Varicella,a highly contagious respiratory infection caused by the varicella-zoster virus(VZV),predominantly affects children and is characterized by symptoms such as low-grade fever and vesicular rash[1,2].In China,va...Varicella,a highly contagious respiratory infection caused by the varicella-zoster virus(VZV),predominantly affects children and is characterized by symptoms such as low-grade fever and vesicular rash[1,2].In China,varicella remains prevalent,with a steady increase in incidence,peaking at 70.14 cases per 100,000 individuals in 2019[3].Although the number of reported outbreaks and cases from 2020 to 2022 was lower than those from 2006 to 2012 and 2013 to 2019,varicella continues to pose a significant public health challenge[3].展开更多
目的通过评价学校发生聚集性水痘疫情时的疫苗保护效果(VE),为水痘疫苗(VarV)接种程序的优化提供数据支持。方法检索中国知网、万方、维普、中华医学杂志、PubMed、Web of Science、Embase等中英文数据库,收集数据库中关于中国幼托机构...目的通过评价学校发生聚集性水痘疫情时的疫苗保护效果(VE),为水痘疫苗(VarV)接种程序的优化提供数据支持。方法检索中国知网、万方、维普、中华医学杂志、PubMed、Web of Science、Embase等中英文数据库,收集数据库中关于中国幼托机构、小学、中学聚集性疫情相关病例-对照和队列研究文献,使用非随机对照临床试验的质量评价表(NOS)进行质量评价,R软件进行Meta分析。结果共纳入27篇文献,总样本量35462人。病例-对照研究分析结果显示,水痘疫苗在聚集性疫情中的VE为60.6%(95%CI:44.6%~72.0%),OR=0.39(95%CI:0.28~0.55);队列研究分析结果显示,VE为64.09%(95%CI:55.4%~71.1%),RR=0.36(95%CI:0.29~0.45);两种研究合并结果显示,VE为66.5%(95%CI:59.0%~72.6%),OR=0.33(95%CI:0.27~0.41)。亚组分析显示,不同学校层次间VE存在统计学差异,其中幼托机构VE最高为72%(95%CI:50%~84%);接种2剂次VE高于仅单剂次接种疫苗人群的水痘发病严重程度,差异具有统计学意义(P<0.05)。结论VarV能有效预防学校聚集性水痘疫情并减轻水痘临床症状,但随着年龄增长VE呈现显著下降的趋势,且2剂次疫苗接种率较低。展开更多
文摘Varicella,a highly contagious respiratory infection caused by the varicella-zoster virus(VZV),predominantly affects children and is characterized by symptoms such as low-grade fever and vesicular rash[1,2].In China,varicella remains prevalent,with a steady increase in incidence,peaking at 70.14 cases per 100,000 individuals in 2019[3].Although the number of reported outbreaks and cases from 2020 to 2022 was lower than those from 2006 to 2012 and 2013 to 2019,varicella continues to pose a significant public health challenge[3].
文摘目的通过评价学校发生聚集性水痘疫情时的疫苗保护效果(VE),为水痘疫苗(VarV)接种程序的优化提供数据支持。方法检索中国知网、万方、维普、中华医学杂志、PubMed、Web of Science、Embase等中英文数据库,收集数据库中关于中国幼托机构、小学、中学聚集性疫情相关病例-对照和队列研究文献,使用非随机对照临床试验的质量评价表(NOS)进行质量评价,R软件进行Meta分析。结果共纳入27篇文献,总样本量35462人。病例-对照研究分析结果显示,水痘疫苗在聚集性疫情中的VE为60.6%(95%CI:44.6%~72.0%),OR=0.39(95%CI:0.28~0.55);队列研究分析结果显示,VE为64.09%(95%CI:55.4%~71.1%),RR=0.36(95%CI:0.29~0.45);两种研究合并结果显示,VE为66.5%(95%CI:59.0%~72.6%),OR=0.33(95%CI:0.27~0.41)。亚组分析显示,不同学校层次间VE存在统计学差异,其中幼托机构VE最高为72%(95%CI:50%~84%);接种2剂次VE高于仅单剂次接种疫苗人群的水痘发病严重程度,差异具有统计学意义(P<0.05)。结论VarV能有效预防学校聚集性水痘疫情并减轻水痘临床症状,但随着年龄增长VE呈现显著下降的趋势,且2剂次疫苗接种率较低。
