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非骨髓清除性预处理方案加异基因外周血干细胞移植治疗复发性淋巴瘤4例 被引量:1
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作者 陈盛亭 朱康儿 +3 位作者 李菊香 曾慧兰 thomas held Wolfgang Siegert 《中国肿瘤临床》 CAS CSCD 北大核心 2001年第9期685-688,共4页
目的:探讨非骨髓清除性预处理方案(nonmyeloablative conditioning regimen, NACR)加异基因造血干细胞移植(allo-HSCT)治疗血液系恶性肿瘤的可行性及其效果。方法:本报告用Fludarabine 180mg/m2, ATG 40mg/kg, 马利兰 8mg... 目的:探讨非骨髓清除性预处理方案(nonmyeloablative conditioning regimen, NACR)加异基因造血干细胞移植(allo-HSCT)治疗血液系恶性肿瘤的可行性及其效果。方法:本报告用Fludarabine 180mg/m2, ATG 40mg/kg, 马利兰 8mg/kg加异基因外周血干细胞移植治疗复发性难治性淋巴瘤4例。4例供者均系患者亲属,其中1例供受者HLA有一个位点不合,其余3例供受者HLA完全相合。结果:4例患者对预处理方案耐受良好,移植后无1例发生移植物排斥。迄今4例患者已完全缓解8~15个月。结论:用非骨髓清除性方案作造血干细胞移植预处理,安全有效,毒性低,可应用于年老体弱或有实质内脏损伤者。 展开更多
关键词 非骨髓清除性预处理方案 异基因外周血干细胞移植 淋巴瘤 病例报告
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Ganciclovir预防异基因造血干细胞移植后巨细胞病毒感染 被引量:4
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作者 陈盛亭 thomas held Wolfgang Siegert 《临床血液学杂志》 CAS 2002年第2期75-77,共3页
目的 :评价Ganciclovir在异基因造血干细胞移植 (allo HSCT)后预防巨细胞病毒 (CMV)感染的效果。方法 :观察allo HSCT患者 46例 ,全部病例均系移植前受者和 (或 )供者的CMV IgG阳性 ,分为预防组 2 4例 ,对照组 2 2例。allo HSCT后当患... 目的 :评价Ganciclovir在异基因造血干细胞移植 (allo HSCT)后预防巨细胞病毒 (CMV)感染的效果。方法 :观察allo HSCT患者 46例 ,全部病例均系移植前受者和 (或 )供者的CMV IgG阳性 ,分为预防组 2 4例 ,对照组 2 2例。allo HSCT后当患者血中性粒细胞 >1.0× 10 9/L时 ,预防组开始用GCV 10mg·kg-1·d-1,分两次静滴 ,连续 5d ;然后改为 5mg·kg-1·d-1,每周用 5d ,直至 +10 0d。对照组未预防性使用GCV。结果 :在 +10 0d内 ,预防组和对照组的CMV感染率分别为 8% (2 / 2 4)、32 % (7/ 2 2 ) ,P <0 .0 5 ;CMV病发病率分别为 0 %、18% (4 / 2 2 ) ,P <0 .0 5。两组患者在 +10 0d和 +180d内的死亡率分别为 4% (1/ 2 4)和 5 % (1/ 2 2 ) ,P >0 .0 5 ;12 .5 % (3/ 2 4)和 9% (2 / 2 2 ) ,P >0 .0 5。预防组的死因分别为并发细菌和真菌感染、CMV间质性肺炎或原发病复发 ;对照组的死因均是CMV间质性肺炎。结论 :allo HSCT后预防性使用GCV能明显抑制CMV感染 ,减少CMV病发病率。GCV的主要毒副作用是导致中性粒细胞减少 ,使患者继发感染甚至死亡的机率增加。GCV预防性使用的最佳剂量。 展开更多
关键词 巨细胞病毒 异基因造血干细胞移植 GANCICLOVIR 病毒感染
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A simulation study for a cost-effective PET-like detector system intended to track particles in granular assemblies 被引量:2
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作者 Josephine Oppotsch Antonios Athanassiadis +6 位作者 Miriam Fritsch Fritz-Herbert Heinsius thomas held Nikoline Hilse Viktor Scherer Matthias Steinke Ulrich Wiedner 《Particuology》 SCIE EI CAS CSCD 2024年第1期117-125,共9页
Since many industrial applications rely on the processing of densely packed and moving granular ma-terial,obtaining bulk internal information on the particle movement inside the reactors is of great importance.Such in... Since many industrial applications rely on the processing of densely packed and moving granular ma-terial,obtaining bulk internal information on the particle movement inside the reactors is of great importance.Such information can be delivered by Positron Emission Particle Tracking(PEPT).By marking pellets with a positron-emitting radioisotope,the position of these tracer particles can be determined via the time-of-flight differences of the emitted gamma-ray pairs.The current paper proposes a PET-like detector system based on cost-effective organic plastic scintillators instead of the more common but expensive inorganic scintillators.This system is currently under construction and was tested for its resolution and efficiency in this simulation study.Using Monte Carlo simulations and the software toolkit Geant4,three different geometries(an empty glass box,a generic grate system,and a cubic box of 1 m3 completely filled with pellets)were investigated,leading to a spatial resolution in the millimeter range and an efficiency,defined as the ratio of reconstructed decay locations to simulated decays,of 2.7%,1.4%,and 0.3%. 展开更多
关键词 Positron emission particle tracking GEANT4 Monte Carlo method TIME-OF-FLIGHT Plastic scintillators Silicon photomultipliers(SiPMs)
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A simulation study on spatial and time resolution for a cost-effective positron emission particle tracking system
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作者 Josephine Oppotsch Matthias Steinke +5 位作者 Miriam Fritsch Fritz-Herbert Heinsius thomas held Nikoline Hilse Viktor Scherer Ulrich Wiedner 《Particuology》 SCIE EI CAS CSCD 2024年第5期312-322,共11页
This work is the second part of a simulation study investigating the processing of densely packed and moving granular assemblies by positron emission particle tracking (PEPT).Since medical positron emission tomography... This work is the second part of a simulation study investigating the processing of densely packed and moving granular assemblies by positron emission particle tracking (PEPT).Since medical positron emission tomography (PET) scanners commonly used for PEPT are very expensive,a PET-like detector system based on cost-effective organic plastic scintillator bars is being developed and tested for its capabilities.In this context,the spatial resolution of a resting positron source,a source moving on a freely designed model path,and a particle motion given by a discrete element method (DEM) simulation is studied using Monte Carlo simulations and the software toolkit Geant4.This not only extended the simulation and reconstruction to a moving source but also significantly improved the spatial resolution compared to previous work by adding oversampling and iteration to the reconstruction algorithm.Furthermore,in the case of a source following a trajectory developed from DEM simulations,a very good resolution of about 1 mm in all three directions and an average 3D deviation between simulated and reconstructed events of 2.3 mm could be determined.Thus,the resolution for realistic particle motion within the generic grate system (which is the test rig for further experimental studies) is well below the smallest particle size.The simulation of the dependence of the reconstruction accuracy on tracer particle location revealed a nearly constant efficiency within the entire detector system,which demonstrates that boundary effects can be neglected. 展开更多
关键词 Positron emission particle tracking Monte Carlo method TIME-OF-FLIGHT Plastic scintillators Silicon photomultipliers(SiPMs)
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