The Late Permian to Early Triassic marked a pivotal phase in paleoenvironmental and tectonic shifts.The Kaijiang-Liangping intracratonic sag,a tectonic geomorphology formed by Emei taphrogenesis in the Sichuan Basin,i...The Late Permian to Early Triassic marked a pivotal phase in paleoenvironmental and tectonic shifts.The Kaijiang-Liangping intracratonic sag,a tectonic geomorphology formed by Emei taphrogenesis in the Sichuan Basin,is situated within a clear water carbonate platform.Under these conditions,the black shales of the Dalong Formation in the sag have ultrahigh organic matter content.However,the mechanism by which these conditions control the accumulation of such organic matter remains unclear.Petrological and geochemical analyses of well DY-1H revealed four distinct units within the Dalong Formation:A,B,C,and D,with average total organic carbon contents of 3.00%,9.59%,4.57%,and 0.27%,respectively.The kerogen maceral,carbon isotope,and pyrolysis results show that the organic matter mainly comprises Type Ⅱ_(2) kerogen.Benthic plants growing in clear water may be the primary source of this kerogen.Shallow water,suboxic conditions,strong volcanism,and high productivity characterize Unit A.Unit B features restricted ocean circulation,anoxic conditions,weak upwelling,moderate volcanism,and high productivity.Unit C is characterized by anoxic conditions,strong upwelling,weak volcanism,and moderate productivity.Oxic conditions and low productivity define Unit D.These findings challenge traditional models that struggle to explain the accumulation of ultrahigh organic matter in Unit A under suboxic conditions,Unit C under moderate productivity,and Unit B with abnormally high organic matter content.The flourishing of benthic plants,a considerable source of Type Ⅱ_(2) kerogen that resists decomposition and favors preservation,is the dominant factor controlling the ultrahigh organic matter accumulation of black shales in Units A,B,and C under clear water conditions.Oxidized bottom waters and decreased benthic plant growth were crucial to the sharp decline in organic matter.展开更多
Taking modern indoor building construction as an example,this study analyzes the path planning and navigation of a smart plastering robot.It includes a basic introduction to smart plastering robots,an analysis of mult...Taking modern indoor building construction as an example,this study analyzes the path planning and navigation of a smart plastering robot.It includes a basic introduction to smart plastering robots,an analysis of multi-sensor fusion localization algorithms for smart plastering robots,and an analysis of path planning and navigation functions for smart plastering robots.It is hoped that through this analysis,a reference is provided for the path planning and navigation design of such robots to meet their practical application needs.展开更多
Sodium-ion batteries(SIBs)are emerging as a promising alternative for large-scale energy storage,particularly in grid applications.Within the array of potential cathode materials,Fe/Mn-based layered oxides are notable...Sodium-ion batteries(SIBs)are emerging as a promising alternative for large-scale energy storage,particularly in grid applications.Within the array of potential cathode materials,Fe/Mn-based layered oxides are notable for their advantageous theoretical specific capacity,economic viability,and environmental sustainability.Nevertheless,the practical application of Fe/Mn-based layered oxides is constrained by their suboptimal cycle performance and rate capability during actual charging and discharging.Ion doping is an effective approach for addressing the aforementioned issues.In this context,we have successfully developed a novel K^(+) and Mg^(2+) codoped P2-Na_(0.7)Fe_(0.5)Mn_(0.5)O_(2) cathode to address these challenges.By doping with 0.05 K^(+) and 0.2 Mg^(2+),the cathode demonstrated excellent cycling stability,retaining 95% of its capacity after 50 cycles at 0.2C,whereas the undoped material retained only 59.7%.Even within a wider voltage range,the co-doped cathode retained 88% of its capacity after 100 cycles at 1C.This work integrated Mg^(2+) to activate oxygen redox reactions in Fe/Mn-based layered cathodes,thereby promoting a reversible hybrid redox process involving both anions and cations.Building on the Mg doping,larger K^(+) ions were introduced into the edge-sharing Na^(+) sites,enhancing the material's cyclic stability and expanding the interplanar distance.The significant improvement of Na^(+) diffusion coefficient by K^(+)/Mg^(2+) co-doping has been further confirmed via the galvanostatic intermittent titration technique(GITT).The study emphasizes the importance of co-doping with different coordination environments in future material design,aiming to achieve high operating voltage and energy density.展开更多
Fluorescent probes have wide applications in biological and environmental analysis due to their advantages of simple operation, convenient flexibility, high sensitivity and efficiency. They are considered to be promis...Fluorescent probes have wide applications in biological and environmental analysis due to their advantages of simple operation, convenient flexibility, high sensitivity and efficiency. They are considered to be promising tools for accurate analysis of agriculture- and food-related hazardous substances. In this review, the types and characteristics of the near-infrared fluorescence probes (NIFPs) are briefly described. The recent advances of NIFPs for precisely detecting various hazardous substances including heavy metals, sulfite and related sulfiting agents and hydrogen peroxide are summarized. Finally, the present challenges and future perspectives faced by NIFPs in food safety analysis are discussed.展开更多
AIM:To investigate the inhibitory effect of acetylshikonin on human gastric carcinoma cell line SGC-7901 and its mechanism. METHODS:MTT assay was used to assess the inhibitory effect of acetylshikonin on proliferation...AIM:To investigate the inhibitory effect of acetylshikonin on human gastric carcinoma cell line SGC-7901 and its mechanism. METHODS:MTT assay was used to assess the inhibitory effect of acetylshikonin on proliferation of SGC-7901 cells.Apopt osis-inducing effect was determined by flow cytometry and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling with Hoechst staining.Expression of mRNA and protein in Bcl-2 and Bax was analyzed by reverse transcription-polymerase chain reaction and Western blot.Antitumor effect of acetylshikonin on a mouse SGC-7901 model was also determined. RESULTS:Forty-eight hours after treatment with acetylshikonin,MTT assay showed that acetylshikonin inhibited the proliferation of SGC-7901 cells in a dose-dependent manner.The half maximal inhibitory concentration of acetylshikonin to SGC-7901 cells was 0.428±0.07 mg/L.Cell shrinkage,nuclear pyknosis and chromatin condensation,which are the characteristics of cell apoptosis,were observed in treated SGC-7901 cells and the percentage of apoptosis increased in a dose-dependent manner.Acetylshikonin downregulated the expression of Bcl-2 and up-regulated the expression of Bax in the treated SGC-7901 cells compared with the controls.The experiment in vivo showed that 0.5,1,and 2 mg/kg of acetylshikonin significantly inhibited the growth of tumor in the mouse SGC-7901 model,with an inhibitory rate of 25.00%-55.76%. CONCLUSION:Acetylshikonin inhibits the growth of SGC-7901 cells in vitro and in vivo by inducing cell apoptosis.展开更多
AIM: To investigate the mechanisms of chloride intracellular channel 1 (CLIC1) in the metastasis of colon cancer under hypoxia-reoxygenation (H-R) conditions.
Thrombosis is a global health issue and one of the leading factors of death.However,its diagnosis has been limited to the late stages,and its therapeutic window is too narrow to provide reasonable and effective treatm...Thrombosis is a global health issue and one of the leading factors of death.However,its diagnosis has been limited to the late stages,and its therapeutic window is too narrow to provide reasonable and effective treatment.In addition,clinical thrombolytics suffer from a short half-life,allergic reactions,inactivation,and unwanted tissue hemorrhage.Nano-medicines have gained extensive attention in diagnosis,drug delivery,and photo/sound/magnetic-theranostics due to their convertible properties.Furthermore,diagnosis and treatment of thrombosis using nano-medicines have also been widely studied.This review summarizes the recent advances in this area,which revealed six types of nanoparticle approaches:(1)in vitro diagnostic kits using“synthetic biomarkers”;(2)in vivo imaging using nano-contrast agents;(3)targeted drug delivery systems using artificial nanoparticles;(4)microenvironment responsive drug delivery systems;(5)drug delivery systems using biological nanostructures;and(6)treatments with external irradiation.The investigations of nano-medicines are believed to be of great significance,and some of the advanced drug delivery systems show potential applications in clinical theranotics.展开更多
Objective： Non-small cell lung cancer （NSCLC） patients with epidermal growth factor receptor （EGFR）-activating mutations have higher response rate and more prolonged survival following treatment with single-agent...Objective： Non-small cell lung cancer （NSCLC） patients with epidermal growth factor receptor （EGFR）-activating mutations have higher response rate and more prolonged survival following treatment with single-agent EGFR tyrosine kinase inhibitor （EGFR-TKI） compared with patients with wild-type EGFR. However, all patients treated with reversible inhibitors develop acquired resistance over time. The mechanisms of resistance are complicated. The lack of established therapeutic options for patients after a failed EGFR-TKI treatment poses a great challenge to physicians in managing this group of lung cancer patients. This study evaluates the influence of EGFR-TKI retreatment following chemotherapy after failure of initial EGFR-TKI within at least 6 months on NSCLC patients. Methods： ＇i-he data of 27 patients who experienced treatment failure from their initial use of EGFR-TKI within at least 6 months were analyzed. After chemotherapy, the patients were retreated with EGFR-TKI （gefitinib 250 mg qd or erlotinib 150 mg qd）, and the tumor progression was observed. The patients were assessed for adverse events and response to therapy. Targeted tumor lesions were assessed with CT scan. Results： Of the 27 patients who received EGFR-TKI retreatment~ 1 （3.7%） patient was observed in complete response （CR）, 8 （29.6%） patients in partial response （PR）, 14 （51.9%） patients in stable disease （SD）, and 4 （14.8%） patients in progressive disease （PD）. The disease control rate （DCR） was 85.2% （95% CI： 62%-94%）. The median progression-free survival （mPFS） was 6 months （95% CI： 1-29）. Of the 13 patients who received the same EGFR-TKI, 1 patient in CR, 3 patients in PR, 8 patients in SD, and 2 patients in PD were observed. The DCRwas 84.6%, and the mPFS was 5 months. Of the 14 patients who received another EGFR-TKI, no patient in CR~ 6 patients in PR, 6 patients in SD, and 2 patients in PD were observed. The DCRwas 85.7%, and the mPFS was 9.5 months. Significant difference was found between the two groups in PFS but not in response rate or D CR. Conclusion： Retreatment of EGFR-TKIs can be considered an option after failure of chemotherapy for patients who were previously controlled by EGFR-TKI treatment.展开更多
A pot experiment was conducted to investigate the effects of nitrogen content [Nl （no fertilizer）, N2 （0.15 g.kg-l）, and N3 （0.3 g.kg 1）] on the growth and the hydraulic characteristics of peach seedlings under ...A pot experiment was conducted to investigate the effects of nitrogen content [Nl （no fertilizer）, N2 （0.15 g.kg-l）, and N3 （0.3 g.kg 1）] on the growth and the hydraulic characteristics of peach seedlings under different soil moisture conditions （Wl, W2 and W3, in which the soil water content was 45% to 55%, 60% to 70%, and 75% to 80% of the field water capacity, respectively） by using a specialized high pressure flow meter with a root chamber and a coupling, which was connected to plant organs. Leaf area and leaf hydraulic conductivity （KL） increased significantly in the seedlings because of increased soil moisture and N content. KL increased with leaf area. A linear correlation was documented between KL and leaf area. KL was higher in the morning and began to decline sharply after 16：00, at which KL declined after an initial increase. Soil moisture and N content enhanced shoot （Ks） and root （Kr） hydraulic conductivities, thereby improving the low soil moisture condition to a large extent. Ks and Kr of the seedlings were reduced by 32% and 27% respectively in N~, and by 14.7% and 9.4%, respectively in N2, and both in Wb compared with the control treatment. N3 had no significant effect on Ks and Kr under similar conditions. Linear negative correlations were observed between Kr and the excised root diameter as well as between Ks and the shoot stem diameter. The shoot-to-root ratio increased with in- crease in N content. The shoot-to-root ratio in N3 was increased by 14.37%, compared with N1 in W1 as well as by 12% and 4.39% in Wz and W3, respectively. Knowledge of the effects of soil moisture and N fertilizer on hydraulic characteristics and growth is important. Our results provide basic guidelines for the implementation of water-saving irrigation and fertilization management of nursery stock.展开更多
Circularly polarized light(CPL)has been given great attention because of its extensive application.While several devices for CPL detection have been studied,their performance is affected by the magnitude of photocurre...Circularly polarized light(CPL)has been given great attention because of its extensive application.While several devices for CPL detection have been studied,their performance is affected by the magnitude of photocurrent.In this paper,a self-powered photodetector based on hot electrons in chiral metamaterials is proposed and optimized.CPL can be distinguished by the direction of photocurrent without external bias owing to the interdigital electrodes with asymmetric chiral metamaterials.Distinguished by the direction of photocurrent,the device can easily detect the rotation direction of the CPL electric field,even if it only has a very weak responsivity.The responsivity of the proposed detector is near 1.9 mA/W at the wavelength of 1322 nm,which is enough to distinguish CPL.The detector we proposed has the potential for application in optical communication.展开更多
Objective: To compare the efficacy and toxicity between gemcitabine plus cisplatin and plus carboplatin in first-line treatment of advanced non-small cell lung cancer (NSCLC). Methods: Gemcitabine 1000 mg/m2 iv, d1, 8...Objective: To compare the efficacy and toxicity between gemcitabine plus cisplatin and plus carboplatin in first-line treatment of advanced non-small cell lung cancer (NSCLC). Methods: Gemcitabine 1000 mg/m2 iv, d1, 8; cisplatin 75 mg/m2 iv, d1, or 25 mg/m2 iv, d1-3; carboplatin AUC = 5 iv, d1; repeated every 21 days. Results: All 76 cases were available for objective response. Gemcitabine + cisplatin (GCis) group: among 33 cases, CR 1 case, PR 13 cases, MR 3 cases, SD 7 cases, PD 9 cases, response rate, disease control rate, time to progress (TTP), median survival time (MST) and 1-, 2-year survival rates were 42.42% (14/33), 72.73% (24/33), 5 months, 14 months and 66.67% (22/33), 12.12% (4/33), respectively; Gemcitabine + carboplatin (GCarb) group: among 43 cases, PR 13 cases, MR 11 cases, SD 7 cases, PD 12 cases, the results while comparing with those of GCis group were 30.23% (13/43), 72.09% (31/43), 4 months, 11 months and 48.84% (21/43), 2.33% (1/43), respectively. Among them, only MST between the two groups had significant statistic difference (χ2 = 2.45, P = 0.017). Mild to modest myelo-suppression as well as nausea and vomiting were observed. Conclusion: Both GCis and GCarb regimens had active and well-tolerated toxicity for advanced NSCLC. Cisplatin-based chemotherapy yields a substantial effective advantage over carboplatin-based regimens. Therefore, carboplatin and cisplatin are not equal-active and that cisplatin-based doublet regimens should remain the standard first-line therapy for patients with advanced NSCLC with good performance status.展开更多
Pregnancy is a critical stimulator of bone mineral resorption. We used to find the MTHFR gene polymorphisms are related with blood lead levels among pregnant women. Pregnancy-stimulated bone turnover may be associated...Pregnancy is a critical stimulator of bone mineral resorption. We used to find the MTHFR gene polymorphisms are related with blood lead levels among pregnant women. Pregnancy-stimulated bone turnover may be associated with MTHFR gene polymorphisms too. In this article, we aimed to determine the relationship between MTHFR gene polymorphisms and bone turnover rates among the pregnant women. The participants including pregnant and non-pregnant women were selected and recruited during their routine prenatal or physical examination from July to October in 2012. A total of 1000 participants, including 250 pregnant women in the first, second, and third trimesters and 250 non-pregnant women, were enrolled in the study. Finally, after excluding 27 participants unable to provide blood samples, 973 eligible participants （i.e., 234, 249, and 248 pregnant women in the first, second, and third trimesters, respectively, and 242 non-pregnant women） were included in the research. The MTHFR gene 1298CC homozygote carriers were more susceptible to yield higher plasma homocysteine levels than the 1298AA/AC carriers, with standardized coefficients of 0.086 （P〈0.05） and 0.104 （P〈0.01） of all the participants and the pregnant women, respectively. The MTHFR gene 1793AA homozygote carriers more likely showed higher plasma osteocalcin levels （standardized β=0.091, P〈0.01） than the 1793GG/GA carriers among all the subjects. Plasma homocysteine levels were positively correlated with blood lead levels among the participants and the pregnant women with standardized coefficients of 0.320 （P〈0.01） and 0.179 （P〈0.01）, respectively. Plasma osteocalcin levels were positively associated with blood lead levels among pregnant and non-pregnant women with standardized coefficients of 0.084 （P〈0.05） and 0.125 （P〈0.01）, respectively. In conclusion, homocysteine and osteocalcin contents in plasma are associated with the MTHFR gene A1298C polymorphism and blood lead levels among pregnant women. The MTHFR gene A1298C polymorphism-related homocysteine is a possible risk factor for increased blood lead levels among Chinese women.展开更多
Iron-based nanoparticles(Fe-NPs)exhibit promising potential for soil remediation.However,their toxic effects on plants have also been reported.Typical Fe-NPs have been introduced into soil–plant systems to examine th...Iron-based nanoparticles(Fe-NPs)exhibit promising potential for soil remediation.However,their toxic effects on plants have also been reported.Typical Fe-NPs have been introduced into soil–plant systems to examine their possible nanotoxicity and other impacts on plants,while Fe-NPs have been added to pollutant–soil–plant systems to evaluate their performance as remediation agents.Mixed opinions and results have been reported regarding interactions between Fe-NPs and soil or plants.Here,meta-analysis was conducted to evaluate the effects of Fe-NPs on plant morphological and physiological characteristics in soil–plant and pollutant–soil–plant systems.Interestingly,morphological characteristics(dry and fresh weight)were significantly improved by Fe-NPs in both soil–plant and pollutant–soil–plant systems.In terms of plant physiological characteristics,Fe-NPs exerted negative effects on plant pigments in soil–plant systems,but positive effects in pollutant–soil–plant systems.In addition,Fe-NPs greatly increased the Fe contents and decreased the pollutant contents of plants.This study also provides a comprehensive review of the positive and negative effects of Fe-NPs on soil–plant systems and summarizes the pollutant remediation mechanisms of Fe-NPs in soil–plant systems.The results underscore the potential of Fe-NPs in agricultural applications and the future development of food safety.展开更多
Background： Prospective real-life data on the safety and effectiveness of rituximab in Chinese patients with diffuse large B-cell lymphoma （DLBCL） or follicular lymphoma （FL） are limited. This real-world study ai...Background： Prospective real-life data on the safety and effectiveness of rituximab in Chinese patients with diffuse large B-cell lymphoma （DLBCL） or follicular lymphoma （FL） are limited. This real-world study aimed to evaluate long-term safety and effectiveness outcomes ofrituximab plus chemotherapy （R-chemo） as first-line treatment in Chinese patients with DLBCL or FL. Hepatitis B virus （HBV） reactivation management was also investigated. Methods： A prospective, multicenter, single-arm, noninterventional study of previously untreated CD20-positive DLBCL or FL patients receiving first-line R-chemo treatment at 24 centers in China was conducted between January 17, 2011 and October 31, 2016. Enrolled patients underwent safety and effectiveness assessments after the last rituximab dose and were followed up for 3 years. Effectiveness endpoints included progression-free survival （PFS） and overall survival （OS）. Safety endpoints were adverse events （AEs）, serious AEs, drug-related AEs, and AEs of special interest. We also reported data on the incidence of HBV reactivation. Results： In total, 283 previously untreated CD20-positive DLBCL and 31 FL patients from 24 centers were enrolled. Three-year PFS was 59% （95% confidence interval [CI]： 50-67%） for DLBCL patients and 46% （95% CI： 20-69%） for FL patients. For DLBCL patients, multivariate analyses showed that PFS was not associated with international prognostic index, tumor maximum diameter, HBV infection status, or number ofrituximab treatment cycles, and OS was only associated with age 〉60 years （P 〈 0.05）. R-chemo was well tolerated. The incidence of HBV reactivation in hepatitis B surface antigen （HBsAg）-positive and HBsAg-negative/hepatitis B core antibody-positive patients was 13% （3/24） and 4% （3/69）, respectively. Conclusions： R-chemo is effective and safe in real-world clinical practice as first-line treatment for DLBCL and FL in China, and that HBV reactivation during R-chemo is manageable with preventive measures and treatment.展开更多
The carbon films are prepared by r.f. plasma method with n butylamine as carbon source. The analysis of Raman spectrosecopy shows that this kind of carbon film has diamond_like structure, and IR spectroscopy measureme...The carbon films are prepared by r.f. plasma method with n butylamine as carbon source. The analysis of Raman spectrosecopy shows that this kind of carbon film has diamond_like structure, and IR spectroscopy measurement indicats that there are SP 2 bonding, SP 3 bonding and amino group in the film. It is the existence of amino group and hydrogen atom that cause the amorphous structure and the deformation of bonding to increase, thus leading the Raman spectrum to form a broad absorption band. The quartz crystal microbalance (QCM) deposited with this kind of carbon film as recognizing coating is very sensitive to formic acid vapors. This QCM sensor has good reproducibility, high stability, rapid response and long lifetime.展开更多
Tumor hypoxia is intimately associated with gliomas,which represents a significant threat to human health and are resistant to the first-line chemotherapeutic drug temozolomide(TMZ)due to hypoxia.In this work,to overc...Tumor hypoxia is intimately associated with gliomas,which represents a significant threat to human health and are resistant to the first-line chemotherapeutic drug temozolomide(TMZ)due to hypoxia.In this work,to overcome TMZ resistance in orthotopic gliomas,aptamer-functionalized liposomes are manufactured to encapsulate TMZ and photothermal agent IR780,and can cross the blood-brain barrier and actively target gliomas.It is possible to employ liposomes for both fluorescence and photoacoustic imaging simultaneously due to their stability and excellent photothermal conversion capabilities.This chemo/photothermal synergistic therapeutic effect of liposomes on gliomas is demonstrated by their abilities to target orthotopic gliomas,alleviate tumor hypoxia and consequently reverse resistance of glioma cells to TMZ,thereby extending the survival time of tumor-bearing mice,making the nanoplatforms and their synergistic chemo/photothermal therapy as a potential clinical treatment for gliomas.展开更多
Cardiovascular diseases (CVDs) are the most prominent cause of disability and mortality in the world. Although there have been a variety of therapeutic options for the management of CVDs, most of the traditional thera...Cardiovascular diseases (CVDs) are the most prominent cause of disability and mortality in the world. Although there have been a variety of therapeutic options for the management of CVDs, most of the traditional therapeutic strategies could not sufficiently stop or reduce the progression of these diseases and may result in some side effects. With the advance in nanotechnology, a number of metal-based nanoparticles have been developed and shown promising potentials in the treatment of CVDs. In this review, we provide a comprehensive review of researches on recent development of metal-based nanoparticles in diagnosis and therapy in CVDs as biomedical materials. We also discuss the challenges in the clinical translation and potential risks in their application of CVD therapy. Based on the ongoing research and applications, we can conclude metal-based nanoparticles are expected to become potential therapeutics for the treatment of CVDs. But their application is still in its infancy and much more efforts should be made to enforce a clinical breakthrough.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.U2344209,U42230310,U42207293)Natural Science Foundation of Sichuan Province,China(Grant No.2023NSFSC0262).
文摘The Late Permian to Early Triassic marked a pivotal phase in paleoenvironmental and tectonic shifts.The Kaijiang-Liangping intracratonic sag,a tectonic geomorphology formed by Emei taphrogenesis in the Sichuan Basin,is situated within a clear water carbonate platform.Under these conditions,the black shales of the Dalong Formation in the sag have ultrahigh organic matter content.However,the mechanism by which these conditions control the accumulation of such organic matter remains unclear.Petrological and geochemical analyses of well DY-1H revealed four distinct units within the Dalong Formation:A,B,C,and D,with average total organic carbon contents of 3.00%,9.59%,4.57%,and 0.27%,respectively.The kerogen maceral,carbon isotope,and pyrolysis results show that the organic matter mainly comprises Type Ⅱ_(2) kerogen.Benthic plants growing in clear water may be the primary source of this kerogen.Shallow water,suboxic conditions,strong volcanism,and high productivity characterize Unit A.Unit B features restricted ocean circulation,anoxic conditions,weak upwelling,moderate volcanism,and high productivity.Unit C is characterized by anoxic conditions,strong upwelling,weak volcanism,and moderate productivity.Oxic conditions and low productivity define Unit D.These findings challenge traditional models that struggle to explain the accumulation of ultrahigh organic matter in Unit A under suboxic conditions,Unit C under moderate productivity,and Unit B with abnormally high organic matter content.The flourishing of benthic plants,a considerable source of Type Ⅱ_(2) kerogen that resists decomposition and favors preservation,is the dominant factor controlling the ultrahigh organic matter accumulation of black shales in Units A,B,and C under clear water conditions.Oxidized bottom waters and decreased benthic plant growth were crucial to the sharp decline in organic matter.
基金Science and Technology Research Project of Chongqing Education Commission(Project No.:KJQN202401902)Chongqing Construction Science and Technology Plan Project(Project No.:Chinese Society For Urban Studies,2024:3-24)+1 种基金cientific Research Fund Project of Chongqing Institute of Engineering(Project No.:2022gcky01)College Student Innovation and Entrepreneurship Training Program Project of Chongqing Institute of Engineering(Project No.:CXCY2024018)。
文摘Taking modern indoor building construction as an example,this study analyzes the path planning and navigation of a smart plastering robot.It includes a basic introduction to smart plastering robots,an analysis of multi-sensor fusion localization algorithms for smart plastering robots,and an analysis of path planning and navigation functions for smart plastering robots.It is hoped that through this analysis,a reference is provided for the path planning and navigation design of such robots to meet their practical application needs.
基金financially supported by the National Natural Science Foundation of China(12175089,12205127,52220105010)the Key Research and Development Program of Yunnan Province(202103AF140006)+3 种基金the Applied Basic Research Programs of Yunnan Provincial Science and Technology Department(202001AW070004,202301AS070051,202301AU070064)Yunnan Industrial Innovative Talents Program for“Xingdian Talent Support Plan”(KKXY202252001)Yunnan Program for Introducing Foreign Talents(202305AO350042)Yunnan Major Scientific and Technological Projects(202202AG050003).
文摘Sodium-ion batteries(SIBs)are emerging as a promising alternative for large-scale energy storage,particularly in grid applications.Within the array of potential cathode materials,Fe/Mn-based layered oxides are notable for their advantageous theoretical specific capacity,economic viability,and environmental sustainability.Nevertheless,the practical application of Fe/Mn-based layered oxides is constrained by their suboptimal cycle performance and rate capability during actual charging and discharging.Ion doping is an effective approach for addressing the aforementioned issues.In this context,we have successfully developed a novel K^(+) and Mg^(2+) codoped P2-Na_(0.7)Fe_(0.5)Mn_(0.5)O_(2) cathode to address these challenges.By doping with 0.05 K^(+) and 0.2 Mg^(2+),the cathode demonstrated excellent cycling stability,retaining 95% of its capacity after 50 cycles at 0.2C,whereas the undoped material retained only 59.7%.Even within a wider voltage range,the co-doped cathode retained 88% of its capacity after 100 cycles at 1C.This work integrated Mg^(2+) to activate oxygen redox reactions in Fe/Mn-based layered cathodes,thereby promoting a reversible hybrid redox process involving both anions and cations.Building on the Mg doping,larger K^(+) ions were introduced into the edge-sharing Na^(+) sites,enhancing the material's cyclic stability and expanding the interplanar distance.The significant improvement of Na^(+) diffusion coefficient by K^(+)/Mg^(2+) co-doping has been further confirmed via the galvanostatic intermittent titration technique(GITT).The study emphasizes the importance of co-doping with different coordination environments in future material design,aiming to achieve high operating voltage and energy density.
基金supported by the National Natural Science Foundation of China (Nos. 81925019, 81801817 and U22A20333)the National Key Research and Development Program of China (Nos. 2023YFB3810000 and 2023YFB3810003)+1 种基金the Fundamental Research Funds for the Central Universities and the Fujian Basic Research Foundation (Nos. 2022J011403, 2023XAKJ0101009, B2302014 and 2020Y4003)the Program for New Century Excellent Talents in University, China (No. NCET-13-0502).
文摘Fluorescent probes have wide applications in biological and environmental analysis due to their advantages of simple operation, convenient flexibility, high sensitivity and efficiency. They are considered to be promising tools for accurate analysis of agriculture- and food-related hazardous substances. In this review, the types and characteristics of the near-infrared fluorescence probes (NIFPs) are briefly described. The recent advances of NIFPs for precisely detecting various hazardous substances including heavy metals, sulfite and related sulfiting agents and hydrogen peroxide are summarized. Finally, the present challenges and future perspectives faced by NIFPs in food safety analysis are discussed.
文摘AIM:To investigate the inhibitory effect of acetylshikonin on human gastric carcinoma cell line SGC-7901 and its mechanism. METHODS:MTT assay was used to assess the inhibitory effect of acetylshikonin on proliferation of SGC-7901 cells.Apopt osis-inducing effect was determined by flow cytometry and terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end-labeling with Hoechst staining.Expression of mRNA and protein in Bcl-2 and Bax was analyzed by reverse transcription-polymerase chain reaction and Western blot.Antitumor effect of acetylshikonin on a mouse SGC-7901 model was also determined. RESULTS:Forty-eight hours after treatment with acetylshikonin,MTT assay showed that acetylshikonin inhibited the proliferation of SGC-7901 cells in a dose-dependent manner.The half maximal inhibitory concentration of acetylshikonin to SGC-7901 cells was 0.428±0.07 mg/L.Cell shrinkage,nuclear pyknosis and chromatin condensation,which are the characteristics of cell apoptosis,were observed in treated SGC-7901 cells and the percentage of apoptosis increased in a dose-dependent manner.Acetylshikonin downregulated the expression of Bcl-2 and up-regulated the expression of Bax in the treated SGC-7901 cells compared with the controls.The experiment in vivo showed that 0.5,1,and 2 mg/kg of acetylshikonin significantly inhibited the growth of tumor in the mouse SGC-7901 model,with an inhibitory rate of 25.00%-55.76%. CONCLUSION:Acetylshikonin inhibits the growth of SGC-7901 cells in vitro and in vivo by inducing cell apoptosis.
基金Supported by The "Eleventh Five-year Plan" for Medical Sci-ence Development of PLA,No.06MB243the National Natural Science Foundation of China,No.81101101 and No.51273165+1 种基金the Key Project of Chinese Ministry of Education,No.212149the Projects of Sichuan Province,No.2010SZ0294,No.2011JQ0032 and No.12ZB038
文摘AIM: To investigate the mechanisms of chloride intracellular channel 1 (CLIC1) in the metastasis of colon cancer under hypoxia-reoxygenation (H-R) conditions.
基金supported by the Major State Basic Research Development Program of China(2017YFA0205201 and 2018YFA0107301)the National Natural Science Foundation of China(81901876,81925019,81603015,81871404,81801817,and U1705281)+2 种基金Xiamen science and technology program(3502Z20173012)the Fundamental Research Funds for the Central Universities(20720190088 and 20720200019)the Program for New Century Excellent Talents in University,China(NCET-13-0502).
文摘Thrombosis is a global health issue and one of the leading factors of death.However,its diagnosis has been limited to the late stages,and its therapeutic window is too narrow to provide reasonable and effective treatment.In addition,clinical thrombolytics suffer from a short half-life,allergic reactions,inactivation,and unwanted tissue hemorrhage.Nano-medicines have gained extensive attention in diagnosis,drug delivery,and photo/sound/magnetic-theranostics due to their convertible properties.Furthermore,diagnosis and treatment of thrombosis using nano-medicines have also been widely studied.This review summarizes the recent advances in this area,which revealed six types of nanoparticle approaches:(1)in vitro diagnostic kits using“synthetic biomarkers”;(2)in vivo imaging using nano-contrast agents;(3)targeted drug delivery systems using artificial nanoparticles;(4)microenvironment responsive drug delivery systems;(5)drug delivery systems using biological nanostructures;and(6)treatments with external irradiation.The investigations of nano-medicines are believed to be of great significance,and some of the advanced drug delivery systems show potential applications in clinical theranotics.
文摘Objective： Non-small cell lung cancer （NSCLC） patients with epidermal growth factor receptor （EGFR）-activating mutations have higher response rate and more prolonged survival following treatment with single-agent EGFR tyrosine kinase inhibitor （EGFR-TKI） compared with patients with wild-type EGFR. However, all patients treated with reversible inhibitors develop acquired resistance over time. The mechanisms of resistance are complicated. The lack of established therapeutic options for patients after a failed EGFR-TKI treatment poses a great challenge to physicians in managing this group of lung cancer patients. This study evaluates the influence of EGFR-TKI retreatment following chemotherapy after failure of initial EGFR-TKI within at least 6 months on NSCLC patients. Methods： ＇i-he data of 27 patients who experienced treatment failure from their initial use of EGFR-TKI within at least 6 months were analyzed. After chemotherapy, the patients were retreated with EGFR-TKI （gefitinib 250 mg qd or erlotinib 150 mg qd）, and the tumor progression was observed. The patients were assessed for adverse events and response to therapy. Targeted tumor lesions were assessed with CT scan. Results： Of the 27 patients who received EGFR-TKI retreatment~ 1 （3.7%） patient was observed in complete response （CR）, 8 （29.6%） patients in partial response （PR）, 14 （51.9%） patients in stable disease （SD）, and 4 （14.8%） patients in progressive disease （PD）. The disease control rate （DCR） was 85.2% （95% CI： 62%-94%）. The median progression-free survival （mPFS） was 6 months （95% CI： 1-29）. Of the 13 patients who received the same EGFR-TKI, 1 patient in CR, 3 patients in PR, 8 patients in SD, and 2 patients in PD were observed. The DCRwas 84.6%, and the mPFS was 5 months. Of the 14 patients who received another EGFR-TKI, no patient in CR~ 6 patients in PR, 6 patients in SD, and 2 patients in PD were observed. The DCRwas 85.7%, and the mPFS was 9.5 months. Significant difference was found between the two groups in PFS but not in response rate or D CR. Conclusion： Retreatment of EGFR-TKIs can be considered an option after failure of chemotherapy for patients who were previously controlled by EGFR-TKI treatment.
基金supported by the Chinese National Natural Science Fund(Grant No.50579066,50879073)Provincial Education Department Projects(11ZA072)
文摘A pot experiment was conducted to investigate the effects of nitrogen content [Nl （no fertilizer）, N2 （0.15 g.kg-l）, and N3 （0.3 g.kg 1）] on the growth and the hydraulic characteristics of peach seedlings under different soil moisture conditions （Wl, W2 and W3, in which the soil water content was 45% to 55%, 60% to 70%, and 75% to 80% of the field water capacity, respectively） by using a specialized high pressure flow meter with a root chamber and a coupling, which was connected to plant organs. Leaf area and leaf hydraulic conductivity （KL） increased significantly in the seedlings because of increased soil moisture and N content. KL increased with leaf area. A linear correlation was documented between KL and leaf area. KL was higher in the morning and began to decline sharply after 16：00, at which KL declined after an initial increase. Soil moisture and N content enhanced shoot （Ks） and root （Kr） hydraulic conductivities, thereby improving the low soil moisture condition to a large extent. Ks and Kr of the seedlings were reduced by 32% and 27% respectively in N~, and by 14.7% and 9.4%, respectively in N2, and both in Wb compared with the control treatment. N3 had no significant effect on Ks and Kr under similar conditions. Linear negative correlations were observed between Kr and the excised root diameter as well as between Ks and the shoot stem diameter. The shoot-to-root ratio increased with in- crease in N content. The shoot-to-root ratio in N3 was increased by 14.37%, compared with N1 in W1 as well as by 12% and 4.39% in Wz and W3, respectively. Knowledge of the effects of soil moisture and N fertilizer on hydraulic characteristics and growth is important. Our results provide basic guidelines for the implementation of water-saving irrigation and fertilization management of nursery stock.
基金This work was supported by the National Natural Science Foundation of China(No.61705065)Hunan Provincial Natural Science Foundation of China(No.2017JJ3034)+1 种基金Technology Program of Changsha(No.kq1804001)National Training Program of Innovation and Entrepreneurship for undergraduates(No.S201910532166).
文摘Circularly polarized light(CPL)has been given great attention because of its extensive application.While several devices for CPL detection have been studied,their performance is affected by the magnitude of photocurrent.In this paper,a self-powered photodetector based on hot electrons in chiral metamaterials is proposed and optimized.CPL can be distinguished by the direction of photocurrent without external bias owing to the interdigital electrodes with asymmetric chiral metamaterials.Distinguished by the direction of photocurrent,the device can easily detect the rotation direction of the CPL electric field,even if it only has a very weak responsivity.The responsivity of the proposed detector is near 1.9 mA/W at the wavelength of 1322 nm,which is enough to distinguish CPL.The detector we proposed has the potential for application in optical communication.
基金Scientific and Technical Development Project of Jiangsu Province (No. BS2006005)
文摘Objective: To compare the efficacy and toxicity between gemcitabine plus cisplatin and plus carboplatin in first-line treatment of advanced non-small cell lung cancer (NSCLC). Methods: Gemcitabine 1000 mg/m2 iv, d1, 8; cisplatin 75 mg/m2 iv, d1, or 25 mg/m2 iv, d1-3; carboplatin AUC = 5 iv, d1; repeated every 21 days. Results: All 76 cases were available for objective response. Gemcitabine + cisplatin (GCis) group: among 33 cases, CR 1 case, PR 13 cases, MR 3 cases, SD 7 cases, PD 9 cases, response rate, disease control rate, time to progress (TTP), median survival time (MST) and 1-, 2-year survival rates were 42.42% (14/33), 72.73% (24/33), 5 months, 14 months and 66.67% (22/33), 12.12% (4/33), respectively; Gemcitabine + carboplatin (GCarb) group: among 43 cases, PR 13 cases, MR 11 cases, SD 7 cases, PD 12 cases, the results while comparing with those of GCis group were 30.23% (13/43), 72.09% (31/43), 4 months, 11 months and 48.84% (21/43), 2.33% (1/43), respectively. Among them, only MST between the two groups had significant statistic difference (χ2 = 2.45, P = 0.017). Mild to modest myelo-suppression as well as nausea and vomiting were observed. Conclusion: Both GCis and GCarb regimens had active and well-tolerated toxicity for advanced NSCLC. Cisplatin-based chemotherapy yields a substantial effective advantage over carboplatin-based regimens. Therefore, carboplatin and cisplatin are not equal-active and that cisplatin-based doublet regimens should remain the standard first-line therapy for patients with advanced NSCLC with good performance status.
基金This project was supported by grants-from the National Natural Science Foundation of China （No. 81573235）, Health and Family Commission of Hubei Province （No. 2015CFB376）, and Health and Family Commission of Wuhan Municipality （No. WG15D20）.
文摘Pregnancy is a critical stimulator of bone mineral resorption. We used to find the MTHFR gene polymorphisms are related with blood lead levels among pregnant women. Pregnancy-stimulated bone turnover may be associated with MTHFR gene polymorphisms too. In this article, we aimed to determine the relationship between MTHFR gene polymorphisms and bone turnover rates among the pregnant women. The participants including pregnant and non-pregnant women were selected and recruited during their routine prenatal or physical examination from July to October in 2012. A total of 1000 participants, including 250 pregnant women in the first, second, and third trimesters and 250 non-pregnant women, were enrolled in the study. Finally, after excluding 27 participants unable to provide blood samples, 973 eligible participants （i.e., 234, 249, and 248 pregnant women in the first, second, and third trimesters, respectively, and 242 non-pregnant women） were included in the research. The MTHFR gene 1298CC homozygote carriers were more susceptible to yield higher plasma homocysteine levels than the 1298AA/AC carriers, with standardized coefficients of 0.086 （P〈0.05） and 0.104 （P〈0.01） of all the participants and the pregnant women, respectively. The MTHFR gene 1793AA homozygote carriers more likely showed higher plasma osteocalcin levels （standardized β=0.091, P〈0.01） than the 1793GG/GA carriers among all the subjects. Plasma homocysteine levels were positively correlated with blood lead levels among the participants and the pregnant women with standardized coefficients of 0.320 （P〈0.01） and 0.179 （P〈0.01）, respectively. Plasma osteocalcin levels were positively associated with blood lead levels among pregnant and non-pregnant women with standardized coefficients of 0.084 （P〈0.05） and 0.125 （P〈0.01）, respectively. In conclusion, homocysteine and osteocalcin contents in plasma are associated with the MTHFR gene A1298C polymorphism and blood lead levels among pregnant women. The MTHFR gene A1298C polymorphism-related homocysteine is a possible risk factor for increased blood lead levels among Chinese women.
基金supported by the National Natural Science Foundation of China(Nos.52279051 and 52261145701)the 2115 Talent Development Program of China Agricultural University(No.109018)the Chinese Universities Scientific Fund(No.2024TC027).
文摘Iron-based nanoparticles(Fe-NPs)exhibit promising potential for soil remediation.However,their toxic effects on plants have also been reported.Typical Fe-NPs have been introduced into soil–plant systems to examine their possible nanotoxicity and other impacts on plants,while Fe-NPs have been added to pollutant–soil–plant systems to evaluate their performance as remediation agents.Mixed opinions and results have been reported regarding interactions between Fe-NPs and soil or plants.Here,meta-analysis was conducted to evaluate the effects of Fe-NPs on plant morphological and physiological characteristics in soil–plant and pollutant–soil–plant systems.Interestingly,morphological characteristics(dry and fresh weight)were significantly improved by Fe-NPs in both soil–plant and pollutant–soil–plant systems.In terms of plant physiological characteristics,Fe-NPs exerted negative effects on plant pigments in soil–plant systems,but positive effects in pollutant–soil–plant systems.In addition,Fe-NPs greatly increased the Fe contents and decreased the pollutant contents of plants.This study also provides a comprehensive review of the positive and negative effects of Fe-NPs on soil–plant systems and summarizes the pollutant remediation mechanisms of Fe-NPs in soil–plant systems.The results underscore the potential of Fe-NPs in agricultural applications and the future development of food safety.
基金This study was supported by grants from the National Natural Science Foundation of China （No. 81570186） and the Health and Family Planning Commission of Jiangsu Province （No. H201511）.
文摘Background： Prospective real-life data on the safety and effectiveness of rituximab in Chinese patients with diffuse large B-cell lymphoma （DLBCL） or follicular lymphoma （FL） are limited. This real-world study aimed to evaluate long-term safety and effectiveness outcomes ofrituximab plus chemotherapy （R-chemo） as first-line treatment in Chinese patients with DLBCL or FL. Hepatitis B virus （HBV） reactivation management was also investigated. Methods： A prospective, multicenter, single-arm, noninterventional study of previously untreated CD20-positive DLBCL or FL patients receiving first-line R-chemo treatment at 24 centers in China was conducted between January 17, 2011 and October 31, 2016. Enrolled patients underwent safety and effectiveness assessments after the last rituximab dose and were followed up for 3 years. Effectiveness endpoints included progression-free survival （PFS） and overall survival （OS）. Safety endpoints were adverse events （AEs）, serious AEs, drug-related AEs, and AEs of special interest. We also reported data on the incidence of HBV reactivation. Results： In total, 283 previously untreated CD20-positive DLBCL and 31 FL patients from 24 centers were enrolled. Three-year PFS was 59% （95% confidence interval [CI]： 50-67%） for DLBCL patients and 46% （95% CI： 20-69%） for FL patients. For DLBCL patients, multivariate analyses showed that PFS was not associated with international prognostic index, tumor maximum diameter, HBV infection status, or number ofrituximab treatment cycles, and OS was only associated with age 〉60 years （P 〈 0.05）. R-chemo was well tolerated. The incidence of HBV reactivation in hepatitis B surface antigen （HBsAg）-positive and HBsAg-negative/hepatitis B core antibody-positive patients was 13% （3/24） and 4% （3/69）, respectively. Conclusions： R-chemo is effective and safe in real-world clinical practice as first-line treatment for DLBCL and FL in China, and that HBV reactivation during R-chemo is manageable with preventive measures and treatment.
文摘The carbon films are prepared by r.f. plasma method with n butylamine as carbon source. The analysis of Raman spectrosecopy shows that this kind of carbon film has diamond_like structure, and IR spectroscopy measurement indicats that there are SP 2 bonding, SP 3 bonding and amino group in the film. It is the existence of amino group and hydrogen atom that cause the amorphous structure and the deformation of bonding to increase, thus leading the Raman spectrum to form a broad absorption band. The quartz crystal microbalance (QCM) deposited with this kind of carbon film as recognizing coating is very sensitive to formic acid vapors. This QCM sensor has good reproducibility, high stability, rapid response and long lifetime.
基金This work was supported,in part,by the National Natural Science Foundation of China(Nos.32171173,32001074,and 82260473)the Key Research and Development Program in Ningxia Province of China(No.2022BEG03080)+6 种基金the Natural Science Basic Research Plan in Ningxia Province of China(No.2022AAC03522)the Health Commission of Ningxia Hui Autonomous Region Science and Technology Support Project for Quality Development of Medical Institutions(No.2023-NWKYT-019)the State Key Laboratory Grant of Space Medicine Fundamentals and Application(No.SMFA20A02)the Natural Science Basic Research Key Program of Shaanxi Province(No.2023-JC-ZD-53)the Natural Science Basic Research Plan in Shaanxi Province of China(No.2022JQ-201)the Fundamental Research Funds for the Central Universities(Nos.ZYTS23190 and xzy012022134)the Beijing Xisike Clinical Oncology Research Foundation.
文摘Tumor hypoxia is intimately associated with gliomas,which represents a significant threat to human health and are resistant to the first-line chemotherapeutic drug temozolomide(TMZ)due to hypoxia.In this work,to overcome TMZ resistance in orthotopic gliomas,aptamer-functionalized liposomes are manufactured to encapsulate TMZ and photothermal agent IR780,and can cross the blood-brain barrier and actively target gliomas.It is possible to employ liposomes for both fluorescence and photoacoustic imaging simultaneously due to their stability and excellent photothermal conversion capabilities.This chemo/photothermal synergistic therapeutic effect of liposomes on gliomas is demonstrated by their abilities to target orthotopic gliomas,alleviate tumor hypoxia and consequently reverse resistance of glioma cells to TMZ,thereby extending the survival time of tumor-bearing mice,making the nanoplatforms and their synergistic chemo/photothermal therapy as a potential clinical treatment for gliomas.
基金supported by the Major State Basic Research Development Program of China(grant No.2017YFA0205201)the National Natural Science Foundation of China(grant Nos.81801817,81901876,and U1705281)+2 种基金the Fundamental Research Funds for the Central Universities(grant Nos.20720190088 and 20720200019)Fujian Undergraduate Training Program for Inno-vation and Entrepreneurship(grant Nos.201812631010,JT180649,and HXJB-08)the Program for New Century Excellent Talents in University,China(grant No.NCET-13-0502).
文摘Cardiovascular diseases (CVDs) are the most prominent cause of disability and mortality in the world. Although there have been a variety of therapeutic options for the management of CVDs, most of the traditional therapeutic strategies could not sufficiently stop or reduce the progression of these diseases and may result in some side effects. With the advance in nanotechnology, a number of metal-based nanoparticles have been developed and shown promising potentials in the treatment of CVDs. In this review, we provide a comprehensive review of researches on recent development of metal-based nanoparticles in diagnosis and therapy in CVDs as biomedical materials. We also discuss the challenges in the clinical translation and potential risks in their application of CVD therapy. Based on the ongoing research and applications, we can conclude metal-based nanoparticles are expected to become potential therapeutics for the treatment of CVDs. But their application is still in its infancy and much more efforts should be made to enforce a clinical breakthrough.
