Malignant tumours always threaten human health.For tumour diagnosis,positron emission tomography(PET)is the most sensitive and advanced imaging technique by radiotracers,such as radioactive^(18)F,^(11)C,^(64)Cu,^(68)G...Malignant tumours always threaten human health.For tumour diagnosis,positron emission tomography(PET)is the most sensitive and advanced imaging technique by radiotracers,such as radioactive^(18)F,^(11)C,^(64)Cu,^(68)Ga,and^(89)Zr.Among the radiotracers,the radioactive^(18)F-labelled chemical agent as PET probes plays a predominant role in monitoring,detecting,treating,and predicting tumours due to its perfect half-life.In this paper,the^(18)F-labelled chemical materials as PET probes are systematically summarized.First,we introduce various radionuclides of PET and elaborate on the mechanism of PET imaging.It highlights the^(18)F-labelled chemical agents used as PET probes,including[^(18)F]-2-deoxy-2-[^(18)F]fluoro-D-glucose([^(18)F]-FDG),^(18)F-labelled amino acids,^(18)F-labelled nucleic acids,^(18)F-labelled receptors,^(18)F-labelled reporter genes,and^(18)F-labelled hypoxia agents.In addition,some PET probes with metal as a supplementary element are introduced briefly.Meanwhile,the^(18)F-labelled nanoparticles for the PET probe and the multi-modality imaging probe are summarized in detail.The approach and strategies for the fabrication of^(18)F-labelled PET probes are also described briefly.The future development of the PET probe is also prospected.The development and application of^(18)F-labelled PET probes will expand our knowledge and shed light on the diagnosis and theranostics of tumours.展开更多
建立板蓝根茶的薄层色谱鉴别,采用薄层色谱法,以L-脯氨酸、亮氨酸、精氨酸作为指标成分进行定性鉴别。对板蓝根茶中的尿苷、鸟苷、腺苷的含量建立了高效液相色谱检测方法。该方法考察了板蓝根茶中的尿苷、鸟苷、腺苷的线性关系、精密度...建立板蓝根茶的薄层色谱鉴别,采用薄层色谱法,以L-脯氨酸、亮氨酸、精氨酸作为指标成分进行定性鉴别。对板蓝根茶中的尿苷、鸟苷、腺苷的含量建立了高效液相色谱检测方法。该方法考察了板蓝根茶中的尿苷、鸟苷、腺苷的线性关系、精密度、灵敏度及回收率。采用C_(18)柱(250 mm×4.6 mm,5μm),以甲醇和水进行梯度洗脱,柱温30℃,流速为每分钟0.8 m L,进样量10μL。结果表明,尿苷、鸟苷、腺苷在该方法下的相关系数都大于0.999,平均回收率为96.18%~102.72%,精密度和灵敏度的RSD均小于0.3%。此方法线性好,操作方法简单、灵敏度高,可重复性好,提升了板蓝根茶的质量标准。展开更多
文摘Malignant tumours always threaten human health.For tumour diagnosis,positron emission tomography(PET)is the most sensitive and advanced imaging technique by radiotracers,such as radioactive^(18)F,^(11)C,^(64)Cu,^(68)Ga,and^(89)Zr.Among the radiotracers,the radioactive^(18)F-labelled chemical agent as PET probes plays a predominant role in monitoring,detecting,treating,and predicting tumours due to its perfect half-life.In this paper,the^(18)F-labelled chemical materials as PET probes are systematically summarized.First,we introduce various radionuclides of PET and elaborate on the mechanism of PET imaging.It highlights the^(18)F-labelled chemical agents used as PET probes,including[^(18)F]-2-deoxy-2-[^(18)F]fluoro-D-glucose([^(18)F]-FDG),^(18)F-labelled amino acids,^(18)F-labelled nucleic acids,^(18)F-labelled receptors,^(18)F-labelled reporter genes,and^(18)F-labelled hypoxia agents.In addition,some PET probes with metal as a supplementary element are introduced briefly.Meanwhile,the^(18)F-labelled nanoparticles for the PET probe and the multi-modality imaging probe are summarized in detail.The approach and strategies for the fabrication of^(18)F-labelled PET probes are also described briefly.The future development of the PET probe is also prospected.The development and application of^(18)F-labelled PET probes will expand our knowledge and shed light on the diagnosis and theranostics of tumours.
文摘建立板蓝根茶的薄层色谱鉴别,采用薄层色谱法,以L-脯氨酸、亮氨酸、精氨酸作为指标成分进行定性鉴别。对板蓝根茶中的尿苷、鸟苷、腺苷的含量建立了高效液相色谱检测方法。该方法考察了板蓝根茶中的尿苷、鸟苷、腺苷的线性关系、精密度、灵敏度及回收率。采用C_(18)柱(250 mm×4.6 mm,5μm),以甲醇和水进行梯度洗脱,柱温30℃,流速为每分钟0.8 m L,进样量10μL。结果表明,尿苷、鸟苷、腺苷在该方法下的相关系数都大于0.999,平均回收率为96.18%~102.72%,精密度和灵敏度的RSD均小于0.3%。此方法线性好,操作方法简单、灵敏度高,可重复性好,提升了板蓝根茶的质量标准。
