ATP-sensitive potassium channel(KATP) consists of a 4.4 complex of an inwardly rectifying Kir6.x pore plus a sulfonylurea receptor,which is an ATP-binding cassette transporter.KATP has been indentified in a variety of...ATP-sensitive potassium channel(KATP) consists of a 4.4 complex of an inwardly rectifying Kir6.x pore plus a sulfonylurea receptor,which is an ATP-binding cassette transporter.KATP has been indentified in a variety of tissues and recognized as an important drug target.It connects cell metabolism with cell electric activity.KATP has been proposed to play protective roles during heart failure,arrhythmia,myocardial infarction,stress,myocardial ischemia and hypertension.In this review,a summary of KATP is presented with molecular structure,localization,regulation,cardiovascular protective effect and its mechanisms.展开更多
Sulfur dioxide （SO2） is an ordinary air pollutant globally and harm to human health. L-cysteine is the major sulfur-containing amino acid and its normal metabolism can produce hydrogen sulfur （H2S） and SO2. It is ...Sulfur dioxide （SO2） is an ordinary air pollutant globally and harm to human health. L-cysteine is the major sulfur-containing amino acid and its normal metabolism can produce hydrogen sulfur （H2S） and SO2. It is realized that H2S has various bioactivities and is the third gasotransmitter after nitric oxide （NO） and carbon monoxide （CO）. Recently, attention has been paid to the physiologic effects of endogenous SO2 and its derivatives （bisulfite and sulfite） in vivo, and recognized that SO2 and its derivatives can lower blood pressure, change heart rates, participate in inflammatory reactions, and so on, suggesting that endogenous SO2 may modulate the physiologic functions in vivo as a bioactive molecule.展开更多
文摘ATP-sensitive potassium channel(KATP) consists of a 4.4 complex of an inwardly rectifying Kir6.x pore plus a sulfonylurea receptor,which is an ATP-binding cassette transporter.KATP has been indentified in a variety of tissues and recognized as an important drug target.It connects cell metabolism with cell electric activity.KATP has been proposed to play protective roles during heart failure,arrhythmia,myocardial infarction,stress,myocardial ischemia and hypertension.In this review,a summary of KATP is presented with molecular structure,localization,regulation,cardiovascular protective effect and its mechanisms.
文摘Sulfur dioxide （SO2） is an ordinary air pollutant globally and harm to human health. L-cysteine is the major sulfur-containing amino acid and its normal metabolism can produce hydrogen sulfur （H2S） and SO2. It is realized that H2S has various bioactivities and is the third gasotransmitter after nitric oxide （NO） and carbon monoxide （CO）. Recently, attention has been paid to the physiologic effects of endogenous SO2 and its derivatives （bisulfite and sulfite） in vivo, and recognized that SO2 and its derivatives can lower blood pressure, change heart rates, participate in inflammatory reactions, and so on, suggesting that endogenous SO2 may modulate the physiologic functions in vivo as a bioactive molecule.
