目的:探讨黄元御《四圣心源》治疗黄疸的组方用药规律,为当前黄疸的治疗提供一些新的思路。方法:将《四圣心源》中相关方剂及药物做数据规范化处理,建立Excel 2013四圣心源方药数据库,运用SPSS 27.0软件进行统计学分析。结果:筛选出76...目的:探讨黄元御《四圣心源》治疗黄疸的组方用药规律,为当前黄疸的治疗提供一些新的思路。方法:将《四圣心源》中相关方剂及药物做数据规范化处理,建立Excel 2013四圣心源方药数据库,运用SPSS 27.0软件进行统计学分析。结果:筛选出76首方剂,97味中药,用药频次484次,黄疸用药涉及17种,用药频次高于5 (包括5)的中药依次为白术、淡豆豉、桂枝、滑石、粳米、人参、石膏、泽泻、知母、枳实、猪苓、芒硝。药物类别排第一位者为利水渗湿药。体现黄元御以遵循利小便为原则,恢复调整脾胃中气,调畅肝胆气机,辨清寒热偏颇,巧用发汗、渗利、涌吐、通腑之法,因势利导,利湿退黄。结论:黄元御《四圣心源》治疗黄疸以利小便为原则,重视脾土、调畅肝胆气机、辨清寒热。基于数据挖掘可知其用药规律,为临床治疗提供新的思路。Objective: To investigate the prescription and medication rules for treating jaundice in Huang Yuanyu’s “The Source of Four Sages” and provide novel insights for contemporary jaundice management. Methods: Relevant formulas and herbs from “The Source of Four Sages” were standardized and compiled into an Excel 2013 database. Statistical analysis was performed using SPSS 27.0. Results: A total of 76 formulas and 97 herbs were identified, with 484 herb applications. Seventeen herbs were specifically used for jaundice. Herbs with application frequencies ≥ 5 included “Atractylodes macrocephala” (Bai Zhu), “Glycine max” (Dan Dou Chi), “Ramulus Cinnamomi” (Gui Zhi), “Talcum” (Hua Shi), “Oryza sativa” (Jing Mi), “Panax ginseng” (Ren Shen), “Gypsum fibrosum” (Shi Gao), “Alismatis Rhizoma” (Ze Xie), “Anemarrhenae Rhizoma” (Zhi Mu), “Aurantii Fructus Immaturus” (Zhi Shi), “Polyporus” (Zhu Ling), and “Natrii Sulfas” (Mang Xiao). The most frequently used drug category was water-dampness excreting and diuretic agents. Huang Yuanyu’s approach emphasized diuresis as the core principle, restoring spleen-stomach harmony, regulating liver-gallbladder qi dynamics, differentiating cold-heat patterns, and utilizing sweat-inducing, diuretic, emetic, and purgative methods to expel pathogens and resolve jaundice. Conclusion: “The Source of Four Sages” treats jaundice by prioritizing diuresis, emphasizing spleen-stomach regulation, harmonizing liver-gallbladder qi, and differentiating cold-heat patterns. Data mining reveals its systematic medication principles, offering innovative clinical insights for jaundice therapy.展开更多
文摘目的:探讨黄元御《四圣心源》治疗黄疸的组方用药规律,为当前黄疸的治疗提供一些新的思路。方法:将《四圣心源》中相关方剂及药物做数据规范化处理,建立Excel 2013四圣心源方药数据库,运用SPSS 27.0软件进行统计学分析。结果:筛选出76首方剂,97味中药,用药频次484次,黄疸用药涉及17种,用药频次高于5 (包括5)的中药依次为白术、淡豆豉、桂枝、滑石、粳米、人参、石膏、泽泻、知母、枳实、猪苓、芒硝。药物类别排第一位者为利水渗湿药。体现黄元御以遵循利小便为原则,恢复调整脾胃中气,调畅肝胆气机,辨清寒热偏颇,巧用发汗、渗利、涌吐、通腑之法,因势利导,利湿退黄。结论:黄元御《四圣心源》治疗黄疸以利小便为原则,重视脾土、调畅肝胆气机、辨清寒热。基于数据挖掘可知其用药规律,为临床治疗提供新的思路。Objective: To investigate the prescription and medication rules for treating jaundice in Huang Yuanyu’s “The Source of Four Sages” and provide novel insights for contemporary jaundice management. Methods: Relevant formulas and herbs from “The Source of Four Sages” were standardized and compiled into an Excel 2013 database. Statistical analysis was performed using SPSS 27.0. Results: A total of 76 formulas and 97 herbs were identified, with 484 herb applications. Seventeen herbs were specifically used for jaundice. Herbs with application frequencies ≥ 5 included “Atractylodes macrocephala” (Bai Zhu), “Glycine max” (Dan Dou Chi), “Ramulus Cinnamomi” (Gui Zhi), “Talcum” (Hua Shi), “Oryza sativa” (Jing Mi), “Panax ginseng” (Ren Shen), “Gypsum fibrosum” (Shi Gao), “Alismatis Rhizoma” (Ze Xie), “Anemarrhenae Rhizoma” (Zhi Mu), “Aurantii Fructus Immaturus” (Zhi Shi), “Polyporus” (Zhu Ling), and “Natrii Sulfas” (Mang Xiao). The most frequently used drug category was water-dampness excreting and diuretic agents. Huang Yuanyu’s approach emphasized diuresis as the core principle, restoring spleen-stomach harmony, regulating liver-gallbladder qi dynamics, differentiating cold-heat patterns, and utilizing sweat-inducing, diuretic, emetic, and purgative methods to expel pathogens and resolve jaundice. Conclusion: “The Source of Four Sages” treats jaundice by prioritizing diuresis, emphasizing spleen-stomach regulation, harmonizing liver-gallbladder qi, and differentiating cold-heat patterns. Data mining reveals its systematic medication principles, offering innovative clinical insights for jaundice therapy.
