Traditional machine learning(ML)encounters the challenge of parameter adjustment when predicting the compressive strength of reclaimed concrete.To address this issue,we introduce two optimized hybrid models:the Bayesi...Traditional machine learning(ML)encounters the challenge of parameter adjustment when predicting the compressive strength of reclaimed concrete.To address this issue,we introduce two optimized hybrid models:the Bayesian optimization model(B-RF)and the optimal model(Stacking model).These models are applied to a data set comprising 438 observations with five input variables,with the aim of predicting the compressive strength of reclaimed concrete.Furthermore,we evaluate the performance of the optimized models in comparison to traditional machine learning models,such as support vector regression(SVR),decision tree(DT),and random forest(RF).The results reveal that the Stacking model exhibits superior predictive performance,with evaluation indices including R2=0.825,MAE=2.818 and MSE=14.265,surpassing the traditional models.Moreover,we also performed a characteristic importance analysis on the input variables,and we concluded that cement had the greatest influence on the compressive strength of reclaimed concrete,followed by water.Therefore,the Stacking model can be recommended as a compressive strength prediction tool to partially replace laboratory compressive strength testing,resulting in time and cost savings.展开更多
目的 分析复方苦参注射液治疗非小细胞肺癌的疗效及治疗机制。方法 2020年4月—2021年7月郑州市第三人民医院收治的非小细胞肺癌患者90例,以随机数字表法分为观察组(45例)及对照组(45例)。对照组接受注射用培美曲塞二钠、注射用卡铂治疗...目的 分析复方苦参注射液治疗非小细胞肺癌的疗效及治疗机制。方法 2020年4月—2021年7月郑州市第三人民医院收治的非小细胞肺癌患者90例,以随机数字表法分为观察组(45例)及对照组(45例)。对照组接受注射用培美曲塞二钠、注射用卡铂治疗;观察组在此基础上接受复方苦参注射液治疗,3周为1个治疗周期,共治疗2个周期。比较两组治疗前、2个周期后肿瘤生长相关因子、外周血T淋巴细胞亚群、炎性因子与肿瘤标志物、治疗2个周期后近期疗效及治疗期间不良反应发生情况。结果 治疗2个周期后,观察组全血CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)水平较对照组高(P<0.05);观察组全血CD_(8)^(+)水平较对照组低(P<0.05)。治疗2个周期后,两组血清肿瘤特异性生长因子(TSGF)、血管内皮生长因子(VEGF)、转化生长因子-β(TGF-β)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、癌胚抗原(CEA)、人细胞角蛋白21-1片段(CYFRA21-1)水平均低于治疗前,观察组水平更低(P<0.05)。治疗2个周期后观察组总有效率较高[82.22%(37/45) vs 60.00%(27/45)],治疗期间不良反应(Ⅲ级以上骨髓抑制、肝功能损伤、肾功能损害)发生率较低[11.11%(5/45) vs 28.89%(13/45),13.33%(6/45) vs 33.33%(15/45),8.89%(4/45) vs 26.67%(12/45),P<0.05]。结论 复方苦参注射液治疗非小细胞肺癌疗效确切,可降低不良反应,分析与其提高患者免疫功能,抑制机体炎性因子、肿瘤标志物、肿瘤生长相关因子表达有关。展开更多
基金Funded by China National Key Research and Development Program for Application and Verification of Typical Groundwater Contaminated Sites(No.2019YFC1804805)Shenyang Key Laboratory of Safety Evaluation and Disaster Prevention of Engineering Structures(No.S230184)the Funding Project of Northeast Geological S&T Innovation Center of China Geological Survey(No.QCJJ2023-39)。
文摘Traditional machine learning(ML)encounters the challenge of parameter adjustment when predicting the compressive strength of reclaimed concrete.To address this issue,we introduce two optimized hybrid models:the Bayesian optimization model(B-RF)and the optimal model(Stacking model).These models are applied to a data set comprising 438 observations with five input variables,with the aim of predicting the compressive strength of reclaimed concrete.Furthermore,we evaluate the performance of the optimized models in comparison to traditional machine learning models,such as support vector regression(SVR),decision tree(DT),and random forest(RF).The results reveal that the Stacking model exhibits superior predictive performance,with evaluation indices including R2=0.825,MAE=2.818 and MSE=14.265,surpassing the traditional models.Moreover,we also performed a characteristic importance analysis on the input variables,and we concluded that cement had the greatest influence on the compressive strength of reclaimed concrete,followed by water.Therefore,the Stacking model can be recommended as a compressive strength prediction tool to partially replace laboratory compressive strength testing,resulting in time and cost savings.
文摘目的 分析复方苦参注射液治疗非小细胞肺癌的疗效及治疗机制。方法 2020年4月—2021年7月郑州市第三人民医院收治的非小细胞肺癌患者90例,以随机数字表法分为观察组(45例)及对照组(45例)。对照组接受注射用培美曲塞二钠、注射用卡铂治疗;观察组在此基础上接受复方苦参注射液治疗,3周为1个治疗周期,共治疗2个周期。比较两组治疗前、2个周期后肿瘤生长相关因子、外周血T淋巴细胞亚群、炎性因子与肿瘤标志物、治疗2个周期后近期疗效及治疗期间不良反应发生情况。结果 治疗2个周期后,观察组全血CD_(4)^(+)、CD_(4)^(+)/CD_(8)^(+)水平较对照组高(P<0.05);观察组全血CD_(8)^(+)水平较对照组低(P<0.05)。治疗2个周期后,两组血清肿瘤特异性生长因子(TSGF)、血管内皮生长因子(VEGF)、转化生长因子-β(TGF-β)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、癌胚抗原(CEA)、人细胞角蛋白21-1片段(CYFRA21-1)水平均低于治疗前,观察组水平更低(P<0.05)。治疗2个周期后观察组总有效率较高[82.22%(37/45) vs 60.00%(27/45)],治疗期间不良反应(Ⅲ级以上骨髓抑制、肝功能损伤、肾功能损害)发生率较低[11.11%(5/45) vs 28.89%(13/45),13.33%(6/45) vs 33.33%(15/45),8.89%(4/45) vs 26.67%(12/45),P<0.05]。结论 复方苦参注射液治疗非小细胞肺癌疗效确切,可降低不良反应,分析与其提高患者免疫功能,抑制机体炎性因子、肿瘤标志物、肿瘤生长相关因子表达有关。
