羟喜树碱(HCPT)是一种广谱的抗肿瘤药物,对其具有识别作用的荧光分子不但可以用于检测,还可因药物递送性能的提高而获得更高的活性.因此,寻找高选择性识别HCPT的荧光主体分子具有研究价值,但具有一定挑战性.合成了两亲性杯咔唑大环(3),...羟喜树碱(HCPT)是一种广谱的抗肿瘤药物,对其具有识别作用的荧光分子不但可以用于检测,还可因药物递送性能的提高而获得更高的活性.因此,寻找高选择性识别HCPT的荧光主体分子具有研究价值,但具有一定挑战性.合成了两亲性杯咔唑大环(3),利用荧光光谱、核磁共振、扫描电镜和透射电镜等方法研究了其与HCPT的主客体间相互作用.结果表明,化合物3可经荧光共振能量转移效应实现比率型荧光选择性识别HCPT,化学计量比为2∶1,结合常数为1.26×10^(14)(mol/L)^(-2).检测限(Limit of detection,LOD)为11.7 nmol·L^(-1).此外,化合物3的存在显著增强了HCPT体外抑制人乳腺癌细胞(MCF-7)细胞增殖活性,IC50值降低了两个数量级,表明化合物3兼具分子荧光探针和药物分子载体的双重功能,为后续深入研究提供科学依据.展开更多
The liquid phase oxidation of ethylbenzene catalyzed by metal phthalocyanine(CoPc, MnPC, FePc) was investigated at an atmospheric pressure of oxygen at 100 ℃. The catalytic activity of CoPc is higher than that of MnP...The liquid phase oxidation of ethylbenzene catalyzed by metal phthalocyanine(CoPc, MnPC, FePc) was investigated at an atmospheric pressure of oxygen at 100 ℃. The catalytic activity of CoPc is higher than that of MnPc and FePc. The addition of catalytic amount of K\-2Cr\-2O\-7, MnO\-2 or V\-2O\-5 to the catalytic system can lead to a remarkable increase in the catalytic activity or acetophenone selectivity, compared with those of the metal phthalocyanine and catalytic amount of K\-2Cr\-2O\-7, MnO\-2 or V\-2O\-5 used alone.展开更多
The lanthanum molybdovanadophosphoric tetrabasic heteropoly complex was synthesized.Catalytic properties of the title heteropoly complex for selective oxidation of ethylbezene to acetonphenone was investigated.The sui...The lanthanum molybdovanadophosphoric tetrabasic heteropoly complex was synthesized.Catalytic properties of the title heteropoly complex for selective oxidation of ethylbezene to acetonphenone was investigated.The suitable reaction conditions was discussed.展开更多
文摘羟喜树碱(HCPT)是一种广谱的抗肿瘤药物,对其具有识别作用的荧光分子不但可以用于检测,还可因药物递送性能的提高而获得更高的活性.因此,寻找高选择性识别HCPT的荧光主体分子具有研究价值,但具有一定挑战性.合成了两亲性杯咔唑大环(3),利用荧光光谱、核磁共振、扫描电镜和透射电镜等方法研究了其与HCPT的主客体间相互作用.结果表明,化合物3可经荧光共振能量转移效应实现比率型荧光选择性识别HCPT,化学计量比为2∶1,结合常数为1.26×10^(14)(mol/L)^(-2).检测限(Limit of detection,LOD)为11.7 nmol·L^(-1).此外,化合物3的存在显著增强了HCPT体外抑制人乳腺癌细胞(MCF-7)细胞增殖活性,IC50值降低了两个数量级,表明化合物3兼具分子荧光探针和药物分子载体的双重功能,为后续深入研究提供科学依据.
文摘The liquid phase oxidation of ethylbenzene catalyzed by metal phthalocyanine(CoPc, MnPC, FePc) was investigated at an atmospheric pressure of oxygen at 100 ℃. The catalytic activity of CoPc is higher than that of MnPc and FePc. The addition of catalytic amount of K\-2Cr\-2O\-7, MnO\-2 or V\-2O\-5 to the catalytic system can lead to a remarkable increase in the catalytic activity or acetophenone selectivity, compared with those of the metal phthalocyanine and catalytic amount of K\-2Cr\-2O\-7, MnO\-2 or V\-2O\-5 used alone.
文摘The lanthanum molybdovanadophosphoric tetrabasic heteropoly complex was synthesized.Catalytic properties of the title heteropoly complex for selective oxidation of ethylbezene to acetonphenone was investigated.The suitable reaction conditions was discussed.
