Objective:The study aimed to report the distinctive fundus appearance of bilateral asymmetric choroidal melanocytosis and reviewed the clinical and multimodal imaging characteristics to differentiate choroidal melanoc...Objective:The study aimed to report the distinctive fundus appearance of bilateral asymmetric choroidal melanocytosis and reviewed the clinical and multimodal imaging characteristics to differentiate choroidal melanocytosis from malignant pigmented retinal lesions.Methods:An observational case report and literature review.Results:A 60-year-old patient underwent comprehensive ophthalmologic examinations.Underfunduscopic examination,bilateral choroidal melanocytosis with asymmetry choroidal pigmentation change was observed.In the right eye,there was diffuse darker coloration extending from posterior pole to the mid-peripheral retina.In the left eye,flat patches of choroidal hyperpigmentation were present,involving superior and inferior hemisphere region,while other regions were depigmented.Spectral-domain optical coherence tomography revealed that the layers of retina and choroid were basically normal,with no elevation of the retinal pigment epithelium.Near infrared reflectance images provided a clearer view of mottled focal hyperpigmentation area,which corresponded to the choroidal hyperpigmentation.Conclusions:This case highlights the effectiveness of multimodal imaging in distinguishing choroidal melanocytosis from malignant entities.It emphasizes the crucial role of multimodal imaging in guiding clinical management to prevent vision-threatening complications and monitor potential malignant transformation.展开更多
Dear Editor,Oculo-facio-cardio-dental(OFCD)syndrome is a rare X chromosome-linked dominant genetic disease with multiple system and site abnormalities.The typical traits shown in this disease are:1)eye abnormalities,n...Dear Editor,Oculo-facio-cardio-dental(OFCD)syndrome is a rare X chromosome-linked dominant genetic disease with multiple system and site abnormalities.The typical traits shown in this disease are:1)eye abnormalities,notably congenital cataracts,microphthalmia,and secondary glaucoma;2)facial deformities,in particular long and narrow face,high nasal bridge,nasal tip cartilage division,and cleft palate.展开更多
基金found by the Key Research and Development Program of the Ministry of Science and Technology(2022YFF1202901)the National Natural Science Foundation of China(82171404)+3 种基金the Natural Science Foundation of Guangdong Province of China(2023A1515011529)the Science and Technology Planning Project of Guangzhou City(2023A03J0181,2024A04J6481)the Fundamental Research Funds for the Central Universities(22yklj04)the Research Start-up Founds of Sun Yat-sen University(Funded Talent[2020]18).
文摘Objective:The study aimed to report the distinctive fundus appearance of bilateral asymmetric choroidal melanocytosis and reviewed the clinical and multimodal imaging characteristics to differentiate choroidal melanocytosis from malignant pigmented retinal lesions.Methods:An observational case report and literature review.Results:A 60-year-old patient underwent comprehensive ophthalmologic examinations.Underfunduscopic examination,bilateral choroidal melanocytosis with asymmetry choroidal pigmentation change was observed.In the right eye,there was diffuse darker coloration extending from posterior pole to the mid-peripheral retina.In the left eye,flat patches of choroidal hyperpigmentation were present,involving superior and inferior hemisphere region,while other regions were depigmented.Spectral-domain optical coherence tomography revealed that the layers of retina and choroid were basically normal,with no elevation of the retinal pigment epithelium.Near infrared reflectance images provided a clearer view of mottled focal hyperpigmentation area,which corresponded to the choroidal hyperpigmentation.Conclusions:This case highlights the effectiveness of multimodal imaging in distinguishing choroidal melanocytosis from malignant entities.It emphasizes the crucial role of multimodal imaging in guiding clinical management to prevent vision-threatening complications and monitor potential malignant transformation.
基金Supported by National Natural Science Foundation of China(No.82171026).
文摘Dear Editor,Oculo-facio-cardio-dental(OFCD)syndrome is a rare X chromosome-linked dominant genetic disease with multiple system and site abnormalities.The typical traits shown in this disease are:1)eye abnormalities,notably congenital cataracts,microphthalmia,and secondary glaucoma;2)facial deformities,in particular long and narrow face,high nasal bridge,nasal tip cartilage division,and cleft palate.
