combined with stepwise warm rolling(4.5 mm,2 mm),examining the effects of this process on...This study produced wide(900-1200 mm)AZ31 alloy sheets with varying thicknesses via continuous casting direct rolling(7 mm,6 mm)combined with stepwise warm rolling(4.5 mm,2 mm),examining the effects of this process on microstructure,corrosion durability,mechanical properties,and discharge properties.Results showed that the reduced thickness significantly refined the grain size from 131.20µm to 7.90µm with the basal texture intensity reached 52%.Synergistic grain refinement,dislocation,and texture strengthening improved the yield strength(YS),ultimate tensile strength(UTS),and elongation(EL)of the 2 mm-thick sheet by 59.11%,39.75%,and 83.52%,respectively,compared to those of the 7 mm-thick sheet.Corrosion durability was also improved,with a corrosion rate of 2.19 mm·y^(-1)for the 2 mm sheet,which was 41%lower than that of the 7 mm sheet(3.72 mm·y^(-1)),due to the formation of a dense Al(OH)3 and layered double hydroxide corrosion film with mitigated micro-galvanic corrosion.As an Mg-air battery anode,the 2 mm sheet performed the best at 10 mA/cm^(2),achieving an anode efficiency of 61.18%,specific energy of 1660.50 mWh·g^(-1),easy discharge product detachment,and reduced self-corrosion.In summary,this study demonstrates a cost-effective and industrially viable approach that combines continuous casting direct rolling with stepwise warm rolling to produce ultra-wide AZ31 sheets with simultaneously improved overall properties,offering a novel strategy to expand the opportunity for commercial Mg alloys in both structural and functional applications.展开更多
This work investigates the effects of deformation mechanisms on the mechanical properties and anisotropy of rolled AZ31B magnesium alloy under uniaxial tension,combining experimental characterization with Visco-Plasti...This work investigates the effects of deformation mechanisms on the mechanical properties and anisotropy of rolled AZ31B magnesium alloy under uniaxial tension,combining experimental characterization with Visco-Plastic Self Consistent(VPSC)modeling.The research focuses particularly on anisotropic mechanical responses along transverse direction(TD)and rolling direction(RD).Experimental measurements and computational simulations consistently demonstrate that prismaticslip activation significantly reduces the strain hardening rate during the initial stage of tensile deformation.By suppressing the activation of specific deformation mechanisms along RD and TD,the tensile mechanical behavior of the magnesium alloy was further investigated.The results show that basalslip has the greatest impact during the initial deformation stage and basalslip activation substantially affects the deformation behavior of AZ31B alloy,causing marked decreases in both yield and tensile strength along RD.Under tensile loading along TD,prismaticslip not only exhibits a synergistic effect on yield strength,but also dominants work hardening during the initial plastic deformation.展开更多
文摘目的 分析创伤性颅脑损伤血清miR-31-5p、miR-129-5p水平及其与神经功能的关系。方法 回顾性选取2022年8月—2025年8月东南大学附属徐州市中心医院收治的创伤性颅脑损伤患者169例,根据格拉斯哥昏迷量表(Glasgow coma scale,GCS)评分将患者分为轻型组(n=64)、中型组(n=54)、重型组(n=51)。另选同期东南大学附属徐州市中心医院体检的健康者100例为对照组。比较所有受试者血清miR-31-5p、miR-129-5p水平、美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分。采用Pearson相关分析血清miR-31-5p、miR-129-5p水平与NIHSS评分的相关性,采用受试者工作特征(receiver operating characteristic,ROC)曲线分析血清miR-31-5p、miR-129-5p水平对创伤性颅脑损伤患者发生神经功能缺损的诊断价值。结果 重型组、中型组、轻型组血清miR-31-5p水平、NIHSS评分均高于对照组,血清miR-129-5p水平均低于对照组,重型组、中型组血清miR-31-5p水平、NIHSS评分均高于轻型组,血清miR-129-5p水平均低于轻型组,重型组血清miR-31-5p水平、NIHSS评分均高于中型组,血清miR-129-5p水平低于中型组(P<0.05)。血清miR-31-5p水平与NIHSS评分呈正相关(r=0.666,P<0.05),血清miR-129-5p水平与NIHSS评分呈负相关(r=-0.715,P<0.05)。ROC结果显示,血清miR-31-5p、miR-129-5p水平联合诊断创伤性颅脑损伤患者神经功能缺损的敏感度为99.3%,特异度为92.9%,AUC为0.951,预测价值较高。结论 血清miR-31-5p水平升高、miR-129-5p水平降低与创伤性颅脑损伤患者神经功能缺损程度密切相关,二者联合检测对评估神经功能缺损具有较高预测价值。
基金supported by the National Natural Science Foundation of China(52471132,52475356,12272192,52475344,U21A20130)the Natural Science Foundation of Fujian Province for Distinguished Young Scholars(2024J010031)as well as the Natural Science Foundation of Chongqing(grant number CSTB2023NSCQ-MSX0886).
文摘Investigating effect of recrystallization mechanism on deformation mode and texture evolution is conducive to controlling deformation mechanism and texture in magnesium alloys under medium-high temperature impact loading.In the present study,a Johnson-Cook model incorporating twin strengthening was established to simulate macro-deformation,and a twinning induced recrystallization(TDRX)model and bulging recrystallization(GBBDRX)model are introduced into visco-plastic self consistant(VPSC)framework to quantitatively study the deformation mechanism of pre-twinned AZ31 magnesium alloy during medium-high temperature impact loading.Both TDRX and GBBDRX occur,with basal slip as the dominant slip system,followed by pyramidal〈c+a〉slip and prismatic slip.The dynamic recrystallization(DRX)significantly influences basal and pyramidal〈c+a〉slip systems,with minimal impact on secondary deformation mechanism.In addition,the recrystallization mechanism of grain boundary bowing increases the activity of basal slip and decreases the activity of pyramidal〈c+a〉slip.The nucleation and growth of recrystallized grains enhance basal slip activity and suppress pyramidal〈c+a〉slip,leading to the formation of a strong basal texture.As dynamic recrystallization progresses,a bimodal texture develops,characterized by a reduction in basal component pole density and a more pronounced basal slip.
基金funded by the National Natural Science Foundation of China(No.52204407,No.22208220,No.52304408,No.52304398)the Zhejiang Provincial Natural Science Foundation of China(No.LQN25E010012)the Key Industrial Technology Research and Basic public welfare program projects in Shaoxing city(2023B41003,2023A11004 and 2023A11005).
文摘This study produced wide(900-1200 mm)AZ31 alloy sheets with varying thicknesses via continuous casting direct rolling(7 mm,6 mm)combined with stepwise warm rolling(4.5 mm,2 mm),examining the effects of this process on microstructure,corrosion durability,mechanical properties,and discharge properties.Results showed that the reduced thickness significantly refined the grain size from 131.20µm to 7.90µm with the basal texture intensity reached 52%.Synergistic grain refinement,dislocation,and texture strengthening improved the yield strength(YS),ultimate tensile strength(UTS),and elongation(EL)of the 2 mm-thick sheet by 59.11%,39.75%,and 83.52%,respectively,compared to those of the 7 mm-thick sheet.Corrosion durability was also improved,with a corrosion rate of 2.19 mm·y^(-1)for the 2 mm sheet,which was 41%lower than that of the 7 mm sheet(3.72 mm·y^(-1)),due to the formation of a dense Al(OH)3 and layered double hydroxide corrosion film with mitigated micro-galvanic corrosion.As an Mg-air battery anode,the 2 mm sheet performed the best at 10 mA/cm^(2),achieving an anode efficiency of 61.18%,specific energy of 1660.50 mWh·g^(-1),easy discharge product detachment,and reduced self-corrosion.In summary,this study demonstrates a cost-effective and industrially viable approach that combines continuous casting direct rolling with stepwise warm rolling to produce ultra-wide AZ31 sheets with simultaneously improved overall properties,offering a novel strategy to expand the opportunity for commercial Mg alloys in both structural and functional applications.
基金supported by the National Nature Science Foundation of China(52275356).
文摘This work investigates the effects of deformation mechanisms on the mechanical properties and anisotropy of rolled AZ31B magnesium alloy under uniaxial tension,combining experimental characterization with Visco-Plastic Self Consistent(VPSC)modeling.The research focuses particularly on anisotropic mechanical responses along transverse direction(TD)and rolling direction(RD).Experimental measurements and computational simulations consistently demonstrate that prismaticslip activation significantly reduces the strain hardening rate during the initial stage of tensile deformation.By suppressing the activation of specific deformation mechanisms along RD and TD,the tensile mechanical behavior of the magnesium alloy was further investigated.The results show that basalslip has the greatest impact during the initial deformation stage and basalslip activation substantially affects the deformation behavior of AZ31B alloy,causing marked decreases in both yield and tensile strength along RD.Under tensile loading along TD,prismaticslip not only exhibits a synergistic effect on yield strength,but also dominants work hardening during the initial plastic deformation.
