目的:检索国际上关于改善医护人员心理健康的组织干预策略,总结其干预途径及措施,为国内医院提高医护心理健康水平提供参考。方法:以Web of Science等数据库为资料来源,遵循PRISMA准则筛选英文文献,采用叙述性方法对研究进行描述和比较...目的:检索国际上关于改善医护人员心理健康的组织干预策略,总结其干预途径及措施,为国内医院提高医护心理健康水平提供参考。方法:以Web of Science等数据库为资料来源,遵循PRISMA准则筛选英文文献,采用叙述性方法对研究进行描述和比较。结果:共筛选出9项国外组织方案作为医护心理干预的典型案例。通过系统梳理,确定了3类具体的干预途径及20项对应的干预措施。结论:为提升医护人员的心理健康水平,国内医院需借鉴国际先进经验,持续优化组织内部环境、创新心理干预手段、加强专业服务提供,最终达成医护人员心理健康的持续改善与提升。展开更多
As the global population ages,osteoporotic bone fractures leading to bone defects are increasingly becoming a significant challenge in the field of public health.Treating this disease faces many challenges,especially ...As the global population ages,osteoporotic bone fractures leading to bone defects are increasingly becoming a significant challenge in the field of public health.Treating this disease faces many challenges,especially in the context of an imbalance between osteoblast and osteoclast activities.Therefore,the development of new biomaterials has become the key.This article reviews various design strategies and their advantages and disadvantages for biomaterials aimed at osteoporotic bone defects.Overall,current research progress indicates that innovative design,functionalization,and targeting of materials can significantly enhance bone regeneration under osteoporotic conditions.By comprehensively considering biocompatibility,mechanical properties,and bioactivity,these biomaterials can be further optimized,offering a range of choices and strategies for the repair of osteoporotic bone defects.展开更多
定量研究达州市土壤侵蚀的时空分布状况以及不同坡度,海拔高度下的侵蚀状况,可以为达州市开展水土保持工作提供科学参考。本研究选用降雨、土壤、地形、植被覆盖度、土地利用5个侵蚀因子,基于GIS平台结合RUSLE模型得到研究区2000—2020...定量研究达州市土壤侵蚀的时空分布状况以及不同坡度,海拔高度下的侵蚀状况,可以为达州市开展水土保持工作提供科学参考。本研究选用降雨、土壤、地形、植被覆盖度、土地利用5个侵蚀因子,基于GIS平台结合RUSLE模型得到研究区2000—2020年5期的土壤侵蚀值,并分析其时空分布特征。结果表明:①在研究时段以无明显水土流失为主,无明显水土流失的面积占比由53.21%上升至86.44%;②海拔在500~1000 m的区域侵蚀情况最为严重,侵蚀面积达4540.52 km 2,中度及以上高等级侵蚀占比为28.00%;③坡度与侵蚀面积呈负相关关系,与侵蚀严重程度呈正相关关系。展开更多
This review focuses on the metabolic issues related to mitochondrial pyruvate dehydrogenase phosphatase(PDP)in malignant tumors and its potential mechanisms.Recent research on tumor metabolic mechanisms has shown that...This review focuses on the metabolic issues related to mitochondrial pyruvate dehydrogenase phosphatase(PDP)in malignant tumors and its potential mechanisms.Recent research on tumor metabolic mechanisms has shown that PDP dysregulation is closely linked to metabolic reprogramming in tumor cells,and potentially promotes tumor.Research has comprehensively explored the structural-functional characteristics of PDP,its metabolic regulatory mechanisms,and its role in various types of malignant tumors.Nevertheless,several questions still exist regarding its potential mechanisms within acetylation,phosphorylation,hypoxia,immune infiltration,mitochondrial metabolism,drug resistance,oxidative phosphorylation,and tumor prognosis.This article intends to summarize the latest research,examine PDP’s potential as a therapeutic target,and propose future research directions to enhance cancer treatment strategies.展开更多
文摘目的:检索国际上关于改善医护人员心理健康的组织干预策略,总结其干预途径及措施,为国内医院提高医护心理健康水平提供参考。方法:以Web of Science等数据库为资料来源,遵循PRISMA准则筛选英文文献,采用叙述性方法对研究进行描述和比较。结果:共筛选出9项国外组织方案作为医护心理干预的典型案例。通过系统梳理,确定了3类具体的干预途径及20项对应的干预措施。结论:为提升医护人员的心理健康水平,国内医院需借鉴国际先进经验,持续优化组织内部环境、创新心理干预手段、加强专业服务提供,最终达成医护人员心理健康的持续改善与提升。
基金supported by the National Natural Science Foundation of China(Nos.82160419 and 82302772)Guizhou Basic Research Project(No.ZK[2023]General 201)。
文摘As the global population ages,osteoporotic bone fractures leading to bone defects are increasingly becoming a significant challenge in the field of public health.Treating this disease faces many challenges,especially in the context of an imbalance between osteoblast and osteoclast activities.Therefore,the development of new biomaterials has become the key.This article reviews various design strategies and their advantages and disadvantages for biomaterials aimed at osteoporotic bone defects.Overall,current research progress indicates that innovative design,functionalization,and targeting of materials can significantly enhance bone regeneration under osteoporotic conditions.By comprehensively considering biocompatibility,mechanical properties,and bioactivity,these biomaterials can be further optimized,offering a range of choices and strategies for the repair of osteoporotic bone defects.
文摘定量研究达州市土壤侵蚀的时空分布状况以及不同坡度,海拔高度下的侵蚀状况,可以为达州市开展水土保持工作提供科学参考。本研究选用降雨、土壤、地形、植被覆盖度、土地利用5个侵蚀因子,基于GIS平台结合RUSLE模型得到研究区2000—2020年5期的土壤侵蚀值,并分析其时空分布特征。结果表明:①在研究时段以无明显水土流失为主,无明显水土流失的面积占比由53.21%上升至86.44%;②海拔在500~1000 m的区域侵蚀情况最为严重,侵蚀面积达4540.52 km 2,中度及以上高等级侵蚀占比为28.00%;③坡度与侵蚀面积呈负相关关系,与侵蚀严重程度呈正相关关系。
基金funded by National Social Science Foundation if Gansu Province(24JRRA694)Scientific and Technological Development Guiding Plan Project of Lanzhou City(2023-ZD-62,2024-9-52)GanSu Health Industry Planning Project(GSWSKY2024-51).
文摘This review focuses on the metabolic issues related to mitochondrial pyruvate dehydrogenase phosphatase(PDP)in malignant tumors and its potential mechanisms.Recent research on tumor metabolic mechanisms has shown that PDP dysregulation is closely linked to metabolic reprogramming in tumor cells,and potentially promotes tumor.Research has comprehensively explored the structural-functional characteristics of PDP,its metabolic regulatory mechanisms,and its role in various types of malignant tumors.Nevertheless,several questions still exist regarding its potential mechanisms within acetylation,phosphorylation,hypoxia,immune infiltration,mitochondrial metabolism,drug resistance,oxidative phosphorylation,and tumor prognosis.This article intends to summarize the latest research,examine PDP’s potential as a therapeutic target,and propose future research directions to enhance cancer treatment strategies.
