Exogenous neural stem cell transplantation has become one of the most promising treatment methods for chronic stroke.Recent studies have shown that most ischemia-reperfusion model rats recover spontaneously after inju...Exogenous neural stem cell transplantation has become one of the most promising treatment methods for chronic stroke.Recent studies have shown that most ischemia-reperfusion model rats recover spontaneously after injury,which limits the ability to observe long-term behavioral recovery.Here,we used a severe stroke rat model with 150 minutes of ischemia,which produced severe behavioral deficiencies that persisted at 12 weeks,to study the therapeutic effect of neural stem cells on neural restoration in chronic stroke.Our study showed that stroke model rats treated with human neural stem cells had long-term sustained recovery of motor function,reduced infarction volume,long-term human neural stem cell survival,and improved local inflammatory environment and angiogenesis.We also demonstrated that transplanted human neural stem cells differentiated into mature neurons in vivo,formed stable functional synaptic connections with host neurons,and exhibited the electrophysiological properties of functional mature neurons,indicating that they replaced the damaged host neurons.The findings showed that human fetal-derived neural stem cells had long-term effects for neurological recovery in a model of severe stroke,which suggests that human neural stem cells-based therapy may be effective for repairing damaged neural circuits in stroke patients.展开更多
Optical orbital angular momentum(OAM)mode multiplexing has emerged as a promising technique for boosting communication capacity.However,most existing studies have concentrated on channel(de)-multiplexing,overlooking t...Optical orbital angular momentum(OAM)mode multiplexing has emerged as a promising technique for boosting communication capacity.However,most existing studies have concentrated on channel(de)-multiplexing,overlooking the critical aspect of channel routing.This challenge involves the reallocation of multiplexed OAM modes across both spatial and temporal domains—a vital step for developing versatile communication networks.To address this gap,we introduce a novel approach based on the time evolution of OAM modes,utilizing the orthogonal conversion and diffractive modulation capabilities of unitary transformations.This approach facilitates high-dimensional orthogonal transformations of OAM mode vectors,altering both the propagation direction and the spatial location.Using Fresnel diffraction matrices as unitary operators,it manipulates the spatial locations of light beams during transmission,breaking the propagation invariance and enabling temporal evolution.As a demonstration,we have experimentally implemented the deep routing of four OAM modes within two distinct time sequences.Achieving an average diffraction efficiency above 78.31%,we have successfully deep-routed 4.69 Tbit-s^(-1)quadrature phase-shift keying(QPSK)signals carried by four multiplexed OAM channels,with a bit error rate below 10^(-6).These results underscore the efficacy of our routing strategy and its promising prospects for practical applications.展开更多
Objective: To determine the prognostic implications and clinical significance of epidermal growth factor receptor variant Ⅲ(EGFRvⅢ) expression and EGFRvⅢ nuclear translocation in Chinese human gliomas.Methods: We r...Objective: To determine the prognostic implications and clinical significance of epidermal growth factor receptor variant Ⅲ(EGFRvⅢ) expression and EGFRvⅢ nuclear translocation in Chinese human gliomas.Methods: We retrospectively examined EGFRvⅢ expression and EGFRvⅢ nuclear translocation using immunohistochemistry in specimens of 240 Chinese patients with glioma, including 84 World Health Organization(WHO) II gliomas, 84 WHO Ⅲ gliomas and 72 glioblastomas(WHO IV). Factors that correlated with EGFRvⅢ and EGFRvⅢ nuclear translocation expression were analyzed by the Chi-square test. Kaplan-Meier methodology and Cox regression were used for the survival analysis.Results: Log-rank tests showed that patient age, Karnofsky performance scale(KPS) score, tumor grade,EGFRvⅢ expression, EGFRvⅢ nuclear translocation, 1 p/19 q codeletion, isocitrate dehydrogenase(IDH)mutation, Ki-67 labeling index and O6-methylguanine-DNA methyltransferase(MGMT) status(P<0.05) were significantly correlated with overall survival(OS) time. Multivariate Cox regression analysis revealed that patient age, tumor grade, EGFRvⅢ nuclear translocation, 1 p/19 q codeletion, and IDH mutation(P<0.05) were significantly correlated with OS. Patients with a high level of EGFRvⅢ nuclear translocation(≥7%) had both significantly shorter OS [hazard ratio(HR): 1.920, 95% confidence interval(95% CI): 1.228-3.003, P=0.004] and progression-free survival(PFS) times(HR: 1.661, 95% CI: 1.116-2.471, P=0.012) than those with a low level of EGFRvⅢ nuclear translocation(<7%).Conclusions: A high level of EGFRvⅢ nuclear translocation in glioma is an independent factor indicating a poor prognosis, but EGFRvⅢ expression is not an independent clinical prognostic factor. The level of EGFRvⅢ nuclear translocation maybe a novel and crucial prognostic biomarker in glioma.展开更多
Arsenic （As） is ubiquitous in the environment in the carcinogenic inorganic forms, posing risks to human health in many parts of the world. Many microorganisms have evolved a series of mechanisms to cope with inorga...Arsenic （As） is ubiquitous in the environment in the carcinogenic inorganic forms, posing risks to human health in many parts of the world. Many microorganisms have evolved a series of mechanisms to cope with inorganic arsenic in their growth media such as transforming As compounds into volatile derivatives. Bio-volatilization of As has been suggested to play an important role in global As biogeochemical cycling, and can also be explored as a potential method for arsenic bioremediation. This review aims to provide an overview of the quality and quantity of As volatilization by fungi, bacteria, microalga and protozoans. Arsenic bio-volatilization is influenced by both biotic and abiotic factors that can be manipulated/elucidated for the purpose of As bioremediation. Since As bio- volatilization is a resurgent topic for both biogeochemistry and environmental health, our review serves as a concept paper for future research directions.展开更多
Cu@MOF core-shell nanowires are synthesized by introducing oxidizable and CTAB-modified metal nanowires as self-engaged templates and supporting MOFs for a one-dimension nanostructure.The following thermal process is ...Cu@MOF core-shell nanowires are synthesized by introducing oxidizable and CTAB-modified metal nanowires as self-engaged templates and supporting MOFs for a one-dimension nanostructure.The following thermal process is controlled to obtain several one-dimension structure s ofCuCo-mixed materials,such as nanorods,single-shell and double-shell nanowires.The hollow structure for electrode materials enlarges the surface area,provides buffer space for electrolyte to accelerate the ion/charge transfers and for the structure to reduce injuries of volume expansion during cycling.Together with some other merits,such as adequate oxidation of the MOFs,small crystal grains of the material,and well-mixed Cu/Co oxides,the double-shell Cu@MOF nanowires(CuCo-DS5)applied for pseudocapacitors deliver advanced electrochemical performance with a specific capacitance of 563.8 F g^(-1)at 1 A g^(-1)as well as an outstanding cycling stability with a 92%retention after 3000 cycles at 5 A g^(-1).Meanwhile,an asymmetric pseudocapacitor constructed with the CuCo-DS5 and active carbon(AC)shows a high specific capacitance and energy density.展开更多
The use of broadband laser technology is a novel approach for inhibiting processes related to laser plasma interactions(LPIs).In this study,several preliminary experiments into broadband-laser-driven LPIs are carried ...The use of broadband laser technology is a novel approach for inhibiting processes related to laser plasma interactions(LPIs).In this study,several preliminary experiments into broadband-laser-driven LPIs are carried out using a newly established hundreds-of-joules broadband second-harmonic-generation laser facility.Through direct comparison with LPI results for a traditional narrowband laser,the actual LPI-suppression effect of the broadband laser is shown.The broadband laser had a clear suppressive effect on both back-stimulated Raman scattering and back-stimulated Brillouin scattering at laser intensities below 1×10^(15) W cm^(−2).An abnormal hot-electron phenomenon is also investigated,using targets of different thicknesses.展开更多
Single-layered zirconium pentatelluride （ZrTes） has been predicted to be a large-gap two-dimensional （2D） topolog- ical insulator, which has attracted particular attention in topological phase transitions and pote...Single-layered zirconium pentatelluride （ZrTes） has been predicted to be a large-gap two-dimensional （2D） topolog- ical insulator, which has attracted particular attention in topological phase transitions and potential device applications. Herein, we investigated the transport properties in ZrTe5 films as a function of thickness, ranging from a few nm to several hundred nm. We determined that the temperature of the resistivity anomaly peak （Tp） tends to increase as the thickness decreases. Moreover, at a critical thickness of ~ 40 rim, the dominating carriers in the films change from n-type to p-type. A comprehensive investigation of Shubnikov-de Hass （SdH） oscillations and Hall resistance at variable temperatures revealed a multi-carrier transport tendency in the thin films. We determined the carrier densities and mobilities of two majority car- riers using the simplified two-carrier model. The electron carriers can be attributed to the Dirac band with a non-trivial Berry phase ~, while the hole carriers may originate from surface chemical reaction or unintentional doping during the microfabrication process. It is necessary to encapsulate the ZrTe5 film in an inert or vacuum environment to potentially achieve a substantial improvement in device quality.展开更多
We report the observation of in-plane anisotropic magnetoresistance and planar Hall effect in non-magnetic HfTe_(5) thin layers.The observed anisotropic magnetoresistance as well as its sign is strongly dependent on t...We report the observation of in-plane anisotropic magnetoresistance and planar Hall effect in non-magnetic HfTe_(5) thin layers.The observed anisotropic magnetoresistance as well as its sign is strongly dependent on the critical resistivity anomaly temperature T_(p).Below T_(p),the anisotropic magnetoresistance is negative with large negative magnetoresistance.When the in-plane magnetic field is perpendicular to the current,the negative longitudinal magnetoresistance reaches its maximum.The negative longitudinal magnetoresistance effect in HfTe_(5) thin layers is dramatically different from that induced by the chiral anomaly as observed in Weyl and Dirac semimetals.One potential underlying origin may be attributed to the reduced spin scattering,which arises from the in-plane magnetic field driven coupling between the top and bottom surface states.Our findings provide valuable insights for the anisotropic magnetoresistance effect in topological electronic systems and the device potential of HfTe5 in spintronics and quantum sensing.展开更多
River crab industry plays an important role in agriculture in Nanjing City,Jiangsu Province.In recent years,with the renewal of breeding mode,the breeding of improved varieties and the construction of brand,the river ...River crab industry plays an important role in agriculture in Nanjing City,Jiangsu Province.In recent years,with the renewal of breeding mode,the breeding of improved varieties and the construction of brand,the river crab industry has made great progress.Taking the aquaculture enterprises and major breeding farmers in the main producing areas of river crab as the main research object,this paper makes a survey on the river crab industry in Nanjing.Based on fishery statistical data and comparison with advanced areas,this paper makes an in-depth analysis on the current situation,existing problems and development measures of Nanjing river crab industry,and it is recommended to make full use of external opportunities and give full play to its own advantages,in order to make Nanjing river crab industry develop healthily and rapidly.展开更多
T lymphocytes,the main participants of cellular immunity,can express a variety of surface molecules and form different lymphocyte subsets under the induction of different factors to play the functions of immune regula...T lymphocytes,the main participants of cellular immunity,can express a variety of surface molecules and form different lymphocyte subsets under the induction of different factors to play the functions of immune regulation and immune killing.Studies have shown that platelets play a crucial role in maintaining the stable differentiation of lymphocytes and the balance in immunomodulation.Therefore,it is necessary to study the effect of platelets on lymphocytes in vitro to better understand the role of platelets in the immune system and broaden the application of adoptive immunotherapy.Methods:Cell counting and microscopic observation were used to detect the effect of activated platelets on lymphocyte proliferation in vitro;Flow cytometry was used to detect whether changes in platelet activity affect the proportion of lymphocyte subpopulations in vitro,and to detect differences in the expression of granzyme B;lactate dehydrogenase assay(LDH)was used to determine the difference in lymphocyte killing activity caused by platelet activity in vitro.Results:This was the first to promote lymphocyte proliferation through the expression or release of certain molecules in vitro,demonstrating that platelet activation is one of the key factors.Secondly,activated platelets or inactivated platelets promoted lymphocyte subset differentiation by enhancing the proportion of CD3+CD8+T lymphocytes(CTL cells)but had a slight effect on the proportion of CD3+CD4+T(Th cells)and CD4+CD25+T lymphocytes(Treg cells).Then,it was found that either activated platelets or inactivated platelets down-regulated the proportion of natural killer(NK)T lymphocytes,while activated platelets significantly enhance the proportion of NK lymphocytes.Therefore,by further detecting the killing activity of PBMCs treated with platelets,it was found that activated platelets promoted the extensive anti-tumor activity of lymphocytes and significantly increased the expression of granzyme B.Conclusion:Our results suggest that activated platelets promote lymphocyte proliferation,optimize lymphocyte subpopulation ratio,and promote cytotoxic effect of lymphocytes in vitro,which may provide a new strategy for optimizing the adoptive immunotherapy culture system and improving its efficacy.展开更多
Given a pan-space ?and a nonnegative measurable function f on measurable space (X, A), the pan-integral of f with respect to monotone measure μ and pan-operation ?determines a new monotone measure ?on?(X, A). Such th...Given a pan-space ?and a nonnegative measurable function f on measurable space (X, A), the pan-integral of f with respect to monotone measure μ and pan-operation ?determines a new monotone measure ?on?(X, A). Such the new monotone measure ?is absolutely continuous with respect to the monotone measure μ. We show that the new monotone measure preserves some important structural characteristics of the original monotone measures, such as continuity from below, subadditivity, null-additivity, weak null-additivity and (S) property. Since the pan-integral based on a pair of pan-operations ?covers the Sugeno integral (based on ) and the Shilkret integral (based on ), therefore, the previous related results for the Sugeno integral are covered by the results presented here, in the meantime, some special results related the Shilkret integral are also obtained.展开更多
Supercritical carbon dioxide(S-CO_(2))Brayton power cycle power generation technology,has attracted more and more scholars'attention in recent years because of its advantages of high efficiency and flexibility.Com...Supercritical carbon dioxide(S-CO_(2))Brayton power cycle power generation technology,has attracted more and more scholars'attention in recent years because of its advantages of high efficiency and flexibility.Compared with conventional steam boilers,S-CO_(2) has different heat transfer characteristics,it is easy to cause the temperature of the cooling wall of the boiler to rise,which leads to higher combustion gas temperature in the furnace,higher NOX generation concentration.The adoption of flue gas recirculation has a significance impact on the combustion process of pulverized coal in the boiler,and it is the most effective ways to reduce the emission of NOX and the combustion temperature in the boiler.This paper takes 1000MW S-CO_(2) T-type coal-fired boiler as the research target to investigate the combustion and NOX generation characteristics of S-CO_(2) coal-fired boilers under flue gas recirculation condition,the influence of recirculated flue gas distribution along the furnace height on the characteristics of NOX formation and the combustion of pulverized coal.The results show that the recirculated flue gas distribution has the great impact on the concentration of NOX at the boiler outlet.When the bottom recirculation flue gas rate is gradually increased,the average temperature of the lower boiler decreases and the average temperature of the upper boiler increases slightly;The concentration of NOx at the furnace outlet increases.展开更多
Background and aims:Clinical data regarding patients with chronic hepatitis B(CHB)after Omicron BA.5 infection are currently limited.This study aimed to assess the clinical characteristics of patients with CHB and Omi...Background and aims:Clinical data regarding patients with chronic hepatitis B(CHB)after Omicron BA.5 infection are currently limited.This study aimed to assess the clinical characteristics of patients with CHB and Omicron BA.5 infection in South China.Methods:This retrospective study was conducted from January to March 2023 in a cohort of 485 healthy individuals and 553 patients with CHB.Clinical features,encompassing COVID-19-related symptoms,levels of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)antibodies,vaccination status,liver functions,and virological markers of hepatitis B virus(HBV)infection were measured.Results:COVID-19-related symptom patterns were similar in both groups,except for fever,which was notably less prevalent(85.4%vs.90.4%,P?0.047)among patients with CHB who experienced a significantly shorter duration of fever(median 2.2(25the75th percentile,1.0e3.0)days vs.2.3(1.0e3.0)days,P=0.048)and a shorter time for symptom relief(9.2(5.0e14.0)vs.11.1(5.0e14.0)days,P=0.015).The levels of SARS-CoV-2 antibodies were comparable between the two groups but increased after booster vaccinations.In patients with CHB,globulin(GLB)and hepatitis B envelope antibody levels were significantly increased after Omicron BA.5 infection,regardless of nucleos(t)ide analog regimens comparing entecavir(ETV)with tenofovir(TFV).Patients with CHB treated with TFV had significantly higher levels of SARS-CoV-2 antibodies than those treated with ETV(1065.1(346.9e1188.5)COI vs.765.5(24.5e1119.1)COI,P=0.025).Conclusions:No significant exacerbation of COVID-19 symptoms was observed in conjunction with the efficacy of COVID-19 booster vaccinations.There were no notable alterations in liver functions except for GLB.HBV reactivation,as evidenced by increased HBV DNA,was observed among patients with CHB after Omicron BA.5 infection.These changes were not affected by ETV versus TFV administration;however,TFV resulted in a significant increase in SARS-CoV-2 antibody levels.Further studies are required to improve care and therapeutics for patients with CHB who contracted COVID-19.展开更多
Understanding how organisms adapt to their environments is a central question in evolutionary biology.Limestone langurs are unique among pri-mates,as they are exclusively found in karst limestone habitats and have evo...Understanding how organisms adapt to their environments is a central question in evolutionary biology.Limestone langurs are unique among pri-mates,as they are exclusively found in karst limestone habitats and have evolved mechanisms to tolerate high levels of mineral ions,which are typically associated with metal toxicity affecting organs,cells,and genetic material.We generated a high-quality reference genome(Tfra_5.0)for the limestone langur(Trachypithecus francoisi),along with genome resequencing data for 48 langurs representing 15 Trachypithecus species.Genes encoding ion channeis(e.g.,Nat,K+,and Ca?+)exhibited significantly accelerated evolution in limestone langurs.Limestone langur-specific mutations in Nat and Ca2+channels were experimentally confirmed tomodify inward ion currents in vitro.Unexpectedly,scans for posi-tive selection also identified genes involved in DNA damage response/repair pathways,a previously unknown adaptation.This finding highlights an evolutionary adaptation in limestone langurs that mitigates the increased risk of DNA damage posed by elevated metal ion concentrations.Notably,a limestone langur-specific mutation(E94D)of the melanocortin 1 receptor(MC1R)was associated with increased basal cyclic adenosine monophosphate(cAMP)production,contributing to the species'darker coat color,which likely serves as camouflage on limestone rocks.Our find-ings reveal novel adaptive evolutionary mechanisms of limestone langurs and offer broader insights into organismal adaptation to extreme envi-ronments,with potential implications for understanding human health,biological evolution,and biodiversity conservation.展开更多
Defect engineering enables the efficient management of electromagnetic parameters and the enhancement of electromagnetic wave(EMW)absorption.In this study,(Fe_(1−x)Mn_(x))_(2)AlB_(2) transition metal boride(MAB)phases...Defect engineering enables the efficient management of electromagnetic parameters and the enhancement of electromagnetic wave(EMW)absorption.In this study,(Fe_(1−x)Mn_(x))_(2)AlB_(2) transition metal boride(MAB)phases with a layered structure were prepared via Joule heating-driven ultrafast synthesis,and their EMW absorption properties were investigated.The experimental results demonstrate that the incorporation of Mn atoms at the M site can effectively modulate the impedance matching and EMW absorption properties of the material through the introduction of defects and lattice distortions.Notably,(Fe_(0.3)Mn_(0.7))_(2)AlB_(2) exhibits a reflection loss as high as−47.8 dB at 12.24 GHz,with a maximum effective absorption bandwidth of 4.16 GHz(10.24-14.40 GHz)at an ultrasmall thickness of 1.5 mm.This study provides a promising avenue for the development of excellent microwave-absorbing materials,which are essential for meeting the evolving requirements of advanced electronics.Additionally,this work offers a paradigm for enhancing other properties of MAB phases through defect engineering.展开更多
The inert basal plane of molybdenum disulfide (MoS2) restrains its further hydrogen evolution reaction (HER) performance.This work attempts ion irradiation to activate inert basal plane of MoS2 nanosheet to improve it...The inert basal plane of molybdenum disulfide (MoS2) restrains its further hydrogen evolution reaction (HER) performance.This work attempts ion irradiation to activate inert basal plane of MoS2 nanosheet to improve its electrocatalytic performance.Experimental results demonstrate the sulphur vacancies generated by ion irradiation on the basal plane of MoS2 mainly boost the efficiency of HER performance.The moderate fluence of carbon ion irradiation gains the optimum HER performance with an onset potential of 77 mV and Tafel slope of 66 mV/dec.展开更多
文摘Exogenous neural stem cell transplantation has become one of the most promising treatment methods for chronic stroke.Recent studies have shown that most ischemia-reperfusion model rats recover spontaneously after injury,which limits the ability to observe long-term behavioral recovery.Here,we used a severe stroke rat model with 150 minutes of ischemia,which produced severe behavioral deficiencies that persisted at 12 weeks,to study the therapeutic effect of neural stem cells on neural restoration in chronic stroke.Our study showed that stroke model rats treated with human neural stem cells had long-term sustained recovery of motor function,reduced infarction volume,long-term human neural stem cell survival,and improved local inflammatory environment and angiogenesis.We also demonstrated that transplanted human neural stem cells differentiated into mature neurons in vivo,formed stable functional synaptic connections with host neurons,and exhibited the electrophysiological properties of functional mature neurons,indicating that they replaced the damaged host neurons.The findings showed that human fetal-derived neural stem cells had long-term effects for neurological recovery in a model of severe stroke,which suggests that human neural stem cells-based therapy may be effective for repairing damaged neural circuits in stroke patients.
基金the National Natural Science Foundation of China(62271322)the Guangdong Basic and Applied Basic Research Foundation(2022A1515011003 and 2023A1515030152)the Shenzhen Science and Technology Program(JCYJ20210324095610027 and JCYJ20210324095611030).
文摘Optical orbital angular momentum(OAM)mode multiplexing has emerged as a promising technique for boosting communication capacity.However,most existing studies have concentrated on channel(de)-multiplexing,overlooking the critical aspect of channel routing.This challenge involves the reallocation of multiplexed OAM modes across both spatial and temporal domains—a vital step for developing versatile communication networks.To address this gap,we introduce a novel approach based on the time evolution of OAM modes,utilizing the orthogonal conversion and diffractive modulation capabilities of unitary transformations.This approach facilitates high-dimensional orthogonal transformations of OAM mode vectors,altering both the propagation direction and the spatial location.Using Fresnel diffraction matrices as unitary operators,it manipulates the spatial locations of light beams during transmission,breaking the propagation invariance and enabling temporal evolution.As a demonstration,we have experimentally implemented the deep routing of four OAM modes within two distinct time sequences.Achieving an average diffraction efficiency above 78.31%,we have successfully deep-routed 4.69 Tbit-s^(-1)quadrature phase-shift keying(QPSK)signals carried by four multiplexed OAM channels,with a bit error rate below 10^(-6).These results underscore the efficacy of our routing strategy and its promising prospects for practical applications.
基金supported by the National Natural Science Foundation of China (No. 81771309)
文摘Objective: To determine the prognostic implications and clinical significance of epidermal growth factor receptor variant Ⅲ(EGFRvⅢ) expression and EGFRvⅢ nuclear translocation in Chinese human gliomas.Methods: We retrospectively examined EGFRvⅢ expression and EGFRvⅢ nuclear translocation using immunohistochemistry in specimens of 240 Chinese patients with glioma, including 84 World Health Organization(WHO) II gliomas, 84 WHO Ⅲ gliomas and 72 glioblastomas(WHO IV). Factors that correlated with EGFRvⅢ and EGFRvⅢ nuclear translocation expression were analyzed by the Chi-square test. Kaplan-Meier methodology and Cox regression were used for the survival analysis.Results: Log-rank tests showed that patient age, Karnofsky performance scale(KPS) score, tumor grade,EGFRvⅢ expression, EGFRvⅢ nuclear translocation, 1 p/19 q codeletion, isocitrate dehydrogenase(IDH)mutation, Ki-67 labeling index and O6-methylguanine-DNA methyltransferase(MGMT) status(P<0.05) were significantly correlated with overall survival(OS) time. Multivariate Cox regression analysis revealed that patient age, tumor grade, EGFRvⅢ nuclear translocation, 1 p/19 q codeletion, and IDH mutation(P<0.05) were significantly correlated with OS. Patients with a high level of EGFRvⅢ nuclear translocation(≥7%) had both significantly shorter OS [hazard ratio(HR): 1.920, 95% confidence interval(95% CI): 1.228-3.003, P=0.004] and progression-free survival(PFS) times(HR: 1.661, 95% CI: 1.116-2.471, P=0.012) than those with a low level of EGFRvⅢ nuclear translocation(<7%).Conclusions: A high level of EGFRvⅢ nuclear translocation in glioma is an independent factor indicating a poor prognosis, but EGFRvⅢ expression is not an independent clinical prognostic factor. The level of EGFRvⅢ nuclear translocation maybe a novel and crucial prognostic biomarker in glioma.
基金supported by the National Natural Science Foundation of China (No. 21077100, 41090284)
文摘Arsenic （As） is ubiquitous in the environment in the carcinogenic inorganic forms, posing risks to human health in many parts of the world. Many microorganisms have evolved a series of mechanisms to cope with inorganic arsenic in their growth media such as transforming As compounds into volatile derivatives. Bio-volatilization of As has been suggested to play an important role in global As biogeochemical cycling, and can also be explored as a potential method for arsenic bioremediation. This review aims to provide an overview of the quality and quantity of As volatilization by fungi, bacteria, microalga and protozoans. Arsenic bio-volatilization is influenced by both biotic and abiotic factors that can be manipulated/elucidated for the purpose of As bioremediation. Since As bio- volatilization is a resurgent topic for both biogeochemistry and environmental health, our review serves as a concept paper for future research directions.
基金supported by the National Natural Science Fundsgrant number 51821091,51872233the Shaanxi Natural Science Funds grant number 2018JM5044。
文摘Cu@MOF core-shell nanowires are synthesized by introducing oxidizable and CTAB-modified metal nanowires as self-engaged templates and supporting MOFs for a one-dimension nanostructure.The following thermal process is controlled to obtain several one-dimension structure s ofCuCo-mixed materials,such as nanorods,single-shell and double-shell nanowires.The hollow structure for electrode materials enlarges the surface area,provides buffer space for electrolyte to accelerate the ion/charge transfers and for the structure to reduce injuries of volume expansion during cycling.Together with some other merits,such as adequate oxidation of the MOFs,small crystal grains of the material,and well-mixed Cu/Co oxides,the double-shell Cu@MOF nanowires(CuCo-DS5)applied for pseudocapacitors deliver advanced electrochemical performance with a specific capacitance of 563.8 F g^(-1)at 1 A g^(-1)as well as an outstanding cycling stability with a 92%retention after 3000 cycles at 5 A g^(-1).Meanwhile,an asymmetric pseudocapacitor constructed with the CuCo-DS5 and active carbon(AC)shows a high specific capacitance and energy density.
基金supported by the National Science Foundation of China under Award Nos.12074353 and 12075227.
文摘The use of broadband laser technology is a novel approach for inhibiting processes related to laser plasma interactions(LPIs).In this study,several preliminary experiments into broadband-laser-driven LPIs are carried out using a newly established hundreds-of-joules broadband second-harmonic-generation laser facility.Through direct comparison with LPI results for a traditional narrowband laser,the actual LPI-suppression effect of the broadband laser is shown.The broadband laser had a clear suppressive effect on both back-stimulated Raman scattering and back-stimulated Brillouin scattering at laser intensities below 1×10^(15) W cm^(−2).An abnormal hot-electron phenomenon is also investigated,using targets of different thicknesses.
基金Project supported by Guangdong Innovative and Entrepreneurial Research Team Program(Grant No.2016ZT06D348)Shenzhen Peacock Program(Grant No.KQTD2016022619565991)
文摘Single-layered zirconium pentatelluride （ZrTes） has been predicted to be a large-gap two-dimensional （2D） topolog- ical insulator, which has attracted particular attention in topological phase transitions and potential device applications. Herein, we investigated the transport properties in ZrTe5 films as a function of thickness, ranging from a few nm to several hundred nm. We determined that the temperature of the resistivity anomaly peak （Tp） tends to increase as the thickness decreases. Moreover, at a critical thickness of ~ 40 rim, the dominating carriers in the films change from n-type to p-type. A comprehensive investigation of Shubnikov-de Hass （SdH） oscillations and Hall resistance at variable temperatures revealed a multi-carrier transport tendency in the thin films. We determined the carrier densities and mobilities of two majority car- riers using the simplified two-carrier model. The electron carriers can be attributed to the Dirac band with a non-trivial Berry phase ~, while the hole carriers may originate from surface chemical reaction or unintentional doping during the microfabrication process. It is necessary to encapsulate the ZrTe5 film in an inert or vacuum environment to potentially achieve a substantial improvement in device quality.
基金Supported by the National Key R&D Program(Grant Nos.2017YFB0405703,2017YFA0205004,and 2018YFA0306600)the National Natural Science Foundation of China(Grant Nos.11974327,11474265,11674295,11674024,and 11874193)+2 种基金the Fundamental Research Funds for the Central Universities(Grant Nos.WK2030020032 and WK2340000082)Anhui Initiative in Quantum Information Technologies,and the Shenzhen Fundamental Subject Research Program(Grant No.JCYJ20170817110751776)the USTC Center for Micro and Nanoscale Research and Fabrication。
文摘We report the observation of in-plane anisotropic magnetoresistance and planar Hall effect in non-magnetic HfTe_(5) thin layers.The observed anisotropic magnetoresistance as well as its sign is strongly dependent on the critical resistivity anomaly temperature T_(p).Below T_(p),the anisotropic magnetoresistance is negative with large negative magnetoresistance.When the in-plane magnetic field is perpendicular to the current,the negative longitudinal magnetoresistance reaches its maximum.The negative longitudinal magnetoresistance effect in HfTe_(5) thin layers is dramatically different from that induced by the chiral anomaly as observed in Weyl and Dirac semimetals.One potential underlying origin may be attributed to the reduced spin scattering,which arises from the in-plane magnetic field driven coupling between the top and bottom surface states.Our findings provide valuable insights for the anisotropic magnetoresistance effect in topological electronic systems and the device potential of HfTe5 in spintronics and quantum sensing.
基金"Three News"Project of Aquatic Products in Jiangsu Province(Y2016-1).
文摘River crab industry plays an important role in agriculture in Nanjing City,Jiangsu Province.In recent years,with the renewal of breeding mode,the breeding of improved varieties and the construction of brand,the river crab industry has made great progress.Taking the aquaculture enterprises and major breeding farmers in the main producing areas of river crab as the main research object,this paper makes a survey on the river crab industry in Nanjing.Based on fishery statistical data and comparison with advanced areas,this paper makes an in-depth analysis on the current situation,existing problems and development measures of Nanjing river crab industry,and it is recommended to make full use of external opportunities and give full play to its own advantages,in order to make Nanjing river crab industry develop healthily and rapidly.
文摘T lymphocytes,the main participants of cellular immunity,can express a variety of surface molecules and form different lymphocyte subsets under the induction of different factors to play the functions of immune regulation and immune killing.Studies have shown that platelets play a crucial role in maintaining the stable differentiation of lymphocytes and the balance in immunomodulation.Therefore,it is necessary to study the effect of platelets on lymphocytes in vitro to better understand the role of platelets in the immune system and broaden the application of adoptive immunotherapy.Methods:Cell counting and microscopic observation were used to detect the effect of activated platelets on lymphocyte proliferation in vitro;Flow cytometry was used to detect whether changes in platelet activity affect the proportion of lymphocyte subpopulations in vitro,and to detect differences in the expression of granzyme B;lactate dehydrogenase assay(LDH)was used to determine the difference in lymphocyte killing activity caused by platelet activity in vitro.Results:This was the first to promote lymphocyte proliferation through the expression or release of certain molecules in vitro,demonstrating that platelet activation is one of the key factors.Secondly,activated platelets or inactivated platelets promoted lymphocyte subset differentiation by enhancing the proportion of CD3+CD8+T lymphocytes(CTL cells)but had a slight effect on the proportion of CD3+CD4+T(Th cells)and CD4+CD25+T lymphocytes(Treg cells).Then,it was found that either activated platelets or inactivated platelets down-regulated the proportion of natural killer(NK)T lymphocytes,while activated platelets significantly enhance the proportion of NK lymphocytes.Therefore,by further detecting the killing activity of PBMCs treated with platelets,it was found that activated platelets promoted the extensive anti-tumor activity of lymphocytes and significantly increased the expression of granzyme B.Conclusion:Our results suggest that activated platelets promote lymphocyte proliferation,optimize lymphocyte subpopulation ratio,and promote cytotoxic effect of lymphocytes in vitro,which may provide a new strategy for optimizing the adoptive immunotherapy culture system and improving its efficacy.
文摘Given a pan-space ?and a nonnegative measurable function f on measurable space (X, A), the pan-integral of f with respect to monotone measure μ and pan-operation ?determines a new monotone measure ?on?(X, A). Such the new monotone measure ?is absolutely continuous with respect to the monotone measure μ. We show that the new monotone measure preserves some important structural characteristics of the original monotone measures, such as continuity from below, subadditivity, null-additivity, weak null-additivity and (S) property. Since the pan-integral based on a pair of pan-operations ?covers the Sugeno integral (based on ) and the Shilkret integral (based on ), therefore, the previous related results for the Sugeno integral are covered by the results presented here, in the meantime, some special results related the Shilkret integral are also obtained.
基金This paper is supported by the National Key R&D Program of China(2017YFB0601805).
文摘Supercritical carbon dioxide(S-CO_(2))Brayton power cycle power generation technology,has attracted more and more scholars'attention in recent years because of its advantages of high efficiency and flexibility.Compared with conventional steam boilers,S-CO_(2) has different heat transfer characteristics,it is easy to cause the temperature of the cooling wall of the boiler to rise,which leads to higher combustion gas temperature in the furnace,higher NOX generation concentration.The adoption of flue gas recirculation has a significance impact on the combustion process of pulverized coal in the boiler,and it is the most effective ways to reduce the emission of NOX and the combustion temperature in the boiler.This paper takes 1000MW S-CO_(2) T-type coal-fired boiler as the research target to investigate the combustion and NOX generation characteristics of S-CO_(2) coal-fired boilers under flue gas recirculation condition,the influence of recirculated flue gas distribution along the furnace height on the characteristics of NOX formation and the combustion of pulverized coal.The results show that the recirculated flue gas distribution has the great impact on the concentration of NOX at the boiler outlet.When the bottom recirculation flue gas rate is gradually increased,the average temperature of the lower boiler decreases and the average temperature of the upper boiler increases slightly;The concentration of NOx at the furnace outlet increases.
文摘Background and aims:Clinical data regarding patients with chronic hepatitis B(CHB)after Omicron BA.5 infection are currently limited.This study aimed to assess the clinical characteristics of patients with CHB and Omicron BA.5 infection in South China.Methods:This retrospective study was conducted from January to March 2023 in a cohort of 485 healthy individuals and 553 patients with CHB.Clinical features,encompassing COVID-19-related symptoms,levels of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)antibodies,vaccination status,liver functions,and virological markers of hepatitis B virus(HBV)infection were measured.Results:COVID-19-related symptom patterns were similar in both groups,except for fever,which was notably less prevalent(85.4%vs.90.4%,P?0.047)among patients with CHB who experienced a significantly shorter duration of fever(median 2.2(25the75th percentile,1.0e3.0)days vs.2.3(1.0e3.0)days,P=0.048)and a shorter time for symptom relief(9.2(5.0e14.0)vs.11.1(5.0e14.0)days,P=0.015).The levels of SARS-CoV-2 antibodies were comparable between the two groups but increased after booster vaccinations.In patients with CHB,globulin(GLB)and hepatitis B envelope antibody levels were significantly increased after Omicron BA.5 infection,regardless of nucleos(t)ide analog regimens comparing entecavir(ETV)with tenofovir(TFV).Patients with CHB treated with TFV had significantly higher levels of SARS-CoV-2 antibodies than those treated with ETV(1065.1(346.9e1188.5)COI vs.765.5(24.5e1119.1)COI,P=0.025).Conclusions:No significant exacerbation of COVID-19 symptoms was observed in conjunction with the efficacy of COVID-19 booster vaccinations.There were no notable alterations in liver functions except for GLB.HBV reactivation,as evidenced by increased HBV DNA,was observed among patients with CHB after Omicron BA.5 infection.These changes were not affected by ETV versus TFV administration;however,TFV resulted in a significant increase in SARS-CoV-2 antibody levels.Further studies are required to improve care and therapeutics for patients with CHB who contracted COVID-19.
基金supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB31000000)the National Natural Science Foundation of China(Grant Nos.31821001,31761133020,31970390,31772438,and 32170422)+2 种基金the Sino-German Mobility Programme(Grant No.M-0084)the German Research Foundation(Grant No.RO 3055/7-1)the Vietnamese Ministry of Science and Technology's Program 562(Grant No.DTDL.CN-64/19).
文摘Understanding how organisms adapt to their environments is a central question in evolutionary biology.Limestone langurs are unique among pri-mates,as they are exclusively found in karst limestone habitats and have evolved mechanisms to tolerate high levels of mineral ions,which are typically associated with metal toxicity affecting organs,cells,and genetic material.We generated a high-quality reference genome(Tfra_5.0)for the limestone langur(Trachypithecus francoisi),along with genome resequencing data for 48 langurs representing 15 Trachypithecus species.Genes encoding ion channeis(e.g.,Nat,K+,and Ca?+)exhibited significantly accelerated evolution in limestone langurs.Limestone langur-specific mutations in Nat and Ca2+channels were experimentally confirmed tomodify inward ion currents in vitro.Unexpectedly,scans for posi-tive selection also identified genes involved in DNA damage response/repair pathways,a previously unknown adaptation.This finding highlights an evolutionary adaptation in limestone langurs that mitigates the increased risk of DNA damage posed by elevated metal ion concentrations.Notably,a limestone langur-specific mutation(E94D)of the melanocortin 1 receptor(MC1R)was associated with increased basal cyclic adenosine monophosphate(cAMP)production,contributing to the species'darker coat color,which likely serves as camouflage on limestone rocks.Our find-ings reveal novel adaptive evolutionary mechanisms of limestone langurs and offer broader insights into organismal adaptation to extreme envi-ronments,with potential implications for understanding human health,biological evolution,and biodiversity conservation.
文摘Defect engineering enables the efficient management of electromagnetic parameters and the enhancement of electromagnetic wave(EMW)absorption.In this study,(Fe_(1−x)Mn_(x))_(2)AlB_(2) transition metal boride(MAB)phases with a layered structure were prepared via Joule heating-driven ultrafast synthesis,and their EMW absorption properties were investigated.The experimental results demonstrate that the incorporation of Mn atoms at the M site can effectively modulate the impedance matching and EMW absorption properties of the material through the introduction of defects and lattice distortions.Notably,(Fe_(0.3)Mn_(0.7))_(2)AlB_(2) exhibits a reflection loss as high as−47.8 dB at 12.24 GHz,with a maximum effective absorption bandwidth of 4.16 GHz(10.24-14.40 GHz)at an ultrasmall thickness of 1.5 mm.This study provides a promising avenue for the development of excellent microwave-absorbing materials,which are essential for meeting the evolving requirements of advanced electronics.Additionally,this work offers a paradigm for enhancing other properties of MAB phases through defect engineering.
基金the National Natural Science Foundation of China (Nos.21671141,11375018 and 11528508)the National Basic Research Program of China (No.2015CB358600)the Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions for Optical Engineering in Soochow University the National Magnetic Confinement Fusion Energy Research Project (Nos.2015GB121004,2017YFE0302500 and 2018YFE0307100) from Ministry of Science and Technology of China,China-Romania Science and Technology Cooperation committee 43rd Regular Meeting Exchange program and Ion Beam Materials Laboratory (IBML) at Peking University.
文摘The inert basal plane of molybdenum disulfide (MoS2) restrains its further hydrogen evolution reaction (HER) performance.This work attempts ion irradiation to activate inert basal plane of MoS2 nanosheet to improve its electrocatalytic performance.Experimental results demonstrate the sulphur vacancies generated by ion irradiation on the basal plane of MoS2 mainly boost the efficiency of HER performance.The moderate fluence of carbon ion irradiation gains the optimum HER performance with an onset potential of 77 mV and Tafel slope of 66 mV/dec.
