Multiple sclerosis(MS) is a chronic, autoimmune and neuroinflammatory disease of the central nervous system(CNS) with a neurodegenerative component, characterized by demyelination and degeneration of nerve fibers. It ...Multiple sclerosis(MS) is a chronic, autoimmune and neuroinflammatory disease of the central nervous system(CNS) with a neurodegenerative component, characterized by demyelination and degeneration of nerve fibers. It affects mainly young adults(aged 20 to 45 years) and its causes are still unknown, but it is thought that external factors such as viruses and environmental factors trigger the disease in people with a genetic susceptibility.展开更多
目的近年来,静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)已成为无创研究多发性硬化症(multiple sclerosis,MS)脑功能异常的关键技术,但现有研究结论存在分歧。为此,需整合现有rs-fMRI研究证据...目的近年来,静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)已成为无创研究多发性硬化症(multiple sclerosis,MS)脑功能异常的关键技术,但现有研究结论存在分歧。为此,需整合现有rs-fMRI研究证据,明确MS患者脑功能的一致性改变。材料与方法截至2025年4月,系统检索PubMed、Web of Science、Embase、中国知网及万方数据库,筛选采用低频振幅(amplitude of low-frequency fluctuation,ALFF)、分数ALFF(fractional ALFF,fALFF)或局部一致性(regional homogeneity,ReHo)方法探究MS患者自发脑功能活动的研究,并运用各向异性效应量种子点d映射(anisotropic effect size seed-based d mapping,AES-SDM)软件进行数据分析。结果共纳入11项研究(12个数据集),涉及292例MS患者和278例健康对照(healthy controls,HCs)。与HCs相比,MS患者右岛叶、罗兰岛盖、赫氏回、缘上回、双侧丘脑及左侧额下回(眶部)自发性脑功能活动显著增强,而右舌回、楔叶皮层、距状裂/周围皮层、颞中回、纹状体(尾状核)活动显著降低。结论本研究揭示了MS患者一致性脑功能改变,涉及情绪调节、认知、感觉、视觉及运动控制等相关脑区。这些发现不仅深化了对MS神经病理机制的理解,还为疾病诊断、进展监测及治疗效果评估提供了潜在的生物标志物。展开更多
Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple rol...Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.展开更多
Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b...Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated by infiltrating immune cells(Hauser and Cree, 2020).展开更多
Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.
Multiple sclerosis(MS)is the most common chronic disease of the central nervous system(CNS)in young adults and represents the first cause of severe handicap,originally non-traumatic(Oh et al.,2018).MS is chara cterize...Multiple sclerosis(MS)is the most common chronic disease of the central nervous system(CNS)in young adults and represents the first cause of severe handicap,originally non-traumatic(Oh et al.,2018).MS is chara cterized by the infiltration of auto reactive lymphocytes specific to myelin through the blood-brain barrier,which results in the appearance of inflammatory demyelinating lesions caused by the death of the central nervous system myelinating cells,oligodendrocytes(Oh et al.,2018).There is a prevalence sexual with a ratio of three times more affected women than men.展开更多
基金supported by Italian Ministry of Health Ricerca Corrente [RC 2023] and RF-2016-02361294supported by#NEXTGENERATIONEU (NGEU)+3 种基金funded by the Ministry of University and Research (MUR)National Recovery and Resilience Plan (NRRP)project MNESYS (PE0000006)–A Multiscale integrated approach to the study of the nervous system in health and disease (DN. 1553 11.10.2022)(to FRG)partially supported by a grant from Fondazione Romeo ed Enrica Invernizzi (to FRG)。
文摘Multiple sclerosis(MS) is a chronic, autoimmune and neuroinflammatory disease of the central nervous system(CNS) with a neurodegenerative component, characterized by demyelination and degeneration of nerve fibers. It affects mainly young adults(aged 20 to 45 years) and its causes are still unknown, but it is thought that external factors such as viruses and environmental factors trigger the disease in people with a genetic susceptibility.
文摘目的近年来,静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)已成为无创研究多发性硬化症(multiple sclerosis,MS)脑功能异常的关键技术,但现有研究结论存在分歧。为此,需整合现有rs-fMRI研究证据,明确MS患者脑功能的一致性改变。材料与方法截至2025年4月,系统检索PubMed、Web of Science、Embase、中国知网及万方数据库,筛选采用低频振幅(amplitude of low-frequency fluctuation,ALFF)、分数ALFF(fractional ALFF,fALFF)或局部一致性(regional homogeneity,ReHo)方法探究MS患者自发脑功能活动的研究,并运用各向异性效应量种子点d映射(anisotropic effect size seed-based d mapping,AES-SDM)软件进行数据分析。结果共纳入11项研究(12个数据集),涉及292例MS患者和278例健康对照(healthy controls,HCs)。与HCs相比,MS患者右岛叶、罗兰岛盖、赫氏回、缘上回、双侧丘脑及左侧额下回(眶部)自发性脑功能活动显著增强,而右舌回、楔叶皮层、距状裂/周围皮层、颞中回、纹状体(尾状核)活动显著降低。结论本研究揭示了MS患者一致性脑功能改变,涉及情绪调节、认知、感觉、视觉及运动控制等相关脑区。这些发现不仅深化了对MS神经病理机制的理解,还为疾病诊断、进展监测及治疗效果评估提供了潜在的生物标志物。
基金supported by the National Natural Science Foundation of China,Nos.82060219,82271234the Natural Science Foundation of Jiangxi Province,Nos.20212ACB216009,20212BAB216048+1 种基金Jiangxi Province Thousands of Plans,No.jxsq2019201023Youth Team Project of the Second Affiliated Hospital of Nanchang University,No.2019YNTD12003(all to FH)。
文摘Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.
文摘Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated by infiltrating immune cells(Hauser and Cree, 2020).
基金supported by the Christiane and Claudia Hempel Foundation for Regenerative Medicineby the James and Elisabeth Cloppenburg, Peek and Cloppenburg Düsseldorf Stiftung(to PK)。
文摘Introduction to human endogenous retrovirus type-W(HERV-W): Genomic inheritance from the past includes retroviral sequences that have been stably incorporated into our genomes and account for up to 8% of human DNA.
基金supported by a grant from the French Multiple Sclerosis Society(ARSEP,Grant Number:R20163LL)(to AMG)。
文摘Multiple sclerosis(MS)is the most common chronic disease of the central nervous system(CNS)in young adults and represents the first cause of severe handicap,originally non-traumatic(Oh et al.,2018).MS is chara cterized by the infiltration of auto reactive lymphocytes specific to myelin through the blood-brain barrier,which results in the appearance of inflammatory demyelinating lesions caused by the death of the central nervous system myelinating cells,oligodendrocytes(Oh et al.,2018).There is a prevalence sexual with a ratio of three times more affected women than men.
