目的分析新生儿脐动脉血气指标与阿普加(Apgar)评分的相关性。方法选取294例新生儿作为研究对象,根据出生1 min Apgar评分不同分为研究组(Apgar评分≤7分,22例)、对照组(Apgar评分8~10分,272例)。比较两组出生1 min Apgar评分、脐动脉...目的分析新生儿脐动脉血气指标与阿普加(Apgar)评分的相关性。方法选取294例新生儿作为研究对象,根据出生1 min Apgar评分不同分为研究组(Apgar评分≤7分,22例)、对照组(Apgar评分8~10分,272例)。比较两组出生1 min Apgar评分、脐动脉血气指标[pH值、血乳酸(Lac)、剩余碱(BE)],采用Pearson相关性分析法分析脐动脉血气指标与Apgar评分的相关性。结果研究组出生1 min Apgar评分(5.78±0.39)分、pH值(7.18±0.16)、BE(-10.14±1.13)mmol/L低于对照组的(8.59±0.41)分、(7.26±0.02)、(-3.24±1.02)mmol/L,Lac(8.46±1.14)mmol/L高于对照组的(5.02±0.21)mmol/L(P<0.05)。Pearson相关性分析结果显示,pH值、BE与出生1 min Apgar评分呈正相关(r=0.607、0.626,P<0.05);Lac与出生1 min Apgar评分呈负相关(r=-0.780,P<0.05)。结论相较于出生1 min Apgar评分8~10分的新生儿,Apgar评分≤7分的新生儿pH值、BE更低,Lac更高,新生儿脐动脉血气指标(pH值、BE、Lac)与Apgar评分关系密切,将脐动脉血气指标与Apgar评分同时应用可为后续开展临床诊疗新生儿窒息工作提供参考。展开更多
Perinatal exposure to infection/inflammation is highly associated with neural injury,and subsequent impaired cortical growth,disturbances in neuronal connectivity,and impaired neurodevelopment.However,our understandin...Perinatal exposure to infection/inflammation is highly associated with neural injury,and subsequent impaired cortical growth,disturbances in neuronal connectivity,and impaired neurodevelopment.However,our understanding of the pathophysiological substrate underpinning these changes in brain structure and function is limited.The objective of this review is to summarize the growing evidence from animal trials and human cohort studies that suggest exposure to infection/inflammation during the perinatal period promotes regional impairments in neuronal maturation and function,including loss of high-frequency electroencephalographic activity,and reduced growth and arborization of cortical dendrites and dendritic spines resulting in reduced cortical volume.These inflammation-induced disturbances to neuronal structure and function are likely to underpin subsequent disturbances to cortical development and connectivity in fetuses and/or newborns exposed to infection/inflammation during the perinatal period,leading,in the long term,to impaired neurodevelopment.The combined use of early electroencephalography monitoring with neuroimaging techniques that enable detailed evaluation of brain microstructure,and the use of therapeutics that successfully target systemic and central nervous system inflammation could provide an effective strategy for early detection and therapeutic intervention.展开更多
目的探讨血清骨膜蛋白(POSTN)、微小核糖核酸-15b(miR-15b)、Clara细胞分泌蛋白16(CC16)与新生儿支气管肺发育不良(BPD)的相关性。方法选取2022年1月至2024年1月保定市妇幼保健院收治的BPD早产儿186例为BPD组,同期非BPD早产儿186例为非...目的探讨血清骨膜蛋白(POSTN)、微小核糖核酸-15b(miR-15b)、Clara细胞分泌蛋白16(CC16)与新生儿支气管肺发育不良(BPD)的相关性。方法选取2022年1月至2024年1月保定市妇幼保健院收治的BPD早产儿186例为BPD组,同期非BPD早产儿186例为非BPD组,比较两组血清POSTN、miR-15b、CC16水平,基线资料,肺功能指标。Spearman分析BPD患儿血清POSTN、miR-15b、CC16与BPD的相关性。多因素Logistic回归分析BPD患儿的影响因素。结果BPD组血清POSTN、miR-15b高于非BPD组,CC16低于非BPD组,差异有统计学意义(P<0.05)。BPD组50%潮气量时呼气流速(50%TEF)、千克体重潮气量(VT/kg)、达峰容积比(VPEF/VE)低于非BPD组,差异有统计学意义(P<0.05)。Spearman相关性分析显示,POSTN、miR-15b与5 min Apgar评分、1,25-(OH)2D3、50%TEF、VT/kg、VPEF/VE呈负相关,POSTN与机械通气时间、吸氧时间、最高氧浓度呈正相关,miR-15b与呼吸窘迫综合征、机械通气时间、吸氧时间、最高氧浓度呈正相关;CC16与机械通气时间、吸氧时间、最高氧浓度呈负相关,与5 min Apgar评分、1,25-(OH)2D3、50%TEF、VT/kg、VPEF/VE呈正相关(P<0.05)。Logistic回归分析结果显示,呼吸窘迫综合征、机械通气时间、吸氧时间、最高氧浓度、POSTN、miR-15b是BPD患儿的危险因素,5 min Apgar评分、1,25-(OH)2D3、50%TEF、VT/kg、VPEF/VE、CC16是BPD患儿的保护因素(P<0.05)。结论BPD患儿血清POSTN、miR-15b升高,CC16降低,其水平变化与BPD发生密切相关。展开更多
文摘目的分析新生儿脐动脉血气指标与阿普加(Apgar)评分的相关性。方法选取294例新生儿作为研究对象,根据出生1 min Apgar评分不同分为研究组(Apgar评分≤7分,22例)、对照组(Apgar评分8~10分,272例)。比较两组出生1 min Apgar评分、脐动脉血气指标[pH值、血乳酸(Lac)、剩余碱(BE)],采用Pearson相关性分析法分析脐动脉血气指标与Apgar评分的相关性。结果研究组出生1 min Apgar评分(5.78±0.39)分、pH值(7.18±0.16)、BE(-10.14±1.13)mmol/L低于对照组的(8.59±0.41)分、(7.26±0.02)、(-3.24±1.02)mmol/L,Lac(8.46±1.14)mmol/L高于对照组的(5.02±0.21)mmol/L(P<0.05)。Pearson相关性分析结果显示,pH值、BE与出生1 min Apgar评分呈正相关(r=0.607、0.626,P<0.05);Lac与出生1 min Apgar评分呈负相关(r=-0.780,P<0.05)。结论相较于出生1 min Apgar评分8~10分的新生儿,Apgar评分≤7分的新生儿pH值、BE更低,Lac更高,新生儿脐动脉血气指标(pH值、BE、Lac)与Apgar评分关系密切,将脐动脉血气指标与Apgar评分同时应用可为后续开展临床诊疗新生儿窒息工作提供参考。
基金supported by National Health and Medical Research Council of Australia(APP1090890 and APP1164954)Cerebral Palsy Alliance(ERG02123)the Victorian Government’s Operational Infrastructure Support Program。
文摘Perinatal exposure to infection/inflammation is highly associated with neural injury,and subsequent impaired cortical growth,disturbances in neuronal connectivity,and impaired neurodevelopment.However,our understanding of the pathophysiological substrate underpinning these changes in brain structure and function is limited.The objective of this review is to summarize the growing evidence from animal trials and human cohort studies that suggest exposure to infection/inflammation during the perinatal period promotes regional impairments in neuronal maturation and function,including loss of high-frequency electroencephalographic activity,and reduced growth and arborization of cortical dendrites and dendritic spines resulting in reduced cortical volume.These inflammation-induced disturbances to neuronal structure and function are likely to underpin subsequent disturbances to cortical development and connectivity in fetuses and/or newborns exposed to infection/inflammation during the perinatal period,leading,in the long term,to impaired neurodevelopment.The combined use of early electroencephalography monitoring with neuroimaging techniques that enable detailed evaluation of brain microstructure,and the use of therapeutics that successfully target systemic and central nervous system inflammation could provide an effective strategy for early detection and therapeutic intervention.
文摘目的探讨血清骨膜蛋白(POSTN)、微小核糖核酸-15b(miR-15b)、Clara细胞分泌蛋白16(CC16)与新生儿支气管肺发育不良(BPD)的相关性。方法选取2022年1月至2024年1月保定市妇幼保健院收治的BPD早产儿186例为BPD组,同期非BPD早产儿186例为非BPD组,比较两组血清POSTN、miR-15b、CC16水平,基线资料,肺功能指标。Spearman分析BPD患儿血清POSTN、miR-15b、CC16与BPD的相关性。多因素Logistic回归分析BPD患儿的影响因素。结果BPD组血清POSTN、miR-15b高于非BPD组,CC16低于非BPD组,差异有统计学意义(P<0.05)。BPD组50%潮气量时呼气流速(50%TEF)、千克体重潮气量(VT/kg)、达峰容积比(VPEF/VE)低于非BPD组,差异有统计学意义(P<0.05)。Spearman相关性分析显示,POSTN、miR-15b与5 min Apgar评分、1,25-(OH)2D3、50%TEF、VT/kg、VPEF/VE呈负相关,POSTN与机械通气时间、吸氧时间、最高氧浓度呈正相关,miR-15b与呼吸窘迫综合征、机械通气时间、吸氧时间、最高氧浓度呈正相关;CC16与机械通气时间、吸氧时间、最高氧浓度呈负相关,与5 min Apgar评分、1,25-(OH)2D3、50%TEF、VT/kg、VPEF/VE呈正相关(P<0.05)。Logistic回归分析结果显示,呼吸窘迫综合征、机械通气时间、吸氧时间、最高氧浓度、POSTN、miR-15b是BPD患儿的危险因素,5 min Apgar评分、1,25-(OH)2D3、50%TEF、VT/kg、VPEF/VE、CC16是BPD患儿的保护因素(P<0.05)。结论BPD患儿血清POSTN、miR-15b升高,CC16降低,其水平变化与BPD发生密切相关。
