Traumatic spinal cord injury is potentially catastrophic and can lead to permanent disability or even death.China has the largest population of patients with traumatic spinal cord injury.Previous studies of traumatic ...Traumatic spinal cord injury is potentially catastrophic and can lead to permanent disability or even death.China has the largest population of patients with traumatic spinal cord injury.Previous studies of traumatic spinal cord injury in China have mostly been regional in scope;national-level studies have been rare.To the best of our knowledge,no national-level study of treatment status and economic burden has been performed.This retrospective study aimed to examine the epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China at the national level.We included 13,465 traumatic spinal cord injury patients who were injured between January 2013 and December 2018 and treated in 30 hospitals in 11 provinces/municipalities representing all geographical divisions of China.Patient epidemiological and clinical features,treatment status,and total and daily costs were recorded.Trends in the percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department and cost of care were assessed by annual percentage change using the Joinpoint Regression Program.The percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department did not significantly change overall(annual percentage change,-0.5%and 2.1%,respectively).A total of 10,053(74.7%)patients underwent surgery.Only 2.8%of patients who underwent surgery did so within 24 hours of injury.A total of 2005(14.9%)patients were treated with high-dose(≥500 mg)methylprednisolone sodium succinate/methylprednisolone(MPSS/MP);615(4.6%)received it within 8 hours.The total cost for acute traumatic spinal cord injury decreased over the study period(-4.7%),while daily cost did not significantly change(1.0%increase).Our findings indicate that public health initiatives should aim at improving hospitals’ability to complete early surgery within 24 hours,which is associated with improved sensorimotor recovery,increasing the awareness rate of clinical guidelines related to high-dose MPSS/MP to reduce the use of the treatment with insufficient evidence.展开更多
In view of the satellite cloud-derived wind inversion has the characteristics of large scale,intensive computing and time-consuming serial inversion algorithm is very difficult to break through the bottleneck of effic...In view of the satellite cloud-derived wind inversion has the characteristics of large scale,intensive computing and time-consuming serial inversion algorithm is very difficult to break through the bottleneck of efficiency.We proposed a parallel acceleration scheme of cloud-derived wind inversion algorithm based on MPI cluster parallel technique in this paper.The divide-and-conquer idea,assigning winds vector inversion tasks to each computing unit,is identified according to a certain strategy.Each computing unit executes the assigned tasks in parallel,namely divide-and-rule the inversion task,so as to reduce the efficiency bottleneck of long inversion time caused by serial time accumulation.In the scheme of parallel acceleration based on MPI cluster,an algorithm based on performance prediction is proposed to effectively implement load balance of MPI clusters.Through the comparative analysis of experiment data using the parallel scheme of this parallel technology framework,it shows that this parallel technology has a certain acceleration effect on the cloud-derived wind inversion algorithm.The speedup of the MPI-based parallel algorithm reaches 14.96,which achieved the expected estimate.At the same time,this paper also proposes an efficiency optimization algorithm for cloud-derived wind inversion.In the case that the inversion of wind vector accuracy loss is minimal,the optimized algorithm execution time can be up to 13 times faster.展开更多
In this paper,using the research method of grounded theory,with the competitive brand of home gardening—Hongyue Garden Maker as the specific object of study,we collect the data through interviews and surveys,conduct ...In this paper,using the research method of grounded theory,with the competitive brand of home gardening—Hongyue Garden Maker as the specific object of study,we collect the data through interviews and surveys,conduct coding analysis step by step on the data,establish the brand asset creation path model consisting of some main dimensions including " brand salience"," brand performance"," brand image"," brand judgment"," brand feeling",and " brand resonance",and reveal the interaction and logical relationship between the above dimensions,so as to provide theoretical support for the asset creation of many kinds of home gardening and other brands.展开更多
Long intergenic non-coding RNAs(lincRNAs),a subclass of long non-coding RNAs(lncRNAs)that do not overlap with other genes,play pivotal roles in cancer progression.1 The hypoxic tumor microenvironment,characterized by ...Long intergenic non-coding RNAs(lincRNAs),a subclass of long non-coding RNAs(lncRNAs)that do not overlap with other genes,play pivotal roles in cancer progression.1 The hypoxic tumor microenvironment,characterized by an excess of stromal cells and extracellular matrix and insufficient vascularization,is a distinctive feature of pancreatic ductal adenocarcinoma(PDAC).展开更多
To the editor:Pancreatic ductal adenocarcinoma(PDAC)is characterized by extensive desmoplasia,which leads to a dense and fibrotic stroma1.The fibrotic milieu observed in PDAC is predominantly attributed to the crossli...To the editor:Pancreatic ductal adenocarcinoma(PDAC)is characterized by extensive desmoplasia,which leads to a dense and fibrotic stroma1.The fibrotic milieu observed in PDAC is predominantly attributed to the crosslinking of the extracellular matrix(ECM),a process orchestrated by enzymes such as lysyl oxidase(LOX)and transglutaminase.The LOX family comprises LOX and LOX-like(LOXL)proteins 1–4 that catalyze the initial step in the crosslinking of ECM constituents,including collagens and elastin2.展开更多
Lithium-sulfur batteries(LSBs)are broadly considered to be the most promising next-generation energy storage because of their ultrahigh theoretical energy density and cost-effectiveness.However,the“shuttle effect”an...Lithium-sulfur batteries(LSBs)are broadly considered to be the most promising next-generation energy storage because of their ultrahigh theoretical energy density and cost-effectiveness.However,the“shuttle effect”and sluggish conversion kinetics of polysulfides severely hinder their practical application.To address these challenges,a unique Co-doped MnO_(2) nanorod network layer with oxygen vacancies(Co-MnO_(x))was devised by self-assembly on a commercial separator through the chemical growth method for high-performance LSBs.The Co-MnO_(x) modified separators(Co-MnO_(x)@PP)not only effectively alleviate the“shuttle effects”but also accelerate the redox conversion of polysulfides.More importantly,the Co-MnO_(x)@PP demonstrated superior thermostability and flame-retardant properties owing to the chemical growth method.The LSBs with Co-MnO_(x)@PP separators exhibited a high reversible capacity of 902.0 mA h g^(-1) and 562.2 mA h g^(-1) at 0.5 C for 20℃ and 60℃ after 200 cycles,respectively.Even at 3 C,after 500 cycles,a superb cycling performance of 715.2 mA h g^(-1) with an ultra-low decay of 0.069%for each cycle was achieved.Therefore,this proposed strategy of a Co-doped MnO_(2) nanorod network layer with oxygen vacancies will provide a new route for rationally devising durable and efficient LSBs.展开更多
The novel heterometallic polyoxotitanate cage[Ti_(8)O_(7)(OEt)_(21)Er]can be used as a single-source precursor for the formation of nanostructured Er-containing titania materials(Er@TiO_(2)).Based on the electrochromi...The novel heterometallic polyoxotitanate cage[Ti_(8)O_(7)(OEt)_(21)Er]can be used as a single-source precursor for the formation of nanostructured Er-containing titania materials(Er@TiO_(2)).Based on the electrochromic properties and lithium ion storage capacity of Er@TiO_(2),an integrated bifunctional EC supercapacitor has been designed.展开更多
基金supported by the National Key Research and Development Project,No.2019YFA0112100(to SF).
文摘Traumatic spinal cord injury is potentially catastrophic and can lead to permanent disability or even death.China has the largest population of patients with traumatic spinal cord injury.Previous studies of traumatic spinal cord injury in China have mostly been regional in scope;national-level studies have been rare.To the best of our knowledge,no national-level study of treatment status and economic burden has been performed.This retrospective study aimed to examine the epidemiological and clinical features,treatment status,and economic burden of traumatic spinal cord injury in China at the national level.We included 13,465 traumatic spinal cord injury patients who were injured between January 2013 and December 2018 and treated in 30 hospitals in 11 provinces/municipalities representing all geographical divisions of China.Patient epidemiological and clinical features,treatment status,and total and daily costs were recorded.Trends in the percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department and cost of care were assessed by annual percentage change using the Joinpoint Regression Program.The percentage of traumatic spinal cord injuries among all hospitalized patients and among patients hospitalized in the orthopedic department did not significantly change overall(annual percentage change,-0.5%and 2.1%,respectively).A total of 10,053(74.7%)patients underwent surgery.Only 2.8%of patients who underwent surgery did so within 24 hours of injury.A total of 2005(14.9%)patients were treated with high-dose(≥500 mg)methylprednisolone sodium succinate/methylprednisolone(MPSS/MP);615(4.6%)received it within 8 hours.The total cost for acute traumatic spinal cord injury decreased over the study period(-4.7%),while daily cost did not significantly change(1.0%increase).Our findings indicate that public health initiatives should aim at improving hospitals’ability to complete early surgery within 24 hours,which is associated with improved sensorimotor recovery,increasing the awareness rate of clinical guidelines related to high-dose MPSS/MP to reduce the use of the treatment with insufficient evidence.
基金This work was supported in part by the National Natural Science Foundation of China(61872160,51679105,51809112)“Thirteenth Five Plan”Science and Technology Project of Education Department,Jilin Province(JJKH20200990KJ).
文摘In view of the satellite cloud-derived wind inversion has the characteristics of large scale,intensive computing and time-consuming serial inversion algorithm is very difficult to break through the bottleneck of efficiency.We proposed a parallel acceleration scheme of cloud-derived wind inversion algorithm based on MPI cluster parallel technique in this paper.The divide-and-conquer idea,assigning winds vector inversion tasks to each computing unit,is identified according to a certain strategy.Each computing unit executes the assigned tasks in parallel,namely divide-and-rule the inversion task,so as to reduce the efficiency bottleneck of long inversion time caused by serial time accumulation.In the scheme of parallel acceleration based on MPI cluster,an algorithm based on performance prediction is proposed to effectively implement load balance of MPI clusters.Through the comparative analysis of experiment data using the parallel scheme of this parallel technology framework,it shows that this parallel technology has a certain acceleration effect on the cloud-derived wind inversion algorithm.The speedup of the MPI-based parallel algorithm reaches 14.96,which achieved the expected estimate.At the same time,this paper also proposes an efficiency optimization algorithm for cloud-derived wind inversion.In the case that the inversion of wind vector accuracy loss is minimal,the optimized algorithm execution time can be up to 13 times faster.
基金Supported by National College Students'Innovation and Entrepreneurship Training Program in 2017(103-2013200072)National Social Science Fund Project(15BGL088)Zhejiang Higher Education Reform Project in 2016(jg20160092)
文摘In this paper,using the research method of grounded theory,with the competitive brand of home gardening—Hongyue Garden Maker as the specific object of study,we collect the data through interviews and surveys,conduct coding analysis step by step on the data,establish the brand asset creation path model consisting of some main dimensions including " brand salience"," brand performance"," brand image"," brand judgment"," brand feeling",and " brand resonance",and reveal the interaction and logical relationship between the above dimensions,so as to provide theoretical support for the asset creation of many kinds of home gardening and other brands.
基金supported by the National Natural Science Foundation of China(No.82372968)the Shanghai Shenkang Hospital Development Center(No.SHDC2024CRI080)+1 种基金the Medical Engineering Joint Fund of Fudan University,Shanghai,China(No.XM03231533)the Shanghai Science and Technology Development Funds(Shanghai,China)(No.22YF1406200).
文摘Long intergenic non-coding RNAs(lincRNAs),a subclass of long non-coding RNAs(lncRNAs)that do not overlap with other genes,play pivotal roles in cancer progression.1 The hypoxic tumor microenvironment,characterized by an excess of stromal cells and extracellular matrix and insufficient vascularization,is a distinctive feature of pancreatic ductal adenocarcinoma(PDAC).
基金supported by grants from National Natural Science Foundation of China(82173153 and 82372879)Shanghai Pilot Program for Basic Research-Shanghai Jiao Tong University(21TQ1400225,China)Innovative research team of high-level local universities in Shanghai(SHSMU-ZDCX20210802,China).
文摘To the editor:Pancreatic ductal adenocarcinoma(PDAC)is characterized by extensive desmoplasia,which leads to a dense and fibrotic stroma1.The fibrotic milieu observed in PDAC is predominantly attributed to the crosslinking of the extracellular matrix(ECM),a process orchestrated by enzymes such as lysyl oxidase(LOX)and transglutaminase.The LOX family comprises LOX and LOX-like(LOXL)proteins 1–4 that catalyze the initial step in the crosslinking of ECM constituents,including collagens and elastin2.
基金supported by the National Natural Science Foundation of China(No.52176185)the Hubei Provincial Department of Education(grant no.D20201007).
文摘Lithium-sulfur batteries(LSBs)are broadly considered to be the most promising next-generation energy storage because of their ultrahigh theoretical energy density and cost-effectiveness.However,the“shuttle effect”and sluggish conversion kinetics of polysulfides severely hinder their practical application.To address these challenges,a unique Co-doped MnO_(2) nanorod network layer with oxygen vacancies(Co-MnO_(x))was devised by self-assembly on a commercial separator through the chemical growth method for high-performance LSBs.The Co-MnO_(x) modified separators(Co-MnO_(x)@PP)not only effectively alleviate the“shuttle effects”but also accelerate the redox conversion of polysulfides.More importantly,the Co-MnO_(x)@PP demonstrated superior thermostability and flame-retardant properties owing to the chemical growth method.The LSBs with Co-MnO_(x)@PP separators exhibited a high reversible capacity of 902.0 mA h g^(-1) and 562.2 mA h g^(-1) at 0.5 C for 20℃ and 60℃ after 200 cycles,respectively.Even at 3 C,after 500 cycles,a superb cycling performance of 715.2 mA h g^(-1) with an ultra-low decay of 0.069%for each cycle was achieved.Therefore,this proposed strategy of a Co-doped MnO_(2) nanorod network layer with oxygen vacancies will provide a new route for rationally devising durable and efficient LSBs.
基金the National Natural Science Foundation of China(NSFC,No.21501148,21405114 and 21573160)the China Postdoctoral Science Foundation(CPSF-2015M570075)the Zhejiang Provincial Natural Science Foundation of China(No.LQ15E030002 and LY15E030006).
文摘The novel heterometallic polyoxotitanate cage[Ti_(8)O_(7)(OEt)_(21)Er]can be used as a single-source precursor for the formation of nanostructured Er-containing titania materials(Er@TiO_(2)).Based on the electrochromic properties and lithium ion storage capacity of Er@TiO_(2),an integrated bifunctional EC supercapacitor has been designed.
