Background:Our previous study shows that the empirical formula of Chinese medicine Jianpi-yangwei decoction(JYD)can improve the quality of life in patients with gastric cancer undergoing chemotherapy by increasing ben...Background:Our previous study shows that the empirical formula of Chinese medicine Jianpi-yangwei decoction(JYD)can improve the quality of life in patients with gastric cancer undergoing chemotherapy by increasing beneficial gut bacteria and decreasing harmful bacteria.The present study aims to investigate the effect of JYD on gut fungi in patients with gastric cancer undergoing chemotherapy.Methods:A total of 73 patients with gastric cancer undergoing chemotherapy were recruited.Twenty-nine patients in the chemotherapy group were given standard chemotherapy and 44 patients in the observation group were given JYD plus standard chemotherapy.A control group(55 cases)was recruited from the healthy medical examiners.After 3 months of treatment,life-quality score was evaluated and fecal microbiota was tested by high-throughput sequencing based on the 18S rRNA gene.Results:After treatment,life-quality score in the observation group was significantly lower than that in the chemotherapy group(P<0.05).There was no significant difference between the observation and control groups’diversity and richness indices of intestinal fungi.The Chao index for intestinal fungi in the chemotherapy group was significantly lower than that in the observation group(P<0.05).There was a significant difference between the control and chemotherapy groups in the intestinal fungi according to Shannon and Simpson indices(P<0.05).Linear discriminant analysis effect size analysis showed no significant differences among the three groups,but significant difference in intestinal fungi was observed between the observation group and the chemotherapy group.At the genus level,the relative abundance of the Aspergillus genus in the observation and control groups was significantly lower(P<0.05),the relative abundance of the Cutaneotrichosporon,Galactomyces,and Ganoderma genus taxa was significantly higher compared with those in the chemotherapy group(P<0.05),and there was no significant difference between the observation group and control group.Conclusion:JYD can ameliorate chemotherapy-induced fungal dysbacteriosis in patients with gastric cancer undergoing chemotherapy and improve the quality of life of patients.展开更多
为了提升弱纹理区域无监督多视图深度估计性能,文中提出一种基于邻域自适应无监督多视图深度估计算法。算法采用双分支结构,深度估计分支首先采用邻域自适应深度分布方法改善弱纹理区域深度分布;其次采用深度变化概率引导的深度假设范...为了提升弱纹理区域无监督多视图深度估计性能,文中提出一种基于邻域自适应无监督多视图深度估计算法。算法采用双分支结构,深度估计分支首先采用邻域自适应深度分布方法改善弱纹理区域深度分布;其次采用深度变化概率引导的深度假设范围细化后续阶段深度估计。为了提高对场景边缘的识别,采用基于标准差的深度平滑约束。神经渲染分支用于提高深度估计能力,为了增强与深度估计分支间的几何一致性,采用融合图像颜色与深度信息的采样方法。由实验结果可知,该算法在DTU数据集测试完整度误差和整体精度误差优于其他无监督算法,且完整度误差比DS⁃MVSNet减小16.71%。可视化结果表明,针对弱纹理区域深度估计性能提升明显。在Tanks and Temples数据集上进行泛化性验证,整体性能(Mean)为56.22,证明了所提算法的有效性。展开更多
基金The present work was funded by National Natural Science Foundation of China(No.81473458)Project of Clinical Scientific Research of Medicine State Administration of Traditional Chinese Medicine(No.JDZX2015091).
文摘Background:Our previous study shows that the empirical formula of Chinese medicine Jianpi-yangwei decoction(JYD)can improve the quality of life in patients with gastric cancer undergoing chemotherapy by increasing beneficial gut bacteria and decreasing harmful bacteria.The present study aims to investigate the effect of JYD on gut fungi in patients with gastric cancer undergoing chemotherapy.Methods:A total of 73 patients with gastric cancer undergoing chemotherapy were recruited.Twenty-nine patients in the chemotherapy group were given standard chemotherapy and 44 patients in the observation group were given JYD plus standard chemotherapy.A control group(55 cases)was recruited from the healthy medical examiners.After 3 months of treatment,life-quality score was evaluated and fecal microbiota was tested by high-throughput sequencing based on the 18S rRNA gene.Results:After treatment,life-quality score in the observation group was significantly lower than that in the chemotherapy group(P<0.05).There was no significant difference between the observation and control groups’diversity and richness indices of intestinal fungi.The Chao index for intestinal fungi in the chemotherapy group was significantly lower than that in the observation group(P<0.05).There was a significant difference between the control and chemotherapy groups in the intestinal fungi according to Shannon and Simpson indices(P<0.05).Linear discriminant analysis effect size analysis showed no significant differences among the three groups,but significant difference in intestinal fungi was observed between the observation group and the chemotherapy group.At the genus level,the relative abundance of the Aspergillus genus in the observation and control groups was significantly lower(P<0.05),the relative abundance of the Cutaneotrichosporon,Galactomyces,and Ganoderma genus taxa was significantly higher compared with those in the chemotherapy group(P<0.05),and there was no significant difference between the observation group and control group.Conclusion:JYD can ameliorate chemotherapy-induced fungal dysbacteriosis in patients with gastric cancer undergoing chemotherapy and improve the quality of life of patients.
文摘为了提升弱纹理区域无监督多视图深度估计性能,文中提出一种基于邻域自适应无监督多视图深度估计算法。算法采用双分支结构,深度估计分支首先采用邻域自适应深度分布方法改善弱纹理区域深度分布;其次采用深度变化概率引导的深度假设范围细化后续阶段深度估计。为了提高对场景边缘的识别,采用基于标准差的深度平滑约束。神经渲染分支用于提高深度估计能力,为了增强与深度估计分支间的几何一致性,采用融合图像颜色与深度信息的采样方法。由实验结果可知,该算法在DTU数据集测试完整度误差和整体精度误差优于其他无监督算法,且完整度误差比DS⁃MVSNet减小16.71%。可视化结果表明,针对弱纹理区域深度估计性能提升明显。在Tanks and Temples数据集上进行泛化性验证,整体性能(Mean)为56.22,证明了所提算法的有效性。
