Thiamin is essential for energy metabolism in humans.Deficiencies lead to cardiovascular and nervous system decline(Smith et al.,2021).Populations across the globe are estimated to have an inadequate intake of thiamin...Thiamin is essential for energy metabolism in humans.Deficiencies lead to cardiovascular and nervous system decline(Smith et al.,2021).Populations across the globe are estimated to have an inadequate intake of thiamin,particularly those relying on staple food sources such as rice(Whitfield et al.,2018).展开更多
Insufficient dietary intake of micronutHents, known as ＂hidden hunger＂, is a devastating global burden, affecting two billion people. Deficiency of folates （vitamin B9）, which are known to play a central role in C...Insufficient dietary intake of micronutHents, known as ＂hidden hunger＂, is a devastating global burden, affecting two billion people. Deficiency of folates （vitamin B9）, which are known to play a central role in Cl metabolism, causes birth defects in at least a quarter million people annually. Biofortification to enhance the level of naturally occurring folates in crop plants, proves to be an efficient and cost-effective tool in fighting folate deficiency. Previously, introduction of folate biosynthesis genes GTPCHI andADCS, proven to be a successful biofortification strategy in rice and tomato, turned out to be insufficient to adequately increase folate levels in potato tubers. Here, we provide a proof of concept that additional introduction of HPPK/DHPS and/or FPGS, downstream genes in mitochonddal folate biosynthesis, enables augmenta- tion of folates to satisfactory levels （12-fold） and ensures folate stability upon long-term storage of tubers. In conclusion, this engineering strategy can serve as a model in the creation of folate-accumulating potato cultivars, readily applicable in potato-consuming populations suffedng from folate deficiency.展开更多
Micronutrient deficiencies include shortages of vitamins and minerals.They affect billions of people and are associated with long-range effects on health,learning ability,and huge economic losses.Biofortification of m...Micronutrient deficiencies include shortages of vitamins and minerals.They affect billions of people and are associated with long-range effects on health,learning ability,and huge economic losses.Biofortification of multiple micronutrients can play an important role in combating malnutrition.The challenge,however,is to balance plant growth with nutrient requirements for humans.Here,we summarize the major progress about vitamin biosynthesis and its response to the changing environment.We discuss the interactions among vitamins as well as possible strategies for vitamin biofortification.Finally,we propose to integrate new breeding technologies with metabolic pathway modification to facilitate the biofortification of crops,thereby alleviating the hidden hunger of target populations.展开更多
(Molecular Plant 14(1):40–60;January 2021;https://doi.org/10.1016/j.molp.2020.11.019)In the"Molecular Marker-Assisted Breeding"section of this article(page 49),the surname of one reference was wrongly provi...(Molecular Plant 14(1):40–60;January 2021;https://doi.org/10.1016/j.molp.2020.11.019)In the"Molecular Marker-Assisted Breeding"section of this article(page 49),the surname of one reference was wrongly provided."citrus(Hou et al.,2019)"should be corrected as"citrus(Zheng et al.,2019)".In the"REFERENCES"section of this article(page 55),the same reference should be corrected from"Hou,X.,Tang,Y.,Ye,J.,Pan,Z,Tan,M.,Xie,M.,Xie,Z.,Chia,L.,Xu,Q.,Fraser,P.D.,and Deng,X.(2019).SLAF-based construction of a high-density genetic map and its application in QTL mapping of carotenoids content in Citrus fruit.J.Agric.Food Chem.,67,994-1002."to"Zheng,X.,Tang,Y.,Ye,J.,Pan,Z,Tan,M.,Xie,Z.,Chai,L.,Xu,Q.,Fraser,P.D.,and Deng,X.(2019).SLAF-based construction of a high-density genetic map and its application in QTL mapping of carotenoids content in Citrus fruit.J.Agric.Food Chem.,67,994-1002.".展开更多
文摘Thiamin is essential for energy metabolism in humans.Deficiencies lead to cardiovascular and nervous system decline(Smith et al.,2021).Populations across the globe are estimated to have an inadequate intake of thiamin,particularly those relying on staple food sources such as rice(Whitfield et al.,2018).
文摘Insufficient dietary intake of micronutHents, known as ＂hidden hunger＂, is a devastating global burden, affecting two billion people. Deficiency of folates （vitamin B9）, which are known to play a central role in Cl metabolism, causes birth defects in at least a quarter million people annually. Biofortification to enhance the level of naturally occurring folates in crop plants, proves to be an efficient and cost-effective tool in fighting folate deficiency. Previously, introduction of folate biosynthesis genes GTPCHI andADCS, proven to be a successful biofortification strategy in rice and tomato, turned out to be insufficient to adequately increase folate levels in potato tubers. Here, we provide a proof of concept that additional introduction of HPPK/DHPS and/or FPGS, downstream genes in mitochonddal folate biosynthesis, enables augmenta- tion of folates to satisfactory levels （12-fold） and ensures folate stability upon long-term storage of tubers. In conclusion, this engineering strategy can serve as a model in the creation of folate-accumulating potato cultivars, readily applicable in potato-consuming populations suffedng from folate deficiency.
基金This work was supported by Ministry of Science and Technology of the People's Republic of China,China(2016YFD0100503 to L.J.)Ghent University Special Research Fund,Belgium(BOF-GOA18-042 to D.V.D.S.)+3 种基金Research Foundation Flanders,Belgium(3G012609 to D.V.D.S.)Ghent University Research Council,Belgium(BOF-PDOC to S.S.)National Natural Science Foundation of China,China(31870283 to L.J.)Agricultural Science and Technology Innovation Program,China(ZDRW202010 to C.Z).
文摘Micronutrient deficiencies include shortages of vitamins and minerals.They affect billions of people and are associated with long-range effects on health,learning ability,and huge economic losses.Biofortification of multiple micronutrients can play an important role in combating malnutrition.The challenge,however,is to balance plant growth with nutrient requirements for humans.Here,we summarize the major progress about vitamin biosynthesis and its response to the changing environment.We discuss the interactions among vitamins as well as possible strategies for vitamin biofortification.Finally,we propose to integrate new breeding technologies with metabolic pathway modification to facilitate the biofortification of crops,thereby alleviating the hidden hunger of target populations.
文摘(Molecular Plant 14(1):40–60;January 2021;https://doi.org/10.1016/j.molp.2020.11.019)In the"Molecular Marker-Assisted Breeding"section of this article(page 49),the surname of one reference was wrongly provided."citrus(Hou et al.,2019)"should be corrected as"citrus(Zheng et al.,2019)".In the"REFERENCES"section of this article(page 55),the same reference should be corrected from"Hou,X.,Tang,Y.,Ye,J.,Pan,Z,Tan,M.,Xie,M.,Xie,Z.,Chia,L.,Xu,Q.,Fraser,P.D.,and Deng,X.(2019).SLAF-based construction of a high-density genetic map and its application in QTL mapping of carotenoids content in Citrus fruit.J.Agric.Food Chem.,67,994-1002."to"Zheng,X.,Tang,Y.,Ye,J.,Pan,Z,Tan,M.,Xie,Z.,Chai,L.,Xu,Q.,Fraser,P.D.,and Deng,X.(2019).SLAF-based construction of a high-density genetic map and its application in QTL mapping of carotenoids content in Citrus fruit.J.Agric.Food Chem.,67,994-1002.".
