摘要
目的探讨安胎益母丸联合地屈孕酮片在先兆流产治疗中的临床疗效。方法选取100例先兆流产患者,按照随机数字表法将所有患者分为观察组和对照组,各50例。对照组予以地屈孕酮片治疗,观察组在对照组的基础上加用安胎益母丸治疗。比较两组患者临床疗效、中医证候积分、性激素(雌二醇、孕酮、人绒毛膜促性腺激素)水平、血液流变学指标(血浆粘度、全血高切粘度、全血低切粘度)水平、子宫胎盘灌注情况(子宫搏动指数、阻力指数)、妊娠结局、不良反应发生情况。结果治疗后,观察组临床总有效率92.00%高于对照组的76.00%(P<0.05)。治疗后,观察组阴道出血积分(0.63±0.13)分、小腹坠痛积分(0.71±0.20)分、两膝酸软积分(0.75±0.25)分、腰酸痛积分(0.88±0.15)分均低于对照组的(0.71±0.20)、(0.86±0.23)、(1.13±0.31)、(1.11±0.22)分(P<0.05)。治疗后,观察组雌二醇(233.67±25.17)ng/L、孕酮(30.13±4.28)ng/ml、人绒毛膜促性腺激素(24.11±4.33)ng/ml高于对照组的(200.84±23.42)ng/L、(27.64±4.33)ng/ml、(19.65±4.17)ng/ml(P<0.05)。治疗后,观察组血浆粘度(1.35±0.41)mPa·s、全血高切粘度(4.42±0.61)mPa·s、全血低切粘度(10.11±0.93)mPa·s低于对照组的(1.61±0.45)、(4.80±0.66)、(11.02±1.03)mPa·s(P<0.05)。治疗后,观察组子宫搏动指数(1.43±0.11)、阻力指数(0.62±0.10)低于对照组的(1.66±0.10)、(0.71±0.11)(P<0.05)。治疗后,观察组足月分娩率96.00%高于对照组的82.00%(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论安胎益母丸联合地屈孕酮片在提高妊娠成功率、改善临床症状和调节激素水平及血液流变学和子宫胎盘灌注情况方面具有显著效果,是一种安全可靠的治疗方案。
Objective To investigate the clinical efficacy of Antai Yimu pills combined with dydrogesterone tablets in the treatment of threatened miscarriage.Methods 100 patients with threatened abortion were selected,and assigned to either the observation group or the control group according to the random numerical table method,with 50 cases in each group.The control group was treated with dydrogesterone tablets,while the observation group was treated with Antai Yimu pills on the basis of the control group.Patients in both groups were compared in terms of clinical efficacy,traditional Chinese medicine syndrome score,sex hormone(estradiol,progesterone,human chorionic gonadotropin)levels,hemorheological indicators(plasma viscosity,whole blood high-shear viscosity,whole blood low-shear viscosity),utero-placental perfusion(uterine pulsatility index,resistance index),pregnancy outcomes,and occurrence of adverse reactions.Results After treatment,the total clinical effective rate of the observation group was higher than the control group(92.00%vs.76.00%,P<0.05).After treatment,the vaginal bleeding score in the observation group was(0.63±0.13)points,the lower abdominal pain score was(0.71±0.20)points,the knee soreness score was(0.75±0.25)points,and the low back pain score was(0.88±0.15)points,which were lower than those in the control group[(0.71±0.20),(0.86±0.23),(1.13±0.31),and(1.11±0.22)points](P<0.05).After treatment,the estradiol in the observation group was(233.67±25.17)ng/L,the progesterone was(30.13±4.28)ng/ml,and the human chorionic gonadotropin was(24.11±4.33)ng/ml,which were higher than those in the control group[(200.84±23.42)ng/L,(27.64±4.33)ng/ml,and(19.65±4.17)ng/ml](P<0.05).After treatment,the plasma viscosity of the observation group was(1.35±0.41)mPa·s,the whole blood high-shear viscosity was(4.42±0.61)mPa·s,and the whole blood low-shear viscosity was(10.11±0.93)mPa·s,which were lower than those of the control group[(1.61±0.45),(4.80±0.66),and(11.02±1.03)mPa·s](P<0.05).After treatment,the uterine pulsatility index and resistance index in the observation group were(1.43±0.11)and(0.62±0.10),which were lower than those in the control group[(1.66±0.10)and(0.71±0.11)](P<0.05).After treatment,the full-term delivery rate in the observation group was 96.00%,which was higher than the control group's 82.00%(P<0.05).The incidence of adverse reactions between the two groups showed no statistically significant difference(P>0.05).Conclusion Antai Yimu pills combined with dydrogesterone tablets significantly improves success rates of pregnancy,alleviates clinical symptoms,regulates hormone levels,and enhances hemorheology and utero-placental perfusion,proving to be a safe and reliable treatment option.
作者
王荣
刘吉宇
WANG Rong;LIU Ji-yu(Reproductive Medicine Center,Jinhua People's Hospital,Jinhua 321000,China)
出处
《中国现代药物应用》
2026年第1期128-132,共5页
Chinese Journal of Modern Drug Application
关键词
安胎益母丸
地屈孕酮
先兆流产
临床疗效
Antai Yimu pills
Dydrogesterone
Threatened miscarriage
Clinical efficacy
