The known complexity of eukaryotic transcriptomes has been greatly expanded due to the identification of a large family of circular RNAs in recent years [1-3]. As a special form of RNA compared to the ＂common＂ linea...The known complexity of eukaryotic transcriptomes has been greatly expanded due to the identification of a large family of circular RNAs in recent years [1-3]. As a special form of RNA compared to the ＂common＂ linear form, these molecules were first described in 1976, when it was discov- ered that several plant viroids were single-stranded and co- valently closed circular RNAs [4].展开更多
A major portion of the mammalian genome is transcribed to produce large numbers of noncoding RNAs(ncRNAs).During the past decade,the discovery of small RNAs,including the microRNAs(miRNA) and small interfering RNAs(si...A major portion of the mammalian genome is transcribed to produce large numbers of noncoding RNAs(ncRNAs).During the past decade,the discovery of small RNAs,including the microRNAs(miRNA) and small interfering RNAs(siRNA),has led to important advances in biology.The breadth of the ncRNA field of study has substantially expanded and many recent results have revealed a range of functions that can be attributed to the miRNAs and other ncRNAs.For example,H19 RNA,HOTAIR RNA,transcribed ultraconserved regions(T-UCRs),natural antisense RNA,transfer RNA and mitochondrial noncoding RNA have been suggested to play important roles in cancers and other diseases as well as in diverse cellular processes.In this review,we focus on the current status of several classes of ncRNAs associated with cancer with the emphasis on those that are not microRNAs.展开更多
Animals interact with their environments all the time,and must react to all kinds of factors present in the environments.Environmental RNA interference refers to the phenomenon that exogenous RNA molecules can enter c...Animals interact with their environments all the time,and must react to all kinds of factors present in the environments.Environmental RNA interference refers to the phenomenon that exogenous RNA molecules can enter cells of certain animal species and interfere with gene expression of these animals.These exogenous RNAs may be molecules in animal food,or may be present in the living environment from other sources.Molecular pathways for the cell entry of environmental RNAs and further for their functionality in gene interference have started to be revealed in the animal model Caenorhabditis elegans.Here we highlight some known examples of environmental RNA interference(RNAi)in animals and introduce the molecular mechanisms underneath.展开更多
Some two hundred and forty members of the Chinese worm community gathered together for the 3rd Chinese Caeno- rhabditis elegans meeting at School of Life Sciences, Uni- versity of Science and Technology of China.
文摘The known complexity of eukaryotic transcriptomes has been greatly expanded due to the identification of a large family of circular RNAs in recent years [1-3]. As a special form of RNA compared to the ＂common＂ linear form, these molecules were first described in 1976, when it was discov- ered that several plant viroids were single-stranded and co- valently closed circular RNAs [4].
基金supported by the National Basic Research Program of China (2011CBA01103)National Natural Science Foundation of China (31071132)the Fundamental Research Funds for the Central Universities (HUST:2010ZD022)
文摘A major portion of the mammalian genome is transcribed to produce large numbers of noncoding RNAs(ncRNAs).During the past decade,the discovery of small RNAs,including the microRNAs(miRNA) and small interfering RNAs(siRNA),has led to important advances in biology.The breadth of the ncRNA field of study has substantially expanded and many recent results have revealed a range of functions that can be attributed to the miRNAs and other ncRNAs.For example,H19 RNA,HOTAIR RNA,transcribed ultraconserved regions(T-UCRs),natural antisense RNA,transfer RNA and mitochondrial noncoding RNA have been suggested to play important roles in cancers and other diseases as well as in diverse cellular processes.In this review,we focus on the current status of several classes of ncRNAs associated with cancer with the emphasis on those that are not microRNAs.
基金supported by the National Basic Research Program of China(2011CBA01103)National Natural Science Foundation of China(81171074,91232702,and 31071132)the Knowledge Innovation Project of CAS(1731112304041)to G.Shan
文摘Animals interact with their environments all the time,and must react to all kinds of factors present in the environments.Environmental RNA interference refers to the phenomenon that exogenous RNA molecules can enter cells of certain animal species and interfere with gene expression of these animals.These exogenous RNAs may be molecules in animal food,or may be present in the living environment from other sources.Molecular pathways for the cell entry of environmental RNAs and further for their functionality in gene interference have started to be revealed in the animal model Caenorhabditis elegans.Here we highlight some known examples of environmental RNA interference(RNAi)in animals and introduce the molecular mechanisms underneath.
文摘Some two hundred and forty members of the Chinese worm community gathered together for the 3rd Chinese Caeno- rhabditis elegans meeting at School of Life Sciences, Uni- versity of Science and Technology of China.
