摘要
卵巢癌是致死率最高的妇科恶性肿瘤,其复发和耐药与脂质代谢重编程密切相关。研究表明,脂质代谢异常通过核心代谢酶的异常激活,促进脂肪酸和胆固醇合成,改变细胞膜流动性并驱动致癌信号传导。同时,肿瘤微环境中的腹水、外泌体和免疫细胞通过脂质转运与代谢重塑,进一步增强肿瘤转移和铂类耐药。此外,脂质代谢还与表观遗传修饰和免疫检查点调控相互作用,共同重塑免疫应答并诱导免疫逃逸。这些机制协同作用,维持了癌细胞的存活、侵袭和耐药表型。因此,靶向脂质代谢的关键节点或相关通路不仅有望成为卵巢癌诊断和预后的分子标志物,也可为代谢干预与免疫调节的联合治疗策略提供理论依据,展现出重要的临床转化价值。
Ovarian cancer is a gynecological malignant tumor with the highest mortality rate,and its recurrence and drug resistance are closely related to lipid metabolism reprogramming.Studies have shown that abnormal lipid metabolism promotes the synthesis of fatty acid and cholesterol through the abnormal activation of core metabolic enzymes,alters the fluidity of the cell membrane,and drives oncogenic signal transduction.Meanwhile,ascites,exosomes,and immune cells in the tumor microenvironment further enhance tumor metastasis and platinum resistance through lipid transport and metabolic remodeling.Moreover,lipid metabolism interacts with epigenetic modifications and immune checkpoint regulation to reshape the immune response and induce immune escape.These mechanisms work together to maintain the survival,invasion,and drug-resistant phenotypes of cancer cells.Therefore,targeting the key nodes or related pathways of lipid metabolism is not only expected to become molecular markers for the diagnosis and prognosis of ovarian cancer,but also provides a theoretical basis for the combined treatment strategy of metabolic intervention and immune regulation,showing important clinical translational value.
作者
秦晨
张玮
李力
QIN Chen;ZHANG Wei;LI Li(Life Sciences Institute,Guangxi Medical University,Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University),Ministry of Education,Nanning 530021,China;Cancer Prevention and Control Research Institute,Guangxi Zhuang Autonomous Region,Nanning 530021,China;Department of Gynecologic Oncology,Guangxi Medical University Cancer Hospital,Nanning 530021,China)
出处
《国际妇产科学杂志》
2025年第5期492-497,共6页
Journal of International Obstetrics and Gynecology
基金
国家自然科学基金(82160450)。
关键词
卵巢肿瘤
脂类代谢
肿瘤微环境
抗药性
表型
Ovarian neoplasms
Lipid metabolism
Tumor microenvironment
Drug resistance
Phenotype
