The spinal cord links the brain and the peripheral nervous system and has important sensory and motor functions.Impairments in the spinal cord occur in different diseases,such as spinal cord injury,multiple sclerosis,...The spinal cord links the brain and the peripheral nervous system and has important sensory and motor functions.Impairments in the spinal cord occur in different diseases,such as spinal cord injury,multiple sclerosis,pain,motor neuron diseases,and neurodegenerative diseases.Imaging of the spinal cord has been challenging,partly due to its small size and deep anatomical location.Additionally,in an animal model,motion artifacts further influence the in vivo imaging quality of the spinal cord.Recent advances have pushed boundaries for in vivo imaging in living animals(even behaving animals).展开更多
目的近年来,静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)已成为无创研究多发性硬化症(multiple sclerosis,MS)脑功能异常的关键技术,但现有研究结论存在分歧。为此,需整合现有rs-fMRI研究证据...目的近年来,静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)已成为无创研究多发性硬化症(multiple sclerosis,MS)脑功能异常的关键技术,但现有研究结论存在分歧。为此,需整合现有rs-fMRI研究证据,明确MS患者脑功能的一致性改变。材料与方法截至2025年4月,系统检索PubMed、Web of Science、Embase、中国知网及万方数据库,筛选采用低频振幅(amplitude of low-frequency fluctuation,ALFF)、分数ALFF(fractional ALFF,fALFF)或局部一致性(regional homogeneity,ReHo)方法探究MS患者自发脑功能活动的研究,并运用各向异性效应量种子点d映射(anisotropic effect size seed-based d mapping,AES-SDM)软件进行数据分析。结果共纳入11项研究(12个数据集),涉及292例MS患者和278例健康对照(healthy controls,HCs)。与HCs相比,MS患者右岛叶、罗兰岛盖、赫氏回、缘上回、双侧丘脑及左侧额下回(眶部)自发性脑功能活动显著增强,而右舌回、楔叶皮层、距状裂/周围皮层、颞中回、纹状体(尾状核)活动显著降低。结论本研究揭示了MS患者一致性脑功能改变,涉及情绪调节、认知、感觉、视觉及运动控制等相关脑区。这些发现不仅深化了对MS神经病理机制的理解,还为疾病诊断、进展监测及治疗效果评估提供了潜在的生物标志物。展开更多
文摘The spinal cord links the brain and the peripheral nervous system and has important sensory and motor functions.Impairments in the spinal cord occur in different diseases,such as spinal cord injury,multiple sclerosis,pain,motor neuron diseases,and neurodegenerative diseases.Imaging of the spinal cord has been challenging,partly due to its small size and deep anatomical location.Additionally,in an animal model,motion artifacts further influence the in vivo imaging quality of the spinal cord.Recent advances have pushed boundaries for in vivo imaging in living animals(even behaving animals).
文摘目的近年来,静息态功能磁共振成像(resting-state functional magnetic resonance imaging,rs-fMRI)已成为无创研究多发性硬化症(multiple sclerosis,MS)脑功能异常的关键技术,但现有研究结论存在分歧。为此,需整合现有rs-fMRI研究证据,明确MS患者脑功能的一致性改变。材料与方法截至2025年4月,系统检索PubMed、Web of Science、Embase、中国知网及万方数据库,筛选采用低频振幅(amplitude of low-frequency fluctuation,ALFF)、分数ALFF(fractional ALFF,fALFF)或局部一致性(regional homogeneity,ReHo)方法探究MS患者自发脑功能活动的研究,并运用各向异性效应量种子点d映射(anisotropic effect size seed-based d mapping,AES-SDM)软件进行数据分析。结果共纳入11项研究(12个数据集),涉及292例MS患者和278例健康对照(healthy controls,HCs)。与HCs相比,MS患者右岛叶、罗兰岛盖、赫氏回、缘上回、双侧丘脑及左侧额下回(眶部)自发性脑功能活动显著增强,而右舌回、楔叶皮层、距状裂/周围皮层、颞中回、纹状体(尾状核)活动显著降低。结论本研究揭示了MS患者一致性脑功能改变,涉及情绪调节、认知、感觉、视觉及运动控制等相关脑区。这些发现不仅深化了对MS神经病理机制的理解,还为疾病诊断、进展监测及治疗效果评估提供了潜在的生物标志物。
