评价7种食源复配物(样品1~样品7)对KM小鼠的解酒护肝效果差异。采用0.14 mL/10 g 56°白酒诱导急性酒精肝损伤模型,测定醉酒行为学变化、酒后血液乙醇含量、乙醇代谢关键酶活性、肝损伤生化指标以及组织病理学形态变化。结果显示,...评价7种食源复配物(样品1~样品7)对KM小鼠的解酒护肝效果差异。采用0.14 mL/10 g 56°白酒诱导急性酒精肝损伤模型,测定醉酒行为学变化、酒后血液乙醇含量、乙醇代谢关键酶活性、肝损伤生化指标以及组织病理学形态变化。结果显示,各样品组醉酒率均降低,低至33.33%,醉酒时间最高延长54.03%、醒酒时间最高缩短31.65%;其中样品2组酒后1、4 h血液乙醇含量最低仅30.17、3.79μmol/L;样品2组乙醇脱氢酶(ADH)活性显著降低31.92%,样品1组乙醛脱氢酶(ALDH)活性显著降低30.40%;样品5组血清谷草转氨酶(AST)、谷丙转氨酶(ALT)水平显著降低23.87%、39.87%;样品1组丙二醛(MDA)含量显著降低29.66%,样品2组总超氧化物歧化酶(T-SOD)含量显著增加52.94%;病理切片结果显示酒精引起的肝细胞结构异常、脂肪空泡化得到改善。综上所述,7种食源复配物具有明显的解酒护肝功效,其机制部分与促进乙醇代谢酶活性、改善肝脏抗氧化能力相关,各食源复配物的差异化效果与总糖和总酚比例相关,其中样品1和样品2效果最佳,该研究结果可为天然植物活性成分在解酒护肝产品中进一步开发利用提供理论依据。展开更多
为了解决传统装配式预应力框架梁柱节点耗能件施工困难、成本高昂等问题,提出了一种基于塑性铰转移的后张预应力装配式干式连接混凝土框架(post-tensioned precast concrete frames based on plastic hinge relocation,PPFBP).首先,基于...为了解决传统装配式预应力框架梁柱节点耗能件施工困难、成本高昂等问题,提出了一种基于塑性铰转移的后张预应力装配式干式连接混凝土框架(post-tensioned precast concrete frames based on plastic hinge relocation,PPFBP).首先,基于PPFBP梁柱节点试验结果,建立相应的梁单元模型,验证了建模方法的可行性及合理性.然后,设计并建立5层PPFBP及普通现浇框架有限元模型,结合静力弹塑性分析法与动力时程分析法对PPFBP抗震性能进行分析研究.研究结果表明:新型预应力框架结构在不同侧力模式下顶点位移与基底剪力有较大的差异;在相同侧力模式下,新型预应力框架结构层间位移角均能满足规范中的限值要求,较现浇混凝土框架结构有着显著的下降,各层层间位移角变化均匀,无明显薄弱层;动力时程分析法结果与静力弹塑性分析法吻合,新型预应力框架通过合理控制塑性铰位置,使结构成为完全梁铰耗能屈服机制,具有良好的抗震性能.展开更多
Sc_(2)O_(3),as a host for solid-state laser gain materials,has advantage of high thermal conductivity and easy matching with activating ions,which is promising in high-power laser applications.Currently,Yb-doped Sc_(2...Sc_(2)O_(3),as a host for solid-state laser gain materials,has advantage of high thermal conductivity and easy matching with activating ions,which is promising in high-power laser applications.Currently,Yb-doped Sc_(2)O_(3) ceramics have been fabricated at very high sintering temperatures,but their optical quality and sintering process still need further improvement.In this work,5%Yb:Sc_(2)O_(3)(in mass)nano-powders were obtained by co-precipitation,and then transparent ceramics were fabricated by vacuum pre-sintering and hot isostatic pressing(HIP)post-treatment.The cubic Yb:Sc_(2)O_(3) nano-powders with good dispersity and an average crystallite of 29 nm were obtained.Influence of pre-sintering temperatures(1500-1700℃)on densification process,microstructure changes,and optical transmittance of Yb:Sc_(2)O_(3) ceramics was detected.Experimental data revealed that all samples have a uniform microstructure,while the average grain sizes increase with the increase of the sintering temperatures.Impressively,the optimum in-line transmittance of Yb:Sc_(2)O_(3) ceramics,pre-sintered at 1550℃after HIP post-treatment,reaches 78.1%(theoretical value of 80%)at 1100 nm.Spectroscopic properties of the Yb:Sc_(2)O_(3) ceramics reveal that the minimum population inversion parameterβ2 and the luminescence decay time of 5%Yb:Sc_(2)O_(3) ceramics are 0.041 and 0.49 ms,respectively,which demonstrate that the optical quality of the Yb:Sc_(2)O_(3) has been improved.Meanwhile,their best vacuum sintering temperature can be controlled down to a lower temperature(1550℃).In conclusion,Yb:Sc_(2)O_(3) nano-powders are successfully synthesized by co-precipitation method,and good optical quality transparent ceramics are fabricated by vacuum pre-sintering at 1550℃and HIP post-treatment.展开更多
文摘评价7种食源复配物(样品1~样品7)对KM小鼠的解酒护肝效果差异。采用0.14 mL/10 g 56°白酒诱导急性酒精肝损伤模型,测定醉酒行为学变化、酒后血液乙醇含量、乙醇代谢关键酶活性、肝损伤生化指标以及组织病理学形态变化。结果显示,各样品组醉酒率均降低,低至33.33%,醉酒时间最高延长54.03%、醒酒时间最高缩短31.65%;其中样品2组酒后1、4 h血液乙醇含量最低仅30.17、3.79μmol/L;样品2组乙醇脱氢酶(ADH)活性显著降低31.92%,样品1组乙醛脱氢酶(ALDH)活性显著降低30.40%;样品5组血清谷草转氨酶(AST)、谷丙转氨酶(ALT)水平显著降低23.87%、39.87%;样品1组丙二醛(MDA)含量显著降低29.66%,样品2组总超氧化物歧化酶(T-SOD)含量显著增加52.94%;病理切片结果显示酒精引起的肝细胞结构异常、脂肪空泡化得到改善。综上所述,7种食源复配物具有明显的解酒护肝功效,其机制部分与促进乙醇代谢酶活性、改善肝脏抗氧化能力相关,各食源复配物的差异化效果与总糖和总酚比例相关,其中样品1和样品2效果最佳,该研究结果可为天然植物活性成分在解酒护肝产品中进一步开发利用提供理论依据。
文摘为了解决传统装配式预应力框架梁柱节点耗能件施工困难、成本高昂等问题,提出了一种基于塑性铰转移的后张预应力装配式干式连接混凝土框架(post-tensioned precast concrete frames based on plastic hinge relocation,PPFBP).首先,基于PPFBP梁柱节点试验结果,建立相应的梁单元模型,验证了建模方法的可行性及合理性.然后,设计并建立5层PPFBP及普通现浇框架有限元模型,结合静力弹塑性分析法与动力时程分析法对PPFBP抗震性能进行分析研究.研究结果表明:新型预应力框架结构在不同侧力模式下顶点位移与基底剪力有较大的差异;在相同侧力模式下,新型预应力框架结构层间位移角均能满足规范中的限值要求,较现浇混凝土框架结构有着显著的下降,各层层间位移角变化均匀,无明显薄弱层;动力时程分析法结果与静力弹塑性分析法吻合,新型预应力框架通过合理控制塑性铰位置,使结构成为完全梁铰耗能屈服机制,具有良好的抗震性能.
基金National Key R&D Program of China(2023YFE3812005)International Partnership Program of Chinese Academy of Sciences(121631KYSB20200039)+1 种基金National Center for Research and Development(WPC2/1/SCAPOL/2021)Chinese Academy of Sciences President’s International Fellowship Initiative(2024VEA0005,2024VEA0014)。
文摘Sc_(2)O_(3),as a host for solid-state laser gain materials,has advantage of high thermal conductivity and easy matching with activating ions,which is promising in high-power laser applications.Currently,Yb-doped Sc_(2)O_(3) ceramics have been fabricated at very high sintering temperatures,but their optical quality and sintering process still need further improvement.In this work,5%Yb:Sc_(2)O_(3)(in mass)nano-powders were obtained by co-precipitation,and then transparent ceramics were fabricated by vacuum pre-sintering and hot isostatic pressing(HIP)post-treatment.The cubic Yb:Sc_(2)O_(3) nano-powders with good dispersity and an average crystallite of 29 nm were obtained.Influence of pre-sintering temperatures(1500-1700℃)on densification process,microstructure changes,and optical transmittance of Yb:Sc_(2)O_(3) ceramics was detected.Experimental data revealed that all samples have a uniform microstructure,while the average grain sizes increase with the increase of the sintering temperatures.Impressively,the optimum in-line transmittance of Yb:Sc_(2)O_(3) ceramics,pre-sintered at 1550℃after HIP post-treatment,reaches 78.1%(theoretical value of 80%)at 1100 nm.Spectroscopic properties of the Yb:Sc_(2)O_(3) ceramics reveal that the minimum population inversion parameterβ2 and the luminescence decay time of 5%Yb:Sc_(2)O_(3) ceramics are 0.041 and 0.49 ms,respectively,which demonstrate that the optical quality of the Yb:Sc_(2)O_(3) has been improved.Meanwhile,their best vacuum sintering temperature can be controlled down to a lower temperature(1550℃).In conclusion,Yb:Sc_(2)O_(3) nano-powders are successfully synthesized by co-precipitation method,and good optical quality transparent ceramics are fabricated by vacuum pre-sintering at 1550℃and HIP post-treatment.
