The increase in soil temperature associated with climate change has introduced considerable challenges to crop production.Split nitrogen application(SN)represents a potential strategy for improving crop nitrogen use e...The increase in soil temperature associated with climate change has introduced considerable challenges to crop production.Split nitrogen application(SN)represents a potential strategy for improving crop nitrogen use efficiency and enhancing crop stress resistance.Nevertheless,the precise interaction between soil warming(SW)and SN remains unclear.In order to ascertain the impact of SW on maize growth and whether SN can improve the tolerance of maize to SW,a two-year field experiment was conducted(2022-2023).The aim was to examine the influence of two SW ranges(MT,warming 1.40℃;HT,warming 2.75℃)and two nitrogen application methods(N1,one-time basal application of nitrogen fertilizer;N2,one third of base nitrogen fertilizer+two thirds of jointing stage supplemental nitrogen fertilizer)on maize root growth,photosynthetic characteristics,nitrogen use efficiency,and yield.The results demonstrated that SW impeded root growth and precipitated the premature aging of maize leaves following anthesis,particularly in the HT,which led to a notable reduction in maize yield.In comparison to N1,SN has been shown to increase root length density by 8.54%,root bleeding rate by 8.57%,and enhance root distribution ratio in the middle soil layers(20-60 cm).The interaction between SW and SN had a notable impact on maize growth and yield.The SN improved the absorption and utilization efficiency of nitrogen by promoting root development and downward canopy growth,thus improving the tolerance of maize to SW at the later stage of growth.In particular,the N2HT resulted in a 14.51%increase in the photosynthetic rate,a 18.58%increase in nitrogen absorption efficiency,and a 18.32%increase in maize yield compared with N1HT.It can be posited that the SN represents a viable nitrogen management measure with the potential to enhance maize tolerance to soil high-temperature stress.展开更多
Ion implantation technology is a crucial strategy for modulating the degradation behavior of biomedical magnesium alloys.In this study,Ag,Ti,and Zr ions were implanted into the surface of pure Mg at varying doses to i...Ion implantation technology is a crucial strategy for modulating the degradation behavior of biomedical magnesium alloys.In this study,Ag,Ti,and Zr ions were implanted into the surface of pure Mg at varying doses to investigate their effects on the microstructure and properties of pure Mg.The results revealed that differences in the affinities of Mg and the implanted elements for reacting with oxygen led to the formation of implanted layers with distinct compositions and structures.Specifically,Ag ion implantation resulted in a layer predominantly composed of elemental silver,while Ti and Zr ion implantation promoted the formation of a denser layer containing Mg,MgO,the implanted elements,and their respective oxides.This layer significantly enhanced the corrosion resistance of pure Mg by reducing its susceptibility to corrosive media.Electrochemical assessments showed a substantial reduction in corrosion current density following Ti and Zr ion implantation.However,increasing doses of Ag ions induced heightened susceptibility to galvanic corrosion due to the electrode potential differences between Ag and Mg,thereby accelerating the degradation of the pure Mg substrate.Additionally,first-principles calculations of the work functions for both the (0001) basal plane and the(101 0) prism plane of Mg corroborated the observed electrochemical trends.展开更多
Plants deploy a two-layered immune system:pathogen-associated molecular pattern(PAMP)-triggered immunity(PTl)and effector-triggered immunity(ETI).While PTI is initiated by cell surface receptors,ETI relies on intracel...Plants deploy a two-layered immune system:pathogen-associated molecular pattern(PAMP)-triggered immunity(PTl)and effector-triggered immunity(ETI).While PTI is initiated by cell surface receptors,ETI relies on intracellular NLR receptors that recognize pathogen effectors(Jones et al.,2024).The nucleoporin CONSTITUTIVE EXPRESSER OF PATHOGENESIS-RELATED GENES 5(CPR5)is a key negative regulator of ETI.CPR5 integrates nuclear transport,cell cycle control,and RNA processing to suppress immune signaling(Wang et al.,2014;Gu et al.,2016;Peng et al.,2022).Recent work revealed that CPR5 also modulates immunity through another nucleoporin,GUANYLATE-BINDING PROTEIN-LIKE 3(GBPL3),which interaCtS with PWWP-DOMAIN INTERACTOR OF POLYCOMBS1(PWO1),a key component of the chromatin-associated methyltransferase POLYCOMB REPRESSIVE COMPLEX 2(PRC2)(Reimann et al.,2023;Pan et al.,2025).These findings suggest unexplored roles for chromatin remodeling in the CPR5-mediated immunity.展开更多
BACKGROUND Low anterior resection syndrome(LARS)is a prevalent and debilitating complication following sphincter-preserving surgery for rectal cancer.Evidence-based interventions for the concurrent psychological burde...BACKGROUND Low anterior resection syndrome(LARS)is a prevalent and debilitating complication following sphincter-preserving surgery for rectal cancer.Evidence-based interventions for the concurrent psychological burden are limited.Electroacupuncture has been proposed as a potential adjunctive therapy,but its psychological benefits remain inadequately studied.AIM To investigate the therapeutic effect of electroacupuncture on emotional recovery and gastrointestinal function in patients with moderate to severe LARS,and to explore its potential advantages in psychologically vulnerable subgroups.METHODS We conducted a retrospective,controlled study involving 100 patients with moderate to severe LARS(LARS score≥21)treated at two tertiary hospitals in China between January 2022 and December 2024.Patients received either standard postoperative care alone(n=50)or in combination with a standardized 4-week electroacupuncture protocol(n=50).Psychological and functional outcomes were assessed using validated instruments including Hospital Anxiety and Depression Scale(HADS),Body Image Scale(BIS),General Self-Efficacy Scale,Perceived Social Support Scale(PSSS),LARS score,and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 at four time points.The primary endpoint was emotional remission,defined as a≥3-point reduction in HADS-Anxiety subscale(HADS-A).Analyses included repeated-measures comparisons,Kaplan-Meier survival curves,Cox regression models,and subgroup-interaction testing.RESULTS At baseline,demographic,surgical,and psychosocial characteristics were comparable among groups.By week 4,patients receiving electroacupuncture demonstrated significantly greater reductions in anxiety(HADS-A:4.8±2.6 vs 7.3±3.0;P<0.001),depression,and body-image disturbance(BIS:8.7±3.6 vs 11.9±4.2;P<0.001),alongside enhanced coping capacity(Brief Coping Orientation to Problems Experienced),perceived social support(PSSS),and bowel function(LARS score).Emotional remission-defined as a≥3-point HADS-A reduction-was achieved more rapidly in the electroacupuncture group,as confirmed by Kaplan-Meier analysis(log-rank P<0.001;odds ratio=4.7).Multivariate Cox regression identified higher baseline LARS and BIS scores as independent predictors of delayed emotional recovery.Subgroup analyses revealed significantly amplified treatment benefits in patients with high baseline anxiety(HADS-A≥8),elevated body-image disturbance(BIS≥12),or low perceived social support(PSSS<60),with consistent interaction effects(P for interaction<0.05 across subgroups).CONCLUSION Electroacupuncture may accelerate emotional recovery and improve functional and psychosocial outcomes in patients with LARS.Its integration into postoperative care may offer particular benefits for psychologically vulnerable subgroups.展开更多
Liangshan Prefecture in Sichuan province,China,has a high prevalence of HIV infection,which is reflective of a change in the mode of transmission from injection drug use(IDU)to heterosexual intercourse.However,few stu...Liangshan Prefecture in Sichuan province,China,has a high prevalence of HIV infection,which is reflective of a change in the mode of transmission from injection drug use(IDU)to heterosexual intercourse.However,few studies focus on HIV-related heterosexual risk behaviours among the majority Yi population.The objectives of this study were to explore the characteristics of an egocentric sexual network and estimate the prevalence of casual sexual behaviour.Yi villagers(n=108),aged 15-35 years,who reported having had sex within the previous year were interviewed as to their sexual behaviours and networks.In-depth interviews and focus group discussions provided supplementary information on sexual norms.Logistic regression analysis was used to calculate unadjusted odds ratios(ORs)and 95%confidence intervals(CIs).Most of the respondents reported having had casual sex at some time in their life,and 66.7%reported multiple sexual partnerships.Only 21.3%reported ever having used a condom.During the study year,a total of 137 partners were involved in 153 sexual partnerships.Among the reported sexual partnerships,67.3%originated from a casual sexual relationship.For network members in components of size≥3,56,9%were involved in concurrent sexual partnerships.Having never been married(OR:2.11;95%CI:1.03-4.33)and younger age(OR:0.89;95%CI:0.83-0.95)were both associated with being in a component of size≥3.Size(OR:2.99;95%Ch 1.17-7.66),pair(OR:0.54;95%Ch 0.039-0.74),the number of weak components of the egocentric sexual network(OR-30.04;95%Ch 6.47-139.46)and gender(OR.0.19;95%Ch.0.06-0.67)were all associated with being in concurrent sexual partnerships.HIV-related interventions for the Yi ethnic minority in Sichuan province must therefore address concurrent sexual partnerships and promote condom use.展开更多
Construction of advanced electromagnetic interference(EMI)shielding materials with miniaturized,programmable structure and low reflection are promising but challenging.Herein,an integrated transition-metal carbides/ca...Construction of advanced electromagnetic interference(EMI)shielding materials with miniaturized,programmable structure and low reflection are promising but challenging.Herein,an integrated transition-metal carbides/carbon nanotube/polyimide(gradient-conductive MXene/CNT/PI,GCMCP)aerogel frame with hierarchical porous structure and gradient-conductivity has been constructed to achieve EMI shielding with ultra-low reflection.The gradient-conductive structures are obtained by continuous 3D printing of MXene/CNT/poly(amic acid)inks with different CNT contents,where the slightly conductive top layer serves as EM absorption layer and the highly conductive bottom layer as reflection layer.In addition,the hierarchical porous structure could extend the EM dissipation path and dissipate EM by multiple reflections.Consequently,the GCMCP aerogel frames exhibit an excellent average EMI shielding efficiency(68.2 dB)and low reflection(R=0.23).Furthermore,the GCMCP aerogel frames with miniaturized and programmable structures can be used as EMI shielding gaskets and effectively block wireless power transmission,which shows a prosperous application prospect in defense industry and aerospace.展开更多
The materials with thermal insulating and fre-retardant properties are highly demanded for architectures to improve the energy efficiency.The applications of conventional inorganic insulating materials such as silica ...The materials with thermal insulating and fre-retardant properties are highly demanded for architectures to improve the energy efficiency.The applications of conventional inorganic insulating materials such as silica aerogels are restricted by their mechanical fragility and organic insulating materials are either easily ignitable or exhibit unsatisfactory thermal insulation performance.Here,we report an organic/inorganic composite aerogel with integrated double network structure,in which silica constituent homogeneously distribute in the anisotropic polyimide nanofber aerogel matrix and strong interfacial effect is formed between two components.The integrated binary network endows the polyimide/silica composite aerogels with outstanding compressibility and flexibility even with a high inorganic content of 60%,which can withstand 500 cyclic fatigue tests at a compressive strain of 50%in the radial direction.The resulting composite aerogel exhibits a combination of outstanding insulating performance with a low thermal conductivity(21.2 mW m^(-1)K^(-1))and excellent resistance to a 1200℃flame without disintegration.The high-performance polyimide/silica aerogels can decrease the risk brought by the collapse of reinforced concrete structures in a fre,demonstrating great potential as efficient building materials.展开更多
Biogenic silica （BSi） contents in the marsh plants （Phragmites australis, Scirpus mariqueter and Spartina alterniflora） and associated sediments in Chongming Island eastern intertidal flat of the Yangtze Estuary w...Biogenic silica （BSi） contents in the marsh plants （Phragmites australis, Scirpus mariqueter and Spartina alterniflora） and associated sediments in Chongming Island eastern intertidal flat of the Yangtze Estuary were determined. The BSi contents in P. australis, S. mariqueter and S. alterniflora varied from 25.78–42.74 mg/g, 5.71–19.53 mg/g and 6.71–8.92 mg/g, respectively. Over the entire growth season, P. australis and S. mariqueter were characterized by linear accumulation patterns of BSi. The aboveground biomass （leaves and culms） of the marsh plants generally contained more BSi than underground biomass （roots）. BSi contents were relatively higher in dead plant tissues than in live tissues which was probably due to the decomposition and the leaching of labile components of plant tissues such as organic carbon and nitrogen. Comparing with the habitats of S. mariqueter and S. alterniflora, the highest BSi content was recorded in sediments inhabited by P. australis, with an annual average of 15.69 mg/g. Overall, the intertidal marshes in the Yangtze Estuary may act as a net sink of BSi via plant uptake and sedimentary burial.展开更多
BACKGROUND Yigong San(YGS)is a representative prescription for the treatment of digestive disorders,which has been used in clinic for more than 1000 years.However,the mechanism of its anti-gastric cancer and regulate ...BACKGROUND Yigong San(YGS)is a representative prescription for the treatment of digestive disorders,which has been used in clinic for more than 1000 years.However,the mechanism of its anti-gastric cancer and regulate immunity are still remains unclear.AIM To explore the mechanism of YGS anti-gastric cancer and immune regulation.METHODS Firstly,collect the active ingredients and targets of YGS,and the differentially expressed genes of gastric cancer.Secondly,constructed a protein-protein interaction network between the targets of drugs and diseases,and screened hub genes.Then the clinical relevance,mutation and repair,tumor microenvironment and drug sensitivity of the hub gene were analyzed.Finally,molecular docking was used to verify the binding ability of YGS active ingredient and hub genes.RESULTS Firstly,obtained 55 common targets of gastric cancer and YGS.The Kyoto Encyclopedia of Genes and Genomes screened the microtubule-associated protein kinase signaling axis as the key pathway and IL6,EGFR,MMP2,MMP9 and TGFB1 as the hub genes.The 5 hub genes were involved in gastric carcinogenesis,staging,typing and prognosis,and their mutations promote gastric cancer progression.Finally,molecular docking results confirmed that the components of YGS can effectively bind to therapeutic targets.CONCLUSION YGS has the effect of anti-gastric cancer and immune regulation.展开更多
Dear Editor, Eukaryotic transcriptional regulation networks are extremely complex. Usually, multiple transcription factors (TFs) bind to the promoter region of a gene and cooperate to control gene expression precisely...Dear Editor, Eukaryotic transcriptional regulation networks are extremely complex. Usually, multiple transcription factors (TFs) bind to the promoter region of a gene and cooperate to control gene expression precisely. Identifying cooperative TFs remains a major challenge in modem biological research. Various types of data, including genomic sequences, expression profiles, ChiP-chip data and protein-protein interactions, have been used to identify mechanisms of cooperative transcriptional regulation.展开更多
Cariogenic Streptococcus mutans(S.mutans)is a leading cause of bacterial-induced oral diseases.Current strategies to kill bacteria based on Host defense peptide(HDP)mimicking polymers hold promise to treat oral bacter...Cariogenic Streptococcus mutans(S.mutans)is a leading cause of bacterial-induced oral diseases.Current strategies to kill bacteria based on Host defense peptide(HDP)mimicking polymers hold promise to treat oral bacterial infection.Here,we explore the impact of hydrophobic subunit and chain length variation on the antibacterial and antibiofilm activity ofβ-peptide polymers.The physicochemical and biological prop-erties,such as the toxicity,the antibacterial activity,and the effect on bacterial transcription ofβ-peptide polymers,were systematically investigated with numerous techniques.The results exhibited that the op-timalβ-peptide polymer has low toxicity towards human periodontal ligament fibroblasts,andβ-peptide polymers(especially P3)have more excellent antibacterial activity against S.mutans than metronidazole.In addition,β-peptide polymers inhibited the reversible and irreversible bacterial adhesion during the formation of biofilms.The polymer can promote biofilm dispersion by decreasing the hydrophobicity of bacterial cells after adhering to cell surfaces.Analysis of the transcriptome for S.mutans treated withβ-peptide polymers demonstrated thatβ-peptide polymers could reduce the cariogenicity of S.mutans by impacting the transcription of the energy and acid metabolism-related genes.β-peptide polymers are promising antimicrobial agents in clinical dentistry due to their high antibacterial efficiency and low tox-icity.展开更多
We report the temperature dependence of the spin pumping effect for Y_(3)Fe_(5)O_(12)(YIG,0.9μm)/NiO(tNiO)/W(6 nm)(tNiO=0 nm,1 nm,2 nm,and 10 nm)heterostructures.All samples exhibit a strong temperature-dependent inv...We report the temperature dependence of the spin pumping effect for Y_(3)Fe_(5)O_(12)(YIG,0.9μm)/NiO(tNiO)/W(6 nm)(tNiO=0 nm,1 nm,2 nm,and 10 nm)heterostructures.All samples exhibit a strong temperature-dependent inverse spin Hall effect(ISHE)signal I_(c)and sensitivity to the NiO layer thickness.We observe a dramatic decrease of I_(c)with inserting thin NiO layer between YIG and W layers indicating that the inserting of NiO layer significantly suppresses the spin transport from YIG to W.In contrast to the noticeable enhancement in YIG/NiO(tNiO≈1-2 nm)/Pt,the suppression of spin transport may be closely related to the specific interface-dependent spin scattering,spin memory loss,and spin conductance at the NiO/W interface.Besides,the I_(c)of YIG/Ni O/W exhibits a maximum near the TNof the AF NiO layer because the spins are transported dominantly by incoherent thermal magnons.展开更多
Objective To explore prevalence of casual sex among the Yi. Methods Cross-sectional survey of 89 Yi male villagers was used. In-depth interview, interview and focus group discussion were used to collect supplementary ...Objective To explore prevalence of casual sex among the Yi. Methods Cross-sectional survey of 89 Yi male villagers was used. In-depth interview, interview and focus group discussion were used to collect supplementary information. Results About 96.63% respondents had had casual sex at some time in their life, and 78. 65% had had multiple partners （maximum number was 40）; 41.57% respondents had heard of condoms, but only 20.22% had used them and no one used them consistently. In the past one year, 26.97% had had multiple partners （maximum number was 6）. Conclusion Casual sex is a Yi young men＇s lifestyle, but is denied. It is urgent for researchers and policy makers to pay attention to casual sex.展开更多
基金supported by the Natural Science Fund of China(31771724)the Key Research and Development Project of Shaanxi Province(2024NC-ZDCYL-01-10).
文摘The increase in soil temperature associated with climate change has introduced considerable challenges to crop production.Split nitrogen application(SN)represents a potential strategy for improving crop nitrogen use efficiency and enhancing crop stress resistance.Nevertheless,the precise interaction between soil warming(SW)and SN remains unclear.In order to ascertain the impact of SW on maize growth and whether SN can improve the tolerance of maize to SW,a two-year field experiment was conducted(2022-2023).The aim was to examine the influence of two SW ranges(MT,warming 1.40℃;HT,warming 2.75℃)and two nitrogen application methods(N1,one-time basal application of nitrogen fertilizer;N2,one third of base nitrogen fertilizer+two thirds of jointing stage supplemental nitrogen fertilizer)on maize root growth,photosynthetic characteristics,nitrogen use efficiency,and yield.The results demonstrated that SW impeded root growth and precipitated the premature aging of maize leaves following anthesis,particularly in the HT,which led to a notable reduction in maize yield.In comparison to N1,SN has been shown to increase root length density by 8.54%,root bleeding rate by 8.57%,and enhance root distribution ratio in the middle soil layers(20-60 cm).The interaction between SW and SN had a notable impact on maize growth and yield.The SN improved the absorption and utilization efficiency of nitrogen by promoting root development and downward canopy growth,thus improving the tolerance of maize to SW at the later stage of growth.In particular,the N2HT resulted in a 14.51%increase in the photosynthetic rate,a 18.58%increase in nitrogen absorption efficiency,and a 18.32%increase in maize yield compared with N1HT.It can be posited that the SN represents a viable nitrogen management measure with the potential to enhance maize tolerance to soil high-temperature stress.
基金financially supported by the National Natural Science Foundation of China(Nos.52271117 and 52401064)Hunan Provincial Natural Science Foundation of China(Nos.2021JJ30646 and 2023JJ10020)+2 种基金Educational Commission of Hunan Province of China(No.23A0107)Scientific Research Fund of Hunan Provincial Education Department(No.24B0172)Shaanxi Provincial Key R&D Program(No.2024CY2-GJHX-71)
文摘Ion implantation technology is a crucial strategy for modulating the degradation behavior of biomedical magnesium alloys.In this study,Ag,Ti,and Zr ions were implanted into the surface of pure Mg at varying doses to investigate their effects on the microstructure and properties of pure Mg.The results revealed that differences in the affinities of Mg and the implanted elements for reacting with oxygen led to the formation of implanted layers with distinct compositions and structures.Specifically,Ag ion implantation resulted in a layer predominantly composed of elemental silver,while Ti and Zr ion implantation promoted the formation of a denser layer containing Mg,MgO,the implanted elements,and their respective oxides.This layer significantly enhanced the corrosion resistance of pure Mg by reducing its susceptibility to corrosive media.Electrochemical assessments showed a substantial reduction in corrosion current density following Ti and Zr ion implantation.However,increasing doses of Ag ions induced heightened susceptibility to galvanic corrosion due to the electrode potential differences between Ag and Mg,thereby accelerating the degradation of the pure Mg substrate.Additionally,first-principles calculations of the work functions for both the (0001) basal plane and the(101 0) prism plane of Mg corroborated the observed electrochemical trends.
基金supported by grants from the National Natural Science Foundation of China(32270290)the Shanghai Engineering Research Center of Plant Germplasm Resources(17DZ2252700).
文摘Plants deploy a two-layered immune system:pathogen-associated molecular pattern(PAMP)-triggered immunity(PTl)and effector-triggered immunity(ETI).While PTI is initiated by cell surface receptors,ETI relies on intracellular NLR receptors that recognize pathogen effectors(Jones et al.,2024).The nucleoporin CONSTITUTIVE EXPRESSER OF PATHOGENESIS-RELATED GENES 5(CPR5)is a key negative regulator of ETI.CPR5 integrates nuclear transport,cell cycle control,and RNA processing to suppress immune signaling(Wang et al.,2014;Gu et al.,2016;Peng et al.,2022).Recent work revealed that CPR5 also modulates immunity through another nucleoporin,GUANYLATE-BINDING PROTEIN-LIKE 3(GBPL3),which interaCtS with PWWP-DOMAIN INTERACTOR OF POLYCOMBS1(PWO1),a key component of the chromatin-associated methyltransferase POLYCOMB REPRESSIVE COMPLEX 2(PRC2)(Reimann et al.,2023;Pan et al.,2025).These findings suggest unexplored roles for chromatin remodeling in the CPR5-mediated immunity.
文摘BACKGROUND Low anterior resection syndrome(LARS)is a prevalent and debilitating complication following sphincter-preserving surgery for rectal cancer.Evidence-based interventions for the concurrent psychological burden are limited.Electroacupuncture has been proposed as a potential adjunctive therapy,but its psychological benefits remain inadequately studied.AIM To investigate the therapeutic effect of electroacupuncture on emotional recovery and gastrointestinal function in patients with moderate to severe LARS,and to explore its potential advantages in psychologically vulnerable subgroups.METHODS We conducted a retrospective,controlled study involving 100 patients with moderate to severe LARS(LARS score≥21)treated at two tertiary hospitals in China between January 2022 and December 2024.Patients received either standard postoperative care alone(n=50)or in combination with a standardized 4-week electroacupuncture protocol(n=50).Psychological and functional outcomes were assessed using validated instruments including Hospital Anxiety and Depression Scale(HADS),Body Image Scale(BIS),General Self-Efficacy Scale,Perceived Social Support Scale(PSSS),LARS score,and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 at four time points.The primary endpoint was emotional remission,defined as a≥3-point reduction in HADS-Anxiety subscale(HADS-A).Analyses included repeated-measures comparisons,Kaplan-Meier survival curves,Cox regression models,and subgroup-interaction testing.RESULTS At baseline,demographic,surgical,and psychosocial characteristics were comparable among groups.By week 4,patients receiving electroacupuncture demonstrated significantly greater reductions in anxiety(HADS-A:4.8±2.6 vs 7.3±3.0;P<0.001),depression,and body-image disturbance(BIS:8.7±3.6 vs 11.9±4.2;P<0.001),alongside enhanced coping capacity(Brief Coping Orientation to Problems Experienced),perceived social support(PSSS),and bowel function(LARS score).Emotional remission-defined as a≥3-point HADS-A reduction-was achieved more rapidly in the electroacupuncture group,as confirmed by Kaplan-Meier analysis(log-rank P<0.001;odds ratio=4.7).Multivariate Cox regression identified higher baseline LARS and BIS scores as independent predictors of delayed emotional recovery.Subgroup analyses revealed significantly amplified treatment benefits in patients with high baseline anxiety(HADS-A≥8),elevated body-image disturbance(BIS≥12),or low perceived social support(PSSS<60),with consistent interaction effects(P for interaction<0.05 across subgroups).CONCLUSION Electroacupuncture may accelerate emotional recovery and improve functional and psychosocial outcomes in patients with LARS.Its integration into postoperative care may offer particular benefits for psychologically vulnerable subgroups.
文摘Liangshan Prefecture in Sichuan province,China,has a high prevalence of HIV infection,which is reflective of a change in the mode of transmission from injection drug use(IDU)to heterosexual intercourse.However,few studies focus on HIV-related heterosexual risk behaviours among the majority Yi population.The objectives of this study were to explore the characteristics of an egocentric sexual network and estimate the prevalence of casual sexual behaviour.Yi villagers(n=108),aged 15-35 years,who reported having had sex within the previous year were interviewed as to their sexual behaviours and networks.In-depth interviews and focus group discussions provided supplementary information on sexual norms.Logistic regression analysis was used to calculate unadjusted odds ratios(ORs)and 95%confidence intervals(CIs).Most of the respondents reported having had casual sex at some time in their life,and 66.7%reported multiple sexual partnerships.Only 21.3%reported ever having used a condom.During the study year,a total of 137 partners were involved in 153 sexual partnerships.Among the reported sexual partnerships,67.3%originated from a casual sexual relationship.For network members in components of size≥3,56,9%were involved in concurrent sexual partnerships.Having never been married(OR:2.11;95%CI:1.03-4.33)and younger age(OR:0.89;95%CI:0.83-0.95)were both associated with being in a component of size≥3.Size(OR:2.99;95%Ch 1.17-7.66),pair(OR:0.54;95%Ch 0.039-0.74),the number of weak components of the egocentric sexual network(OR-30.04;95%Ch 6.47-139.46)and gender(OR.0.19;95%Ch.0.06-0.67)were all associated with being in concurrent sexual partnerships.HIV-related interventions for the Yi ethnic minority in Sichuan province must therefore address concurrent sexual partnerships and promote condom use.
基金the National Natural Science Foundation of China(52073053,52233006)Young Elite Scientists Sponsorship Program by CAST(2021QNRC001)+3 种基金Shanghai Rising-Star Program(21QA1400300)Innovation Program of Shanghai Municipal Education Commission(2021-01-0700-03-E00108)Science and Technology Commission of Shanghai Municipality(20520741100)China Postdoctoral Science Foundation(2021M690596)。
文摘Construction of advanced electromagnetic interference(EMI)shielding materials with miniaturized,programmable structure and low reflection are promising but challenging.Herein,an integrated transition-metal carbides/carbon nanotube/polyimide(gradient-conductive MXene/CNT/PI,GCMCP)aerogel frame with hierarchical porous structure and gradient-conductivity has been constructed to achieve EMI shielding with ultra-low reflection.The gradient-conductive structures are obtained by continuous 3D printing of MXene/CNT/poly(amic acid)inks with different CNT contents,where the slightly conductive top layer serves as EM absorption layer and the highly conductive bottom layer as reflection layer.In addition,the hierarchical porous structure could extend the EM dissipation path and dissipate EM by multiple reflections.Consequently,the GCMCP aerogel frames exhibit an excellent average EMI shielding efficiency(68.2 dB)and low reflection(R=0.23).Furthermore,the GCMCP aerogel frames with miniaturized and programmable structures can be used as EMI shielding gaskets and effectively block wireless power transmission,which shows a prosperous application prospect in defense industry and aerospace.
基金supported by the Fundamental Research Funds for the Central Universities(2232019A3-03)the National Natural Science Foundation of China(52073053,21674019)+3 种基金Shanghai Rising-Star Program(21QA1400300)Shanghai Municipal Education Commission(17CG33)Innovation Program of Shanghai Municipal Education Commission(2021-01-07-00-03-E00108)Science and Technology Commission of Shanghai Municipality(20520741100)。
文摘The materials with thermal insulating and fre-retardant properties are highly demanded for architectures to improve the energy efficiency.The applications of conventional inorganic insulating materials such as silica aerogels are restricted by their mechanical fragility and organic insulating materials are either easily ignitable or exhibit unsatisfactory thermal insulation performance.Here,we report an organic/inorganic composite aerogel with integrated double network structure,in which silica constituent homogeneously distribute in the anisotropic polyimide nanofber aerogel matrix and strong interfacial effect is formed between two components.The integrated binary network endows the polyimide/silica composite aerogels with outstanding compressibility and flexibility even with a high inorganic content of 60%,which can withstand 500 cyclic fatigue tests at a compressive strain of 50%in the radial direction.The resulting composite aerogel exhibits a combination of outstanding insulating performance with a low thermal conductivity(21.2 mW m^(-1)K^(-1))and excellent resistance to a 1200℃flame without disintegration.The high-performance polyimide/silica aerogels can decrease the risk brought by the collapse of reinforced concrete structures in a fre,demonstrating great potential as efficient building materials.
基金supported by the National Natural Science Foundation of China (No. 40701167, 40671171)the Doctoral Program Foundation of Ministry of Education of China (No. 20070269006)the State Key Laboratory of Estuarine and Coastal Research (No. 2008KYQN01,2008KYYW07)
文摘Biogenic silica （BSi） contents in the marsh plants （Phragmites australis, Scirpus mariqueter and Spartina alterniflora） and associated sediments in Chongming Island eastern intertidal flat of the Yangtze Estuary were determined. The BSi contents in P. australis, S. mariqueter and S. alterniflora varied from 25.78–42.74 mg/g, 5.71–19.53 mg/g and 6.71–8.92 mg/g, respectively. Over the entire growth season, P. australis and S. mariqueter were characterized by linear accumulation patterns of BSi. The aboveground biomass （leaves and culms） of the marsh plants generally contained more BSi than underground biomass （roots）. BSi contents were relatively higher in dead plant tissues than in live tissues which was probably due to the decomposition and the leaching of labile components of plant tissues such as organic carbon and nitrogen. Comparing with the habitats of S. mariqueter and S. alterniflora, the highest BSi content was recorded in sediments inhabited by P. australis, with an annual average of 15.69 mg/g. Overall, the intertidal marshes in the Yangtze Estuary may act as a net sink of BSi via plant uptake and sedimentary burial.
基金Supported by Ningxia Key Research and Development Program,No.2023BEG02015Ningxia Science and Technology Benefiting People Program,No.2022CMG03064+1 种基金Ningxia Natural Science Foundation,No.2022AAC02039National Natural Science Foundation of China,No.82260879 and No.82374261.
文摘BACKGROUND Yigong San(YGS)is a representative prescription for the treatment of digestive disorders,which has been used in clinic for more than 1000 years.However,the mechanism of its anti-gastric cancer and regulate immunity are still remains unclear.AIM To explore the mechanism of YGS anti-gastric cancer and immune regulation.METHODS Firstly,collect the active ingredients and targets of YGS,and the differentially expressed genes of gastric cancer.Secondly,constructed a protein-protein interaction network between the targets of drugs and diseases,and screened hub genes.Then the clinical relevance,mutation and repair,tumor microenvironment and drug sensitivity of the hub gene were analyzed.Finally,molecular docking was used to verify the binding ability of YGS active ingredient and hub genes.RESULTS Firstly,obtained 55 common targets of gastric cancer and YGS.The Kyoto Encyclopedia of Genes and Genomes screened the microtubule-associated protein kinase signaling axis as the key pathway and IL6,EGFR,MMP2,MMP9 and TGFB1 as the hub genes.The 5 hub genes were involved in gastric carcinogenesis,staging,typing and prognosis,and their mutations promote gastric cancer progression.Finally,molecular docking results confirmed that the components of YGS can effectively bind to therapeutic targets.CONCLUSION YGS has the effect of anti-gastric cancer and immune regulation.
基金This work was supported by the National Basic Research Program of China (Grant Nos. 2009CB918404 and 2006CB910700), International S&T Cooperation Program of China (Grant No. 2007DFA31040) and the National Natural Science Foundation of China (Grant Nos. 30700154 and 31070746).
文摘Dear Editor, Eukaryotic transcriptional regulation networks are extremely complex. Usually, multiple transcription factors (TFs) bind to the promoter region of a gene and cooperate to control gene expression precisely. Identifying cooperative TFs remains a major challenge in modem biological research. Various types of data, including genomic sequences, expression profiles, ChiP-chip data and protein-protein interactions, have been used to identify mechanisms of cooperative transcriptional regulation.
基金supported by the National Natural Science Foundation of China(No.51871050)the National Natural Science Foundation of China(No.U2106206)+3 种基金the Natural Science Foundation of Liaoning Province(No.20180510041)the Liaon-ing Revitalization Talents Program(No.XLYC1907158)the Gen-eral Project of Natural Science Foundation of Science and Tech-nology Department of Liaoning Province(No.2021-MS-308)the Fundamental Research Funds for the Central Universities(No.N2120007).
文摘Cariogenic Streptococcus mutans(S.mutans)is a leading cause of bacterial-induced oral diseases.Current strategies to kill bacteria based on Host defense peptide(HDP)mimicking polymers hold promise to treat oral bacterial infection.Here,we explore the impact of hydrophobic subunit and chain length variation on the antibacterial and antibiofilm activity ofβ-peptide polymers.The physicochemical and biological prop-erties,such as the toxicity,the antibacterial activity,and the effect on bacterial transcription ofβ-peptide polymers,were systematically investigated with numerous techniques.The results exhibited that the op-timalβ-peptide polymer has low toxicity towards human periodontal ligament fibroblasts,andβ-peptide polymers(especially P3)have more excellent antibacterial activity against S.mutans than metronidazole.In addition,β-peptide polymers inhibited the reversible and irreversible bacterial adhesion during the formation of biofilms.The polymer can promote biofilm dispersion by decreasing the hydrophobicity of bacterial cells after adhering to cell surfaces.Analysis of the transcriptome for S.mutans treated withβ-peptide polymers demonstrated thatβ-peptide polymers could reduce the cariogenicity of S.mutans by impacting the transcription of the energy and acid metabolism-related genes.β-peptide polymers are promising antimicrobial agents in clinical dentistry due to their high antibacterial efficiency and low tox-icity.
基金support from the National Natural Science Foundation of China(Grant Nos.11774160,61427812,61805116,12004171,61774081,and 62171096)the Natural Science Foundation of Jiangsu Province of China(Grant No.BK20192006)+4 种基金the National Key Scientific Instrument and Equipment Development Project of China(Grant No.51827802)the Natural Science Foundation of Jiangsu Province of China(Grant Nos.BK20180056 and BK20200307)the Applied Basic Research Programs of the Science and Technology Commission Foundation of Jiangsu Province,China(Grant No.BK20200309)the Open Research Fund of Jiangsu Provincial Key Laboratory for Nanotechnology,the Scientific Foundation of Nanjing University of Posts and Telecommunications(NUPTSF)(Grant No.NY220164)the State Key R&D Project of Guangdong,China(Grant No.2020B010174002)
文摘We report the temperature dependence of the spin pumping effect for Y_(3)Fe_(5)O_(12)(YIG,0.9μm)/NiO(tNiO)/W(6 nm)(tNiO=0 nm,1 nm,2 nm,and 10 nm)heterostructures.All samples exhibit a strong temperature-dependent inverse spin Hall effect(ISHE)signal I_(c)and sensitivity to the NiO layer thickness.We observe a dramatic decrease of I_(c)with inserting thin NiO layer between YIG and W layers indicating that the inserting of NiO layer significantly suppresses the spin transport from YIG to W.In contrast to the noticeable enhancement in YIG/NiO(tNiO≈1-2 nm)/Pt,the suppression of spin transport may be closely related to the specific interface-dependent spin scattering,spin memory loss,and spin conductance at the NiO/W interface.Besides,the I_(c)of YIG/Ni O/W exhibits a maximum near the TNof the AF NiO layer because the spins are transported dominantly by incoherent thermal magnons.
基金supported by Sichuan Branch of Global Fund AIDS Office (Round 4)
文摘Objective To explore prevalence of casual sex among the Yi. Methods Cross-sectional survey of 89 Yi male villagers was used. In-depth interview, interview and focus group discussion were used to collect supplementary information. Results About 96.63% respondents had had casual sex at some time in their life, and 78. 65% had had multiple partners （maximum number was 40）; 41.57% respondents had heard of condoms, but only 20.22% had used them and no one used them consistently. In the past one year, 26.97% had had multiple partners （maximum number was 6）. Conclusion Casual sex is a Yi young men＇s lifestyle, but is denied. It is urgent for researchers and policy makers to pay attention to casual sex.
