Zwitterions(ZIs)are considered as an ideal,novel ionic conductive medium due to their high dipole moment and good solubility of lithium salts.However,the strong interactions between ZIs and Li^(+)severely hinder Li^(+...Zwitterions(ZIs)are considered as an ideal,novel ionic conductive medium due to their high dipole moment and good solubility of lithium salts.However,the strong interactions between ZIs and Li^(+)severely hinder Li^(+)migration.Herein,a quasi-solid electrolyte(MSQSE-2Na)was fabricated by adding sodium bis(fluorosulfonyl)imide(NaFSI)to sulfobetaine methacrylate(SBMA,a ZI)based polymerization system.Na^(+)occupies the–SO_(3)^(-)site in SBMA prior to Li^(+),which weakens the self-crosslinking of SBMA and frees the Li^(+)bound to the polymer segments.Thus,the polymer conformation of MSQSE-2Na changes to a relaxed,homogeneous"sea-island"type.Meanwhile,Na^(+),due to its electron-withdrawing effect,decreases the electron cloud density of the polymer segments,building a weakly coordinated environment in MSQSE-2Na.Consequently,MSQSE-2Na exhibits excellent ionic conductivity of 7.38×10^(-4)S cm^(-1)and a high Li^(+)transference number of 0.632 at 25℃.The(-)Li|MSQSE-2Na|Li(+)cells exhibit super stability,sustaining operation for over 6182h.The(-)Li|MSQSE-2Na|LiFePO_(4)(+)cells demonstrate outstanding charge/discharge reversibility with a Coulombic efficiency exceeding 99.9%over 270 cycles(≈4500 h),with a capacity retention of 70.0%.This work proposes a new design concept for regulating the polymer conformation and charge characteristics through competitive coordination,thereby advancing the application of ZI-based polymer electrolytes in lithium metal batteries.展开更多
Chinese cabbage(Brassica rapa subsp.pekinensis)is a widely cultivated vegetable crop in Asia with significant economic importance(Li et al.,2024;Yu et al.,2024).As a potyvirus with the broad host range,turnip mosaic v...Chinese cabbage(Brassica rapa subsp.pekinensis)is a widely cultivated vegetable crop in Asia with significant economic importance(Li et al.,2024;Yu et al.,2024).As a potyvirus with the broad host range,turnip mosaic virus(TuMV)is a major pathogen affecting Chinese cabbages,leading to severe yield losses(Li et al.,2019).Traditional control measures have shown limited efficacy,and the long-term use of chemical pesticides has led to significant issues such as environmental pollution and pathogen resistance(Samara et al.,2021;Lu et al.,2022).Biologicallyderived pesticides have garnered considerable attention owing to their eco-friendly attributes(Ayilara et al.,2023).γ-Aminobutyric acid(GABA),initially discovered in potato tubers,has been proven to regulate immune responses and enhance resistance to fungal and bacterial pathogens by modulating reactive oxygen species and stress-related hormone signals(Tarkowski et al.,2020;Wang et al.,2025).But biologically-derived agents typically face challenges such as large particle size and instability,which limit their practical application and bioavailability(Daraban et al.,2023).展开更多
0 INTRODUCTION.The global availability of digital elevation model(DEM)data,such as 90-m Shuttle Radar Topography Mission(SRTM)DEM and 30-m Advanced Spaceborne Thermal Emission and Reflection Radiometer Global Digital ...0 INTRODUCTION.The global availability of digital elevation model(DEM)data,such as 90-m Shuttle Radar Topography Mission(SRTM)DEM and 30-m Advanced Spaceborne Thermal Emission and Reflection Radiometer Global Digital Elevation Model(ASTER GDEM),has been extensively utilized in morphotectonic analyses(e.g.,Wang et al.,2024;Cheng et al.,2018;Pérez-Pe?a et al.,2010;El Hamdouni et al.,2008).展开更多
In-depth study of the components of polymyxins is the key to controlling the quality of this class of antibiotics.Similarities and variations of components present significant analytical challenges.A two-dimensional(2...In-depth study of the components of polymyxins is the key to controlling the quality of this class of antibiotics.Similarities and variations of components present significant analytical challenges.A two-dimensional(2D)liquid chromatography-mass spectrometry(LC-MS)method was established for screening and comprehensive profiling of compositions of the antibiotic colistimethate sodium(CMS).A high concentration of phosphate buffer mobile phase was used in the first-dimensional LC system to get the components well separated.For efficient and high-accuracy screening of CMS,a targeted method based on a self-constructed high resolution(HR)mass spectrum database of CMS components was established.The database was built based on the commercial MassHunter Personal Compound Database and Library(PCDL)software and its accuracy of the compound matching result was verified with six known components before being applied to genuine sample screening.On this basis,the unknown peaks in the CMS chromatograms were deduced and assigned.The molecular formula,group composition,and origins of a total of 99 compounds,of which the combined area percentage accounted for more than 95%of CMS components,were deduced by this 2D-LC-MS method combined with the MassHunter PCDL.This profiling method was highly efficient and could distinguish hundreds of components within 3 h,providing reliable results for quality control of this kind of complex drugs.展开更多
Temperate forests exert significant biogeophysical influences on local and regional climates through modulating the energy and moisture exchanges between the land surface and the atmosphere,thereby serving as crucial ...Temperate forests exert significant biogeophysical influences on local and regional climates through modulating the energy and moisture exchanges between the land surface and the atmosphere,thereby serving as crucial barriers with significant buffering impacts on the productivity of adjacent agricultural ecosystems.However,the extent and underlying mechanisms of these biogeophysical and buffering effects of temperate forest barriers remains insufficiently understood.In this study,we integrated the dynamic crop model Noah-MP-Crop with the Weather Research and Forecasting(WRF)model to investigate the biogeophysical climate regulation of temperate forests and its buffering effects on crop yields in adjacent agricultural lands across Northeast China.Our findings revealed that temperate forest barriers induced significant local climate effects by cooling air and surface temperatures and reducing wind speeds within forested areas during the growing season,while also regulating non-local climate,particularly by altering regional precipitation patterns,2 m water vapor mixing ratio(Q2),and soil moisture,predominantly in adjacent cropland areas.Furthermore,these forest barriers were found to modulate climate extremes,through affecting maximum temperature and wind speed on a local scale,as well as both maximum and minimum Q2 in non-local croplands.Our study also observed that temperate forest barriers,through biogeophysical climate regulation,enhanced GPP,NPP,and grain yields across most cropland areas.This productivity boost was especially pronounced,with yield increases up to 20%in certain regions during the extreme drought conditions of 2017,underscoring the critical role of temperate forest barriers in sustaining and enhancing crop yields under severe climatic stress.Our findings underscore the significant buffering effects of temperate forest barriers on regional agricultural production,having important implications for climate adaptation strategies aimed at bolstering agricultural resilience in the face of increasing climate variability and extremes.展开更多
Covalent organic framework nanosheets(CONs)with porous crystalline features and ultrathin thickness are ideal candidates as membrane building blocks to form well-defined transfer nanochannels.The formidable challenge ...Covalent organic framework nanosheets(CONs)with porous crystalline features and ultrathin thickness are ideal candidates as membrane building blocks to form well-defined transfer nanochannels.The formidable challenge behind self-supporting CONs membrane lies in weak noncovalent interlayer interactions and thus loose stacking,insufficient strength and structure stabilities.Herein,we propose the fabrication of interlayer force-strengthened freestanding CONs membrane through the electrostatic attraction bridge effect of positively-charged amino-rich CONs(CON-NH2)to negatively-charged sulfonated CONs(CON-SO_(3)H).Ultrathin and large lateral sized CON-SO_(3)H and CON-NH2 are synthesized,followed by restacking to prepare freestanding CONs membrane with CON-SO_(3)H as the membrane bulk.Benefiting from effective interlayer interconnection due to strong electrostatic interaction,the obtained CON-SO_(3)H/CON-NH2 membrane displays features of ultrahigh integrity,dense stacking,eminent water/acid/base/organic solvents stabilities and mechanical strength(109 MPa).The shortened-SO_(3)H distance contributes to construct site-continuous transfer pathways,and the deprotonated-SO_(3)H and protonated-NH2 form acid-base pairs to decrease interfacial resistance,which impart membrane superior proton conductivity of 486 mS cm^(-1)(80℃,100%RH).This interlayer force enhancement strategy offers a promising perspective on achieving densely-stacked CONs membrane with ultrahigh mechanical property and conduction performance for fuel cell application.展开更多
A meticulous design of the local environment at the interface between active species and the support,aimed at optimizing the adsorption of H_(2)O molecules and BH_(4)^(-)anion,offers an ideal strategy for enhancing hy...A meticulous design of the local environment at the interface between active species and the support,aimed at optimizing the adsorption of H_(2)O molecules and BH_(4)^(-)anion,offers an ideal strategy for enhancing hydrogen generation via Na BH4hydrolysis through dual activation pathways.Theoretical predictions based on d-band center analysis and electron transfer calculations suggest that introducing-OH functional groups induce charge redistribution,enhancing charge concentration on alk-Ti_(3)C_(2)and facilitating the adsorption and activation of dual active species,H2O molecules and BH4-anion.Inspired by these predictions,the optimized alk-Ti_(3)C_(2)/Ru Oxcatalyst demonstrates the highest catalytic activity,achieving a hydrogen generation rate(HGR)of 9468 m L min^(-1)gcat.^(-1).Both experimental data and theoretical analyses confirm that the-OH functional groups promote charge enrichment on alk-Ti_(3)C_(2),optimizing the adsorption of H_(2)O molecules and BH_(4)^(-)anion,and reducing the dissociation energy barrier of the*OH–H-TS intermediate.This dual activation pathways mechanism lowers the activation energy for Na BH4hydrolysis,significantly enhancing the HGR performance.These findings,guided by theoretical insights,establish alk-Ti_(3)C_(2)/Ru Oxas an efficient catalyst for Na BH4hydrolysis and provide a strong foundation for future hydrogen generation catalyst designs.展开更多
Electron-positron colliders operating in the GeV center-of-mass range,or tau-charm energy region,have been proved to enable competitive frontier research due to several unique features.With the progress of high-energy...Electron-positron colliders operating in the GeV center-of-mass range,or tau-charm energy region,have been proved to enable competitive frontier research due to several unique features.With the progress of high-energy physics in the last two decades,a new-generation Tau-Charm factory,called the Super Tau-Charm Facility(STCF),has been actively promoted by the particle physics community in China.STCF has the potential to address fundamental questions such as the essence of color confinement and the matter-antimatter asymmetry within the next decades.The main design goals of the STCF are a center-of-mass energy ranging from 2 to 7 GeV and a luminosity surpassing 5×10^(34)cm^(−2)s^(−1)that is optimized at a center-of-mass energy of 4 GeV,which is approximately 50 times that of the currently operating Tau-Charm factory-BEPCII.The STCF accelerator has two main parts:a double-ring collider with a crab-waist collision scheme and an injector that provides top-up injections for both electron and positron beams.As a typical third-generation electron-positron circular collider,the STCF accelerator faces many challenges in both accelerator physics and technology.In this paper,the conceptual design of the STCF accelerator complex is presented,including the ongoing efforts and plans for technological research and develop-ment,as well as the required infrastructure.The STCF project aims to secure support from the Chinese central government for its construction during the 15th Five-Year Plan(2026-2030).展开更多
The Qinghai-Xizang Plateau serves as an extensive gene pool for plateau species and a crucial focal point for global biodiversity conservation.Being a climate-sensitive region,the impacts of climate change have led to...The Qinghai-Xizang Plateau serves as an extensive gene pool for plateau species and a crucial focal point for global biodiversity conservation.Being a climate-sensitive region,the impacts of climate change have led to habitat loss,population extinction,and ecological imbalances,posing formidable challenges to the sustained ef-fectiveness of existing protected areas.Despite substantial advancements in understanding species distribution,assessing habitat changes,and evaluating the efficiency of protected areas in recent decades,comprehensive evaluations encompassing all protected species are lacking,impeding conservation strategies.In this study,we gathered 137,856 observations,encompassing 2,605 species,and utilized the MaxEnt model to simulate changes in the current distribution patterns of endangered species and suitable habitats under future scenarios.We further proposed a climate smart approach to optimize the boundaries of protected areas in response to climate change.Key findings indicate that(1)the Qinghai-Xizang Plateau harbors 2,605 endangered species,constituting 34.04%of the total endangered species catalog in China;(2)current high-adaptation habitats of Qinghai-Xizang Plateau cover a mere 7%of the plateau,showing minimal alteration in protected efficiency under climate change sce-narios(0.50%increase);(3)incorporating the effects of climate change in adjusting protected area boundaries enhances their efficiency by an average of 20.52%.Our proposed methodology holds promise for safeguard-ing endangered species on the Qinghai-Xizang Plateau and offers significant implications for analogous regions worldwide.展开更多
Background Weaning stress-induced diarrhea is widely recognized as being associated with gut microbiota dysbio-sis.However,it has been challenging to clarify which specific intestinal microbiota and their metabolites ...Background Weaning stress-induced diarrhea is widely recognized as being associated with gut microbiota dysbio-sis.However,it has been challenging to clarify which specific intestinal microbiota and their metabolites play a crucial role in the antidiarrhea process of weaned piglets.Results In this study,we first observed that piglets with diarrhea exhibited a lower average daily gain and higher diarrhea score,and elevated levels of lipopolysaccharide(LPS)and D-lactate(D-LA)compared to healthy piglets.Subsequently,we analyzed the differences in intestinal microbial composition and metabolite levels between healthy and diarrheal weaned piglets.Diarrheal piglets demonstrated intestinal microbiota dysbiosis,characterized pri-marily by a higher Firmicutes to Bacteroidota ratio,a deficiency of Lactobacillus amylovorus and Lactobacillus reuteri,and an increased abundance of Bacteroides sp.HF-5287 and Bacteroides thetaiotaomicron.Functional pro-filing of the gut microbiota based on Kyoto Encyclopedia of Genes and Genomes(KEGG)data was performed,and the results showed that tryptophan metabolism was the most significantly inhibited pathway in piglets with diar-rhea.Most tryptophan metabolites were detected at lower concentrations in diarrheal piglets than in healthy piglets.Furthermore,we explored the effects of dietary indole-3-aldehyde(IAld),a key tryptophan metabolite,on intestinal development and gut barrier function in weaned piglets.Supplementation with 100 mg/kg IAld in the diet increased the small intestine index and improved intestinal barrier function by promoting intestinal stem cell(ISC)expansion in piglets.The promotion of ISC expansion by IAld was also confirmed in porcine intestinal organoids.Conclusions These findings revealed that intestinal microbial tryptophan metabolite IAld alleviates impaired intesti-nal development by promoting ISC expansion in weaned piglets.展开更多
Phenology shifts influence regional climate by altering energy,and water fluxes through biophysical processes.However,a quantitative understanding of the phenological control on vegetation’s biophysical feedbacks to ...Phenology shifts influence regional climate by altering energy,and water fluxes through biophysical processes.However,a quantitative understanding of the phenological control on vegetation’s biophysical feedbacks to re gional climate remains elusive.Using long-term remote sensing observations and Weather Research and Fore casting(WRF)model simulations,we investigated vegetation phenology changes from 2003 to 2020 and quan tified their biophysical controls on the regional climate in Northeast China.Our findings elucidated that earlier green-up contributed to a prolonged growing season in forests,while advanced green-up and delayed dormancy extended the growing season in croplands.This prolonged presence and increased maximum green cover in tensified climate-vegetation interactions,resulting in more significant surface cooling in croplands compared to forests.Surface cooling from forest phenology changes was prominent during May’s green-up(-0.53±0.07°C),while crop phenology changes induced cooling throughout the growing season,particularly in June(-0.47±0.15°C),July(-0.48±0.11°C),and September(-0.28±0.09°C).Furthermore,we unraveled the contributions of different biophysical pathways to temperature feedback using a two-resistance attribution model,with aero dynamic resistance emerging as the dominant factor.Crucially,our findings underscored that the land surface temperature(LST)sensitivity,exhibited substantially higher values in croplands rather than temperate forests.These strong sensitivities,coupled with the projected continuation of phenology shifts,portend further growing season cooling in croplands.These findings contribute to a more comprehensive understanding of the intricate feedback mechanisms between vegetation phenology and surface temperature,emphasizing the significance of vegetation phenology dynamics in shaping regional climate pattern and seasonality.展开更多
<div style="text-align:justify;"> A photonics approach to generate a linearly chirped waveform with increased TBWP is proposed and investigated. The time bandwidth product (TBWP) of the linearly chirpe...<div style="text-align:justify;"> A photonics approach to generate a linearly chirped waveform with increased TBWP is proposed and investigated. The time bandwidth product (TBWP) of the linearly chirped waveform is improved based on optical microwave frequency multiplying combined with temporal synthesis. An integrated dual-polarization modulator and an optical filter are utilized to perform frequency doubling operation by generating an orthogonally polarized optical signal, which consists of an optical carrier in one polarization direction and a second-order chirped optical sideband in another. Then the orthogonally polarized optical signal puts into a polarization modulator (PolM) to perform phase coding process. By driving a Pseudorandom (PN) sequence to the PolM, the time duration of the generated bandwidth doubled linearly chirped waveform can be synthesized to arbitrary length. The approach is verified by simulation. A linearly chirped waveform with central frequency of 8.25 GHz, bandwidth of 500 MHz, time duration of 6.4 ns is used to generate a synthesized waveform with central frequency of 16.5 GHz, bandwidth of 1 GHz, time duration of 819.2 ns. The TBWP of the linearly chirped signal is improved from 3.2 to 819.2. The proposed method features arbitrary large TBWP, and it can be used in a radar system to improve its resolution. </div>展开更多
<div style="text-align:justify;"> A generalized optical filterless approach to achieve photonic generation of frequency 16-tupling millimeter-wave (mm-wave) signal based on two cascaded dual-parallel M...<div style="text-align:justify;"> A generalized optical filterless approach to achieve photonic generation of frequency 16-tupling millimeter-wave (mm-wave) signal based on two cascaded dual-parallel Mach-Zehnder modulators (DPMZMs) is presented. A theoretical analysis leading to the operating conditions to achieve frequency 16-tupling is developed. Different modulation indices (MIs) can be implemented to achieve the frequency multiplication by adjusting the delay of tunable optical delay line (TODL). It is confirmed by simulation that the proposed scheme is effective, and the radio frequency spurious suppression ratio (RFSSR) of the generated frequency 16-tupling signal can be as high as 40 dB when the sub-MZMs have extinction ratios of 30 dB. Influencing factors such as extinction ratio, DC bias drift, phase shift deviation and RF voltage deviation on the performance of optical sideband suppression ratio (OSSR) and RFSSR are also investigated. </div>展开更多
AIM:To evaluate the therapeutic effects of ranibizumab on optic disc and macular microvascular perfusion in central retinal vein occlusion(CRVO)with macular edema(ME).METHODS:Optical coherence tomography angiology(OCT...AIM:To evaluate the therapeutic effects of ranibizumab on optic disc and macular microvascular perfusion in central retinal vein occlusion(CRVO)with macular edema(ME).METHODS:Optical coherence tomography angiology(OCTA)parameters,including optic disc vessel density(VD;including whole-disc VD,intra-disc VD,and peripapillary VD),superficial/deep capillary plexus(SCP/DCP)VD,and central macular thickness(CMT)were analyzed.Additional assessments included best-corrected visual acuity(BCVA)via Early Treatment Diabetic Retinopathy Study(ETDRS)chart and hemorheological profiling.CRVO patients received monthly intravitreal ranibizumab injections for three consecutive months.Pre-and post-treatment parameters were statistically compared.RESULTS:The study comprised 60 CRVO-ME patients(28 males;32 females),aged 50-78y(mean 63.3±7.6y)and 60 age-/sex-matched healthy controls.As compared with participants exhibiting normal funduscopic findings,CRVO patients demonstrated significantly elevated levels of low-shear-rate whole blood viscosity(LSR-WBV),high-shearrate whole blood viscosity(HSR-WBV),and aggregation index(AI,all P<0.05).In CRVO-affected eyes,vertical cupto-disc(C/D)ratio and optic cup volume were significantly smaller,whereas retinal nerve fiber layer(RNFL)thickness was significantly greater,compared to both unaffected contralateral eyes and normal control eyes(all P<0.05).Following treatment,VD of the entire optic disc(P<0.05),intra-disc VD(P<0.05),and peripapillary VD(P<0.05)all increased significantly relative to baseline.CMT decreased significantly(P<0.05),whereas macular SCP-VD and macular DCP-VD showed non-significant slight reductions(P>0.05).At baseline,BCVA of CRVO eyes correlated with whole-disc VD(r=-0.276,P=0.033),intra-disc VD(r=-0.342,P=0.009),and peripapillary VD(r=-0.335,P=0.007),with intra-disc VD demonstrating the strongest association.Besides,BCVA improvement,after the treatment,correlated positively with whole-disc VD(r=0.342,P=0.008)and intradisc VD(r=0.396,P=0.002).CONCLUSION:Optic disc blood perfusion is more closely associated with visual acuity than macular perfusion,suggesting intra-disc VD may serve as a potential biomarker for monitoring visual acuity changes in CRVO.Multiple ranibizumab injections significantly improve optic disc perfusion but may have exerted detrimental effects on the macula.CRVO patients shows higher hemorheological parameters than those with normal fundi.Reduced vertical C/D ratio and optic cup volume may be linked to CRVO incidence,potentially acting as susceptibility factors.展开更多
The highly dynamic nature,strong uncertainty,and coupled multiple safety constraints inherent in carrier aircraft recovery operations pose severe challenges for real-time decision-making.Addressing bolter scenarios,th...The highly dynamic nature,strong uncertainty,and coupled multiple safety constraints inherent in carrier aircraft recovery operations pose severe challenges for real-time decision-making.Addressing bolter scenarios,this study proposes an intelligent decision-making framework based on a deep long short-term memory Q-network.This framework transforms the real-time sequencing for bolter recovery problem into a partially observable Markov decision process.It employs a stacked long shortterm memory network to accurately capture the long-range temporal dependencies of bolter event chains and fuel consumption.Furthermore,it integrates a prioritized experience replay training mechanism to construct a safe and adaptive scheduling system capable of millisecond-level real-time decision-making.Experimental demonstrates that,within large-scale mass recovery scenarios,the framework achieves zero safety violations in static environments and maintains a fuel safety violation rate below 10%in dynamic scenarios,with single-step decision times at the millisecond level.The model exhibits strong generalization capability,effectively responding to unforeseen emergent situations—such as multiple bolters and fuel emergencies—without requiring retraining.This provides robust support for efficient carrier-based aircraft recovery operations.展开更多
THE well-known ancient Chinese philosopher Lao Tzu(老子)or Laozi(6th~4th century BC during the Spring and Autumn period)started his classic Tao Teh Ching《道德经》or Dao De Jing(see Fig.1)with six Chinese characters:&...THE well-known ancient Chinese philosopher Lao Tzu(老子)or Laozi(6th~4th century BC during the Spring and Autumn period)started his classic Tao Teh Ching《道德经》or Dao De Jing(see Fig.1)with six Chinese characters:"道(Dao)可(Ke)道(Dao)非(Fei)常(Chang)道(Dao)",which has been traditionally interpreted as“道可道,非常道”or"The Dao that can be spoken is not the eternal Dao".展开更多
DURING our discussion at workshops for writing“What Does ChatGPT Say:The DAO from Algorithmic Intelligence to Linguistic Intelligence”[1],we had expected the next milestone for Artificial Intelligence(AI)would be in...DURING our discussion at workshops for writing“What Does ChatGPT Say:The DAO from Algorithmic Intelligence to Linguistic Intelligence”[1],we had expected the next milestone for Artificial Intelligence(AI)would be in the direction of Imaginative Intelligence(II),i.e.,something similar to automatic wordsto-videos generation or intelligent digital movies/theater technology that could be used for conducting new“Artificiofactual Experiments”[2]to replace conventional“Counterfactual Experiments”in scientific research and technical development for both natural and social studies[2]-[6].Now we have OpenAI’s Sora,so soon,but this is not the final,actually far away,and it is just the beginning.展开更多
The effects of different cadmium(Cd)concentrations(0,20,60,and 100μmol/L)on hydroponically grown Artemisia annua L.were investigated.Cd treatments applied for 0,4,12,24,72,144,216,and 336 hr were assessed by measurin...The effects of different cadmium(Cd)concentrations(0,20,60,and 100μmol/L)on hydroponically grown Artemisia annua L.were investigated.Cd treatments applied for 0,4,12,24,72,144,216,and 336 hr were assessed by measuring the changes in photosynthetic pigments,electrolyte leakage,malondialdehyde(MDA)and antioxidants(ascorbic acid and glutathione),while the artemisinin content was tested after 0,12,144,216,and 336 hr.A significant decrease was observed in photosynthetic pigment levels over time with increasing Cd concentration.Chlorophyll b levels were more affected by Cd than were chlorophyll a or carotenoid levels.The cell membrane was sensitive to Cd stress,as MDA content in all treatment groups showed insignificant differences from the control group,except at 12 hr treatment time.Ascorbic acid(AsA)content changed slightly over time,while glutathione(GSH)content took less time to reach a maximum as Cd concentration increased.Cd was found to promote synthesis and accumulation of artemisinin,especially at concentrations of 20 and 100~tmol/L.In conclusion,Cd stress can damage to photosynthetic pigments,and vigorously growing A.annua showed a strong tolerance for Cd stress.Appropriate amounts of added Cd aided synthesis and accumulation of artemisinin.展开更多
The article presents a review of new techniques being used for the preparation of liposomes.A total of 28 publications were examined.In addition to the theories,characteristics and problems associated with traditional...The article presents a review of new techniques being used for the preparation of liposomes.A total of 28 publications were examined.In addition to the theories,characteristics and problems associated with traditional methods,the advantages and drawbacks of the latest techniques were reviewed.In the light of developments in many relevant areas,a variety of new techniques are being used for liposome preparation and each of these new technique has particular advantages over conventional preparation methods.However,there are still some problems associated with these new techniques that could hinder their applications and further improvements are needed.Generally speaking,due to the introduction of these latest techniques,liposome preparation is now an improved procedure.These applications promote not only advances in liposome research but also the methods for their production on an industrial scale.展开更多
基金supported by the National Natural Science Foundation of China(22078228)。
文摘Zwitterions(ZIs)are considered as an ideal,novel ionic conductive medium due to their high dipole moment and good solubility of lithium salts.However,the strong interactions between ZIs and Li^(+)severely hinder Li^(+)migration.Herein,a quasi-solid electrolyte(MSQSE-2Na)was fabricated by adding sodium bis(fluorosulfonyl)imide(NaFSI)to sulfobetaine methacrylate(SBMA,a ZI)based polymerization system.Na^(+)occupies the–SO_(3)^(-)site in SBMA prior to Li^(+),which weakens the self-crosslinking of SBMA and frees the Li^(+)bound to the polymer segments.Thus,the polymer conformation of MSQSE-2Na changes to a relaxed,homogeneous"sea-island"type.Meanwhile,Na^(+),due to its electron-withdrawing effect,decreases the electron cloud density of the polymer segments,building a weakly coordinated environment in MSQSE-2Na.Consequently,MSQSE-2Na exhibits excellent ionic conductivity of 7.38×10^(-4)S cm^(-1)and a high Li^(+)transference number of 0.632 at 25℃.The(-)Li|MSQSE-2Na|Li(+)cells exhibit super stability,sustaining operation for over 6182h.The(-)Li|MSQSE-2Na|LiFePO_(4)(+)cells demonstrate outstanding charge/discharge reversibility with a Coulombic efficiency exceeding 99.9%over 270 cycles(≈4500 h),with a capacity retention of 70.0%.This work proposes a new design concept for regulating the polymer conformation and charge characteristics through competitive coordination,thereby advancing the application of ZI-based polymer electrolytes in lithium metal batteries.
基金supported by the National Natural Science Foundation of China(Grant Nos.32402564,32330096,32372631)Hebei Natural Science Foundation(Grant No.C2024204246)+1 种基金the Pinduoduo-China Agricultural University Research Fund(Grant No.PC2023B02018)the 2115 Talent Development Program of China Agricultural University.
文摘Chinese cabbage(Brassica rapa subsp.pekinensis)is a widely cultivated vegetable crop in Asia with significant economic importance(Li et al.,2024;Yu et al.,2024).As a potyvirus with the broad host range,turnip mosaic virus(TuMV)is a major pathogen affecting Chinese cabbages,leading to severe yield losses(Li et al.,2019).Traditional control measures have shown limited efficacy,and the long-term use of chemical pesticides has led to significant issues such as environmental pollution and pathogen resistance(Samara et al.,2021;Lu et al.,2022).Biologicallyderived pesticides have garnered considerable attention owing to their eco-friendly attributes(Ayilara et al.,2023).γ-Aminobutyric acid(GABA),initially discovered in potato tubers,has been proven to regulate immune responses and enhance resistance to fungal and bacterial pathogens by modulating reactive oxygen species and stress-related hormone signals(Tarkowski et al.,2020;Wang et al.,2025).But biologically-derived agents typically face challenges such as large particle size and instability,which limit their practical application and bioavailability(Daraban et al.,2023).
基金supported by the National Key Research and Development Project of China(No.2023YFC3007303)the Open Research Project of the Hubei Key Laboratory of Intelligent Geo-Information Processing(No.KLIGIP-2019B08)。
文摘0 INTRODUCTION.The global availability of digital elevation model(DEM)data,such as 90-m Shuttle Radar Topography Mission(SRTM)DEM and 30-m Advanced Spaceborne Thermal Emission and Reflection Radiometer Global Digital Elevation Model(ASTER GDEM),has been extensively utilized in morphotectonic analyses(e.g.,Wang et al.,2024;Cheng et al.,2018;Pérez-Pe?a et al.,2010;El Hamdouni et al.,2008).
基金support from the Science Research Program Project for Drug Regulation,Jiangsu Medical Products Administration,China(Grant No.:202207)the National Drug Standards Revision Project,China(Grant No.:2023Y41)+1 种基金the National Natural Science Foundation of China(Grant No.:22276080)the Foreign Expert Project,China(Grant No.:G2022014096L).
文摘In-depth study of the components of polymyxins is the key to controlling the quality of this class of antibiotics.Similarities and variations of components present significant analytical challenges.A two-dimensional(2D)liquid chromatography-mass spectrometry(LC-MS)method was established for screening and comprehensive profiling of compositions of the antibiotic colistimethate sodium(CMS).A high concentration of phosphate buffer mobile phase was used in the first-dimensional LC system to get the components well separated.For efficient and high-accuracy screening of CMS,a targeted method based on a self-constructed high resolution(HR)mass spectrum database of CMS components was established.The database was built based on the commercial MassHunter Personal Compound Database and Library(PCDL)software and its accuracy of the compound matching result was verified with six known components before being applied to genuine sample screening.On this basis,the unknown peaks in the CMS chromatograms were deduced and assigned.The molecular formula,group composition,and origins of a total of 99 compounds,of which the combined area percentage accounted for more than 95%of CMS components,were deduced by this 2D-LC-MS method combined with the MassHunter PCDL.This profiling method was highly efficient and could distinguish hundreds of components within 3 h,providing reliable results for quality control of this kind of complex drugs.
基金supported by National Key R&D Program of China(Grant No.2024YFD1501600)the National Natural Science Foundation of China(Grants No.42071025,42371075)the Youth Innovation Promotion Association of Chinese Academy of Sciences(Grant No.2023240).
文摘Temperate forests exert significant biogeophysical influences on local and regional climates through modulating the energy and moisture exchanges between the land surface and the atmosphere,thereby serving as crucial barriers with significant buffering impacts on the productivity of adjacent agricultural ecosystems.However,the extent and underlying mechanisms of these biogeophysical and buffering effects of temperate forest barriers remains insufficiently understood.In this study,we integrated the dynamic crop model Noah-MP-Crop with the Weather Research and Forecasting(WRF)model to investigate the biogeophysical climate regulation of temperate forests and its buffering effects on crop yields in adjacent agricultural lands across Northeast China.Our findings revealed that temperate forest barriers induced significant local climate effects by cooling air and surface temperatures and reducing wind speeds within forested areas during the growing season,while also regulating non-local climate,particularly by altering regional precipitation patterns,2 m water vapor mixing ratio(Q2),and soil moisture,predominantly in adjacent cropland areas.Furthermore,these forest barriers were found to modulate climate extremes,through affecting maximum temperature and wind speed on a local scale,as well as both maximum and minimum Q2 in non-local croplands.Our study also observed that temperate forest barriers,through biogeophysical climate regulation,enhanced GPP,NPP,and grain yields across most cropland areas.This productivity boost was especially pronounced,with yield increases up to 20%in certain regions during the extreme drought conditions of 2017,underscoring the critical role of temperate forest barriers in sustaining and enhancing crop yields under severe climatic stress.Our findings underscore the significant buffering effects of temperate forest barriers on regional agricultural production,having important implications for climate adaptation strategies aimed at bolstering agricultural resilience in the face of increasing climate variability and extremes.
文摘Covalent organic framework nanosheets(CONs)with porous crystalline features and ultrathin thickness are ideal candidates as membrane building blocks to form well-defined transfer nanochannels.The formidable challenge behind self-supporting CONs membrane lies in weak noncovalent interlayer interactions and thus loose stacking,insufficient strength and structure stabilities.Herein,we propose the fabrication of interlayer force-strengthened freestanding CONs membrane through the electrostatic attraction bridge effect of positively-charged amino-rich CONs(CON-NH2)to negatively-charged sulfonated CONs(CON-SO_(3)H).Ultrathin and large lateral sized CON-SO_(3)H and CON-NH2 are synthesized,followed by restacking to prepare freestanding CONs membrane with CON-SO_(3)H as the membrane bulk.Benefiting from effective interlayer interconnection due to strong electrostatic interaction,the obtained CON-SO_(3)H/CON-NH2 membrane displays features of ultrahigh integrity,dense stacking,eminent water/acid/base/organic solvents stabilities and mechanical strength(109 MPa).The shortened-SO_(3)H distance contributes to construct site-continuous transfer pathways,and the deprotonated-SO_(3)H and protonated-NH2 form acid-base pairs to decrease interfacial resistance,which impart membrane superior proton conductivity of 486 mS cm^(-1)(80℃,100%RH).This interlayer force enhancement strategy offers a promising perspective on achieving densely-stacked CONs membrane with ultrahigh mechanical property and conduction performance for fuel cell application.
基金supported by the Hebei province Natural Science Foundation(No.B2023108012)the Science Research Project of Hebei Education Department(No.BJK2024137)+2 种基金the S&T Program of Xingtai(No.2023ZZ096)the National Natural Science Foundation of China(No.62004143)the Key R&D Program of Hubei Province(No.2022BAA084)。
文摘A meticulous design of the local environment at the interface between active species and the support,aimed at optimizing the adsorption of H_(2)O molecules and BH_(4)^(-)anion,offers an ideal strategy for enhancing hydrogen generation via Na BH4hydrolysis through dual activation pathways.Theoretical predictions based on d-band center analysis and electron transfer calculations suggest that introducing-OH functional groups induce charge redistribution,enhancing charge concentration on alk-Ti_(3)C_(2)and facilitating the adsorption and activation of dual active species,H2O molecules and BH4-anion.Inspired by these predictions,the optimized alk-Ti_(3)C_(2)/Ru Oxcatalyst demonstrates the highest catalytic activity,achieving a hydrogen generation rate(HGR)of 9468 m L min^(-1)gcat.^(-1).Both experimental data and theoretical analyses confirm that the-OH functional groups promote charge enrichment on alk-Ti_(3)C_(2),optimizing the adsorption of H_(2)O molecules and BH_(4)^(-)anion,and reducing the dissociation energy barrier of the*OH–H-TS intermediate.This dual activation pathways mechanism lowers the activation energy for Na BH4hydrolysis,significantly enhancing the HGR performance.These findings,guided by theoretical insights,establish alk-Ti_(3)C_(2)/Ru Oxas an efficient catalyst for Na BH4hydrolysis and provide a strong foundation for future hydrogen generation catalyst designs.
基金supported by the National Key Research and Development Program of China(No.2022YFA1602200)the National Natural Science Foundation of China(Nos.12341501 and 12405174)the Hefei Comprehensive National Science Center for the strong support on the STCF key technology research project.
文摘Electron-positron colliders operating in the GeV center-of-mass range,or tau-charm energy region,have been proved to enable competitive frontier research due to several unique features.With the progress of high-energy physics in the last two decades,a new-generation Tau-Charm factory,called the Super Tau-Charm Facility(STCF),has been actively promoted by the particle physics community in China.STCF has the potential to address fundamental questions such as the essence of color confinement and the matter-antimatter asymmetry within the next decades.The main design goals of the STCF are a center-of-mass energy ranging from 2 to 7 GeV and a luminosity surpassing 5×10^(34)cm^(−2)s^(−1)that is optimized at a center-of-mass energy of 4 GeV,which is approximately 50 times that of the currently operating Tau-Charm factory-BEPCII.The STCF accelerator has two main parts:a double-ring collider with a crab-waist collision scheme and an injector that provides top-up injections for both electron and positron beams.As a typical third-generation electron-positron circular collider,the STCF accelerator faces many challenges in both accelerator physics and technology.In this paper,the conceptual design of the STCF accelerator complex is presented,including the ongoing efforts and plans for technological research and develop-ment,as well as the required infrastructure.The STCF project aims to secure support from the Chinese central government for its construction during the 15th Five-Year Plan(2026-2030).
基金funded by the National Natural Science Foun-dation of China(Grant No.41925005)the National Key R&D Pro-gram of China(Grant No.2024YFF1306103)the Second Tibetan Plateau Scientific Expedition and Research Program(STEP)(Grant No.2019QZKK0307).
文摘The Qinghai-Xizang Plateau serves as an extensive gene pool for plateau species and a crucial focal point for global biodiversity conservation.Being a climate-sensitive region,the impacts of climate change have led to habitat loss,population extinction,and ecological imbalances,posing formidable challenges to the sustained ef-fectiveness of existing protected areas.Despite substantial advancements in understanding species distribution,assessing habitat changes,and evaluating the efficiency of protected areas in recent decades,comprehensive evaluations encompassing all protected species are lacking,impeding conservation strategies.In this study,we gathered 137,856 observations,encompassing 2,605 species,and utilized the MaxEnt model to simulate changes in the current distribution patterns of endangered species and suitable habitats under future scenarios.We further proposed a climate smart approach to optimize the boundaries of protected areas in response to climate change.Key findings indicate that(1)the Qinghai-Xizang Plateau harbors 2,605 endangered species,constituting 34.04%of the total endangered species catalog in China;(2)current high-adaptation habitats of Qinghai-Xizang Plateau cover a mere 7%of the plateau,showing minimal alteration in protected efficiency under climate change sce-narios(0.50%increase);(3)incorporating the effects of climate change in adjusting protected area boundaries enhances their efficiency by an average of 20.52%.Our proposed methodology holds promise for safeguard-ing endangered species on the Qinghai-Xizang Plateau and offers significant implications for analogous regions worldwide.
基金National Natural Science Foundation of China(32372830 and 31972528).
文摘Background Weaning stress-induced diarrhea is widely recognized as being associated with gut microbiota dysbio-sis.However,it has been challenging to clarify which specific intestinal microbiota and their metabolites play a crucial role in the antidiarrhea process of weaned piglets.Results In this study,we first observed that piglets with diarrhea exhibited a lower average daily gain and higher diarrhea score,and elevated levels of lipopolysaccharide(LPS)and D-lactate(D-LA)compared to healthy piglets.Subsequently,we analyzed the differences in intestinal microbial composition and metabolite levels between healthy and diarrheal weaned piglets.Diarrheal piglets demonstrated intestinal microbiota dysbiosis,characterized pri-marily by a higher Firmicutes to Bacteroidota ratio,a deficiency of Lactobacillus amylovorus and Lactobacillus reuteri,and an increased abundance of Bacteroides sp.HF-5287 and Bacteroides thetaiotaomicron.Functional pro-filing of the gut microbiota based on Kyoto Encyclopedia of Genes and Genomes(KEGG)data was performed,and the results showed that tryptophan metabolism was the most significantly inhibited pathway in piglets with diar-rhea.Most tryptophan metabolites were detected at lower concentrations in diarrheal piglets than in healthy piglets.Furthermore,we explored the effects of dietary indole-3-aldehyde(IAld),a key tryptophan metabolite,on intestinal development and gut barrier function in weaned piglets.Supplementation with 100 mg/kg IAld in the diet increased the small intestine index and improved intestinal barrier function by promoting intestinal stem cell(ISC)expansion in piglets.The promotion of ISC expansion by IAld was also confirmed in porcine intestinal organoids.Conclusions These findings revealed that intestinal microbial tryptophan metabolite IAld alleviates impaired intesti-nal development by promoting ISC expansion in weaned piglets.
基金supported by the Strategic Pri-ority Research Program(A)of the Chinese Academy of Sciences(Grant No.XDA28080503)the National Natural Science Foundation of China(Grant No.42071025)+1 种基金the Youth Innovation Promotion Associa-tion of Chinese Academy of Sciences(Grant No.2023240)the Pacific Northwest National Laboratory which is operated for DOE by Battelle Memorial Institute under Contract DE-A06-76RLO 1830.
文摘Phenology shifts influence regional climate by altering energy,and water fluxes through biophysical processes.However,a quantitative understanding of the phenological control on vegetation’s biophysical feedbacks to re gional climate remains elusive.Using long-term remote sensing observations and Weather Research and Fore casting(WRF)model simulations,we investigated vegetation phenology changes from 2003 to 2020 and quan tified their biophysical controls on the regional climate in Northeast China.Our findings elucidated that earlier green-up contributed to a prolonged growing season in forests,while advanced green-up and delayed dormancy extended the growing season in croplands.This prolonged presence and increased maximum green cover in tensified climate-vegetation interactions,resulting in more significant surface cooling in croplands compared to forests.Surface cooling from forest phenology changes was prominent during May’s green-up(-0.53±0.07°C),while crop phenology changes induced cooling throughout the growing season,particularly in June(-0.47±0.15°C),July(-0.48±0.11°C),and September(-0.28±0.09°C).Furthermore,we unraveled the contributions of different biophysical pathways to temperature feedback using a two-resistance attribution model,with aero dynamic resistance emerging as the dominant factor.Crucially,our findings underscored that the land surface temperature(LST)sensitivity,exhibited substantially higher values in croplands rather than temperate forests.These strong sensitivities,coupled with the projected continuation of phenology shifts,portend further growing season cooling in croplands.These findings contribute to a more comprehensive understanding of the intricate feedback mechanisms between vegetation phenology and surface temperature,emphasizing the significance of vegetation phenology dynamics in shaping regional climate pattern and seasonality.
文摘<div style="text-align:justify;"> A photonics approach to generate a linearly chirped waveform with increased TBWP is proposed and investigated. The time bandwidth product (TBWP) of the linearly chirped waveform is improved based on optical microwave frequency multiplying combined with temporal synthesis. An integrated dual-polarization modulator and an optical filter are utilized to perform frequency doubling operation by generating an orthogonally polarized optical signal, which consists of an optical carrier in one polarization direction and a second-order chirped optical sideband in another. Then the orthogonally polarized optical signal puts into a polarization modulator (PolM) to perform phase coding process. By driving a Pseudorandom (PN) sequence to the PolM, the time duration of the generated bandwidth doubled linearly chirped waveform can be synthesized to arbitrary length. The approach is verified by simulation. A linearly chirped waveform with central frequency of 8.25 GHz, bandwidth of 500 MHz, time duration of 6.4 ns is used to generate a synthesized waveform with central frequency of 16.5 GHz, bandwidth of 1 GHz, time duration of 819.2 ns. The TBWP of the linearly chirped signal is improved from 3.2 to 819.2. The proposed method features arbitrary large TBWP, and it can be used in a radar system to improve its resolution. </div>
文摘<div style="text-align:justify;"> A generalized optical filterless approach to achieve photonic generation of frequency 16-tupling millimeter-wave (mm-wave) signal based on two cascaded dual-parallel Mach-Zehnder modulators (DPMZMs) is presented. A theoretical analysis leading to the operating conditions to achieve frequency 16-tupling is developed. Different modulation indices (MIs) can be implemented to achieve the frequency multiplication by adjusting the delay of tunable optical delay line (TODL). It is confirmed by simulation that the proposed scheme is effective, and the radio frequency spurious suppression ratio (RFSSR) of the generated frequency 16-tupling signal can be as high as 40 dB when the sub-MZMs have extinction ratios of 30 dB. Influencing factors such as extinction ratio, DC bias drift, phase shift deviation and RF voltage deviation on the performance of optical sideband suppression ratio (OSSR) and RFSSR are also investigated. </div>
基金Central High-Level Traditional Chinese Medicine Hospital Project of Eye Hospital China Academy of Chinese Medical Science(No.GSP5-83,No.GSP4-02No.GSP5-06)+1 种基金Supported by National Natural Science Foundation of China(General ProgramNo.82474582).
文摘AIM:To evaluate the therapeutic effects of ranibizumab on optic disc and macular microvascular perfusion in central retinal vein occlusion(CRVO)with macular edema(ME).METHODS:Optical coherence tomography angiology(OCTA)parameters,including optic disc vessel density(VD;including whole-disc VD,intra-disc VD,and peripapillary VD),superficial/deep capillary plexus(SCP/DCP)VD,and central macular thickness(CMT)were analyzed.Additional assessments included best-corrected visual acuity(BCVA)via Early Treatment Diabetic Retinopathy Study(ETDRS)chart and hemorheological profiling.CRVO patients received monthly intravitreal ranibizumab injections for three consecutive months.Pre-and post-treatment parameters were statistically compared.RESULTS:The study comprised 60 CRVO-ME patients(28 males;32 females),aged 50-78y(mean 63.3±7.6y)and 60 age-/sex-matched healthy controls.As compared with participants exhibiting normal funduscopic findings,CRVO patients demonstrated significantly elevated levels of low-shear-rate whole blood viscosity(LSR-WBV),high-shearrate whole blood viscosity(HSR-WBV),and aggregation index(AI,all P<0.05).In CRVO-affected eyes,vertical cupto-disc(C/D)ratio and optic cup volume were significantly smaller,whereas retinal nerve fiber layer(RNFL)thickness was significantly greater,compared to both unaffected contralateral eyes and normal control eyes(all P<0.05).Following treatment,VD of the entire optic disc(P<0.05),intra-disc VD(P<0.05),and peripapillary VD(P<0.05)all increased significantly relative to baseline.CMT decreased significantly(P<0.05),whereas macular SCP-VD and macular DCP-VD showed non-significant slight reductions(P>0.05).At baseline,BCVA of CRVO eyes correlated with whole-disc VD(r=-0.276,P=0.033),intra-disc VD(r=-0.342,P=0.009),and peripapillary VD(r=-0.335,P=0.007),with intra-disc VD demonstrating the strongest association.Besides,BCVA improvement,after the treatment,correlated positively with whole-disc VD(r=0.342,P=0.008)and intradisc VD(r=0.396,P=0.002).CONCLUSION:Optic disc blood perfusion is more closely associated with visual acuity than macular perfusion,suggesting intra-disc VD may serve as a potential biomarker for monitoring visual acuity changes in CRVO.Multiple ranibizumab injections significantly improve optic disc perfusion but may have exerted detrimental effects on the macula.CRVO patients shows higher hemorheological parameters than those with normal fundi.Reduced vertical C/D ratio and optic cup volume may be linked to CRVO incidence,potentially acting as susceptibility factors.
基金supported by the National Natural Science Foundation of China(Grant No.62403486)。
文摘The highly dynamic nature,strong uncertainty,and coupled multiple safety constraints inherent in carrier aircraft recovery operations pose severe challenges for real-time decision-making.Addressing bolter scenarios,this study proposes an intelligent decision-making framework based on a deep long short-term memory Q-network.This framework transforms the real-time sequencing for bolter recovery problem into a partially observable Markov decision process.It employs a stacked long shortterm memory network to accurately capture the long-range temporal dependencies of bolter event chains and fuel consumption.Furthermore,it integrates a prioritized experience replay training mechanism to construct a safe and adaptive scheduling system capable of millisecond-level real-time decision-making.Experimental demonstrates that,within large-scale mass recovery scenarios,the framework achieves zero safety violations in static environments and maintains a fuel safety violation rate below 10%in dynamic scenarios,with single-step decision times at the millisecond level.The model exhibits strong generalization capability,effectively responding to unforeseen emergent situations—such as multiple bolters and fuel emergencies—without requiring retraining.This provides robust support for efficient carrier-based aircraft recovery operations.
基金partially supported by the National Key R&D Program of China(2020YFB2104001)the National Natural Science Foundation of China(62271485,61903363,62203250,U1811463)。
文摘THE well-known ancient Chinese philosopher Lao Tzu(老子)or Laozi(6th~4th century BC during the Spring and Autumn period)started his classic Tao Teh Ching《道德经》or Dao De Jing(see Fig.1)with six Chinese characters:"道(Dao)可(Ke)道(Dao)非(Fei)常(Chang)道(Dao)",which has been traditionally interpreted as“道可道,非常道”or"The Dao that can be spoken is not the eternal Dao".
基金the National Natural Science Foundation of China(62271485,61903363,U1811463,62103411,62203250)the Science and Technology Development Fund of Macao SAR(0093/2023/RIA2,0050/2020/A1)。
文摘DURING our discussion at workshops for writing“What Does ChatGPT Say:The DAO from Algorithmic Intelligence to Linguistic Intelligence”[1],we had expected the next milestone for Artificial Intelligence(AI)would be in the direction of Imaginative Intelligence(II),i.e.,something similar to automatic wordsto-videos generation or intelligent digital movies/theater technology that could be used for conducting new“Artificiofactual Experiments”[2]to replace conventional“Counterfactual Experiments”in scientific research and technical development for both natural and social studies[2]-[6].Now we have OpenAI’s Sora,so soon,but this is not the final,actually far away,and it is just the beginning.
基金supported by the National Natural Science Foundation of China(No.81130070,81072989)the Research Projects of State Administration of Traditional Chinese Medicine of China(No.201107009)+1 种基金the Important National Science&Technology Specific Projects(No.2009ZX09502-026,2009ZX09301-005)the Research Projects of China Academy of Chinese Medical Sciences(No.ZZ20090302)
文摘The effects of different cadmium(Cd)concentrations(0,20,60,and 100μmol/L)on hydroponically grown Artemisia annua L.were investigated.Cd treatments applied for 0,4,12,24,72,144,216,and 336 hr were assessed by measuring the changes in photosynthetic pigments,electrolyte leakage,malondialdehyde(MDA)and antioxidants(ascorbic acid and glutathione),while the artemisinin content was tested after 0,12,144,216,and 336 hr.A significant decrease was observed in photosynthetic pigment levels over time with increasing Cd concentration.Chlorophyll b levels were more affected by Cd than were chlorophyll a or carotenoid levels.The cell membrane was sensitive to Cd stress,as MDA content in all treatment groups showed insignificant differences from the control group,except at 12 hr treatment time.Ascorbic acid(AsA)content changed slightly over time,while glutathione(GSH)content took less time to reach a maximum as Cd concentration increased.Cd was found to promote synthesis and accumulation of artemisinin,especially at concentrations of 20 and 100~tmol/L.In conclusion,Cd stress can damage to photosynthetic pigments,and vigorously growing A.annua showed a strong tolerance for Cd stress.Appropriate amounts of added Cd aided synthesis and accumulation of artemisinin.
文摘The article presents a review of new techniques being used for the preparation of liposomes.A total of 28 publications were examined.In addition to the theories,characteristics and problems associated with traditional methods,the advantages and drawbacks of the latest techniques were reviewed.In the light of developments in many relevant areas,a variety of new techniques are being used for liposome preparation and each of these new technique has particular advantages over conventional preparation methods.However,there are still some problems associated with these new techniques that could hinder their applications and further improvements are needed.Generally speaking,due to the introduction of these latest techniques,liposome preparation is now an improved procedure.These applications promote not only advances in liposome research but also the methods for their production on an industrial scale.
