目的分析先兆早产住院患者应用硫酸镁治疗的效果。方法选取先兆早产患者60例,应用随机抽签法分为对照组(n=30,给予常规疗法治疗)及观察组(n=30,在对照组基础上给予硫酸镁治疗)。比较两组患者的生命体征、临床指标、不良母婴结局以及用...目的分析先兆早产住院患者应用硫酸镁治疗的效果。方法选取先兆早产患者60例,应用随机抽签法分为对照组(n=30,给予常规疗法治疗)及观察组(n=30,在对照组基础上给予硫酸镁治疗)。比较两组患者的生命体征、临床指标、不良母婴结局以及用药不良反应发生情况。结果治疗后,观察组患者收缩压(105.29±3.68)mm Hg(1 mm Hg=0.133 kPa)、舒张压(68.27±3.45)mm Hg和心率(80.14±3.15)次/min均低于对照组的(112.48±3.51)mm Hg、(72.76±3.30)mm Hg、(85.62±3.07)次/min(P<0.05)。观察组患者症状消失时间(45.62±7.38)h、宫缩消失时间(7.34±1.27)h均短于对照组的(64.65±7.24)、(10.28±1.54)h,妊娠延长时间(21.08±2.34)d长于对照组的(17.26±2.17)d,新生儿出生1 min Apgar评分(8.46±0.85)分高于对照组的(7.34±0.72)分(P<0.05)。结论在先兆早产住院患者治疗中应用硫酸镁能够改善患者临床症状,有效控制患者血压和心率,降低产后出血、新生儿呼吸窘迫、新生儿脑瘫等的发生率,改善母婴结局;同时,治疗期间患者不良反应发生率低,治疗安全性高。展开更多
Objective:To investigate the potential link between chromosomal polymorphisms in couples who had a medical history of idiopathic recurrent pregnancy loss.Methods:Cytogenetic investigation was conducted with mitogen(Ph...Objective:To investigate the potential link between chromosomal polymorphisms in couples who had a medical history of idiopathic recurrent pregnancy loss.Methods:Cytogenetic investigation was conducted with mitogen(Phytohemagglutinin-M,Gibco)stimulated blood T lymphocytes by Giemsa trypsin Giemsa banding and Ag-NOR banding on 580 couples with a history of idiopathic recurrent pregnancy loss and 240 couples from the general population.Thirty good chromosomal spreads were captured,karyotyped,and analyzed.The karyotypes were designated using the International System for Human Cytogenomic Nomenclature 2024.Pearson Chi-square test was used to compare the frequency of chromosomal polymorphism variations in the idiopathic recurrent pregnancy loss group with the general population group.Results:A conventional cytogenetic investigation revealed that 45.43%of couples experiencing idiopathic recurrent pregnancy loss presented with various types of chromosomal polymorphic variants,compared to 11.88%in the general population.The overall frequency of these chromosomal polymorphic variants was significantly higher in the idiopathic recurrent pregnancy loss group compared to the general population group(OR 9.97,95%CI 6.99-14.21;P<0.05).Additionally,the prevalence of polymorphic variants was higher among males(49.14%)than females(41.72%)(P=0.01).Conclusions:Chromosomal polymorphic analysis may play a crucial role in the assessment and careful clinical management of cases with idiopathic recurrent pregnancy loss,especially when no other conclusive reasons are identified during the initial evaluation.Therefore,heteromorphism should not be overlooked while investigating the causes of idiopathic recurrent pregnancy loss.展开更多
文摘目的分析先兆早产住院患者应用硫酸镁治疗的效果。方法选取先兆早产患者60例,应用随机抽签法分为对照组(n=30,给予常规疗法治疗)及观察组(n=30,在对照组基础上给予硫酸镁治疗)。比较两组患者的生命体征、临床指标、不良母婴结局以及用药不良反应发生情况。结果治疗后,观察组患者收缩压(105.29±3.68)mm Hg(1 mm Hg=0.133 kPa)、舒张压(68.27±3.45)mm Hg和心率(80.14±3.15)次/min均低于对照组的(112.48±3.51)mm Hg、(72.76±3.30)mm Hg、(85.62±3.07)次/min(P<0.05)。观察组患者症状消失时间(45.62±7.38)h、宫缩消失时间(7.34±1.27)h均短于对照组的(64.65±7.24)、(10.28±1.54)h,妊娠延长时间(21.08±2.34)d长于对照组的(17.26±2.17)d,新生儿出生1 min Apgar评分(8.46±0.85)分高于对照组的(7.34±0.72)分(P<0.05)。结论在先兆早产住院患者治疗中应用硫酸镁能够改善患者临床症状,有效控制患者血压和心率,降低产后出血、新生儿呼吸窘迫、新生儿脑瘫等的发生率,改善母婴结局;同时,治疗期间患者不良反应发生率低,治疗安全性高。
基金funded by the Technology Development Board(TDB)of India's Ministry of Science and Technology(TDB/M-25/2018-19).
文摘Objective:To investigate the potential link between chromosomal polymorphisms in couples who had a medical history of idiopathic recurrent pregnancy loss.Methods:Cytogenetic investigation was conducted with mitogen(Phytohemagglutinin-M,Gibco)stimulated blood T lymphocytes by Giemsa trypsin Giemsa banding and Ag-NOR banding on 580 couples with a history of idiopathic recurrent pregnancy loss and 240 couples from the general population.Thirty good chromosomal spreads were captured,karyotyped,and analyzed.The karyotypes were designated using the International System for Human Cytogenomic Nomenclature 2024.Pearson Chi-square test was used to compare the frequency of chromosomal polymorphism variations in the idiopathic recurrent pregnancy loss group with the general population group.Results:A conventional cytogenetic investigation revealed that 45.43%of couples experiencing idiopathic recurrent pregnancy loss presented with various types of chromosomal polymorphic variants,compared to 11.88%in the general population.The overall frequency of these chromosomal polymorphic variants was significantly higher in the idiopathic recurrent pregnancy loss group compared to the general population group(OR 9.97,95%CI 6.99-14.21;P<0.05).Additionally,the prevalence of polymorphic variants was higher among males(49.14%)than females(41.72%)(P=0.01).Conclusions:Chromosomal polymorphic analysis may play a crucial role in the assessment and careful clinical management of cases with idiopathic recurrent pregnancy loss,especially when no other conclusive reasons are identified during the initial evaluation.Therefore,heteromorphism should not be overlooked while investigating the causes of idiopathic recurrent pregnancy loss.
