Development of on-chip coherent light sources with desired single-mode operation and straightforward spectral tunability has attracted intense interest due to ever-increasing demand for photonic devices and optoelectr...Development of on-chip coherent light sources with desired single-mode operation and straightforward spectral tunability has attracted intense interest due to ever-increasing demand for photonic devices and optoelectronic integration,but still faces serious challenges.Herein,we propose a facile method to synthesize cesium lead halide(CsPbX3)microstructures with well-defined morphologies,sizes,and constituent element gradient.The scheme is conducted using a chemical vapor deposition(CVD),which is subsequently associated with annealing-assisted solid-solid anion exchange.For the plate-shaped structures,the controllability on the cross-sectional dimension enables to precisely modulate the lasing modes,thus achieving single-mode operation;while tuning the stoichiometric of the halogen anion components in the plate-shaped CsPbI_(x)Br_(3−x) alloy samples,the lasing wavelengths are straightforwardly varied to span the entire visible spectrum.By comparison,the experimental scheme on synthesizing alloyed CsPbI_(x)Br_(3−x) perovskites is conducted using an in-situ approach,thereby achieving precise modulation of bandgap-controlled microlasers by controlling the reaction time.Such laser properties like controllable microcavity modes and broad stoichiometry-dependent tunability of light-emitting/lasing colors,associated with the facile synthesizing method of monocrystalline CsPbI_(x)Br_(3−x) structures,make lead halide perovskites ideal materials for the development of wavelength-controlled microlasers toward practical photonic integration.展开更多
BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly aggressive cancer with poor prognosis.When it metastasizes to the liver,treatment options become particularly limited and challenging.Current treatment opti...BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly aggressive cancer with poor prognosis.When it metastasizes to the liver,treatment options become particularly limited and challenging.Current treatment options for liver metastatic PDAC are limited,and chemotherapy alone often proves insufficient.Immunotherapy,particularly programmed cell death 1(PD-1)inhibitors like sintilimab,shows potential efficacy for various cancers but has limited reports on PDAC.This study compares the efficacy and safety of sintilimab plus S-1 and gemcitabine vs S-1 and gemcitabine alone in liver metastatic PDAC.AIM To explore the feasibility and effectiveness of combined PD-1 inhibitor sintilimab and S-1 and gemcitabine(combination group)vs S-1 and gemcitabine used alone(chemotherapy group)for treating liver metastatic pancreatic adenocarcinoma.METHODS Eligible patients were those with only liver metastatic PDAC,an Eastern Cooperative Oncology Group performance status of 0-1,adequate organ and marrow functions,and no prior anticancer therapy.Participants in the combination group received intravenous sintilimab 200 mg every 3 weeks,oral S-140 mg/m²twice daily on days 1-14 of a 21-day cycle,and intravenous gemcitabine 1000 mg/m²on days 1 and 8 of the same cycle for up to eight cycles or until disease progression,death,or unacceptable toxicity.Participants in the chemotherapy group received oral S-140 mg/m²twice daily on days 1-14 of a 21-day cycle and intravenous gemcitabine 1000 mg/m²on days 1 and 8 of the same cycle for up to eight cycles.Between June 2020 and December 2021,66 participants were enrolled,with 32 receiving the combination treatment and 34 receiving chemotherapy alone.RESULTS The group receiving the combined therapy exhibited a markedly prolonged median overall survival(18.8 months compared to 10.3 months,P<0.05)and progression-free survival(9.6 months vs 5.4 months,P<0.05).compared to the chemotherapy group.The incidence of severe adverse events did not differ significantly between the two groups(P>0.05).CONCLUSION The combination of PD-1 inhibitor sintilimab with S-1 and gemcitabine demonstrated effectiveness and safety for treating liver metastatic PDAC,meriting further investigation.展开更多
The rapid growth in global energy demand has necessitated the development of efficient energy storage and conversion devices,with the aim of enhancing grid stability,promoting the adoption of electric vehicles,and pow...The rapid growth in global energy demand has necessitated the development of efficient energy storage and conversion devices,with the aim of enhancing grid stability,promoting the adoption of electric vehicles,and powering portable electronics.However,the performance of these devices is constrained by the limitations of traditional electrode materials and catalysts.Bimetallic tellurides have emerged as a promising solution due to their exceptional synergistic effects,high electronic conductivity,abundant redox-active sites,and outstanding electrochemical stability.Nevertheless,achieving cost-effective synthesis and stable applications remains a significant challenge.Hence,the most recent advances of bimetallic tellurides electrodes from synthesis to application are systematically reviewed.Several synthetic strategies for exquisite bimetallic tellurides nanostructures,including tellurization,ball-milling,solvo/hydrothermal,electrodeposition,wet chemical,and template method,are discussed.Moreover,the applications of bimetallic tellurides are extensively summarized in energy storage and conversion devices,which include alkali metal-ion batteries(Li-ion,Na-ion,and K-ion),supercapacitor,hydrogen evolution reaction(HER),and oxygen evolution reaction(OER).Besides,the challenges and potential solutions of bimetallic telluride for energy applications are also suggested.This work provides fundamental insight and guidelines for the future design of bimetallic tellurides in energy storage and conversion technologies.展开更多
Pancreatic ductal adenocarcinoma(PDAC),a"silent killer"with elusive early symptoms and poor prognosis,sees nearly half of patients experience recurrence within a year post-curative-intent surgery.Very early ...Pancreatic ductal adenocarcinoma(PDAC),a"silent killer"with elusive early symptoms and poor prognosis,sees nearly half of patients experience recurrence within a year post-curative-intent surgery.Very early recurrence(VER),defined as recurrence within 12 weeks postoperatively and first termed"biological R^(2) resection"by Belfiori et al,remains a clinical puzzle.Martlıet al’s recent retrospective cohort study offers crucial insights into this understudied issue,identifies predictive factors that challenge long-held beliefs,and calls for a rethink of risk stratification and postoperative management for PDAC patients.Martlıet al studied 303 PDAC patients at a high-volume center from 2019 to 2024,with VER affecting 9.24%(28 patients)of the cohort.The study’s strength lies in combining traditional statistical analyses and machine learning(random forest modeling)to capture nonlinear relationships between clinicopathological factors and VER risk.Key findings include:(1)Poorly differentiated(G3)tumors are the strongest VER predictor(OR=2.43,P<0.001;random forest importance score=0.35),with 92.85%of VER patients having G3 tumors(vs 45.81%of non-VER patients);(2)Contrary to prior studies,pancreatic head tumors(89.28%of VER patients vs 83.66%of non-VER patients,P=0.031)were linked to VER;(3)Elevated red cell distribution width is a weaker predictor(random forest importance score=0.20,P=0.03 for group difference,P=0.079 in multivariate analysis);and(4)VER correlates with significantly higher 6-month mortality(32.44%vs 14.77%in non-VER patients,P=0.032).展开更多
Rational laboratory layout design and scientific management systems are key to improving overall laboratory efficiency and safety,providing a solid foundation and guarantee for the smooth progress of scientific resear...Rational laboratory layout design and scientific management systems are key to improving overall laboratory efficiency and safety,providing a solid foundation and guarantee for the smooth progress of scientific research.This article addresses a series of issues such as low testing efficiency caused by unreasonable laboratory layouts,incomplete or outdated equipment configurations affecting testing accuracy,and safety hazards arising from the lack of effective laboratory management systems.It conducts an in-depth exploration of the design and planning strategies for physicochemical laboratories.By proposing specific designs and guidelines for the location selection,functional zoning,and layout requirements of physicochemical laboratories,the aim is to optimize laboratory space utilization,enhance testing efficiency,and ensure the advancement of equipment configurations and the accuracy of testing precision.Simultaneously,it emphasizes the establishment of an effective laboratory management system to prevent and control safety hazards,safeguarding the lives of laboratory personnel and ensuring stable laboratory operations.展开更多
The reuse of green sand in casting production is hindered by the accumulation of oolitic deposits,primarily composed of clay binder with surface degradation,which may adversely affect the the moulding sand performance...The reuse of green sand in casting production is hindered by the accumulation of oolitic deposits,primarily composed of clay binder with surface degradation,which may adversely affect the the moulding sand performance.Currently,there is a lack of standardized methods for quantifying the oolitic content.Accurate measurement of oolitic content is of great significance to the reuse of green sand.Attempts to determine oolitic content using potassium hydroxide(KOH)and phosphoric acid(H_(3)PO_(4))methods encounter challenges due to their excessive reactions with SiO_(2) in the sand.In this study,an improved method for measuring the oolitic content of green sand with repeated approximations was proposed.This method judges the chemical activity of the sample surface through the change of its mass to accurately obtain the mass of the reaction oolitic deposits.The test result of the used sand samples from the foundry shows that the oolitic deposits are completely removed after reacting with KOH solution three times at 300℃ for 20 min.SEM and EDS also show that after three times of reactions,the surface of green sand becomes smooth and the content of Al-containing oolitic deposits is very low.This indicates that the method can accurately control the extent of the reaction.Implementation of this method at Huangshi Dongbei Casting Co.,Ltd.has yielded consistent and reliable test results,effectively mirroring variations in green sand oolitic content on the production line.This new method is expected to be widely adopted to improve the efficiency and quality of reused green sand in casting operations.展开更多
According to the announcement of General Administration of Quality Supervision,Inspection and Quarantine of the People's Republic of China,the risk of microbial items in frozen drinks is very high,and it is diffic...According to the announcement of General Administration of Quality Supervision,Inspection and Quarantine of the People's Republic of China,the risk of microbial items in frozen drinks is very high,and it is difficult to improve.For example,a recent spot check showed that 42 kinds of frozen drinks had microbial indicators exceeding the standard.Part of the reason is that the design of the production workshop is not conducive to the rapid removal of production water,resulting in continuous moisture throughout the workshop,which provides a breeding bed for microorganisms to breed and then contaminates the product.Therefore,research is carried out from the design point of view to fundamentally reduce the moisture in the workshop and build a dry workshop for frozen drinks production,so as to effectively reduce the risk of microbial contamination of frozen drinks.展开更多
基金supported by the National Natural Science Foundation of China(No.12374257)。
文摘Development of on-chip coherent light sources with desired single-mode operation and straightforward spectral tunability has attracted intense interest due to ever-increasing demand for photonic devices and optoelectronic integration,but still faces serious challenges.Herein,we propose a facile method to synthesize cesium lead halide(CsPbX3)microstructures with well-defined morphologies,sizes,and constituent element gradient.The scheme is conducted using a chemical vapor deposition(CVD),which is subsequently associated with annealing-assisted solid-solid anion exchange.For the plate-shaped structures,the controllability on the cross-sectional dimension enables to precisely modulate the lasing modes,thus achieving single-mode operation;while tuning the stoichiometric of the halogen anion components in the plate-shaped CsPbI_(x)Br_(3−x) alloy samples,the lasing wavelengths are straightforwardly varied to span the entire visible spectrum.By comparison,the experimental scheme on synthesizing alloyed CsPbI_(x)Br_(3−x) perovskites is conducted using an in-situ approach,thereby achieving precise modulation of bandgap-controlled microlasers by controlling the reaction time.Such laser properties like controllable microcavity modes and broad stoichiometry-dependent tunability of light-emitting/lasing colors,associated with the facile synthesizing method of monocrystalline CsPbI_(x)Br_(3−x) structures,make lead halide perovskites ideal materials for the development of wavelength-controlled microlasers toward practical photonic integration.
文摘BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly aggressive cancer with poor prognosis.When it metastasizes to the liver,treatment options become particularly limited and challenging.Current treatment options for liver metastatic PDAC are limited,and chemotherapy alone often proves insufficient.Immunotherapy,particularly programmed cell death 1(PD-1)inhibitors like sintilimab,shows potential efficacy for various cancers but has limited reports on PDAC.This study compares the efficacy and safety of sintilimab plus S-1 and gemcitabine vs S-1 and gemcitabine alone in liver metastatic PDAC.AIM To explore the feasibility and effectiveness of combined PD-1 inhibitor sintilimab and S-1 and gemcitabine(combination group)vs S-1 and gemcitabine used alone(chemotherapy group)for treating liver metastatic pancreatic adenocarcinoma.METHODS Eligible patients were those with only liver metastatic PDAC,an Eastern Cooperative Oncology Group performance status of 0-1,adequate organ and marrow functions,and no prior anticancer therapy.Participants in the combination group received intravenous sintilimab 200 mg every 3 weeks,oral S-140 mg/m²twice daily on days 1-14 of a 21-day cycle,and intravenous gemcitabine 1000 mg/m²on days 1 and 8 of the same cycle for up to eight cycles or until disease progression,death,or unacceptable toxicity.Participants in the chemotherapy group received oral S-140 mg/m²twice daily on days 1-14 of a 21-day cycle and intravenous gemcitabine 1000 mg/m²on days 1 and 8 of the same cycle for up to eight cycles.Between June 2020 and December 2021,66 participants were enrolled,with 32 receiving the combination treatment and 34 receiving chemotherapy alone.RESULTS The group receiving the combined therapy exhibited a markedly prolonged median overall survival(18.8 months compared to 10.3 months,P<0.05)and progression-free survival(9.6 months vs 5.4 months,P<0.05).compared to the chemotherapy group.The incidence of severe adverse events did not differ significantly between the two groups(P>0.05).CONCLUSION The combination of PD-1 inhibitor sintilimab with S-1 and gemcitabine demonstrated effectiveness and safety for treating liver metastatic PDAC,meriting further investigation.
基金supported by the Young Elite Scientists Sponsorship Program by CAST(grant No.2022QNRC001)the National Natural Science Foundation of China(No.52474318)+1 种基金the Beijing Nova Program(Z211100002121082)the Interdisciplinary Research Project for Young Teachers of USTB(Fundamental Research Funds for the Central Universities,FRF-IDRY-GD23-005)。
文摘The rapid growth in global energy demand has necessitated the development of efficient energy storage and conversion devices,with the aim of enhancing grid stability,promoting the adoption of electric vehicles,and powering portable electronics.However,the performance of these devices is constrained by the limitations of traditional electrode materials and catalysts.Bimetallic tellurides have emerged as a promising solution due to their exceptional synergistic effects,high electronic conductivity,abundant redox-active sites,and outstanding electrochemical stability.Nevertheless,achieving cost-effective synthesis and stable applications remains a significant challenge.Hence,the most recent advances of bimetallic tellurides electrodes from synthesis to application are systematically reviewed.Several synthetic strategies for exquisite bimetallic tellurides nanostructures,including tellurization,ball-milling,solvo/hydrothermal,electrodeposition,wet chemical,and template method,are discussed.Moreover,the applications of bimetallic tellurides are extensively summarized in energy storage and conversion devices,which include alkali metal-ion batteries(Li-ion,Na-ion,and K-ion),supercapacitor,hydrogen evolution reaction(HER),and oxygen evolution reaction(OER).Besides,the challenges and potential solutions of bimetallic telluride for energy applications are also suggested.This work provides fundamental insight and guidelines for the future design of bimetallic tellurides in energy storage and conversion technologies.
文摘Pancreatic ductal adenocarcinoma(PDAC),a"silent killer"with elusive early symptoms and poor prognosis,sees nearly half of patients experience recurrence within a year post-curative-intent surgery.Very early recurrence(VER),defined as recurrence within 12 weeks postoperatively and first termed"biological R^(2) resection"by Belfiori et al,remains a clinical puzzle.Martlıet al’s recent retrospective cohort study offers crucial insights into this understudied issue,identifies predictive factors that challenge long-held beliefs,and calls for a rethink of risk stratification and postoperative management for PDAC patients.Martlıet al studied 303 PDAC patients at a high-volume center from 2019 to 2024,with VER affecting 9.24%(28 patients)of the cohort.The study’s strength lies in combining traditional statistical analyses and machine learning(random forest modeling)to capture nonlinear relationships between clinicopathological factors and VER risk.Key findings include:(1)Poorly differentiated(G3)tumors are the strongest VER predictor(OR=2.43,P<0.001;random forest importance score=0.35),with 92.85%of VER patients having G3 tumors(vs 45.81%of non-VER patients);(2)Contrary to prior studies,pancreatic head tumors(89.28%of VER patients vs 83.66%of non-VER patients,P=0.031)were linked to VER;(3)Elevated red cell distribution width is a weaker predictor(random forest importance score=0.20,P=0.03 for group difference,P=0.079 in multivariate analysis);and(4)VER correlates with significantly higher 6-month mortality(32.44%vs 14.77%in non-VER patients,P=0.032).
文摘Rational laboratory layout design and scientific management systems are key to improving overall laboratory efficiency and safety,providing a solid foundation and guarantee for the smooth progress of scientific research.This article addresses a series of issues such as low testing efficiency caused by unreasonable laboratory layouts,incomplete or outdated equipment configurations affecting testing accuracy,and safety hazards arising from the lack of effective laboratory management systems.It conducts an in-depth exploration of the design and planning strategies for physicochemical laboratories.By proposing specific designs and guidelines for the location selection,functional zoning,and layout requirements of physicochemical laboratories,the aim is to optimize laboratory space utilization,enhance testing efficiency,and ensure the advancement of equipment configurations and the accuracy of testing precision.Simultaneously,it emphasizes the establishment of an effective laboratory management system to prevent and control safety hazards,safeguarding the lives of laboratory personnel and ensuring stable laboratory operations.
基金financially supported by the National Key Research and Development Program of China(Grant No.2022YFB3706800)the National Natural Science Foundation of China(Grant Nos.51905188 and 51775205).
文摘The reuse of green sand in casting production is hindered by the accumulation of oolitic deposits,primarily composed of clay binder with surface degradation,which may adversely affect the the moulding sand performance.Currently,there is a lack of standardized methods for quantifying the oolitic content.Accurate measurement of oolitic content is of great significance to the reuse of green sand.Attempts to determine oolitic content using potassium hydroxide(KOH)and phosphoric acid(H_(3)PO_(4))methods encounter challenges due to their excessive reactions with SiO_(2) in the sand.In this study,an improved method for measuring the oolitic content of green sand with repeated approximations was proposed.This method judges the chemical activity of the sample surface through the change of its mass to accurately obtain the mass of the reaction oolitic deposits.The test result of the used sand samples from the foundry shows that the oolitic deposits are completely removed after reacting with KOH solution three times at 300℃ for 20 min.SEM and EDS also show that after three times of reactions,the surface of green sand becomes smooth and the content of Al-containing oolitic deposits is very low.This indicates that the method can accurately control the extent of the reaction.Implementation of this method at Huangshi Dongbei Casting Co.,Ltd.has yielded consistent and reliable test results,effectively mirroring variations in green sand oolitic content on the production line.This new method is expected to be widely adopted to improve the efficiency and quality of reused green sand in casting operations.
文摘According to the announcement of General Administration of Quality Supervision,Inspection and Quarantine of the People's Republic of China,the risk of microbial items in frozen drinks is very high,and it is difficult to improve.For example,a recent spot check showed that 42 kinds of frozen drinks had microbial indicators exceeding the standard.Part of the reason is that the design of the production workshop is not conducive to the rapid removal of production water,resulting in continuous moisture throughout the workshop,which provides a breeding bed for microorganisms to breed and then contaminates the product.Therefore,research is carried out from the design point of view to fundamentally reduce the moisture in the workshop and build a dry workshop for frozen drinks production,so as to effectively reduce the risk of microbial contamination of frozen drinks.
