Rheumatoid arthritis(RA)patients face significant psychological challenges alongside physical symptoms,necessitating a comprehensive understanding of how psychological vulnerability and adaptation patterns evolve thro...Rheumatoid arthritis(RA)patients face significant psychological challenges alongside physical symptoms,necessitating a comprehensive understanding of how psychological vulnerability and adaptation patterns evolve throughout the disease course.This review examined 95 studies(2000-2025)from PubMed,Web of Science,and CNKI databases including longitudinal cohorts,randomized controlled trials,and mixed-methods research,to characterize the complex interplay between biological,psychological,and social factors affecting RA patients’mental health.Findings revealed three distinct vulnerability trajectories(45%persistently low,30%fluctuating improvement,25%persistently high)and four adaptation stages,with critical intervention periods occurring 3-6 months postdiagnosis and during disease flares.Multiple factors significantly influence psychological outcomes,including gender(females showing 1.8-fold increased risk),age(younger patients experiencing 42%higher vulnerability),pain intensity,inflammatory markers,and neuroendocrine dysregulation(48%showing cortisol rhythm disruption).Early psychological intervention(within 3 months of diagnosis)demonstrated robust benefits,reducing depression incidence by 42%with effects persisting 24-36 months,while different modalities showed complementary advantages:Cognitive behavioral therapy for depression(Cohen’s d=0.68),mindfulness for pain acceptance(38%improvement),and peer support for meaning reconstruction(25.6%increase).These findings underscore the importance of integrating routine psychological assessment into standard RA care,developing stage-appropriate interventions,and advancing research toward personalized biopsychosocial approaches that address the dynamic psychological dimensions of the disease.展开更多
将Ti/Nb/V与Ce联合微合金化的MA414N焊丝用于连铸辊硬面层的堆焊,对比测试了MA414N(MA为microalloying的缩写)与未微合金化414N硬面层抗氧化和抗热震性能,通过透射电子显微镜(transmission electron microscope,TEM)、扫描电子显微镜(sc...将Ti/Nb/V与Ce联合微合金化的MA414N焊丝用于连铸辊硬面层的堆焊,对比测试了MA414N(MA为microalloying的缩写)与未微合金化414N硬面层抗氧化和抗热震性能,通过透射电子显微镜(transmission electron microscope,TEM)、扫描电子显微镜(scanning electron microscope,SEM)/能谱仪(energy disperse X-ray,EDX)、X射线衍射仪(X-ray diffraction,XRD)等分析方法研究微合金化对硬面层氧化、热震性能的影响及作用机理.结果表明,MA414N的抗氧化、抗热震性能较414N得到显著改善,650℃氧化360 h时,MA414N氧化增重和氧化速率常数较414N分别降低16%和31%,热震循环300次时,MA414N热震表面损伤因子较414N显著下降53%.热震裂纹的萌生和扩展受热应力、组织应力和氧化共同作用,MA414N的抗热震性能显著改善主要得益于第二相析出产生的强化,少的马氏体(M)与奥氏体(A)的组织转变,及结构相对稳定的氧化膜.展开更多
Silk fibroin(SF)can be used to construct various stiff material interfaces to support bone formation.An essential preparatory step is to partially transform SF molecules from random coils toβ-sheets to render the mat...Silk fibroin(SF)can be used to construct various stiff material interfaces to support bone formation.An essential preparatory step is to partially transform SF molecules from random coils toβ-sheets to render the material water insoluble.However,the influence of the SF conformation on osteogenic cell behavior at the material interface remains unknown.Herein,three stiff SF substrates were prepared by varying theβ-sheet content(high,medium,and low).The substrates had a comparable chemical composition,surface topography,and wettability.When adsorbed fibronectin was used as a model cellular adhesive protein,the stability of the adsorbed protein-material interface,in terms of the surface stability of the SF substrates and the accompanying fibronectin detachment resistance,increased with the increasingβ-sheet content of the SF substrates.Furthermore,(i)larger areas of cytoskeleton-associated focal adhesions,(ii)higher orders of cytoskeletal organization and(iii)more elongated cell spreading were observed for bone marrow-derived mesenchymal stromal cells(BMSCs)cultured on SF substrates with high vs.lowβ-sheet contents,along with enhanced nuclear translocation and activation of YAP/TAZ and RUNX2.Consequently,osteogenic differentiation of BMSCs was stimulated on highβ-sheet substrates.These results indicated that theβ-sheet content influences osteogenic differentiation of BMSCs on SF materials in vitro by modulating the stability of the adsorbed protein-material interface,which proceeds via protein-focal adhesion-cytoskeleton links and subsequent intracellular mechanotransduction.Our findings emphasize the role of the stability of the adsorbed protein-material interface in cellular mechanotransduction and the perception of stiff SF substrates with differentβ-sheet contents,which should not be overlooked when engineering stiff biomaterials.展开更多
The oxygen evolution reaction(OER)plays an important role in the development of energy conversation and storage technologies including water splitting and metal-air batteries,where the development of electrocatalysts ...The oxygen evolution reaction(OER)plays an important role in the development of energy conversation and storage technologies including water splitting and metal-air batteries,where the development of electrocatalysts is paramount.In this study,cobalt-nickel phosphide/N-doped porous carbon polyhedron electrocatalysts(CoNiP/NC)were prepared by a facile two-step carbonization method and subsequent phosphorization calcination in an Ar atmosphere using cobalt-based zeolitic imidazolate frameworks(ZIFs)as precursors.Among the electrocatalysts obtained by controlling the carbonization and phosphorization temperature,the CoNiP/NC700 catalyst,where 700 refers to the calcination temperature(°C),exhibited superior electrocatalytic activity for the OER with an onset overpotential of approximate 220 mV and an overpotential of approximate 300 mV in alkaline solution at a current density of 10 mA/cm2.The CoNi/NC and Co/NC Samples were also tested for comparison and CoNiP/NC exhibited the better electrocatalytic activity at all the temperatures tested.The superior electrocatalytic activity of the phosphorization hybrid material can be attributed to the superior synergistic effect of Co,Ni,P and C due to their strong electron coupling interactions.The interconnected amorphous carbon anchored the active Co compounds to avoid aggregation and maintained conducting channels for electron transfer.The composite electrocatalyst prepared herein is a promising candidate for use in electrocatalytic OERs.展开更多
Vacuum gaps have rapid dynamic dielectric recovery speed while SF6 gaps have high insulation strength. The series-connected vacuum and SF6 gaps are used as the main switch(MS), which combines their advantages. The wor...Vacuum gaps have rapid dynamic dielectric recovery speed while SF6 gaps have high insulation strength. The series-connected vacuum and SF6 gaps are used as the main switch(MS), which combines their advantages. The work aims to verify the feasibility of serial vacuum and SF6 gaps in mechanical HVDC interruption. The test circuit of the dynamic dielectric recovery performance(DDRP) is set up. The DDRP is tested under free recovery condition by the high voltage pulse source. The DDRP of the vacuum circuit breaker(VCB) and SF6 gas circuit breaker(GCB) in DC interruption with active current injection is analyzed and compared. The test results indicate that the dielectric recovery duration of the VCB is below 30 μs while that of the GCB is above 100 μs. In order to achieve the cooperation between the VCB and GCB, a novel hybrid HVDC circuit breaker(CB) based on series-connected vacuum and SF6 gaps is proposed. The ‘voltage-zero’ duration is created by introducing the follow current loop and there more recovery time for the dielectric recovery of the MS. The voltage distribution is controlled by the voltage dividing method so that the VCB undertakes the initial transient recovery voltage(TRV) and the later TRV is took by the GCB. The theoretical synergy characteristic of the novel HVDC CB is obtained. The paper supplies a new method to improve the custom mechanical HVDC CB, which is useful to achieve the HVDC CB with less serial breaks.展开更多
The therapeutic precision and clinical applicability of drug-eluting coatings can be substantially improved by facilitating tunable drug delivery.However,the design of coatings which allows for precise control over dr...The therapeutic precision and clinical applicability of drug-eluting coatings can be substantially improved by facilitating tunable drug delivery.However,the design of coatings which allows for precise control over drug release kinetics is still a major challenge.Here,a double-layered silk fibroin(SF)coating system was constructed by sequential electrophoretic deposition.A mixture of dissolved Bombyx mori SF(bmSF)molecules and pre-made bmSF nanospheres at different ratios was deposited as under-layer.Subsequently,this underlayer was covered by a top-layer comprising Antheraea pernyi SF(apSF)molecules(rich in arginylglycylaspartic acid,RGD)to improve the cellular response of the resulting double-layered coatings.Additionally,model drug doxycycline was either pre-mixed with dissolved bmSF molecules or pre-loaded into pre-made bmSF nanospheres at the same amount before their mixing and deposition.The thickness and nanosphere content of the under-layer architecture were proportional to the deposition time and nanosphere concentration in precursor mixtures,respectively.The surface topography,wettability,degradation rate and adhesion strength were comparable within the double-layered coating system.As expected,RGD-rich apSF top-layer improved cell adhesion,spreading and proliferation compared with bmSF top-layer.Furthermore,the amount and duration of drug release increased linearly with increasing nanosphere concentration at fixed deposition time,whereas drug release amount increased linearly with increasing deposition time.These results indicate that the dosage and kinetics of loaded drugs can be quantitatively tailored by altering nanosphere concentration and deposition time as main processing parameters.Overall,this study illustrates the strong potential of pre-defining coating architecture to facilitate control over drug delivery.展开更多
基金Supported by Chongqing Health Commission and Chongqing Science and Technology Bureau,No.2023MSXM182。
文摘Rheumatoid arthritis(RA)patients face significant psychological challenges alongside physical symptoms,necessitating a comprehensive understanding of how psychological vulnerability and adaptation patterns evolve throughout the disease course.This review examined 95 studies(2000-2025)from PubMed,Web of Science,and CNKI databases including longitudinal cohorts,randomized controlled trials,and mixed-methods research,to characterize the complex interplay between biological,psychological,and social factors affecting RA patients’mental health.Findings revealed three distinct vulnerability trajectories(45%persistently low,30%fluctuating improvement,25%persistently high)and four adaptation stages,with critical intervention periods occurring 3-6 months postdiagnosis and during disease flares.Multiple factors significantly influence psychological outcomes,including gender(females showing 1.8-fold increased risk),age(younger patients experiencing 42%higher vulnerability),pain intensity,inflammatory markers,and neuroendocrine dysregulation(48%showing cortisol rhythm disruption).Early psychological intervention(within 3 months of diagnosis)demonstrated robust benefits,reducing depression incidence by 42%with effects persisting 24-36 months,while different modalities showed complementary advantages:Cognitive behavioral therapy for depression(Cohen’s d=0.68),mindfulness for pain acceptance(38%improvement),and peer support for meaning reconstruction(25.6%increase).These findings underscore the importance of integrating routine psychological assessment into standard RA care,developing stage-appropriate interventions,and advancing research toward personalized biopsychosocial approaches that address the dynamic psychological dimensions of the disease.
文摘将Ti/Nb/V与Ce联合微合金化的MA414N焊丝用于连铸辊硬面层的堆焊,对比测试了MA414N(MA为microalloying的缩写)与未微合金化414N硬面层抗氧化和抗热震性能,通过透射电子显微镜(transmission electron microscope,TEM)、扫描电子显微镜(scanning electron microscope,SEM)/能谱仪(energy disperse X-ray,EDX)、X射线衍射仪(X-ray diffraction,XRD)等分析方法研究微合金化对硬面层氧化、热震性能的影响及作用机理.结果表明,MA414N的抗氧化、抗热震性能较414N得到显著改善,650℃氧化360 h时,MA414N氧化增重和氧化速率常数较414N分别降低16%和31%,热震循环300次时,MA414N热震表面损伤因子较414N显著下降53%.热震裂纹的萌生和扩展受热应力、组织应力和氧化共同作用,MA414N的抗热震性能显著改善主要得益于第二相析出产生的强化,少的马氏体(M)与奥氏体(A)的组织转变,及结构相对稳定的氧化膜.
基金supported by the National Key R&D Program of China(2017YFC1104301,to L.C.)the National Natural Science Foundation of China for Distinguished Young Scholars(31725011,to L.C.)the China Scholarship Council(201606160095,to X.C.)。
文摘Silk fibroin(SF)can be used to construct various stiff material interfaces to support bone formation.An essential preparatory step is to partially transform SF molecules from random coils toβ-sheets to render the material water insoluble.However,the influence of the SF conformation on osteogenic cell behavior at the material interface remains unknown.Herein,three stiff SF substrates were prepared by varying theβ-sheet content(high,medium,and low).The substrates had a comparable chemical composition,surface topography,and wettability.When adsorbed fibronectin was used as a model cellular adhesive protein,the stability of the adsorbed protein-material interface,in terms of the surface stability of the SF substrates and the accompanying fibronectin detachment resistance,increased with the increasingβ-sheet content of the SF substrates.Furthermore,(i)larger areas of cytoskeleton-associated focal adhesions,(ii)higher orders of cytoskeletal organization and(iii)more elongated cell spreading were observed for bone marrow-derived mesenchymal stromal cells(BMSCs)cultured on SF substrates with high vs.lowβ-sheet contents,along with enhanced nuclear translocation and activation of YAP/TAZ and RUNX2.Consequently,osteogenic differentiation of BMSCs was stimulated on highβ-sheet substrates.These results indicated that theβ-sheet content influences osteogenic differentiation of BMSCs on SF materials in vitro by modulating the stability of the adsorbed protein-material interface,which proceeds via protein-focal adhesion-cytoskeleton links and subsequent intracellular mechanotransduction.Our findings emphasize the role of the stability of the adsorbed protein-material interface in cellular mechanotransduction and the perception of stiff SF substrates with differentβ-sheet contents,which should not be overlooked when engineering stiff biomaterials.
文摘The oxygen evolution reaction(OER)plays an important role in the development of energy conversation and storage technologies including water splitting and metal-air batteries,where the development of electrocatalysts is paramount.In this study,cobalt-nickel phosphide/N-doped porous carbon polyhedron electrocatalysts(CoNiP/NC)were prepared by a facile two-step carbonization method and subsequent phosphorization calcination in an Ar atmosphere using cobalt-based zeolitic imidazolate frameworks(ZIFs)as precursors.Among the electrocatalysts obtained by controlling the carbonization and phosphorization temperature,the CoNiP/NC700 catalyst,where 700 refers to the calcination temperature(°C),exhibited superior electrocatalytic activity for the OER with an onset overpotential of approximate 220 mV and an overpotential of approximate 300 mV in alkaline solution at a current density of 10 mA/cm2.The CoNi/NC and Co/NC Samples were also tested for comparison and CoNiP/NC exhibited the better electrocatalytic activity at all the temperatures tested.The superior electrocatalytic activity of the phosphorization hybrid material can be attributed to the superior synergistic effect of Co,Ni,P and C due to their strong electron coupling interactions.The interconnected amorphous carbon anchored the active Co compounds to avoid aggregation and maintained conducting channels for electron transfer.The composite electrocatalyst prepared herein is a promising candidate for use in electrocatalytic OERs.
基金supported by National Natural Science Foundation of China (Nos. 51407163, 51777025)National Rail Transportation Electrification and Automation Engineering Technology Research Center (No. NEEC-2017B07)+1 种基金China Postdoctoral Science Foundation (No. 2017M622370)Key scientific research projects of colleges and universities in Henan(16A470014, 19A470008)
文摘Vacuum gaps have rapid dynamic dielectric recovery speed while SF6 gaps have high insulation strength. The series-connected vacuum and SF6 gaps are used as the main switch(MS), which combines their advantages. The work aims to verify the feasibility of serial vacuum and SF6 gaps in mechanical HVDC interruption. The test circuit of the dynamic dielectric recovery performance(DDRP) is set up. The DDRP is tested under free recovery condition by the high voltage pulse source. The DDRP of the vacuum circuit breaker(VCB) and SF6 gas circuit breaker(GCB) in DC interruption with active current injection is analyzed and compared. The test results indicate that the dielectric recovery duration of the VCB is below 30 μs while that of the GCB is above 100 μs. In order to achieve the cooperation between the VCB and GCB, a novel hybrid HVDC circuit breaker(CB) based on series-connected vacuum and SF6 gaps is proposed. The ‘voltage-zero’ duration is created by introducing the follow current loop and there more recovery time for the dielectric recovery of the MS. The voltage distribution is controlled by the voltage dividing method so that the VCB undertakes the initial transient recovery voltage(TRV) and the later TRV is took by the GCB. The theoretical synergy characteristic of the novel HVDC CB is obtained. The paper supplies a new method to improve the custom mechanical HVDC CB, which is useful to achieve the HVDC CB with less serial breaks.
基金X.C.is funded by China Scholarship Council(Project No.201606160095)。
文摘The therapeutic precision and clinical applicability of drug-eluting coatings can be substantially improved by facilitating tunable drug delivery.However,the design of coatings which allows for precise control over drug release kinetics is still a major challenge.Here,a double-layered silk fibroin(SF)coating system was constructed by sequential electrophoretic deposition.A mixture of dissolved Bombyx mori SF(bmSF)molecules and pre-made bmSF nanospheres at different ratios was deposited as under-layer.Subsequently,this underlayer was covered by a top-layer comprising Antheraea pernyi SF(apSF)molecules(rich in arginylglycylaspartic acid,RGD)to improve the cellular response of the resulting double-layered coatings.Additionally,model drug doxycycline was either pre-mixed with dissolved bmSF molecules or pre-loaded into pre-made bmSF nanospheres at the same amount before their mixing and deposition.The thickness and nanosphere content of the under-layer architecture were proportional to the deposition time and nanosphere concentration in precursor mixtures,respectively.The surface topography,wettability,degradation rate and adhesion strength were comparable within the double-layered coating system.As expected,RGD-rich apSF top-layer improved cell adhesion,spreading and proliferation compared with bmSF top-layer.Furthermore,the amount and duration of drug release increased linearly with increasing nanosphere concentration at fixed deposition time,whereas drug release amount increased linearly with increasing deposition time.These results indicate that the dosage and kinetics of loaded drugs can be quantitatively tailored by altering nanosphere concentration and deposition time as main processing parameters.Overall,this study illustrates the strong potential of pre-defining coating architecture to facilitate control over drug delivery.
