本文旨在系统评价不同氧体积分数(fraction of inspired oxygen,FiO_(2))下低氧运动对肥胖人群体成分、葡萄糖代谢及脂代谢的干预效果,并明确最佳FiO_(2)区间,为个体化、精准化的低氧运动处方提供科学依据。通过检索Cochrane Library、P...本文旨在系统评价不同氧体积分数(fraction of inspired oxygen,FiO_(2))下低氧运动对肥胖人群体成分、葡萄糖代谢及脂代谢的干预效果,并明确最佳FiO_(2)区间,为个体化、精准化的低氧运动处方提供科学依据。通过检索Cochrane Library、PubMed、Web of Science、Embase与中国知网(CNKI)等数据库,筛选截至2025年3月31日前发表的关于低氧运动干预肥胖人群的随机对照试验和前后对照研究。采用RevMan 5.4软件进行荟萃(Meta)分析,评估不同FiO_(2)(FiO_(2)≤14%与FiO_(2)>14%)下干预对身体质量指数(BMI)、体脂率、腰围、空腹血糖、胰岛素、胰岛素抵抗指数(HOMA-IR)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)及高密度脂蛋白胆固醇(HDL-C)的影响,并进行亚组分析。本研究共纳入22项研究,合计样本量为292人。Meta分析结果显示,低氧运动可显著改善肥胖人群的体成分、糖代谢与脂代谢指标,在FiO_(2)大于14%的中等低氧环境进行运动干预效果更优。FiO_(2)作为低氧运动中的关键参数,其精准设定对优化干预效果至关重要。展开更多
The second near-infrared window(NIR-II,900-1880 nm)overcomes critical limitations of visible(360-760 nm)and NIR-I(760-900 nm)imaging—including restricted penetration depth,low signal-to-back⁃ground ratio,and tissue a...The second near-infrared window(NIR-II,900-1880 nm)overcomes critical limitations of visible(360-760 nm)and NIR-I(760-900 nm)imaging—including restricted penetration depth,low signal-to-back⁃ground ratio,and tissue autofluorescence—establishing its pivotal role for in vivo deep-tissue bioimaging.With exponential growth in NIR-II photodiagnosis and phototherapy research over the past decade,bibliometric analy⁃sis is essential to map the evolving landscape and guide strategic priorities.We systematically analyzed 2,491 NIR-II-related publications(2009-2023)from the Web of Science Core Collection,employing scientometric tools for distinct analytical purposes:(a)VOSviewer,SCImago Graphica,and Gephi for co-authorship and co-occur⁃rence network mapping;(b)the R bibliometrix package for tracking field evolution and identifying high-impact publications/journals.The search retrieved 2491 studies from 359 journals originating from 54 countries.The country with the most published articles is China.Chinese institutions drive>60%of publications,with Stanford University(USA)and Nanyang Technological University(Singapore)ranked as the top two institutions by re⁃search quality.International cooperation is becoming increasingly frequent.Fan Quli,Tang Benzhong and Dai Hongjie are the top 3 productive authors in this field.Keyword evolution identifies"photodynamic therapy"and"immunotherapy"as pivotal future directions.We summarize the most cited literatures and NIR-II imaging clini⁃cal trials.This study delineates the NIR-II research trajectory,highlighting China's leadership,intensifying glob⁃al collaboration,and interdisciplinary convergence.Future efforts should prioritize the novel NIR-II probe devel⁃opment for NIR-II imaging and clinical translation of photodynamic/immunotherapy combinational platforms.展开更多
文摘本文旨在系统评价不同氧体积分数(fraction of inspired oxygen,FiO_(2))下低氧运动对肥胖人群体成分、葡萄糖代谢及脂代谢的干预效果,并明确最佳FiO_(2)区间,为个体化、精准化的低氧运动处方提供科学依据。通过检索Cochrane Library、PubMed、Web of Science、Embase与中国知网(CNKI)等数据库,筛选截至2025年3月31日前发表的关于低氧运动干预肥胖人群的随机对照试验和前后对照研究。采用RevMan 5.4软件进行荟萃(Meta)分析,评估不同FiO_(2)(FiO_(2)≤14%与FiO_(2)>14%)下干预对身体质量指数(BMI)、体脂率、腰围、空腹血糖、胰岛素、胰岛素抵抗指数(HOMA-IR)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)及高密度脂蛋白胆固醇(HDL-C)的影响,并进行亚组分析。本研究共纳入22项研究,合计样本量为292人。Meta分析结果显示,低氧运动可显著改善肥胖人群的体成分、糖代谢与脂代谢指标,在FiO_(2)大于14%的中等低氧环境进行运动干预效果更优。FiO_(2)作为低氧运动中的关键参数,其精准设定对优化干预效果至关重要。
基金Supported by National Natural Science Foundation of China(81874059 and 82102105)the Natural Science Foundation of Zhejiang Province(LQ22H160017)the China Postdoctoral Science Foundation(2021M702825).
文摘The second near-infrared window(NIR-II,900-1880 nm)overcomes critical limitations of visible(360-760 nm)and NIR-I(760-900 nm)imaging—including restricted penetration depth,low signal-to-back⁃ground ratio,and tissue autofluorescence—establishing its pivotal role for in vivo deep-tissue bioimaging.With exponential growth in NIR-II photodiagnosis and phototherapy research over the past decade,bibliometric analy⁃sis is essential to map the evolving landscape and guide strategic priorities.We systematically analyzed 2,491 NIR-II-related publications(2009-2023)from the Web of Science Core Collection,employing scientometric tools for distinct analytical purposes:(a)VOSviewer,SCImago Graphica,and Gephi for co-authorship and co-occur⁃rence network mapping;(b)the R bibliometrix package for tracking field evolution and identifying high-impact publications/journals.The search retrieved 2491 studies from 359 journals originating from 54 countries.The country with the most published articles is China.Chinese institutions drive>60%of publications,with Stanford University(USA)and Nanyang Technological University(Singapore)ranked as the top two institutions by re⁃search quality.International cooperation is becoming increasingly frequent.Fan Quli,Tang Benzhong and Dai Hongjie are the top 3 productive authors in this field.Keyword evolution identifies"photodynamic therapy"and"immunotherapy"as pivotal future directions.We summarize the most cited literatures and NIR-II imaging clini⁃cal trials.This study delineates the NIR-II research trajectory,highlighting China's leadership,intensifying glob⁃al collaboration,and interdisciplinary convergence.Future efforts should prioritize the novel NIR-II probe devel⁃opment for NIR-II imaging and clinical translation of photodynamic/immunotherapy combinational platforms.
