外阴硬化性苔藓(Vulvar Lichen Sclerosus, VLS)是一种慢性炎症性皮肤病,主要累及外阴和肛周区域,是女性健康领域中一个重要但常被忽视的问题。VLS的典型临床特征包括剧烈瘙痒、疼痛、皮肤瘢痕形成以及潜在的恶性病变风险,这些症状不仅...外阴硬化性苔藓(Vulvar Lichen Sclerosus, VLS)是一种慢性炎症性皮肤病,主要累及外阴和肛周区域,是女性健康领域中一个重要但常被忽视的问题。VLS的典型临床特征包括剧烈瘙痒、疼痛、皮肤瘢痕形成以及潜在的恶性病变风险,这些症状不仅严重影响患者的生活质量(Quality of Life, QoL),还可能导致长期的身心困扰。尽管目前有多种治疗方法,如局部皮质类固醇激素、免疫调节剂等,但治疗效果往往有限,且尚无根治手段。本文系统分析了现有治疗方法的优势与局限性,阐述VLS对女性生理、心理及性功能的多方面影响,旨在提高临床对VLS的认知和重视,倡导早期诊断和积极干预,避免VLS对QoL的长期负面影响,并降低其癌变风险,为改善患者预后提供理论支持和实践指导。Vulvar Lichen Sclerosus (VLS) is a chronic inflammatory skin disease primarily affecting the vulvar and perianal regions, representing a significant yet often overlooked issue in women’s health. The typical clinical features of VLS include intense itching, pain, scar formation, and a potential risk of malignant transformation. These symptoms not only severely impact patients’ quality of life (QoL) but may also lead to long-term physical and psychological distress. Although various treatment methods, such as topical corticosteroids and immunomodulators, are currently available, their efficacy is often limited, and no definitive cure exists. This paper systematically analyzes the advantages and limitations of existing treatments, discusses the multifaceted impact of VLS on women’s physiological, psychological, and sexual health, and aims to enhance clinical awareness and attention to VLS. It advocates for early diagnosis and active intervention to mitigate the long-term negative effects of VLS on QoL, reduce the risk of malignant transformation, and provide theoretical support and practical guidance for improving patient outcomes.展开更多
外阴硬化性苔藓(Vulva Lichen Sclerosus, VLS)是一种病因不明的慢性炎症性皮肤病,严重影响患者的生活质量和心理健康。准确的诊断和评估对于制定有效的治疗方案至关重要。本文就外阴硬化性苔藓的诊断和病情评估方法进行综述,为临床诊...外阴硬化性苔藓(Vulva Lichen Sclerosus, VLS)是一种病因不明的慢性炎症性皮肤病,严重影响患者的生活质量和心理健康。准确的诊断和评估对于制定有效的治疗方案至关重要。本文就外阴硬化性苔藓的诊断和病情评估方法进行综述,为临床诊疗方案的选择提供参考。Vulvar lichen sclerosus (VLS) is a chronic inflammatory dermatological condition of unknown etiology that significantly impacts patients’ quality of life and psychological well-being. Accurate diagnosis and disease assessment are essential for formulating effective treatment strategies. This paper reviews the current diagnostic and disease evaluation methods for VLS, providing a reference for clinical decision-making.展开更多
女性外阴硬化性苔藓(vulvar lichen sclerosus,VLS)是一种影响所有年龄段的炎症性皮肤病,呈慢性进展性,病程往往较长。一项来自瑞典的全国数据显示,2001~2020年间,平均每年每10万例女性中有114例经临床确诊为VLS[1];而在丹麦,经活检确诊...女性外阴硬化性苔藓(vulvar lichen sclerosus,VLS)是一种影响所有年龄段的炎症性皮肤病,呈慢性进展性,病程往往较长。一项来自瑞典的全国数据显示,2001~2020年间,平均每年每10万例女性中有114例经临床确诊为VLS[1];而在丹麦,经活检确诊的VLS年龄标准化发病率从1997~1998年间的4.9/10万人年上升至2021~2022年间的35.7/10万人年,大约增加了7倍[2]。在女性中其发病呈双峰状,青春期前和绝经后妇女是两个高峰[3,4],且绝经后女性更多见。旧的术语如“外阴干枯症”、“外阴白斑”、“外阴硬化性萎缩”等不应再被使用。VLS对患者的生活质量有显著影响,包括心理障碍、性功能障碍和排尿功能障碍等,甚至会增加进展为外阴癌的风险。因此,早期识别和干预对于减少瘢痕形成和降低癌变风险至关重要。2024年6月,欧洲皮肤病与性病学会(European Academy of Dermatology and Venereology,EADV)发布了关于VLS的指南,旨在为VLS的诊断、治疗和管理提供全面的指导。本文将对该指南中的要点进行总结和解读。展开更多
本文综述了中西医结合治疗外阴白斑的研究进展。外阴白斑是一种常见的妇科疾病,传统中医疗法和现代西医疗法各有优势。近年来,中西医结合治疗外阴白斑取得了显著进展,通过综合运用中药内服、外用以及西医药物和物理治疗等手段,显著提高...本文综述了中西医结合治疗外阴白斑的研究进展。外阴白斑是一种常见的妇科疾病,传统中医疗法和现代西医疗法各有优势。近年来,中西医结合治疗外阴白斑取得了显著进展,通过综合运用中药内服、外用以及西医药物和物理治疗等手段,显著提高了临床疗效。本文旨在综述中西医结合治疗外阴白斑的最新研究进展,为临床实践提供参考,并展望了未来研究方向,为外阴白斑的治疗提供证据支持。This article reviews the research progress of integrated traditional Chinese and Western medicine in the treatment of vulvar leukoplakia. Vulvar leukoplakia is a common gynecological disease, and both traditional Chinese medicine and modern Western medicine have their own advantages. In recent years, significant progress has been made in the treatment of vulvar leukoplakia with the combination of traditional Chinese medicine and Western medicine. Through the comprehensive use of traditional Chinese medicine orally and externally, as well as Western medicine and physical therapy, the clinical efficacy has been significantly improved. This article aims to review the latest research progress in the combination of traditional Chinese and Western medicine for the treatment of vulvar leukoplakia, provide reference for clinical practice, and look forward to future research directions, providing evidence support for the treatment of vulvar leukoplakia.展开更多
文摘外阴硬化性苔藓(Vulvar Lichen Sclerosus, VLS)是一种慢性炎症性皮肤病,主要累及外阴和肛周区域,是女性健康领域中一个重要但常被忽视的问题。VLS的典型临床特征包括剧烈瘙痒、疼痛、皮肤瘢痕形成以及潜在的恶性病变风险,这些症状不仅严重影响患者的生活质量(Quality of Life, QoL),还可能导致长期的身心困扰。尽管目前有多种治疗方法,如局部皮质类固醇激素、免疫调节剂等,但治疗效果往往有限,且尚无根治手段。本文系统分析了现有治疗方法的优势与局限性,阐述VLS对女性生理、心理及性功能的多方面影响,旨在提高临床对VLS的认知和重视,倡导早期诊断和积极干预,避免VLS对QoL的长期负面影响,并降低其癌变风险,为改善患者预后提供理论支持和实践指导。Vulvar Lichen Sclerosus (VLS) is a chronic inflammatory skin disease primarily affecting the vulvar and perianal regions, representing a significant yet often overlooked issue in women’s health. The typical clinical features of VLS include intense itching, pain, scar formation, and a potential risk of malignant transformation. These symptoms not only severely impact patients’ quality of life (QoL) but may also lead to long-term physical and psychological distress. Although various treatment methods, such as topical corticosteroids and immunomodulators, are currently available, their efficacy is often limited, and no definitive cure exists. This paper systematically analyzes the advantages and limitations of existing treatments, discusses the multifaceted impact of VLS on women’s physiological, psychological, and sexual health, and aims to enhance clinical awareness and attention to VLS. It advocates for early diagnosis and active intervention to mitigate the long-term negative effects of VLS on QoL, reduce the risk of malignant transformation, and provide theoretical support and practical guidance for improving patient outcomes.
文摘外阴硬化性苔藓(Vulva Lichen Sclerosus, VLS)是一种病因不明的慢性炎症性皮肤病,严重影响患者的生活质量和心理健康。准确的诊断和评估对于制定有效的治疗方案至关重要。本文就外阴硬化性苔藓的诊断和病情评估方法进行综述,为临床诊疗方案的选择提供参考。Vulvar lichen sclerosus (VLS) is a chronic inflammatory dermatological condition of unknown etiology that significantly impacts patients’ quality of life and psychological well-being. Accurate diagnosis and disease assessment are essential for formulating effective treatment strategies. This paper reviews the current diagnostic and disease evaluation methods for VLS, providing a reference for clinical decision-making.
文摘女性外阴硬化性苔藓(vulvar lichen sclerosus,VLS)是一种影响所有年龄段的炎症性皮肤病,呈慢性进展性,病程往往较长。一项来自瑞典的全国数据显示,2001~2020年间,平均每年每10万例女性中有114例经临床确诊为VLS[1];而在丹麦,经活检确诊的VLS年龄标准化发病率从1997~1998年间的4.9/10万人年上升至2021~2022年间的35.7/10万人年,大约增加了7倍[2]。在女性中其发病呈双峰状,青春期前和绝经后妇女是两个高峰[3,4],且绝经后女性更多见。旧的术语如“外阴干枯症”、“外阴白斑”、“外阴硬化性萎缩”等不应再被使用。VLS对患者的生活质量有显著影响,包括心理障碍、性功能障碍和排尿功能障碍等,甚至会增加进展为外阴癌的风险。因此,早期识别和干预对于减少瘢痕形成和降低癌变风险至关重要。2024年6月,欧洲皮肤病与性病学会(European Academy of Dermatology and Venereology,EADV)发布了关于VLS的指南,旨在为VLS的诊断、治疗和管理提供全面的指导。本文将对该指南中的要点进行总结和解读。
文摘本文综述了中西医结合治疗外阴白斑的研究进展。外阴白斑是一种常见的妇科疾病,传统中医疗法和现代西医疗法各有优势。近年来,中西医结合治疗外阴白斑取得了显著进展,通过综合运用中药内服、外用以及西医药物和物理治疗等手段,显著提高了临床疗效。本文旨在综述中西医结合治疗外阴白斑的最新研究进展,为临床实践提供参考,并展望了未来研究方向,为外阴白斑的治疗提供证据支持。This article reviews the research progress of integrated traditional Chinese and Western medicine in the treatment of vulvar leukoplakia. Vulvar leukoplakia is a common gynecological disease, and both traditional Chinese medicine and modern Western medicine have their own advantages. In recent years, significant progress has been made in the treatment of vulvar leukoplakia with the combination of traditional Chinese medicine and Western medicine. Through the comprehensive use of traditional Chinese medicine orally and externally, as well as Western medicine and physical therapy, the clinical efficacy has been significantly improved. This article aims to review the latest research progress in the combination of traditional Chinese and Western medicine for the treatment of vulvar leukoplakia, provide reference for clinical practice, and look forward to future research directions, providing evidence support for the treatment of vulvar leukoplakia.
