Novel benzo-bridged hexaphyrin(2.1.2.1.2.1)and its copper complex were synthesized.Single-crystal structures showed typical figure-of-eight Huckel topologies.NMR,NICS,HOMA,ACID,and EDDB analysis supported their non-ar...Novel benzo-bridged hexaphyrin(2.1.2.1.2.1)and its copper complex were synthesized.Single-crystal structures showed typical figure-of-eight Huckel topologies.NMR,NICS,HOMA,ACID,and EDDB analysis supported their non-aromatic properties owning to the strong local aromatic benzo rings cutting the global aromatic ring of the benzo-bridged figure-of-eight hexaphyrin(2.1.2.1.2.1).The redox properties and degenerate HOMOs and LUMOs levels indicate multielectron donating and accepting abilities.展开更多
目的:分析T细胞大颗粒淋巴细胞白血病(T-cell large granular lymphocytic leukemia,T-LGLL)患者的临床特征、治疗方案及生存情况。方法:回顾性分析2009年2月至2019年12月山东大学齐鲁医院收治的21例T-LGLL患者的临床及实验室检查资料,...目的:分析T细胞大颗粒淋巴细胞白血病(T-cell large granular lymphocytic leukemia,T-LGLL)患者的临床特征、治疗方案及生存情况。方法:回顾性分析2009年2月至2019年12月山东大学齐鲁医院收治的21例T-LGLL患者的临床及实验室检查资料,总结其临床特征、治疗方案及预后情况。结果:T-LGLL患者多为中老年男性,主要临床表现为乏力(61.9%)、感染(28.6%)、脾肿大(61.9%),6例患者合并自身免疫性疾病。T-LGLL患者血常规通常表现为白细胞减少(42.9%)和(或)贫血(71.4%),骨髓涂片可见大颗粒淋巴细胞增多,骨髓活检可见粒红系增生受抑,典型的T-LGLL免疫表型为CD3^+CD4^-CD8^+CD57^+CD16^+,88.9%患者TCR基因重排阳性。T-LGLL通常疾病进展缓慢,免疫抑制治疗总有效率为60%,血液学完全缓解率为20%,部分缓解率为40%。结论:T-LGLL为一种以血细胞减少、骨髓及外周血中大颗粒淋巴细胞克隆性增多为特征的疾病,常合并自身免疫性疾病,其疾病进展较慢,一线免疫抑制治疗效果尚可。展开更多
Single SAR image direct positioning is to determine the ground coordinate for each pixel in the SAR image assisted with a reference DEM.During this procedure,an iterative procedure is essentially needed to solve the u...Single SAR image direct positioning is to determine the ground coordinate for each pixel in the SAR image assisted with a reference DEM.During this procedure,an iterative procedure is essentially needed to solve the uncertainty in elevation of each pixel in the SAR image.However,such an iterative procedure may suffer from the problem of divergence in shaded and serious layover areas.To investigate this problem,we performed a theoretical analysis on the convergence conditions that has not been intensively studied till now.The Range-Doppler(RD)model was simplified and then the general surface is degenerated into a planar surface.Mathematical deduction was then carried out to derive the convergence conditions and the impact factors for the convergence speed were evaluated.The theoretical findings were validated by experiments for both simulated and real scenarios.展开更多
The solitary elderly people in rural areas are not only an important part of the rural population,but also an important issue that can not be ignored in the battle to get rid of poverty. In recent years,according to t...The solitary elderly people in rural areas are not only an important part of the rural population,but also an important issue that can not be ignored in the battle to get rid of poverty. In recent years,according to the working thinking of ' accurate statistics,scientific arrangement,classified implementation,and rapid progress',Xundian County has gone through joint exploration and practice at the county and township levels,and has found out the path of work of ' Five Batches Project' to solve the problem of poverty alleviation for the solitary elderly people and make them live in their own homes. This has effectively solved the problem of safe and stable housing for 4 443 solitary elderly people in the county. It has found a new way to solve the housing problem of the solitary elderly people. At the end of 2017,the incidence of poverty in the county dropped to 0. 35%,and it was successfully listed as one of the first counties in Yunnan Province to get rid of poverty. Based on field research and interviews,this paper analyzes and summarizes the concrete methods,main achievements,practical experience,lessons and reference of the poverty alleviation model of ' Five Batches Project' in Xundian County to solve the problem of housing for the elderly,in order to provide necessary reference for the poor counties in Yunnan Province and other similar provinces( cities,autonomous regions) to solve the problem of housing for ' solitary elderly people' in Yunnan Province.展开更多
Conceptually,rural complex is actually a comprehensive sustainable development model for new agricultural and rural areas across industries and functions.From the perspective of rural complex,combined with the actual ...Conceptually,rural complex is actually a comprehensive sustainable development model for new agricultural and rural areas across industries and functions.From the perspective of rural complex,combined with the actual case of Idyllic Orient in Yangshan,Wuxi,the first rural complex in China,this paper analyzes the current benefits of relevant projects.Considering the basic situation of Luodeli Village in Luquan County,Yunnan Province,the direction,development model and spatial allocation of land use are initially determined.Finally,the overall development path is proposed for Luodeli Village in Luquan County,in order to provide some ideas for its next development.展开更多
Land is the foundation for human survival and development,and all human social and economic activities are inseparable from the land as a space carrier.With the continuous development of China's social economy,Chi...Land is the foundation for human survival and development,and all human social and economic activities are inseparable from the land as a space carrier.With the continuous development of China's social economy,China is facing new social development needs such as urban-rural integration and rural revitalization.At the same time,China starts to attach great importance to ecology and has proposed the concept that lucid waters and lush mountains are invaluable assets.In this situation,the rational use of land resources,the optimization of land use structure and layout are also facing new challenges and problems,and more comprehensive consideration is required to make relevant optimization.Using the method of literature comparative analysis,from the conceptual connotation,basic theory,method model,and specific practice of land use structure and layout optimization,this paper analyzed and summarized the current research situations and problems,and finally came up with recommendations for the future research.展开更多
Small cell lung cancer(SCLC)is a highly malignant and heterogeneous cancer with limited therapeutic options and prognosis prediction models.Here,we analyzed formalin-fixed,paraffin-embedded(FFPE)samples of surgical re...Small cell lung cancer(SCLC)is a highly malignant and heterogeneous cancer with limited therapeutic options and prognosis prediction models.Here,we analyzed formalin-fixed,paraffin-embedded(FFPE)samples of surgical resections by proteomic profiling,and stratified SCLC into three proteomic subtypes(S-I,S-II,and S-III)with distinct clinical outcomes and chemotherapy responses.The proteomic subtyping was an independent prognostic factor and performed better than current tumor–node–metastasis or Veterans Administration Lung Study Group staging methods.The subtyping results could be further validated using FFPE biopsy samples from an independent cohort,extending the analysis to both surgical and biopsy samples.The signatures of the S-II subtype in particular suggested potential benefits from immunotherapy.Differentially overexpressed proteins in S-III,the worst prognostic subtype,allowed us to nominate potential therapeutic targets,indicating that patient selection may bring new hope for previously failed clinical trials.Finally,analysis of an independent cohort of SCLC patients who had received immunotherapy validated the prediction that the S-II patients had better progression-free survival and overall survival after first-line immunotherapy.Collectively,our study provides the rationale for future clinical investigations to validate the current findings for more accurate prognosis prediction and precise treatments.展开更多
基金partly supported by the National Natural Science Foundation of China(No.22301108)the Project Startup Foundation for Distinguished Scholars of Jiangsu University(Nos.4111310026 and 5501310014).
文摘Novel benzo-bridged hexaphyrin(2.1.2.1.2.1)and its copper complex were synthesized.Single-crystal structures showed typical figure-of-eight Huckel topologies.NMR,NICS,HOMA,ACID,and EDDB analysis supported their non-aromatic properties owning to the strong local aromatic benzo rings cutting the global aromatic ring of the benzo-bridged figure-of-eight hexaphyrin(2.1.2.1.2.1).The redox properties and degenerate HOMOs and LUMOs levels indicate multielectron donating and accepting abilities.
文摘目的:分析T细胞大颗粒淋巴细胞白血病(T-cell large granular lymphocytic leukemia,T-LGLL)患者的临床特征、治疗方案及生存情况。方法:回顾性分析2009年2月至2019年12月山东大学齐鲁医院收治的21例T-LGLL患者的临床及实验室检查资料,总结其临床特征、治疗方案及预后情况。结果:T-LGLL患者多为中老年男性,主要临床表现为乏力(61.9%)、感染(28.6%)、脾肿大(61.9%),6例患者合并自身免疫性疾病。T-LGLL患者血常规通常表现为白细胞减少(42.9%)和(或)贫血(71.4%),骨髓涂片可见大颗粒淋巴细胞增多,骨髓活检可见粒红系增生受抑,典型的T-LGLL免疫表型为CD3^+CD4^-CD8^+CD57^+CD16^+,88.9%患者TCR基因重排阳性。T-LGLL通常疾病进展缓慢,免疫抑制治疗总有效率为60%,血液学完全缓解率为20%,部分缓解率为40%。结论:T-LGLL为一种以血细胞减少、骨髓及外周血中大颗粒淋巴细胞克隆性增多为特征的疾病,常合并自身免疫性疾病,其疾病进展较慢,一线免疫抑制治疗效果尚可。
基金The authors would like to thank the German Aerospace Center(DLR)for providing the test data-sets via the DLR AO LAN0793 and LAN0634,and Prof.Miaozhong Xu of LIESMARS for providing the photogrammetric DEM with spatial resolution of 3 mThis work was supported by the National Natural Science Foundation of China[grant number 41271457]the Demonstration System of High Resolution Remote Sensing Applications in Urban Fine Management Area[grant number 06-Y30B04–9002-13/15].
文摘Single SAR image direct positioning is to determine the ground coordinate for each pixel in the SAR image assisted with a reference DEM.During this procedure,an iterative procedure is essentially needed to solve the uncertainty in elevation of each pixel in the SAR image.However,such an iterative procedure may suffer from the problem of divergence in shaded and serious layover areas.To investigate this problem,we performed a theoretical analysis on the convergence conditions that has not been intensively studied till now.The Range-Doppler(RD)model was simplified and then the general surface is degenerated into a planar surface.Mathematical deduction was then carried out to derive the convergence conditions and the impact factors for the convergence speed were evaluated.The theoretical findings were validated by experiments for both simulated and real scenarios.
基金Supported by Project of the Office of the Leading Group of Rural Work of Kunming Municipal Party Committee
文摘The solitary elderly people in rural areas are not only an important part of the rural population,but also an important issue that can not be ignored in the battle to get rid of poverty. In recent years,according to the working thinking of ' accurate statistics,scientific arrangement,classified implementation,and rapid progress',Xundian County has gone through joint exploration and practice at the county and township levels,and has found out the path of work of ' Five Batches Project' to solve the problem of poverty alleviation for the solitary elderly people and make them live in their own homes. This has effectively solved the problem of safe and stable housing for 4 443 solitary elderly people in the county. It has found a new way to solve the housing problem of the solitary elderly people. At the end of 2017,the incidence of poverty in the county dropped to 0. 35%,and it was successfully listed as one of the first counties in Yunnan Province to get rid of poverty. Based on field research and interviews,this paper analyzes and summarizes the concrete methods,main achievements,practical experience,lessons and reference of the poverty alleviation model of ' Five Batches Project' in Xundian County to solve the problem of housing for the elderly,in order to provide necessary reference for the poor counties in Yunnan Province and other similar provinces( cities,autonomous regions) to solve the problem of housing for ' solitary elderly people' in Yunnan Province.
文摘Conceptually,rural complex is actually a comprehensive sustainable development model for new agricultural and rural areas across industries and functions.From the perspective of rural complex,combined with the actual case of Idyllic Orient in Yangshan,Wuxi,the first rural complex in China,this paper analyzes the current benefits of relevant projects.Considering the basic situation of Luodeli Village in Luquan County,Yunnan Province,the direction,development model and spatial allocation of land use are initially determined.Finally,the overall development path is proposed for Luodeli Village in Luquan County,in order to provide some ideas for its next development.
文摘Land is the foundation for human survival and development,and all human social and economic activities are inseparable from the land as a space carrier.With the continuous development of China's social economy,China is facing new social development needs such as urban-rural integration and rural revitalization.At the same time,China starts to attach great importance to ecology and has proposed the concept that lucid waters and lush mountains are invaluable assets.In this situation,the rational use of land resources,the optimization of land use structure and layout are also facing new challenges and problems,and more comprehensive consideration is required to make relevant optimization.Using the method of literature comparative analysis,from the conceptual connotation,basic theory,method model,and specific practice of land use structure and layout optimization,this paper analyzed and summarized the current research situations and problems,and finally came up with recommendations for the future research.
基金supported by the National Key R&D Program of China(Grant Nos.2018YFA0507503,2017YFA0505102,2017YFA0505103,and 2017YFA0505104)the National Natural Science Foundation of China(Grant Nos.82072597,62131009,31770892,31970725,31870828,81874237,and 81974016)+2 种基金the Beijing Municipal Natural Science Foundation(Grant No.7192199)the State Key Laboratory of Proteomics(Grant No.SKLP-K202002)the Kaifeng Science and Technology Development Plan Project(Grant No.1806005),China.
文摘Small cell lung cancer(SCLC)is a highly malignant and heterogeneous cancer with limited therapeutic options and prognosis prediction models.Here,we analyzed formalin-fixed,paraffin-embedded(FFPE)samples of surgical resections by proteomic profiling,and stratified SCLC into three proteomic subtypes(S-I,S-II,and S-III)with distinct clinical outcomes and chemotherapy responses.The proteomic subtyping was an independent prognostic factor and performed better than current tumor–node–metastasis or Veterans Administration Lung Study Group staging methods.The subtyping results could be further validated using FFPE biopsy samples from an independent cohort,extending the analysis to both surgical and biopsy samples.The signatures of the S-II subtype in particular suggested potential benefits from immunotherapy.Differentially overexpressed proteins in S-III,the worst prognostic subtype,allowed us to nominate potential therapeutic targets,indicating that patient selection may bring new hope for previously failed clinical trials.Finally,analysis of an independent cohort of SCLC patients who had received immunotherapy validated the prediction that the S-II patients had better progression-free survival and overall survival after first-line immunotherapy.Collectively,our study provides the rationale for future clinical investigations to validate the current findings for more accurate prognosis prediction and precise treatments.
