Selecting the initial antipsychotic dose is a high-impact decision in acute schizophrenia.A randomized study found that starting lurasidone at 80 mg/day for 1 week(then flexible titration)produced earlier reductions i...Selecting the initial antipsychotic dose is a high-impact decision in acute schizophrenia.A randomized study found that starting lurasidone at 80 mg/day for 1 week(then flexible titration)produced earlier reductions in Positive and Negative Syndrome Scale positive symptoms than 40 mg/day,without higher discontinuations for adverse events or a metabolic penalty over 6 weeks.These data support an individualized approach:Start at 80 mg/day when rapid control of positive symptoms or agitation is needed and tolerance permits;start at 40 mg/day when akathisia risk or patient preference argues for caution,with a planned day-7 review for up-titration.The open-label design,dose convergence after week 1,and the lack of stratified randomization limit attribution of longer-term advantages to starting dose.Even so,the trial reframes initial dose as a modifiable lever for the early course rather than a one-size-fits-all rule and warrants confirmation in larger,double-blind randomized trials.展开更多
Chrysanthemum morifolium’Chuju’is a famous medicinal species in traditional Chinese medicine.’Chuju’contains various active ingredients that can be used to treat multiple diseases without toxic side effects.In the...Chrysanthemum morifolium’Chuju’is a famous medicinal species in traditional Chinese medicine.’Chuju’contains various active ingredients that can be used to treat multiple diseases without toxic side effects.In the present study,we combined metabolomics and network pharmacology to further explore the active ingredients in’Chuju’,as well as the target and pharmacological mechanisms of the active ingredients.A visualized network analysis model based on chemistry,pharmacokinetics,and pharmacology was constructed to predict the potential pharmacological mechanism of’Chuju’.A total of 424 metabolites of’Chuju’were identified,of which 21 ingredients had positive pharmacological effects after ADME screening.The network pharmacology revealed that acacetin and beta-sitosterol in’Chuju’could act on GSK3B,MAPK14,ADRA1R,and NOS2 to regulate diabetes mellitus,Alzheimer’s disease,breast cancer,and inflammatory diseases.These results indicated the potential pharmacological effects of the active components in’Chuju’.展开更多
深部咸水含水层具有巨大的CO_(2)封存潜力,研究致密砂岩CO_(2)-水两相驱替机制对实现高效安全的CO_(2)咸水层封存具有重要意义。对两个具有不同孔隙结构特征的低渗透砂岩开展了CO_(2)-水两相驱替试验,利用核磁共振(nuclear magnetic res...深部咸水含水层具有巨大的CO_(2)封存潜力,研究致密砂岩CO_(2)-水两相驱替机制对实现高效安全的CO_(2)咸水层封存具有重要意义。对两个具有不同孔隙结构特征的低渗透砂岩开展了CO_(2)-水两相驱替试验,利用核磁共振(nuclear magnetic resonance,NMR)和磁共振成像(magnetic resonance imaging,MRI)技术对气驱和吸水两个阶段气水两相的分布进行了定量及可视化研究,分析了岩芯孔径分布、非均质性及渗透率差异等对两相驱替特征的影响机制。研究表明在气驱阶段CO_(2)相优先被捕获在较大的孔隙中,大孔分布较多的岩芯表现出更高的CO_(2)饱和度;但在吸水阶段小孔占比更高、渗透率更低的岩芯内捕获的CO_(2)相不易被水驱走,表现出更高的CO_(2)封存效率;岩芯局部渗透率变化对最终的残余气分布影响显著,渗透率较低的区域具有更高的最终残余气饱和度和封存效率。研究可进一步完善CO_(2)咸水含水层封存项目中的储层优选、高效封存以及安全性评估等理论体系。展开更多
A new polyoxygenated dihydropyrano[2,3-c]pyrrole-4,5-dione derivative, pyranonigrin F （1）, together with a related known compound, pyranonigrin A （2）, were isolated and identified from Penicillium brocae MA-231, a...A new polyoxygenated dihydropyrano[2,3-c]pyrrole-4,5-dione derivative, pyranonigrin F （1）, together with a related known compound, pyranonigrin A （2）, were isolated and identified from Penicillium brocae MA-231, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of these metabolites were determined based on comprehensive spectral interpretation and the absolute configuration of compound 1 was established by X-ray crystallographic analysis. Compounds 1 and 2 showed potent activity against a broad spectrum of human-, aqua-, and plant-pathogens.展开更多
The construction of emergency water sources is the material basis for ensuring urban water safety,and it is also an inherent requirement for maintaining social stability and development.The hydrogeological characteris...The construction of emergency water sources is the material basis for ensuring urban water safety,and it is also an inherent requirement for maintaining social stability and development.The hydrogeological characteristics of groundwater in Luoyang City from the aspects of the division of groundwater aquifer groups,water yield property and groundwater dynamics were described in this paper.Two emergency water sources were selected on basis of comprehensively considering groundwater resources and ecological environmental effects,groundwater quality and exploitation technology,etc.Then it further analysed the aquifer types,water yield properties and groundwater recharge,runoff and discharge conditions of the two emergency water sources,and evaluate the groundwater resources quantity of the water sources.The results are that the shallow underground aquifer in Luoyang City is thick,coarse,and stable in lithology and thickness.The two water sources enjoy good exploitation potential and can be used as backup water sources to supply water in the event of a water source crisis.展开更多
文摘Selecting the initial antipsychotic dose is a high-impact decision in acute schizophrenia.A randomized study found that starting lurasidone at 80 mg/day for 1 week(then flexible titration)produced earlier reductions in Positive and Negative Syndrome Scale positive symptoms than 40 mg/day,without higher discontinuations for adverse events or a metabolic penalty over 6 weeks.These data support an individualized approach:Start at 80 mg/day when rapid control of positive symptoms or agitation is needed and tolerance permits;start at 40 mg/day when akathisia risk or patient preference argues for caution,with a planned day-7 review for up-titration.The open-label design,dose convergence after week 1,and the lack of stratified randomization limit attribution of longer-term advantages to starting dose.Even so,the trial reframes initial dose as a modifiable lever for the early course rather than a one-size-fits-all rule and warrants confirmation in larger,double-blind randomized trials.
基金Key Project of Natural Science Research in Colleges and Universities in Anhui Province(Grant No.KJ2019A0639,KJ2020A0715)Open Foundation of the Key Laboratory of Crop Gene Resources and Germplasm Creation in East China,Ministry of Agriculture(Grant No.ECG2018001)+1 种基金the Key Project of Excellent Young Talents Support Program in Universities of Anhui Province(Grant No.gxyq ZD2021133)Chuzhou Science and Technology Plan Project(Grant No.2020ZN013)。
文摘Chrysanthemum morifolium’Chuju’is a famous medicinal species in traditional Chinese medicine.’Chuju’contains various active ingredients that can be used to treat multiple diseases without toxic side effects.In the present study,we combined metabolomics and network pharmacology to further explore the active ingredients in’Chuju’,as well as the target and pharmacological mechanisms of the active ingredients.A visualized network analysis model based on chemistry,pharmacokinetics,and pharmacology was constructed to predict the potential pharmacological mechanism of’Chuju’.A total of 424 metabolites of’Chuju’were identified,of which 21 ingredients had positive pharmacological effects after ADME screening.The network pharmacology revealed that acacetin and beta-sitosterol in’Chuju’could act on GSK3B,MAPK14,ADRA1R,and NOS2 to regulate diabetes mellitus,Alzheimer’s disease,breast cancer,and inflammatory diseases.These results indicated the potential pharmacological effects of the active components in’Chuju’.
文摘深部咸水含水层具有巨大的CO_(2)封存潜力,研究致密砂岩CO_(2)-水两相驱替机制对实现高效安全的CO_(2)咸水层封存具有重要意义。对两个具有不同孔隙结构特征的低渗透砂岩开展了CO_(2)-水两相驱替试验,利用核磁共振(nuclear magnetic resonance,NMR)和磁共振成像(magnetic resonance imaging,MRI)技术对气驱和吸水两个阶段气水两相的分布进行了定量及可视化研究,分析了岩芯孔径分布、非均质性及渗透率差异等对两相驱替特征的影响机制。研究表明在气驱阶段CO_(2)相优先被捕获在较大的孔隙中,大孔分布较多的岩芯表现出更高的CO_(2)饱和度;但在吸水阶段小孔占比更高、渗透率更低的岩芯内捕获的CO_(2)相不易被水驱走,表现出更高的CO_(2)封存效率;岩芯局部渗透率变化对最终的残余气分布影响显著,渗透率较低的区域具有更高的最终残余气饱和度和封存效率。研究可进一步完善CO_(2)咸水含水层封存项目中的储层优选、高效封存以及安全性评估等理论体系。
基金Financial support from the National Natural Science Foundation of China(No.31270403)from the Ministry of Science and Technology of China(No.2010CB833802) is gratefully acknowledged
文摘A new polyoxygenated dihydropyrano[2,3-c]pyrrole-4,5-dione derivative, pyranonigrin F （1）, together with a related known compound, pyranonigrin A （2）, were isolated and identified from Penicillium brocae MA-231, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of these metabolites were determined based on comprehensive spectral interpretation and the absolute configuration of compound 1 was established by X-ray crystallographic analysis. Compounds 1 and 2 showed potent activity against a broad spectrum of human-, aqua-, and plant-pathogens.
基金The study was supported by the China Geological Survey Geological Survey Project(12120113004600).
文摘The construction of emergency water sources is the material basis for ensuring urban water safety,and it is also an inherent requirement for maintaining social stability and development.The hydrogeological characteristics of groundwater in Luoyang City from the aspects of the division of groundwater aquifer groups,water yield property and groundwater dynamics were described in this paper.Two emergency water sources were selected on basis of comprehensively considering groundwater resources and ecological environmental effects,groundwater quality and exploitation technology,etc.Then it further analysed the aquifer types,water yield properties and groundwater recharge,runoff and discharge conditions of the two emergency water sources,and evaluate the groundwater resources quantity of the water sources.The results are that the shallow underground aquifer in Luoyang City is thick,coarse,and stable in lithology and thickness.The two water sources enjoy good exploitation potential and can be used as backup water sources to supply water in the event of a water source crisis.
