Low heat input welding is widely used in the industry.The microstructure and toughness of the welded joints under low heat input conditions have received less attention than those under high heat input.The impact toug...Low heat input welding is widely used in the industry.The microstructure and toughness of the welded joints under low heat input conditions have received less attention than those under high heat input.The impact toughness,microstructure and failure mechanisms of the coarse-grain heat-affected zone(CGHAZ)in a micro-alloyed steel were investigated by welding thermal simulation with the heat input ranging from 15 to 65 kJ/cm.The impact toughness of CGHAZ is highly sensitive to variations in low heat input.The failure mechanisms were discussed from the viewpoints of micro-voids formation and micro-cracks propagation.The micro-voids are preferred to be formed and grow at soft phase of grain boundary ferrite(GBF).At the heat inputs no more than 22 kJ/cm,martensite was dominantly formed,and the micro-cracks initiated from the GBF were propagated into the grain interiors,leading to the brittle fracture and low toughness.When the heat input was increased to 31.2 kJ/cm,granular bainite became the dominant constitute,causing cracks to deflect away from GBF and propagate into prior austenite grains.The high density high-angle and low-angle grain boundaries and the presence of retained austenite,effectively restricted the crack propagation,resulting in ductile fracture behavior and enhanced toughness.High heat input(62.3 kJ/cm)promoted coarse GBF formation,providing continuous paths for microcrack propagation.This direct intergranular crack progression caused brittle fracture and low toughness.Industrial cold cracking in the CGHAZ can thus be controlled by heat input optimization to maximize toughness.展开更多
Zokors in the genus Eospalax,which are endemic to northern and western China,are subterranean rodents that inhabit various niches,including grasslands,high-altitude meadows,forests,and farmlands.Six species in Eospala...Zokors in the genus Eospalax,which are endemic to northern and western China,are subterranean rodents that inhabit various niches,including grasslands,high-altitude meadows,forests,and farmlands.Six species in Eospalax were described a century ago but their taxonomy and phylogeny remain controversial.In this study,we performed high-depth whole-genome sequencing of 47 zokor samples,comprising all six previously described species.Genomic analyses revealed a reliable and robust phylogeny of Eospalax and supported the validity of the six named species.According to the inferred phylogenetic relationships,Eospalax first divergent into two clades in the early Pliocene(ca.4.68 million years ago(Ma)),one inhabiting the highaltitude Qinghai-Xizang(Tibet)Plateau(QTP)and adjacent regions,and the another inhabiting the lowaltitude Loess Plateau and Qinling-Daba Mountains.The most recent divergences occurred between E.baileyi and E.smithii and between E.rufescens and E.rothschildi in the late Pliocene(ca.2.09 and 2.19 Ma,respectively).We also collected specimens of zokors in the southern Hengduan Mountains(Muli County,Sichuan Province),far from the known distributions of all other zokors.Morphological and molecular analyses strongly suggested that the specimens represent a new species,formally described here as Eospalax muliensis sp.nov.The new species belongs to the high-altitude clade and diverged from closely related species(ca.4.22 Ma)shortly after the first divergence in Eospalax.Interestingly,Eospalax muliensis sp.nov.possesses more supposedly plesiomorphic characters,suggesting a possible origin of the genus in the Hengduan Mountains.展开更多
Isotopic fractionation is the basis of tracing the water cycle using hydrogen and oxygen isotopes. Isotopic fractionation factors in water evaporating from free water bodies are mainly affected by temperature and rela...Isotopic fractionation is the basis of tracing the water cycle using hydrogen and oxygen isotopes. Isotopic fractionation factors in water evaporating from free water bodies are mainly affected by temperature and relative humidity, and vary significantly with these atmospheric factors over the course of a day. The evaporation rate （E） can reveal the effects of atmospheric factors. Therefore, there should be a certain functional relationship between isotopic fractionation factors and E. An average isotopic fractionation factor （ t~＊ ） was defined to describe isotopic differences between vapor and liquid phases in evaporation with time intervals of days. The relationship between or＊ and E based on the isotopic mass balance was investigated through an evaporation pan experiment with no inflow. The experimental results showed that the isotopic compositions of residual water were more enriched with time; tr＊ was affected by air temperature, relative humidity, and other atmospheric factors, and had a strong functional relation with E. The values of 0~＊ can be easily calculated with the known values of E, the initial volume of water in the pan, and isotopic compositions of residual water.展开更多
针对燃气-蒸汽联合循环且余热锅炉不补燃的热电联产机组(combined power and heat unit,CHP),首先,基于能量守恒建立天然气流量与电力电压、电流的等值关系,进而考虑功率进行变换的物理特性,构建CHP的气电变换等效电路;考虑功率进行传...针对燃气-蒸汽联合循环且余热锅炉不补燃的热电联产机组(combined power and heat unit,CHP),首先,基于能量守恒建立天然气流量与电力电压、电流的等值关系,进而考虑功率进行变换的物理特性,构建CHP的气电变换等效电路;考虑功率进行传递、释放的物理特性,构建CHP的气热转换、烟气排放及运行热损失方程;据此,确立CHP的物理特性等值模型,并定义该模型“以热定电”和“以电定热”策略下的控制参量。其次,利用牛顿法和管网水力计算基本原理,推导电潮流和气、热能流的修正方程及其雅可比元素表达式,提出计及CHP固有特性参数随系统运行状态变化的气-电-热混合能流统一分析方法。最后,通过具有不同CHP控制策略的气-电-热混合系统,验证所提方法的有效性及可行性。展开更多
This paper addresses the consensus problem of nonlinear multi-agent systems subject to external disturbances and uncertainties under denial-ofservice(DoS)attacks.Firstly,an observer-based state feedback control method...This paper addresses the consensus problem of nonlinear multi-agent systems subject to external disturbances and uncertainties under denial-ofservice(DoS)attacks.Firstly,an observer-based state feedback control method is employed to achieve secure control by estimating the system's state in real time.Secondly,by combining a memory-based adaptive eventtriggered mechanism with neural networks,the paper aims to approximate the nonlinear terms in the networked system and efficiently conserve system resources.Finally,based on a two-degree-of-freedom model of a vehicle affected by crosswinds,this paper constructs a multi-unmanned ground vehicle(Multi-UGV)system to validate the effectiveness of the proposed method.Simulation results show that the proposed control strategy can effectively handle external disturbances such as crosswinds in practical applications,ensuring the stability and reliable operation of the Multi-UGV system.展开更多
This guideline summarizes evidence-based recommendations for cleansing and antisepsis in chronic wounds.It defines target populations,assessment and decision frameworks,preferred cleansing solutions and pressures,indi...This guideline summarizes evidence-based recommendations for cleansing and antisepsis in chronic wounds.It defines target populations,assessment and decision frameworks,preferred cleansing solutions and pressures,indications and limits for antiseptics,biofilm-oriented strategies,pain control,and adaptations for high-risk patients and low-resource settings.The aim is to optimize wound bed preparation,protect viable tissue,reduce infection and iatrogenic injury,and standardize outpatient and home-care practice.展开更多
Enhancing homogenization efficiency and hot-workability is the key issue for wrought superalloys in the industry.A novel approach for simultaneous accelerating the homogenization kinetics and improving hot-workability...Enhancing homogenization efficiency and hot-workability is the key issue for wrought superalloys in the industry.A novel approach for simultaneous accelerating the homogenization kinetics and improving hot-workability via a simple way of prior hot-deformation was proposed,which was not widely accepted for wrought superalloys.The homogenization efficiency is increased by 40%-70%via performing 10%-20%prior hot-deformation.Both theoretical and experimental analyses revealed that the increment in homogenization efficiency is mainly attributed to the decrease in interdendritic-segregation spacing,and thus the necessary diffusion distance,rather than that of dislocations.In addition,dynamic and static recrystallizations occurred during the prior hot-deformation and diffusion-annealing processes,and the grains were significantly refined even after the homogenization.Furthermore,the size of the precipitates was refined as well.These enhanced the hot-workability of the homogenized ingot for the subsequent cogging process.展开更多
Regulating lithium(Li)salt decomposition to construct a stable solid electrolyte interphase(SEI)represents a pivotal strategy for mitigating Li dendrite and unlocking the full potential of polymer-based all-solid-stat...Regulating lithium(Li)salt decomposition to construct a stable solid electrolyte interphase(SEI)represents a pivotal strategy for mitigating Li dendrite and unlocking the full potential of polymer-based all-solid-state Li metal batteries.However,this approach necessitates precise manipulation of the coordination chemistry and decomposition kinetics of Li-salt anions,which remains a formidable challenge in the field.Herein,we unveil a molecular docking-guided design framework that correlates the molecular topology of ligands with bis(trifluoromethanesulfonyl)imide(TFSI-)anion coordination chemistry in poly(ethylene oxide)(PEO)-based solid polymer electrolytes.Theoretical calculations and experimental investigations elucidate that short-chain dithiols(e.g.,1,2-ethanedithiol,C2)exhibit optimal spatial complementarity and superior molecular docking efficacy with TFSI-compared to long-chain analogues.Intermolecular hydrogen bonding redistributes electron density toward TFSI-,promoting its decomposition and enhancing LiF content in the SEI,thereby effectively suppressing Li dendrite growth.Consequently,the Li||LiFePO_(4)cells equipped with PEO-LiTFSI-C2 electrolyte achieve a remarkable 99.2%capacity retention after 580 cycles at 1.0 C,surpassing both long-chain dithiol systems and most previously reported electrolytes.This work provides mechanistic insights into the anion-coordination-mediated SEI formation process.Furthermore,the molecular docking is expected to play a significant role in understanding and researching the interfacial chemistry of allsolid-state Li metal batteries.展开更多
Transcatheter arterial embolization(TAE)is the mainstay for treating advanced hepatocellular carcinoma(HCC),and the performance of the embolization material is crucial in TAE.With the development of medical imaging an...Transcatheter arterial embolization(TAE)is the mainstay for treating advanced hepatocellular carcinoma(HCC),and the performance of the embolization material is crucial in TAE.With the development of medical imaging and the birth of“X-ray-free”technologies,we designed a new dual-mode imaging material of dimethoxy tetraphenyl ethylene(DMTPE)via emulsification by mixing poly(N-isopropylacrylamide-co-acrylic acid)(PNA)with lipiodol and fluorocarbons,which was evaluated for temperature sensitivity,stability,and dual-mode visualization in vitro.Additionally,blood vessel casting embolization and renal artery imaging were assessed in healthy rabbits.In a rabbit model with a VX2 tumor,the effectiveness of TAE for treating HCC was examined,with an emphasis on evaluating long-term outcomes of embolization and its effects on tumor growth,necrosis,and proliferation through imaging techniques.In vitro experiments confirmed that the temperature-sensitive dual-oil-phase Pickering emulsion had good flow,stable contrast,and embolism when the oil-to-oil ratio and water-to-oil ratio were both 7:3(v/v)and stabilized with 8%PNA.Similarly,in vivo,arterial embolization confirmed the excellent properties of DMTPE prepared at the abovementioned ratios.It was observed that DMTPE not only has an antitumor effect but can also achieve dual imaging using X-rays and ultrasound,making it a promising excellent vascular embolization material for TAE in tumor treatment.展开更多
Crohn’s Disease (CD) is a chronic recurrent inflammatory bowel disease with unknown etiology, most common in the terminal ileum and adjacent colon. In the past 30 years, the global prevalence of CD has continued to r...Crohn’s Disease (CD) is a chronic recurrent inflammatory bowel disease with unknown etiology, most common in the terminal ileum and adjacent colon. In the past 30 years, the global prevalence of CD has continued to rise. Although the etiology is unknown, studies have shown that it is closely related to geographical environment, microfold cell damage, intestinal flora changes, epithelial barrier damage, immune dysfunction and low. The main clinical manifestations of CD are abdominal pain, chronic diarrhea, fatigue, fever and weight loss. At present, 5-aminosalicylic acid, antibiotics, glucocorticoids, immunosuppressants and biological agents are mainly used for treatment, but the drug effect is limited and the effect is not good. Recent studies have shown that Mesenchymal Stem Cells (MSC) can down-regulate immune response and promote tissue healing, which has certain safety and effectiveness in the treatment of moderate and severe CD, and has broad application prospects, but also has certain limitations. This paper summarizes the application and efficacy of related therapies in CD, providing a reference for clinicians.展开更多
[目的/意义]随着人工智能技术的发展与应用,其衍生的伦理问题日益受到关注,但是国内从理论或技术层面防范人工智能伦理冲突的情报评述非常有限,收集人工智能伦理知识情报是当下人工智能健康发展的迫切需求。[方法/过程]借助CitespaceⅢ...[目的/意义]随着人工智能技术的发展与应用,其衍生的伦理问题日益受到关注,但是国内从理论或技术层面防范人工智能伦理冲突的情报评述非常有限,收集人工智能伦理知识情报是当下人工智能健康发展的迫切需求。[方法/过程]借助CitespaceⅢ对选自Web of Science的人工智能伦理领域文献进行知识图谱分析,分别利用检索式#1“人工智能伦理”主题文献与检索式#2“机器人伦理”主题文献进行全面且科学的知识聚类议题探析。[结果/结论]在聚类分析的基础上从人工智能载体的道德主体性研究、机器人的伦理价值敏感设计、人工道德智慧研究与人工智能技术的伦理控制四个方面对人工智能伦理研究领域进行了总结与展望。展开更多
基金supported by the National Natural Science Foundation of China(No.51804232)Beijing Municipal Natural Science Foundation(No.2212041)+1 种基金supported by the Interdisciplinary Research Project for Young Teachers of USTB(Fundamental Research Funds for the Central Universities)(FRF-IDRY-20-020)GIMRT Program of the Institute for Materials Research,Tohoku University(202303-RDKGE-0518).
文摘Low heat input welding is widely used in the industry.The microstructure and toughness of the welded joints under low heat input conditions have received less attention than those under high heat input.The impact toughness,microstructure and failure mechanisms of the coarse-grain heat-affected zone(CGHAZ)in a micro-alloyed steel were investigated by welding thermal simulation with the heat input ranging from 15 to 65 kJ/cm.The impact toughness of CGHAZ is highly sensitive to variations in low heat input.The failure mechanisms were discussed from the viewpoints of micro-voids formation and micro-cracks propagation.The micro-voids are preferred to be formed and grow at soft phase of grain boundary ferrite(GBF).At the heat inputs no more than 22 kJ/cm,martensite was dominantly formed,and the micro-cracks initiated from the GBF were propagated into the grain interiors,leading to the brittle fracture and low toughness.When the heat input was increased to 31.2 kJ/cm,granular bainite became the dominant constitute,causing cracks to deflect away from GBF and propagate into prior austenite grains.The high density high-angle and low-angle grain boundaries and the presence of retained austenite,effectively restricted the crack propagation,resulting in ductile fracture behavior and enhanced toughness.High heat input(62.3 kJ/cm)promoted coarse GBF formation,providing continuous paths for microcrack propagation.This direct intergranular crack progression caused brittle fracture and low toughness.Industrial cold cracking in the CGHAZ can thus be controlled by heat input optimization to maximize toughness.
基金supported by the Second Tibetan Plateau Scientific Expedition and Research(STEP)Program(2019QZKK05010218,2019QZKK05010110)National Natural Science Foundation of China(32100339,31871277)+2 种基金supported by the Yunling Scholar ProjectTen-Thousand Talents Plan of Yunnan Provincesupported by the Youth Innovation Promotion Association,Chinese Academy of Sciences。
文摘Zokors in the genus Eospalax,which are endemic to northern and western China,are subterranean rodents that inhabit various niches,including grasslands,high-altitude meadows,forests,and farmlands.Six species in Eospalax were described a century ago but their taxonomy and phylogeny remain controversial.In this study,we performed high-depth whole-genome sequencing of 47 zokor samples,comprising all six previously described species.Genomic analyses revealed a reliable and robust phylogeny of Eospalax and supported the validity of the six named species.According to the inferred phylogenetic relationships,Eospalax first divergent into two clades in the early Pliocene(ca.4.68 million years ago(Ma)),one inhabiting the highaltitude Qinghai-Xizang(Tibet)Plateau(QTP)and adjacent regions,and the another inhabiting the lowaltitude Loess Plateau and Qinling-Daba Mountains.The most recent divergences occurred between E.baileyi and E.smithii and between E.rufescens and E.rothschildi in the late Pliocene(ca.2.09 and 2.19 Ma,respectively).We also collected specimens of zokors in the southern Hengduan Mountains(Muli County,Sichuan Province),far from the known distributions of all other zokors.Morphological and molecular analyses strongly suggested that the specimens represent a new species,formally described here as Eospalax muliensis sp.nov.The new species belongs to the high-altitude clade and diverged from closely related species(ca.4.22 Ma)shortly after the first divergence in Eospalax.Interestingly,Eospalax muliensis sp.nov.possesses more supposedly plesiomorphic characters,suggesting a possible origin of the genus in the Hengduan Mountains.
基金supported by the National Natural Science Foundation of China (Grants No.50679024,40901015,and 41001011)the Fundamental Research Funds for the Central Universities (Grants No.B1020072 and B1020062)+2 种基金the Ph. D. Programs Foundation of the Ministry of Education of China (Grant No.20090094120008)the Special Fund of the State Key Laboratory of China (Grant No.2009586412)the Science Foundation of the HydroChina Chengdu Engineering Corporation (Grant No.P058)
文摘Isotopic fractionation is the basis of tracing the water cycle using hydrogen and oxygen isotopes. Isotopic fractionation factors in water evaporating from free water bodies are mainly affected by temperature and relative humidity, and vary significantly with these atmospheric factors over the course of a day. The evaporation rate （E） can reveal the effects of atmospheric factors. Therefore, there should be a certain functional relationship between isotopic fractionation factors and E. An average isotopic fractionation factor （ t~＊ ） was defined to describe isotopic differences between vapor and liquid phases in evaporation with time intervals of days. The relationship between or＊ and E based on the isotopic mass balance was investigated through an evaporation pan experiment with no inflow. The experimental results showed that the isotopic compositions of residual water were more enriched with time; tr＊ was affected by air temperature, relative humidity, and other atmospheric factors, and had a strong functional relation with E. The values of 0~＊ can be easily calculated with the known values of E, the initial volume of water in the pan, and isotopic compositions of residual water.
文摘针对燃气-蒸汽联合循环且余热锅炉不补燃的热电联产机组(combined power and heat unit,CHP),首先,基于能量守恒建立天然气流量与电力电压、电流的等值关系,进而考虑功率进行变换的物理特性,构建CHP的气电变换等效电路;考虑功率进行传递、释放的物理特性,构建CHP的气热转换、烟气排放及运行热损失方程;据此,确立CHP的物理特性等值模型,并定义该模型“以热定电”和“以电定热”策略下的控制参量。其次,利用牛顿法和管网水力计算基本原理,推导电潮流和气、热能流的修正方程及其雅可比元素表达式,提出计及CHP固有特性参数随系统运行状态变化的气-电-热混合能流统一分析方法。最后,通过具有不同CHP控制策略的气-电-热混合系统,验证所提方法的有效性及可行性。
基金The National Natural Science Foundation of China(W2431048)The Science and Technology Research Program of Chongqing Municipal Education Commission,China(KJZDK202300807)The Chongqing Natural Science Foundation,China(CSTB2024NSCQQCXMX0052).
文摘This paper addresses the consensus problem of nonlinear multi-agent systems subject to external disturbances and uncertainties under denial-ofservice(DoS)attacks.Firstly,an observer-based state feedback control method is employed to achieve secure control by estimating the system's state in real time.Secondly,by combining a memory-based adaptive eventtriggered mechanism with neural networks,the paper aims to approximate the nonlinear terms in the networked system and efficiently conserve system resources.Finally,based on a two-degree-of-freedom model of a vehicle affected by crosswinds,this paper constructs a multi-unmanned ground vehicle(Multi-UGV)system to validate the effectiveness of the proposed method.Simulation results show that the proposed control strategy can effectively handle external disturbances such as crosswinds in practical applications,ensuring the stability and reliable operation of the Multi-UGV system.
文摘This guideline summarizes evidence-based recommendations for cleansing and antisepsis in chronic wounds.It defines target populations,assessment and decision frameworks,preferred cleansing solutions and pressures,indications and limits for antiseptics,biofilm-oriented strategies,pain control,and adaptations for high-risk patients and low-resource settings.The aim is to optimize wound bed preparation,protect viable tissue,reduce infection and iatrogenic injury,and standardize outpatient and home-care practice.
基金supported by the National Natural Science Foundation of China(No.51804232)Beijing Municipal Natural Science Foundation(No.2212041)+1 种基金supported by the Interdisciplinary Research Project for Young Teachers of USTB(Fundamental Research Funds for the Central Universities)(FRF-IDRY-20-020)GIMRT Program of the Institute for Materials Research,Tohoku University(202303-RDKGE-0518).
文摘Enhancing homogenization efficiency and hot-workability is the key issue for wrought superalloys in the industry.A novel approach for simultaneous accelerating the homogenization kinetics and improving hot-workability via a simple way of prior hot-deformation was proposed,which was not widely accepted for wrought superalloys.The homogenization efficiency is increased by 40%-70%via performing 10%-20%prior hot-deformation.Both theoretical and experimental analyses revealed that the increment in homogenization efficiency is mainly attributed to the decrease in interdendritic-segregation spacing,and thus the necessary diffusion distance,rather than that of dislocations.In addition,dynamic and static recrystallizations occurred during the prior hot-deformation and diffusion-annealing processes,and the grains were significantly refined even after the homogenization.Furthermore,the size of the precipitates was refined as well.These enhanced the hot-workability of the homogenized ingot for the subsequent cogging process.
基金financial support from the National Natural Science Foundation of China(grants 52225208,52171225,U21A20174,52222317)the Energy Revolution S&T Program of Yulin Innovation Institute of Clean Energy(grant E411010316)+1 种基金the “Pioneer”and “Leading Goose”R&D Program of Zhejiang(grants 2025C01157,2025C01182)the Natural Science Foundation of Zhejiang province(grants LZ24E020006,LQN25B030005)。
文摘Regulating lithium(Li)salt decomposition to construct a stable solid electrolyte interphase(SEI)represents a pivotal strategy for mitigating Li dendrite and unlocking the full potential of polymer-based all-solid-state Li metal batteries.However,this approach necessitates precise manipulation of the coordination chemistry and decomposition kinetics of Li-salt anions,which remains a formidable challenge in the field.Herein,we unveil a molecular docking-guided design framework that correlates the molecular topology of ligands with bis(trifluoromethanesulfonyl)imide(TFSI-)anion coordination chemistry in poly(ethylene oxide)(PEO)-based solid polymer electrolytes.Theoretical calculations and experimental investigations elucidate that short-chain dithiols(e.g.,1,2-ethanedithiol,C2)exhibit optimal spatial complementarity and superior molecular docking efficacy with TFSI-compared to long-chain analogues.Intermolecular hydrogen bonding redistributes electron density toward TFSI-,promoting its decomposition and enhancing LiF content in the SEI,thereby effectively suppressing Li dendrite growth.Consequently,the Li||LiFePO_(4)cells equipped with PEO-LiTFSI-C2 electrolyte achieve a remarkable 99.2%capacity retention after 580 cycles at 1.0 C,surpassing both long-chain dithiol systems and most previously reported electrolytes.This work provides mechanistic insights into the anion-coordination-mediated SEI formation process.Furthermore,the molecular docking is expected to play a significant role in understanding and researching the interfacial chemistry of allsolid-state Li metal batteries.
基金supported by the Hubei Province Nature Science Foundation of China(Grant No.:2023AFB1077)the National Natural Science Foundation of China(Grant No.:82003308)+2 种基金the Doctoral Start-up Fund Project of Hubei University of Science and Technology,China(Grant No.:BK202118)the Innovation team and Medical research program of Hubei University of Science and Technology,China(Grant Nos.:2023T10 and 2022YKY05)the Hubei Province Key R&D Plan Big Health Local Special Project,China(Grant No.:2022BCE042).
文摘Transcatheter arterial embolization(TAE)is the mainstay for treating advanced hepatocellular carcinoma(HCC),and the performance of the embolization material is crucial in TAE.With the development of medical imaging and the birth of“X-ray-free”technologies,we designed a new dual-mode imaging material of dimethoxy tetraphenyl ethylene(DMTPE)via emulsification by mixing poly(N-isopropylacrylamide-co-acrylic acid)(PNA)with lipiodol and fluorocarbons,which was evaluated for temperature sensitivity,stability,and dual-mode visualization in vitro.Additionally,blood vessel casting embolization and renal artery imaging were assessed in healthy rabbits.In a rabbit model with a VX2 tumor,the effectiveness of TAE for treating HCC was examined,with an emphasis on evaluating long-term outcomes of embolization and its effects on tumor growth,necrosis,and proliferation through imaging techniques.In vitro experiments confirmed that the temperature-sensitive dual-oil-phase Pickering emulsion had good flow,stable contrast,and embolism when the oil-to-oil ratio and water-to-oil ratio were both 7:3(v/v)and stabilized with 8%PNA.Similarly,in vivo,arterial embolization confirmed the excellent properties of DMTPE prepared at the abovementioned ratios.It was observed that DMTPE not only has an antitumor effect but can also achieve dual imaging using X-rays and ultrasound,making it a promising excellent vascular embolization material for TAE in tumor treatment.
文摘Crohn’s Disease (CD) is a chronic recurrent inflammatory bowel disease with unknown etiology, most common in the terminal ileum and adjacent colon. In the past 30 years, the global prevalence of CD has continued to rise. Although the etiology is unknown, studies have shown that it is closely related to geographical environment, microfold cell damage, intestinal flora changes, epithelial barrier damage, immune dysfunction and low. The main clinical manifestations of CD are abdominal pain, chronic diarrhea, fatigue, fever and weight loss. At present, 5-aminosalicylic acid, antibiotics, glucocorticoids, immunosuppressants and biological agents are mainly used for treatment, but the drug effect is limited and the effect is not good. Recent studies have shown that Mesenchymal Stem Cells (MSC) can down-regulate immune response and promote tissue healing, which has certain safety and effectiveness in the treatment of moderate and severe CD, and has broad application prospects, but also has certain limitations. This paper summarizes the application and efficacy of related therapies in CD, providing a reference for clinicians.
文摘[目的/意义]随着人工智能技术的发展与应用,其衍生的伦理问题日益受到关注,但是国内从理论或技术层面防范人工智能伦理冲突的情报评述非常有限,收集人工智能伦理知识情报是当下人工智能健康发展的迫切需求。[方法/过程]借助CitespaceⅢ对选自Web of Science的人工智能伦理领域文献进行知识图谱分析,分别利用检索式#1“人工智能伦理”主题文献与检索式#2“机器人伦理”主题文献进行全面且科学的知识聚类议题探析。[结果/结论]在聚类分析的基础上从人工智能载体的道德主体性研究、机器人的伦理价值敏感设计、人工道德智慧研究与人工智能技术的伦理控制四个方面对人工智能伦理研究领域进行了总结与展望。
