Recently, the study on the extraction, component analysis and function of angiogenic factor (AF) has become an important subject in anti-tumor research and made a great progress. Therefore, the imitation of the tumor&...Recently, the study on the extraction, component analysis and function of angiogenic factor (AF) has become an important subject in anti-tumor research and made a great progress. Therefore, the imitation of the tumor's angiogenic activity (AGA) possibly helps to find a new method to treat ischemic diseases by blood vessel proliferation. Most of the parenchymatous malignant tumors have AGA. We studied the early stage condyloma acuminatum (CA) . After transplanting CA onto the chorioallantoic membrane (CAM) of chick embryos, we observed the AGA of CA and carefully compared it with that of basal cell carcinoma which is generally considered to have strong AGA. Meanwhile, we explored the way by which the AF of CA comes into being. The results demonstrated that CA, a benign neoplastic lesion, at its early stage, also has AGA. It is postulated that the responsible material is a certain form of AF. Therefore, the study on AGA of benign lesions (such as CA) and its physical basis will have potential clinical significance.展开更多
目的探讨不同麻醉方式联合腹横肌平面阻滞对老年结肠癌患者胃肠功能及可溶性上皮型钙黏蛋白(sE-cad)、单核细胞人白血病抗原-DR(mHLA-DR)水平的影响。方法选取2018年9月至2019年9月该院收治的98例需要行结肠癌根治术的老年结肠癌患者,...目的探讨不同麻醉方式联合腹横肌平面阻滞对老年结肠癌患者胃肠功能及可溶性上皮型钙黏蛋白(sE-cad)、单核细胞人白血病抗原-DR(mHLA-DR)水平的影响。方法选取2018年9月至2019年9月该院收治的98例需要行结肠癌根治术的老年结肠癌患者,按照随机数字表法分为观察组(49例)和对照组(49例)。两组患者均采用常规诱导,对照组采用吸入七氟烷(控制MAC值在1.0~2.0)维持,并以瑞芬太尼0.1~0.2μg·kg^-1·min^-1进行镇痛。观察组输注右美托咪定0.5μg·kg^-1·h^-1维持镇静和瑞芬太尼0.1~0.2μg·kg^-1·min^-1进行镇痛。观察并记录两组患者一般资料、术后疼痛评分、胃肠激素水平、胃肠功能恢复时间、住院时间,以及手术前后sE-cad、mHLA-DR水平和不良反应等。结果观察组患者术后6、12、48 h VAS评分显著低于对照组(P<0.05);观察组术后胃动素及胃泌素水平均优于对照组(P<0.05);观察组患者胃肠功能恢复时间(包括腹胀消失时间、腹痛消失时间、排气排便恢复时间、肠鸣音恢复时间等)及住院时间均明显低于对照组(P<0.05);术后1、3、7 d,观察组sE-cad明显低于对照组(P<0.05),mHLA-DR显著高于对照组(P<0.05)。两组患者术后均未出现严重不良反应,观察组术后出现嗜睡3例,恶心呕吐3例,低血压4例;对照组术后出现嗜睡1例,恶心呕吐5例,低血压1例。结论右美托咪定静脉麻醉能有效改善老年结肠癌患者术后疼痛及胃肠功能,并降低应激反应,值得临床推广。展开更多
文摘Recently, the study on the extraction, component analysis and function of angiogenic factor (AF) has become an important subject in anti-tumor research and made a great progress. Therefore, the imitation of the tumor's angiogenic activity (AGA) possibly helps to find a new method to treat ischemic diseases by blood vessel proliferation. Most of the parenchymatous malignant tumors have AGA. We studied the early stage condyloma acuminatum (CA) . After transplanting CA onto the chorioallantoic membrane (CAM) of chick embryos, we observed the AGA of CA and carefully compared it with that of basal cell carcinoma which is generally considered to have strong AGA. Meanwhile, we explored the way by which the AF of CA comes into being. The results demonstrated that CA, a benign neoplastic lesion, at its early stage, also has AGA. It is postulated that the responsible material is a certain form of AF. Therefore, the study on AGA of benign lesions (such as CA) and its physical basis will have potential clinical significance.
文摘目的探讨不同麻醉方式联合腹横肌平面阻滞对老年结肠癌患者胃肠功能及可溶性上皮型钙黏蛋白(sE-cad)、单核细胞人白血病抗原-DR(mHLA-DR)水平的影响。方法选取2018年9月至2019年9月该院收治的98例需要行结肠癌根治术的老年结肠癌患者,按照随机数字表法分为观察组(49例)和对照组(49例)。两组患者均采用常规诱导,对照组采用吸入七氟烷(控制MAC值在1.0~2.0)维持,并以瑞芬太尼0.1~0.2μg·kg^-1·min^-1进行镇痛。观察组输注右美托咪定0.5μg·kg^-1·h^-1维持镇静和瑞芬太尼0.1~0.2μg·kg^-1·min^-1进行镇痛。观察并记录两组患者一般资料、术后疼痛评分、胃肠激素水平、胃肠功能恢复时间、住院时间,以及手术前后sE-cad、mHLA-DR水平和不良反应等。结果观察组患者术后6、12、48 h VAS评分显著低于对照组(P<0.05);观察组术后胃动素及胃泌素水平均优于对照组(P<0.05);观察组患者胃肠功能恢复时间(包括腹胀消失时间、腹痛消失时间、排气排便恢复时间、肠鸣音恢复时间等)及住院时间均明显低于对照组(P<0.05);术后1、3、7 d,观察组sE-cad明显低于对照组(P<0.05),mHLA-DR显著高于对照组(P<0.05)。两组患者术后均未出现严重不良反应,观察组术后出现嗜睡3例,恶心呕吐3例,低血压4例;对照组术后出现嗜睡1例,恶心呕吐5例,低血压1例。结论右美托咪定静脉麻醉能有效改善老年结肠癌患者术后疼痛及胃肠功能,并降低应激反应,值得临床推广。
