应用流式细胞仪测定27例成人不同类型白血病和10例正常对照者的骨髓细胞和/或外周血细胞的DNA指数(DNA index,DI)、增殖指数(Proliferating index,PI)、DNA倍体、变异系数(Coefficient of variation,CV)。结果,白血病患者骨髓及血细胞...应用流式细胞仪测定27例成人不同类型白血病和10例正常对照者的骨髓细胞和/或外周血细胞的DNA指数(DNA index,DI)、增殖指数(Proliferating index,PI)、DNA倍体、变异系数(Coefficient of variation,CV)。结果,白血病患者骨髓及血细胞的PI值比对照组显著增高(P<0.05和P<0.01),急非淋组较急淋、急早白组增高尤为明显:完全缓解者10例的骨髓及血细胞PI值及非整倍率均显示低于17例未缓解者,两者有显著差异。表明动态观察PI值可作为临床估价疗效、预测预后的参考依据。展开更多
The relationship between the change of chromosome and theraputic response or prognosis in podiatric leukemia was investigated in our study. Conditions in chromosome preparation of leukemic cell were also studied. In o...The relationship between the change of chromosome and theraputic response or prognosis in podiatric leukemia was investigated in our study. Conditions in chromosome preparation of leukemic cell were also studied. In our study, 12 patients were observed with theirclinic characters. chemotherapy protocal. the response to chemotherapy and the changes ofcell chromosome. The result of our study suggested that the development of podiatricleukemia was closely related to the changes of chromosome. Therefore, Karyotype should bedetermined for leukemic children as a biomark of evaluation of pragnosis.展开更多
文摘应用流式细胞仪测定27例成人不同类型白血病和10例正常对照者的骨髓细胞和/或外周血细胞的DNA指数(DNA index,DI)、增殖指数(Proliferating index,PI)、DNA倍体、变异系数(Coefficient of variation,CV)。结果,白血病患者骨髓及血细胞的PI值比对照组显著增高(P<0.05和P<0.01),急非淋组较急淋、急早白组增高尤为明显:完全缓解者10例的骨髓及血细胞PI值及非整倍率均显示低于17例未缓解者,两者有显著差异。表明动态观察PI值可作为临床估价疗效、预测预后的参考依据。
文摘The relationship between the change of chromosome and theraputic response or prognosis in podiatric leukemia was investigated in our study. Conditions in chromosome preparation of leukemic cell were also studied. In our study, 12 patients were observed with theirclinic characters. chemotherapy protocal. the response to chemotherapy and the changes ofcell chromosome. The result of our study suggested that the development of podiatricleukemia was closely related to the changes of chromosome. Therefore, Karyotype should bedetermined for leukemic children as a biomark of evaluation of pragnosis.
