The sex pheromone of grapholitha molesta 8(Z/E)-dodecen-1-ol acetate (6) was synthesized by using oleic acids as the raw material. 1,8(Z)-Heptadecadiene (2) was obtained from the decarbonylation reaction of oleic acid...The sex pheromone of grapholitha molesta 8(Z/E)-dodecen-1-ol acetate (6) was synthesized by using oleic acids as the raw material. 1,8(Z)-Heptadecadiene (2) was obtained from the decarbonylation reaction of oleic acid (1) in the presence of palladium complexes catalyst. Selective hydroboration and oxidation of 2 by Ca(BH 4) 2/H 2O 2 system gave 8(Z)-heptadecen-1-ol (3), which then was acetylized by treatment with Ac 2O/pyridine to afford 8(Z)-heptadecen-ol acetate(4). The compound 4 was ozonized to form the key intermediate 8-acetoxyoctanal (5), then compound 5 was coupled with the Wittig regents to obtain the title compound 8(Z/E)dodecen-1-ol acetate (6), Z/E molar ratio is 25∶75. The overall yield was 45%. The structures of all the compounds were confirmed by IR, MS and NMR spectra.展开更多
A HPLC method for determination of N,N-diethyl-m-toluamide(DEET)loaded in microspheres was established. An ODS column was used with the mobile phase of methanol-water(65∶35)at the detection wavelength of 210nm. The c...A HPLC method for determination of N,N-diethyl-m-toluamide(DEET)loaded in microspheres was established. An ODS column was used with the mobile phase of methanol-water(65∶35)at the detection wavelength of 210nm. The calibration curve was linear in the range of 10 - 150μg/ml, and the detection limit was 4ng. The average recovery was 99.8% with RSD of 0.65%. The average drug loading of three batches of DEET microspheres were 16.1%, 16.3% and 17.7%.展开更多
S)-2-Acetoxyltridecane, which is the aggregation pheromone of Drosophila Mulleric and the sex pheromone component of the pea midge (Contarinia pisi), was synthesized from ethyl acetoacetate by enzymatic reduction with...S)-2-Acetoxyltridecane, which is the aggregation pheromone of Drosophila Mulleric and the sex pheromone component of the pea midge (Contarinia pisi), was synthesized from ethyl acetoacetate by enzymatic reduction with bakers yeast in the presence of ethyl chloroacetate as a key step. The optical purity of the target product is about 98%e.e.展开更多
文摘The sex pheromone of grapholitha molesta 8(Z/E)-dodecen-1-ol acetate (6) was synthesized by using oleic acids as the raw material. 1,8(Z)-Heptadecadiene (2) was obtained from the decarbonylation reaction of oleic acid (1) in the presence of palladium complexes catalyst. Selective hydroboration and oxidation of 2 by Ca(BH 4) 2/H 2O 2 system gave 8(Z)-heptadecen-1-ol (3), which then was acetylized by treatment with Ac 2O/pyridine to afford 8(Z)-heptadecen-ol acetate(4). The compound 4 was ozonized to form the key intermediate 8-acetoxyoctanal (5), then compound 5 was coupled with the Wittig regents to obtain the title compound 8(Z/E)dodecen-1-ol acetate (6), Z/E molar ratio is 25∶75. The overall yield was 45%. The structures of all the compounds were confirmed by IR, MS and NMR spectra.
文摘A HPLC method for determination of N,N-diethyl-m-toluamide(DEET)loaded in microspheres was established. An ODS column was used with the mobile phase of methanol-water(65∶35)at the detection wavelength of 210nm. The calibration curve was linear in the range of 10 - 150μg/ml, and the detection limit was 4ng. The average recovery was 99.8% with RSD of 0.65%. The average drug loading of three batches of DEET microspheres were 16.1%, 16.3% and 17.7%.
文摘S)-2-Acetoxyltridecane, which is the aggregation pheromone of Drosophila Mulleric and the sex pheromone component of the pea midge (Contarinia pisi), was synthesized from ethyl acetoacetate by enzymatic reduction with bakers yeast in the presence of ethyl chloroacetate as a key step. The optical purity of the target product is about 98%e.e.
