摘要
Malignant tumours always threaten human health.For tumour diagnosis,positron emission tomography(PET)is the most sensitive and advanced imaging technique by radiotracers,such as radioactive^(18)F,^(11)C,^(64)Cu,^(68)Ga,and^(89)Zr.Among the radiotracers,the radioactive^(18)F-labelled chemical agent as PET probes plays a predominant role in monitoring,detecting,treating,and predicting tumours due to its perfect half-life.In this paper,the^(18)F-labelled chemical materials as PET probes are systematically summarized.First,we introduce various radionuclides of PET and elaborate on the mechanism of PET imaging.It highlights the^(18)F-labelled chemical agents used as PET probes,including[^(18)F]-2-deoxy-2-[^(18)F]fluoro-D-glucose([^(18)F]-FDG),^(18)F-labelled amino acids,^(18)F-labelled nucleic acids,^(18)F-labelled receptors,^(18)F-labelled reporter genes,and^(18)F-labelled hypoxia agents.In addition,some PET probes with metal as a supplementary element are introduced briefly.Meanwhile,the^(18)F-labelled nanoparticles for the PET probe and the multi-modality imaging probe are summarized in detail.The approach and strategies for the fabrication of^(18)F-labelled PET probes are also described briefly.The future development of the PET probe is also prospected.The development and application of^(18)F-labelled PET probes will expand our knowledge and shed light on the diagnosis and theranostics of tumours.
恶性肿瘤一直威胁着人类的健康。对于肿瘤的诊断,正电子发射断层扫描(PET)是利用放射性核素^(18)F、^(11)C、^(64)Cu、^(68)Ga、^(89)Zr等成像。它是最灵敏、最先进的放射性示踪成像技术。在放射性示踪剂中,放射性^(18)F由于其理想的半衰期,常用来标记化学试剂作为PET探针,在肿瘤监测、检测、治疗、预防等方面发挥着重要作用。该综述系统总结了基于^(18)F标记化学物质的PET探针。首先,介绍了PET的各种放射性核素,阐述了PET成像的机理。重点介绍了放射性^(18)F标记的PET探针,包括[^(18)F]-2-脱氧-2-[^(18)F]氟-D-葡萄糖([^(18)F]-FDG)、^(18)F标记的氨基酸PET探针、^(18)F标记的核酸PET探针、^(18)F标记的受体PET探针、基因表达PET探针和厌氧PET探针。此外,还简要介绍了一些辅助的金属PET探针以及^(18)F标记的纳米PET探针和^(18)F多模态成像探针。接着,介绍了^(18)F标记的PET探针的制备方法和策略。最后,对PET探针未来的发展进行了展望。该综述将扩大我们对^(18)F标记PET探针的开发和应用方面的认识,并为肿瘤的诊断和治疗提供新的思路。
出处
《无机化学学报》
北大核心
2025年第9期1702-1718,共17页
Chinese Journal of Inorganic Chemistry
基金
陕西省重点研发计划项目(No.2024GX-YBXM-318)
秦创原总窗口“四链”融合(No.2024PT-ZCK-38)
陕西省科技厅项目(No.2025JC-YBMS-146,2025SF-YBXM-475)
国家自然科学基金面上项目(No.22177066)资助。
