[Objectives]To establish a multi-indicator quality control method for the retention of Longqing Capsule based on the principle of prescription of Chinese medicine.[Methods]High performance liquid chromatography(HPLC)w...[Objectives]To establish a multi-indicator quality control method for the retention of Longqing Capsule based on the principle of prescription of Chinese medicine.[Methods]High performance liquid chromatography(HPLC)with ShimNex CS C 18 as the column;column temperature:35℃;wavelength:270 nm;methanol-0.1%phosphoric acid solution as the mobile phase with gradient elution.[Results]The 12 components of the retention of Longqing Capsule showed good linearity within the investigated range(r≥0.9995),with the average spiked recoveries of 97.83%-100.52%and the RSD of 0.9%-2.1%.[Conclusions]The method is exclusive,sensitive,reproducible,simple and easy to use,and can provide a reference for the construction of the quality standard and control system of Longqing Capsule based on the theory of traditional Chinese medicine.展开更多
依托高压气源,建立了高压临界流文丘里喷嘴气体流量标准装置。在小流量的校准实验中,标准临界流文丘里喷嘴(CFVN)阵列上游的温度场分布对测量不确定度具有重要影响。针对标准CFVN阵列上游的温度场,在喉径8.251 mm CFVN的校准实验中,分...依托高压气源,建立了高压临界流文丘里喷嘴气体流量标准装置。在小流量的校准实验中,标准临界流文丘里喷嘴(CFVN)阵列上游的温度场分布对测量不确定度具有重要影响。针对标准CFVN阵列上游的温度场,在喉径8.251 mm CFVN的校准实验中,分析和对比了3种不同标准CFVN阵列组合方式以及不同流量下的温度场分布特性。实验结果表明:小流量下,标准CFVN阵列上游的最大温差为1.97 K,随着管内流量增加,温度场分布不均匀性降低;3种不同标准CFVN阵列组合方式下,阵列上游最大温差在1.10~1.97 K之间变化。因此,为提高滞止温度测量精度,需要优化小流量下的温度测量方法。展开更多
Constructing silicon(Si)-based composite electrodes that possess high energy density,long cycle life,and fast charging capability simultaneously is critical for the development of high performance lithium-ion batterie...Constructing silicon(Si)-based composite electrodes that possess high energy density,long cycle life,and fast charging capability simultaneously is critical for the development of high performance lithium-ion batteries for mitigating range anxiety and slow charging issues in new energy vehicles.Herein,a thick silicon/carbon composite electrode with vertically aligned channels in the thickness direction(VC-SC)is constructed by employing a bubble formation method.Both experimental characterizations and theoretical simulations confirm that the obtained vertical channel structure can effectively address the problem of sluggish ion transport caused by high tortuosity in conventional thick electrodes,conspicuously enhance reaction kinetics,reduce polarization and side reactions,mitigate stress,increase the utilization of active materials,and promote cycling stability of the thick electrode.Consequently,when paired with LiNi_(0.6)Co_(0.2)Mn_(0.2)O_(2)(NCM622),the VC-SC||NCM622 pouch type full cell(~6.0 mAh cm^(-2))exhibits significantly improved rate performance and capacity retention compared with the SC||NCM622 full cell with the conventional silicon/carbon composite electrode without channels(SC)as the anode.The assembled VC-SC||NCM622 pouch full cell with a high energy density of 490.3 Wh kg^(-1)also reveals a remarkable fast charging capability at a high current density of 2.0 mA cm^(-2),with a capacity retention of 72.0%after 500 cycles.展开更多
AIM： To evaluate the long-term outcome of viscocanalostomy combined with trabeculotomy and mitomycin C in the treatment of primary congenital glaucoma. METHODS： This is a retrospective study. Forty-two eyes of 26 p...AIM： To evaluate the long-term outcome of viscocanalostomy combined with trabeculotomy and mitomycin C in the treatment of primary congenital glaucoma. METHODS： This is a retrospective study. Forty-two eyes of 26 patients with primary congenital glaucoma were enrolled, Intraocular pressure （lOP）, corneal diameter （mm） and cup/disc （C/D） were measured before and after the surgery respectively. Follow-up period was 30mo. RESULTS： The mean preoperative lOP was 30.6：1：7.35 mm Hg. Of the 42 eyes, 2 eyes were required conversion to trabeculectomy for the absence of Schlemm＇s canal. Of remained 40 eyes, 38 eyes （95%） achieved successful lOP control. The average postoperative lOP was 11.69±4.18 mm Hg at 12mo. The mean reduction was 18.91 mm Hg （P〈0.00Ol）. Eighteen （75%） eyes presented a reduction in corneal diameter, and 25 （62.5%） eyes presented a C/D ratio reversal after the surgery. There was no serious complication in any patients over the follow-up period. CONCLUSION： Viscocanalostomy combined with trabeculotomy and mitomycin C is useful in the management of primary congenital glaucoma,展开更多
BACKGROUND Cervical cancer survivors of childbearing age often face heightened reproductive anxiety due to the direct impact of the disease and its treatments on fertility.This anxiety may exacerbate psychological bur...BACKGROUND Cervical cancer survivors of childbearing age often face heightened reproductive anxiety due to the direct impact of the disease and its treatments on fertility.This anxiety may exacerbate psychological burdens,including depressive symptoms and fear of recurrence,significantly impacting quality of life.AIM To examine whether reproductive concerns partially mediate the relationship between depressive symptoms and fear of recurrence in cervical cancer patients of childbearing age.METHODS Utilizing a cross-sectional design with convenience sampling,208 eligible cervical cancer patients(aged 18-45 years,stable condition,and aware of diagnosis)from three tertiary hospitals completed validated questionnaires:The Reproductive Concerns After Cancer Scale,Patient Health Questionnaire-9,and Fear of Cancer Recurrence Questionnaire.Structural equation modeling was used to assess the mediating role of reproductive concerns in the relationship between depression and fear of recurrence.RESULTS Reproductive concerns demonstrated significant positive correlations with depression(r=0.477,P<0.001)and fear of recurrence(r=0.426,P<0.001).Structural equation modeling analysis revealed that reproductive concerns acted as a significant partial mediator between depression and fear of recurrence.The indirect effect via reproductive concerns was significant(β_indirect=0.152,P<0.001),accounting for 28.1% of the total effect of depression on fear of recurrence.CONCLUSION Identified path reveals fertility anxiety links depression to recurrence fear.Targeted psych interventions for repro concerns may ease both in childbearing cervical cancer survivors.展开更多
BACKGROUND Global tumor incidence rises and therapies advance,driving oncology nursing specialization.Granting nurses prescriptive authority optimizes care but polarizes nurses'attitudes due to factors like risk a...BACKGROUND Global tumor incidence rises and therapies advance,driving oncology nursing specialization.Granting nurses prescriptive authority optimizes care but polarizes nurses'attitudes due to factors like risk and competence,hindering policy implementation.AIM To investigate the current status of the attitudes of oncology specialist nurses toward having prescribing authority,specifically concerning symptom management and supportive care in oncology practice,and we conducted a path analysis of their influencing factors.METHODS As participants in the survey,oncology specialist nurses working in hospitals of different grades in Jiangsu Province were selected from March 2025 to May 2025 using a stratified sampling method.The questionnaires were administered using the general information questionnaire,the beliefs and attitudes about nurses'prescriptive authority scale,the nurses'professional identity scale,and the selfefficacy scale.Pearson’s method was used to analyze the correlation between beliefs and attitudes about the prescriptive authority,professional identity,and self-efficacy of nurses.Multiple linear regression was performed to analyze the factors influencing the beliefs and attitudes of nurses’prescriptive authority.The Amos plug-in was used to construct structural equation models to analyze the influencing pathways.RESULTS A total of 329 questionnaires were distributed,and 328 valid questionnaires were returned(effective recovery rate:99.70%).The total score of the 328 oncology nurses on the beliefs and attitudes about nurses'prescriptive authority scale was 101.88±15.13,indicating a moderately high level.Univariate analysis revealed that gender and hospital grade were associated with this score(P<0.05).The Pearson correlation analysis revealed that self-efficacy was positively correlated with the scores of the beliefs and attitudes about nurses’prescriptive authority scale and the nurses’professional identity scale(r=0.4999,P<0.0001 and r=0.7048,P<0.05,respectively),whereas occupational identity was positively correlated only with the former(r=0.6209,P<0.05).Multiple linear regression analysis revealed occupational identity and self-efficacy as the factors influencing the scores of the beliefs and attitudes about nurses’prescriptive authority scale(P<0.05).The results of the path analysis revealed that selfefficacy significantly positively affected nurses’occupational identity and their beliefs and attitudes about having prescriptive authority;occupational identity played a mediating role between the two,with a mediating effect accounting for 54.46% of the total effect,and the structural equation model was well-fitted.CONCLUSION Oncology nurses have more positive attitudes toward prescriptive authority.In addition,self-efficacy positively and indirectly affects nurses’attitudes toward prescriptive authority through the mediating effect of occupational identity.This can be used as a basis for clinical practice to take targeted measures to improve nurses’self-efficacy and occupational identity,thus creating favorable conditions for effectively implementing the policy of prescriptive authority.展开更多
BACKGROUND Cervical cancer,a prevalent gynecological malignancy,exhibits recurrence rates of 30%-50%post-treatment,with recurrent cases facing a dire 10%-20%long-term survival rate,severely impacting patients’mental ...BACKGROUND Cervical cancer,a prevalent gynecological malignancy,exhibits recurrence rates of 30%-50%post-treatment,with recurrent cases facing a dire 10%-20%long-term survival rate,severely impacting patients’mental health and quality of life.Fear of cancer recurrence(FCR)emerges as a critical psychological challenge,often leading to anxiety,social avoidance,and even suicidal tendencies.Despite its high prevalence,structured,evidence-based interventions for FCR in cervical cancer remain scarce,with most studies focusing on general psychological support rather than targeted strategies.The fear of progression theory provides a theoretical framework,highlighting cognitive-emotional conflicts arising from perceived threats of disease recurrence.Addressing this gap,this study developed a specialized,phased psychological intervention program grounded in fear of progression theory,aiming to reduce FCR and enhance resilience in cervical cancer survivors through multi-disciplinary strategies.AIM To establish a psychological intervention program to support the fear of cervical cancer recurrence and to alleviate the psychological pressure of patients after cervical cancer surgery.METHODS Thirteen experts were selected to conduct two rounds of correspondence through literature review and group discussions to amend the psychological intervention draft and form the basis for the psychological intervention.The selected experts also performed two rounds of correspondence to revise the psychological intervention draft and outline the first draft,and pre-experiments were conducted for further improvement of the psychological intervention program.Experiments were performed in 80 patients with cervical cancer to further improve the psychological intervention program of relapse fear support.RESULTS The expert authority coefficient of the first and second rounds was higher than 0.8,indicating high authority.The coordination coefficient>0.8 indicated high consistency with high significance(all P<0.05).The FCR Inventory,Kessler Psychological Distress Scale,Psychological Distress Thermometer,and General Hospital Anxiety and Depression Scale scores at 3 and 6 months in the study group were lower than those of the control group,and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 and Perceived Social Support Scale scores were higher than those of the control group(P<0.05).CONCLUSION The psychological intervention program of relapse fear support which considers the individual differences between patients and expert opinions,has a good scientific and practical basis,and can be used to enhance the quality of life of patients.展开更多
Thick electrode,with its feasibility and cost-effectiveness in lithium-ion batteries(LIBs),has attracted significant attention as a promising approach maximizing the energy density of battery.Through raising the mass ...Thick electrode,with its feasibility and cost-effectiveness in lithium-ion batteries(LIBs),has attracted significant attention as a promising approach maximizing the energy density of battery.Through raising the mass loading of active materials without altering the fundamental chemical attributes,thick electrodes can boost the energy density of the batteries effectively.Nevertheless,as the thickness of the electrode increases,the ionic conductivity of the electrode decreases,leading to abominable polarization in the thickness direction,which severely hampers the practical application of a thick electrode.This work proposes a novel porous gradient design of high-performance thick electrodes for LIBs.By constructing a porous structure that serves as a fast transport pathway for lithium(Li)ions,the ion transport kinetics within thick electrodes are significantly enhanced.Meanwhile,a particle size gradient design is incorporated to further mitigate polarization effects within the electrode,leading to substantial improvements in reaction homogeneity and material utilization.Employing this strategy,we have fabricated a porous gradient nanocellulose-carbon-nanotube based thick electrode,which exhibits an impressive capacity retention of 86.7%at a high mass loading of LiCoO_(2)(LCO)active material(20 mg cm^(-2))and a high current density of 5mA cm^(-2).展开更多
基金Supported by Provincial University Scientific Research Platform Team Project of Guizhou Provincial Department of Education(Qianjiaoji[2022]No.010).
文摘[Objectives]To establish a multi-indicator quality control method for the retention of Longqing Capsule based on the principle of prescription of Chinese medicine.[Methods]High performance liquid chromatography(HPLC)with ShimNex CS C 18 as the column;column temperature:35℃;wavelength:270 nm;methanol-0.1%phosphoric acid solution as the mobile phase with gradient elution.[Results]The 12 components of the retention of Longqing Capsule showed good linearity within the investigated range(r≥0.9995),with the average spiked recoveries of 97.83%-100.52%and the RSD of 0.9%-2.1%.[Conclusions]The method is exclusive,sensitive,reproducible,simple and easy to use,and can provide a reference for the construction of the quality standard and control system of Longqing Capsule based on the theory of traditional Chinese medicine.
文摘依托高压气源,建立了高压临界流文丘里喷嘴气体流量标准装置。在小流量的校准实验中,标准临界流文丘里喷嘴(CFVN)阵列上游的温度场分布对测量不确定度具有重要影响。针对标准CFVN阵列上游的温度场,在喉径8.251 mm CFVN的校准实验中,分析和对比了3种不同标准CFVN阵列组合方式以及不同流量下的温度场分布特性。实验结果表明:小流量下,标准CFVN阵列上游的最大温差为1.97 K,随着管内流量增加,温度场分布不均匀性降低;3种不同标准CFVN阵列组合方式下,阵列上游最大温差在1.10~1.97 K之间变化。因此,为提高滞止温度测量精度,需要优化小流量下的温度测量方法。
基金National Key R&D Program of China,Grant/Award Number:2023YFB2503900National Natural Science Foundation of China,Grant/Award Number:12172143Shenzhen Science and Technology Program,Grant/Award Numbers:JCYJ20220818100418040,JCYJ20220530160816038。
文摘Constructing silicon(Si)-based composite electrodes that possess high energy density,long cycle life,and fast charging capability simultaneously is critical for the development of high performance lithium-ion batteries for mitigating range anxiety and slow charging issues in new energy vehicles.Herein,a thick silicon/carbon composite electrode with vertically aligned channels in the thickness direction(VC-SC)is constructed by employing a bubble formation method.Both experimental characterizations and theoretical simulations confirm that the obtained vertical channel structure can effectively address the problem of sluggish ion transport caused by high tortuosity in conventional thick electrodes,conspicuously enhance reaction kinetics,reduce polarization and side reactions,mitigate stress,increase the utilization of active materials,and promote cycling stability of the thick electrode.Consequently,when paired with LiNi_(0.6)Co_(0.2)Mn_(0.2)O_(2)(NCM622),the VC-SC||NCM622 pouch type full cell(~6.0 mAh cm^(-2))exhibits significantly improved rate performance and capacity retention compared with the SC||NCM622 full cell with the conventional silicon/carbon composite electrode without channels(SC)as the anode.The assembled VC-SC||NCM622 pouch full cell with a high energy density of 490.3 Wh kg^(-1)also reveals a remarkable fast charging capability at a high current density of 2.0 mA cm^(-2),with a capacity retention of 72.0%after 500 cycles.
文摘AIM： To evaluate the long-term outcome of viscocanalostomy combined with trabeculotomy and mitomycin C in the treatment of primary congenital glaucoma. METHODS： This is a retrospective study. Forty-two eyes of 26 patients with primary congenital glaucoma were enrolled, Intraocular pressure （lOP）, corneal diameter （mm） and cup/disc （C/D） were measured before and after the surgery respectively. Follow-up period was 30mo. RESULTS： The mean preoperative lOP was 30.6：1：7.35 mm Hg. Of the 42 eyes, 2 eyes were required conversion to trabeculectomy for the absence of Schlemm＇s canal. Of remained 40 eyes, 38 eyes （95%） achieved successful lOP control. The average postoperative lOP was 11.69±4.18 mm Hg at 12mo. The mean reduction was 18.91 mm Hg （P〈0.00Ol）. Eighteen （75%） eyes presented a reduction in corneal diameter, and 25 （62.5%） eyes presented a C/D ratio reversal after the surgery. There was no serious complication in any patients over the follow-up period. CONCLUSION： Viscocanalostomy combined with trabeculotomy and mitomycin C is useful in the management of primary congenital glaucoma,
基金Supported by National Natural Science Foundation Youth Project,No.72204123China Social Welfare Foundation-Nurse Care Fund,No.HLCXKT-20230130.
文摘BACKGROUND Cervical cancer survivors of childbearing age often face heightened reproductive anxiety due to the direct impact of the disease and its treatments on fertility.This anxiety may exacerbate psychological burdens,including depressive symptoms and fear of recurrence,significantly impacting quality of life.AIM To examine whether reproductive concerns partially mediate the relationship between depressive symptoms and fear of recurrence in cervical cancer patients of childbearing age.METHODS Utilizing a cross-sectional design with convenience sampling,208 eligible cervical cancer patients(aged 18-45 years,stable condition,and aware of diagnosis)from three tertiary hospitals completed validated questionnaires:The Reproductive Concerns After Cancer Scale,Patient Health Questionnaire-9,and Fear of Cancer Recurrence Questionnaire.Structural equation modeling was used to assess the mediating role of reproductive concerns in the relationship between depression and fear of recurrence.RESULTS Reproductive concerns demonstrated significant positive correlations with depression(r=0.477,P<0.001)and fear of recurrence(r=0.426,P<0.001).Structural equation modeling analysis revealed that reproductive concerns acted as a significant partial mediator between depression and fear of recurrence.The indirect effect via reproductive concerns was significant(β_indirect=0.152,P<0.001),accounting for 28.1% of the total effect of depression on fear of recurrence.CONCLUSION Identified path reveals fertility anxiety links depression to recurrence fear.Targeted psych interventions for repro concerns may ease both in childbearing cervical cancer survivors.
文摘BACKGROUND Global tumor incidence rises and therapies advance,driving oncology nursing specialization.Granting nurses prescriptive authority optimizes care but polarizes nurses'attitudes due to factors like risk and competence,hindering policy implementation.AIM To investigate the current status of the attitudes of oncology specialist nurses toward having prescribing authority,specifically concerning symptom management and supportive care in oncology practice,and we conducted a path analysis of their influencing factors.METHODS As participants in the survey,oncology specialist nurses working in hospitals of different grades in Jiangsu Province were selected from March 2025 to May 2025 using a stratified sampling method.The questionnaires were administered using the general information questionnaire,the beliefs and attitudes about nurses'prescriptive authority scale,the nurses'professional identity scale,and the selfefficacy scale.Pearson’s method was used to analyze the correlation between beliefs and attitudes about the prescriptive authority,professional identity,and self-efficacy of nurses.Multiple linear regression was performed to analyze the factors influencing the beliefs and attitudes of nurses’prescriptive authority.The Amos plug-in was used to construct structural equation models to analyze the influencing pathways.RESULTS A total of 329 questionnaires were distributed,and 328 valid questionnaires were returned(effective recovery rate:99.70%).The total score of the 328 oncology nurses on the beliefs and attitudes about nurses'prescriptive authority scale was 101.88±15.13,indicating a moderately high level.Univariate analysis revealed that gender and hospital grade were associated with this score(P<0.05).The Pearson correlation analysis revealed that self-efficacy was positively correlated with the scores of the beliefs and attitudes about nurses’prescriptive authority scale and the nurses’professional identity scale(r=0.4999,P<0.0001 and r=0.7048,P<0.05,respectively),whereas occupational identity was positively correlated only with the former(r=0.6209,P<0.05).Multiple linear regression analysis revealed occupational identity and self-efficacy as the factors influencing the scores of the beliefs and attitudes about nurses’prescriptive authority scale(P<0.05).The results of the path analysis revealed that selfefficacy significantly positively affected nurses’occupational identity and their beliefs and attitudes about having prescriptive authority;occupational identity played a mediating role between the two,with a mediating effect accounting for 54.46% of the total effect,and the structural equation model was well-fitted.CONCLUSION Oncology nurses have more positive attitudes toward prescriptive authority.In addition,self-efficacy positively and indirectly affects nurses’attitudes toward prescriptive authority through the mediating effect of occupational identity.This can be used as a basis for clinical practice to take targeted measures to improve nurses’self-efficacy and occupational identity,thus creating favorable conditions for effectively implementing the policy of prescriptive authority.
文摘BACKGROUND Cervical cancer,a prevalent gynecological malignancy,exhibits recurrence rates of 30%-50%post-treatment,with recurrent cases facing a dire 10%-20%long-term survival rate,severely impacting patients’mental health and quality of life.Fear of cancer recurrence(FCR)emerges as a critical psychological challenge,often leading to anxiety,social avoidance,and even suicidal tendencies.Despite its high prevalence,structured,evidence-based interventions for FCR in cervical cancer remain scarce,with most studies focusing on general psychological support rather than targeted strategies.The fear of progression theory provides a theoretical framework,highlighting cognitive-emotional conflicts arising from perceived threats of disease recurrence.Addressing this gap,this study developed a specialized,phased psychological intervention program grounded in fear of progression theory,aiming to reduce FCR and enhance resilience in cervical cancer survivors through multi-disciplinary strategies.AIM To establish a psychological intervention program to support the fear of cervical cancer recurrence and to alleviate the psychological pressure of patients after cervical cancer surgery.METHODS Thirteen experts were selected to conduct two rounds of correspondence through literature review and group discussions to amend the psychological intervention draft and form the basis for the psychological intervention.The selected experts also performed two rounds of correspondence to revise the psychological intervention draft and outline the first draft,and pre-experiments were conducted for further improvement of the psychological intervention program.Experiments were performed in 80 patients with cervical cancer to further improve the psychological intervention program of relapse fear support.RESULTS The expert authority coefficient of the first and second rounds was higher than 0.8,indicating high authority.The coordination coefficient>0.8 indicated high consistency with high significance(all P<0.05).The FCR Inventory,Kessler Psychological Distress Scale,Psychological Distress Thermometer,and General Hospital Anxiety and Depression Scale scores at 3 and 6 months in the study group were lower than those of the control group,and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 and Perceived Social Support Scale scores were higher than those of the control group(P<0.05).CONCLUSION The psychological intervention program of relapse fear support which considers the individual differences between patients and expert opinions,has a good scientific and practical basis,and can be used to enhance the quality of life of patients.
基金financially supported by the National Key R&D Program of China(2023YFB2503900)the National Natural Science Foundation of China(U22A20140,52072138)the Shenzhen Science and Technology Program(JCYJ20220818100418040,JCYJ20220530160816038)。
文摘Thick electrode,with its feasibility and cost-effectiveness in lithium-ion batteries(LIBs),has attracted significant attention as a promising approach maximizing the energy density of battery.Through raising the mass loading of active materials without altering the fundamental chemical attributes,thick electrodes can boost the energy density of the batteries effectively.Nevertheless,as the thickness of the electrode increases,the ionic conductivity of the electrode decreases,leading to abominable polarization in the thickness direction,which severely hampers the practical application of a thick electrode.This work proposes a novel porous gradient design of high-performance thick electrodes for LIBs.By constructing a porous structure that serves as a fast transport pathway for lithium(Li)ions,the ion transport kinetics within thick electrodes are significantly enhanced.Meanwhile,a particle size gradient design is incorporated to further mitigate polarization effects within the electrode,leading to substantial improvements in reaction homogeneity and material utilization.Employing this strategy,we have fabricated a porous gradient nanocellulose-carbon-nanotube based thick electrode,which exhibits an impressive capacity retention of 86.7%at a high mass loading of LiCoO_(2)(LCO)active material(20 mg cm^(-2))and a high current density of 5mA cm^(-2).
