The dominant annual cycle of sea surface temperature(SST)in the tropical Pacific exhibits an antisymmetric mode,which explains 83.4%total variance,and serves as a background of El Niño-Southern Oscillation(ENSO)....The dominant annual cycle of sea surface temperature(SST)in the tropical Pacific exhibits an antisymmetric mode,which explains 83.4%total variance,and serves as a background of El Niño-Southern Oscillation(ENSO).However,there is no consensus yet on its anomalous impacts on the phase and amplitude of ENSO.Based on data during 1982-2022,results show that anomalies of the antisymmetric mode can affect the evolution of ENSO on the interannual scale via Bjerknes feedback,in which the positive(negative)phase of the antisymmetric mode can strengthen El Niño(La Niña)in boreal winter via an earlier(delayed)seasonal cycle transition and larger(smaller)annual mean.The magnitude of the SST anomalies in the equatorial eastern Pacific can reach more than±0.3◦C,regulated by the changes in the antisymmetric mode based on random sensitivity analysis.Results reveal the spatial pattern of the annual cycle associated with the seasonal phase-locking of ENSO evolution and provide new insight into the impact of the annual cycle of background SST on ENSO,which possibly carries important implications for forecasting ENSO.展开更多
The objective of our study was to explore the possibility of the antifungal efficacy of various micafungin dosage regimens against <i>Candida spp</i> in HIV positive patients with EC. According to pharmaco...The objective of our study was to explore the possibility of the antifungal efficacy of various micafungin dosage regimens against <i>Candida spp</i> in HIV positive patients with EC. According to pharmacokinetic/pharmacodynamics parameters of micafungin in HIV positive patients and MICs distribution of micafungin against <i>Candida spp</i>. in published studies, the dosage regimens of micafungin were 50, 100 and 150 mg QD iv. Monte Carlo Simulation analysed the probability of target attainment and cumulative fraction of response. The results showed that micafungin has good antifungal effect in treating HIV positive patients with EC when pathomycetes are <i>Candida albicans</i>, <i>Candida glabrata</i> or <i>Candida tropicalis</i>, in dosage at 100 mg QD and 150 mg QD.展开更多
Herein,a ternary supramolecular assembly(BPP-BQ?CB[8]-SCD)is successfully constructed by a bromophenylpyridine-tethered-bromoisoquinoline(BPP-BQ),cucurbit[8]uril(CB[8])and sulfonatedβ-cyclodextrin(SCD)via successive ...Herein,a ternary supramolecular assembly(BPP-BQ?CB[8]-SCD)is successfully constructed by a bromophenylpyridine-tethered-bromoisoquinoline(BPP-BQ),cucurbit[8]uril(CB[8])and sulfonatedβ-cyclodextrin(SCD)via successive assembling way,exhibiting progressively enhanced green roomtemperature phosphorescence(RTP).The self-aggregates of BPP-BQ?CB[8]-SCD accommodate an energy acceptor rhodamine B(Rh B)to form a light-harvesting system(BPP-BQ?CB[8]-SCD@Rh B)with further enhanced yellow long-lifetime luminescence with large Stokes shift based on triplet-singlet F?rster resonance energy transfer(TS-FRET).Crucially,the introduction of a photoactive diarylethene achieves the long-lived photoluminescence of BPP-BQ?CB[8]-SCD@Rh B to be switched with the efficiency of up to98%through logically ordered lowering/enhancing RTP performance of the energy donor and intercepting/restoring TS-FRET pathway,when stimulated by host-vip competition and light illumination in sequence.Moreover,BPP-BQ?CB[8]-SCD@Rh B is evenly doped into polyvinyl alcohol or polyacrylamide to obtain high-performance luminescent films with long afterglow.The abovementioned logically ordered stimulus-switched long-lived emission enables the light-harvesting system in both solution and solid state to be applied in high-security-level information encryption and transformation,and anticounterfeiting.展开更多
This paper extends the previous work[1]for the three-temperature gray radiative transfer equations to the frequency-dependent case.Since the additional frequency variable is considered,the equations are more complicat...This paper extends the previous work[1]for the three-temperature gray radiative transfer equations to the frequency-dependent case.Since the additional frequency variable is considered,the equations are more complicated than those in the gray case.Moreover,opacity may be typically a decreasing function of the frequency variable in applications.At the same spatial location,the equations can be in the optically thick case for low frequency photons,while in the optically thin case for high frequency ones.Thus,the resulting discrete equations can significantly increase the computational cost for opacity having the multi-scale property in multiple frequency radiation.Due to the presence of the radiation-electron coupling,electronion coupling,and electron-ion diffusion terms,the model under consideration exhibits strong nonlinearity and strong coupling properties.In this paper,the multigroup method is used to discretize the frequency variable and the H_(N)^(T)method to discretize the angular variable first.Then,within the framework of a unified gas kinetic scheme(UGKS),a multigroup H_(N)^(T)-UGKS method is constructed to solve this complex model iteratively.Furthermore,it can be shown that as the Knudsen number tends to zero,with variations in the electron-ion coupling,absorption,and scattering coefficients,the multigroup H_(N)^(T)-UGKS scheme can converge to numerical schemes for the single-temperature,two-temperature,and the frequency-dependent three-temperature,two-temperature diffusion limit equations,respectively.Finally,several numerical examples are provided to validate the effectiveness and stability of the proposed scheme.展开更多
<b><span style="font-family:Verdana;">Objective: </span></b><span style="font-family:""><span style="font-family:Verdana;">To select the ingredien...<b><span style="font-family:Verdana;">Objective: </span></b><span style="font-family:""><span style="font-family:Verdana;">To select the ingredients and targets of Yiqing capsule in treating COVID-19 based on network pharmacology, then to explore the potential mechanism of Yiqing capsule in treating COVID-19. </span><b><span style="font-family:Verdana;">Methods:</span></b> </span><span style="font-family:Verdana;">We </span><span style="font-family:Verdana;">screened the ingredients and targets of Yiqing capsule on Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), and target genes for COVID-19 in GeneCards database</span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> constructed drug-ingredient-target</span><span style="font-family:Verdana;"> network through software Cytoscape 3.7.2</span><span style="font-family:Verdana;">,</span><span style="font-family:""> </span><span style="font-family:Verdana;">and </span><span style="font-family:Verdana;">constructed protein protein interaction network (PPI) network through STRING database. Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of key gene targets of Yiqing capsule </span><span style="font-family:Verdana;">are used to</span><span style="font-family:""><span style="font-family:Verdana;"> treat COVID-19 through software R5.3.2. </span><b><span style="font-family:Verdana;">Results</span></b></span><b><span style="font-family:Verdana;">: </span></b><span style="font-family:""><span style="font-family:Verdana;">We got 42 ingredients, 42 potential therapeutic targets, 1643 GO items and 970 pathways in our study. The main pathway including IL-17 signaling pathway, Chagas disease (American trypanosomiasis), Influenza A, and TNF signaling pathway. </span><b><span style="font-family:Verdana;">Conclusion</span></b></span><b><span style="font-family:Verdana;">: </span></b><span style="font-family:Verdana;">Yiqing capsule plays a role in treating COVID-19 through multiple ingredients, multiple targets and multiple pathways.展开更多
基金jointly supported by the National Natural Science Foundation of China [grant numbers U2242205 and 41830969]the S&T Development Fund of CAMS [grant number 2023KJ036]the Basic Scientific Research and Operation Foundation of CAMS [grant number 2023Z018]。
文摘The dominant annual cycle of sea surface temperature(SST)in the tropical Pacific exhibits an antisymmetric mode,which explains 83.4%total variance,and serves as a background of El Niño-Southern Oscillation(ENSO).However,there is no consensus yet on its anomalous impacts on the phase and amplitude of ENSO.Based on data during 1982-2022,results show that anomalies of the antisymmetric mode can affect the evolution of ENSO on the interannual scale via Bjerknes feedback,in which the positive(negative)phase of the antisymmetric mode can strengthen El Niño(La Niña)in boreal winter via an earlier(delayed)seasonal cycle transition and larger(smaller)annual mean.The magnitude of the SST anomalies in the equatorial eastern Pacific can reach more than±0.3◦C,regulated by the changes in the antisymmetric mode based on random sensitivity analysis.Results reveal the spatial pattern of the annual cycle associated with the seasonal phase-locking of ENSO evolution and provide new insight into the impact of the annual cycle of background SST on ENSO,which possibly carries important implications for forecasting ENSO.
文摘The objective of our study was to explore the possibility of the antifungal efficacy of various micafungin dosage regimens against <i>Candida spp</i> in HIV positive patients with EC. According to pharmacokinetic/pharmacodynamics parameters of micafungin in HIV positive patients and MICs distribution of micafungin against <i>Candida spp</i>. in published studies, the dosage regimens of micafungin were 50, 100 and 150 mg QD iv. Monte Carlo Simulation analysed the probability of target attainment and cumulative fraction of response. The results showed that micafungin has good antifungal effect in treating HIV positive patients with EC when pathomycetes are <i>Candida albicans</i>, <i>Candida glabrata</i> or <i>Candida tropicalis</i>, in dosage at 100 mg QD and 150 mg QD.
基金the National Natural Science Foundation of China(Nos.21801063,22305070 and U20041101)the Top-Notch Talents Program of Henan Agricultural University(Nos.30501049 and 30501032)for financial support。
文摘Herein,a ternary supramolecular assembly(BPP-BQ?CB[8]-SCD)is successfully constructed by a bromophenylpyridine-tethered-bromoisoquinoline(BPP-BQ),cucurbit[8]uril(CB[8])and sulfonatedβ-cyclodextrin(SCD)via successive assembling way,exhibiting progressively enhanced green roomtemperature phosphorescence(RTP).The self-aggregates of BPP-BQ?CB[8]-SCD accommodate an energy acceptor rhodamine B(Rh B)to form a light-harvesting system(BPP-BQ?CB[8]-SCD@Rh B)with further enhanced yellow long-lifetime luminescence with large Stokes shift based on triplet-singlet F?rster resonance energy transfer(TS-FRET).Crucially,the introduction of a photoactive diarylethene achieves the long-lived photoluminescence of BPP-BQ?CB[8]-SCD@Rh B to be switched with the efficiency of up to98%through logically ordered lowering/enhancing RTP performance of the energy donor and intercepting/restoring TS-FRET pathway,when stimulated by host-vip competition and light illumination in sequence.Moreover,BPP-BQ?CB[8]-SCD@Rh B is evenly doped into polyvinyl alcohol or polyacrylamide to obtain high-performance luminescent films with long afterglow.The abovementioned logically ordered stimulus-switched long-lived emission enables the light-harvesting system in both solution and solid state to be applied in high-security-level information encryption and transformation,and anticounterfeiting.
基金supported by the Beijing Natural Science Foundation(Z230003)for Sunby the National Key R&D Program(2020YFA0712200)+1 种基金the National Key Project(GJXM92579)the Sino-German Science Center(GZ 1465)for Jiang。
文摘This paper extends the previous work[1]for the three-temperature gray radiative transfer equations to the frequency-dependent case.Since the additional frequency variable is considered,the equations are more complicated than those in the gray case.Moreover,opacity may be typically a decreasing function of the frequency variable in applications.At the same spatial location,the equations can be in the optically thick case for low frequency photons,while in the optically thin case for high frequency ones.Thus,the resulting discrete equations can significantly increase the computational cost for opacity having the multi-scale property in multiple frequency radiation.Due to the presence of the radiation-electron coupling,electronion coupling,and electron-ion diffusion terms,the model under consideration exhibits strong nonlinearity and strong coupling properties.In this paper,the multigroup method is used to discretize the frequency variable and the H_(N)^(T)method to discretize the angular variable first.Then,within the framework of a unified gas kinetic scheme(UGKS),a multigroup H_(N)^(T)-UGKS method is constructed to solve this complex model iteratively.Furthermore,it can be shown that as the Knudsen number tends to zero,with variations in the electron-ion coupling,absorption,and scattering coefficients,the multigroup H_(N)^(T)-UGKS scheme can converge to numerical schemes for the single-temperature,two-temperature,and the frequency-dependent three-temperature,two-temperature diffusion limit equations,respectively.Finally,several numerical examples are provided to validate the effectiveness and stability of the proposed scheme.
文摘<b><span style="font-family:Verdana;">Objective: </span></b><span style="font-family:""><span style="font-family:Verdana;">To select the ingredients and targets of Yiqing capsule in treating COVID-19 based on network pharmacology, then to explore the potential mechanism of Yiqing capsule in treating COVID-19. </span><b><span style="font-family:Verdana;">Methods:</span></b> </span><span style="font-family:Verdana;">We </span><span style="font-family:Verdana;">screened the ingredients and targets of Yiqing capsule on Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), and target genes for COVID-19 in GeneCards database</span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> constructed drug-ingredient-target</span><span style="font-family:Verdana;"> network through software Cytoscape 3.7.2</span><span style="font-family:Verdana;">,</span><span style="font-family:""> </span><span style="font-family:Verdana;">and </span><span style="font-family:Verdana;">constructed protein protein interaction network (PPI) network through STRING database. Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of key gene targets of Yiqing capsule </span><span style="font-family:Verdana;">are used to</span><span style="font-family:""><span style="font-family:Verdana;"> treat COVID-19 through software R5.3.2. </span><b><span style="font-family:Verdana;">Results</span></b></span><b><span style="font-family:Verdana;">: </span></b><span style="font-family:""><span style="font-family:Verdana;">We got 42 ingredients, 42 potential therapeutic targets, 1643 GO items and 970 pathways in our study. The main pathway including IL-17 signaling pathway, Chagas disease (American trypanosomiasis), Influenza A, and TNF signaling pathway. </span><b><span style="font-family:Verdana;">Conclusion</span></b></span><b><span style="font-family:Verdana;">: </span></b><span style="font-family:Verdana;">Yiqing capsule plays a role in treating COVID-19 through multiple ingredients, multiple targets and multiple pathways.
