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布洛芬连续流合成技术:进展与挑战
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作者 任彦荣 杨伟臣 +4 位作者 李雯倩 吕洁 罗志强 张有理 袁紫亮 《中国科学:化学》 2025年第11期3197-3211,共15页
布洛芬是临床常用的非甾体抗炎药(NSAIDs),以其镇痛、退热和抗炎作用广泛应用于医药领域.随着医药工业的快速发展,对布洛芬的绿色合成技术提出了更高要求.连续流技术因其绿色高效、溶剂用量少,且有助于产率提升等优势,逐渐成为布洛芬合... 布洛芬是临床常用的非甾体抗炎药(NSAIDs),以其镇痛、退热和抗炎作用广泛应用于医药领域.随着医药工业的快速发展,对布洛芬的绿色合成技术提出了更高要求.连续流技术因其绿色高效、溶剂用量少,且有助于产率提升等优势,逐渐成为布洛芬合成的重要研究方向.本文从连续流技术的基本原理出发,综述了布洛芬合成工艺的主要进展,包括连续流催化技术开发、反应器设计及优化等内容.同时,结合当前研究,分析了现阶段存在的问题和技术瓶颈,并对其未来的工业应用前景进行展望.通过本文的讨论,旨在为布洛芬合成技术的进一步优化和绿色医药工业的可持续发展提供理论支持. 展开更多
关键词 布洛芬 连续流技术 绿色合成 催化反应
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Forecasting Scenario Generation for Multiple Wind Farms Considering Time-series Characteristics and Spatial-temporal Correlation 被引量:6
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作者 Qingyu Tu Shihong Miao +5 位作者 Fuxing Yao Yaowang Li Haoran Yin Ji Han Di Zhang weichen yang 《Journal of Modern Power Systems and Clean Energy》 SCIE EI CSCD 2021年第4期837-848,共12页
Scenario forecasting methods have been widely studied in recent years to cope with the wind power uncertainty problem. The main difficulty of this problem is to accurately and comprehensively reflect the time-series c... Scenario forecasting methods have been widely studied in recent years to cope with the wind power uncertainty problem. The main difficulty of this problem is to accurately and comprehensively reflect the time-series characteristics and spatial-temporal correlation of wind power generation. In this paper, the marginal distribution model and the dependence structure are combined to describe these complex characteristics. On this basis, a scenario generation method for multiple wind farms is proposed. For the marginal distribution model, the autoregressive integrated moving average-generalized autoregressive conditional heteroskedasticity-t (ARIMA-GARCH-t) model is proposed to capture the time-series characteristics of wind power generation. For the dependence structure, a time-varying regular vine mixed Copula (TRVMC) model is established to capture the spatial-temporal correlation of multiple wind farms. Based on the data from 8 wind farms in Northwest China, sufficient scenarios are generated. The effectiveness of the scenarios is evaluated in 3 aspects. The results show that the generated scenarios have similar fluctuation characteristics, autocorrelation, and crosscorrelation with the actual wind power sequences. 展开更多
关键词 Scenario generation wind farm regular vine Copula spatial-temporal correlation time-series characteristics
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Model Predictive Direct Power Control of Grid-connected Converters Considering Unbalanced Filter Inductance and Grid Conditions 被引量:1
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作者 weichen yang Shihong Miao +3 位作者 Zhiwei Liu Ji Han Yulong Xiong Qingyu Tu 《Journal of Modern Power Systems and Clean Energy》 SCIE EI CSCD 2021年第6期1279-1288,共10页
The grid-connected converter(GCC) is widely used as the interface between various distributed generations and the utility grid. To achieve precise power control for GCC, this paper presents a model predictive direct p... The grid-connected converter(GCC) is widely used as the interface between various distributed generations and the utility grid. To achieve precise power control for GCC, this paper presents a model predictive direct power control(MPDPC)with consideration of the unbalanced filter inductance and grid conditions. First, the characteristics of GCC with unbalanced filter inductance are analyzed and a modified voltage control function is derived. On this basis, to compensate for the power oscillation caused by unbalanced filter inductance, a novel power compensation method is proposed for MPDPC to eliminate the DC-side current ripple while maintaining sinusoidal grid current. Besides, to improve the control robustness against mismatched filter inductance, a filter inductance identification scheme is proposed. Through this scheme, the estimated value of filter inductance is updated in each control period and applied in the proposed MPDPC. Finally, simulation results in PSCAD/EMTDC confirm the validity of the proposed MPDPC and the filter inductance identification scheme. 展开更多
关键词 Inductance identification grid-connected converter model predictive control power oscillation elimination unbalanced grid conditions
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