目的评价加味凉血五花汤与强脉冲光结合对玫瑰痤疮(肺胃湿热型)患者疗效影响。方法按照随机数字表法将六安市中医院皮肤科门诊收治的66例红斑毛细血管扩张型和(或)丘疹脓疱型玫瑰痤疮患者(2021年8月-2023年8月)分为对照组、观察组,每组3...目的评价加味凉血五花汤与强脉冲光结合对玫瑰痤疮(肺胃湿热型)患者疗效影响。方法按照随机数字表法将六安市中医院皮肤科门诊收治的66例红斑毛细血管扩张型和(或)丘疹脓疱型玫瑰痤疮患者(2021年8月-2023年8月)分为对照组、观察组,每组33例。对照组予单纯强脉冲光治疗,每3周一次,共4次。观察组在对照组基础上加用加味凉血五花汤,治疗后均要求保湿防晒;比较两组的临床疗效及治疗前后两组患者皮肤敏感性评分及医师主观评分变化、皮肤红斑指数E值及面部皮肤的经皮水分丢失量(transepidermal water loss,TEWL)、角质层含水量(stratum corneum hydration,SCH)变化,观察两组不良反应发生情况。结果对照组总有效率为67.0%(22/33),观察组为90.0%(28/31)(P<0.05);治疗前两组患者的皮肤敏感性评分及医师主观评分、皮肤红斑指数E值与面部皮肤TEWL、SCH数据比较差异无统计学意义(P>0.05),治疗后,两组患者以上指标均改善,而观察组患者指标改善明显优于对照组(P<0.05);对照组(18.2%,6/33)与观察组患者不良反应率(12.9%,4/31)比较,差异有统计学意义(P<0.05)。结论在强脉冲光治疗基础上,加味凉血五花汤治疗肺胃湿热型玫瑰痤疮的临床疗效显著,安全性高,能有效提高面部角质层含水量水平,且同时降低经皮水分丢失量、改善皮肤敏感、红斑等主要症状。展开更多
BACKGROUND At present,the conventional methods for diagnosing cerebral edema in clinical practice are computed tomography(CT)and magnetic resonance imaging(MRI),which can evaluate the location and degree of peripheral...BACKGROUND At present,the conventional methods for diagnosing cerebral edema in clinical practice are computed tomography(CT)and magnetic resonance imaging(MRI),which can evaluate the location and degree of peripheral cerebral edema,but cannot realize quantification.When patients have symptoms of diffuse cerebral edema or high cranial pressure,CT or MRI often suggests that cerebral edema is lagging and cannot be dynamically monitored in real time.Intracranial pressure monitoring is the gold standard,but it is an invasive operation with high cost and complications.For clinical purposes,the ideal cerebral edema monitoring should be non-invasive,real-time,bedside,and continuous dynamic monitoring.The dis-turbance coefficient(DC)was used in this study to dynamically monitor the occu-rrence,development,and evolution of cerebral edema in patients with cerebral hemorrhage in real time,and review head CT or MRI to evaluate the development of the disease and guide further treatment,so as to improve the prognosis of patients with cerebral hemorrhage.AIM To offer a promising new approach for non-invasive adjuvant therapy in cerebral edema treatment.METHODS A total of 160 patients with hypertensive cerebral hemorrhage admitted to the Department of Neurosurgery,Second Affiliated Hospital of Xi’an Medical University from September 2018 to September 2019 were recruited.The patients were randomly divided into a control group(n=80)and an experimental group(n=80).Patients in the control group received conventional empirical treatment,while those in the experimental group were treated with mannitol dehydration under the guidance of DC.Subsequently,we compared the two groups with regards to the total dosage of mannitol,the total course of treatment,the incidence of complications,and prognosis.RESULTS The mean daily consumption of mannitol,the total course of treatment,and the mean hospitalization days were 362.7±117.7 mL,14.8±5.2 days,and 29.4±7.9 in the control group and 283.1±93.6 mL,11.8±4.2 days,and 23.9±8.3 in the experimental group(P<0.05).In the control group,there were 20 patients with pulmonary infection(25%),30 with electrolyte disturbance(37.5%),20 with renal impairment(25%),and 16 with stress ulcer(20%).In the experimental group,pulmonary infection occurred in 18 patients(22.5%),electrolyte disturbance in 6(7.5%),renal impairment in 2(2.5%),and stress ulcers in 15(18.8%)(P<0.05).According to the Glasgow coma scale score 6 months after discharge,the prognosis of the control group was good in 20 patients(25%),fair in 26(32.5%),and poor in 34(42.5%);the prognosis of the experimental group was good in 32(40%),fair in 36(45%),and poor in 12(15%)(P<0.05).CONCLUSION Using DC for non-invasive dynamic monitoring of cerebral edema demonstrates considerable clinical potential.It reduces mannitol dosage,treatment duration,complication rates,and hospital stays,ultimately lowering hospital-ization costs.Additionally,it improves overall patient prognosis,offering a promising new approach for non-invasive adjuvant therapy in cerebral edema treatment.展开更多
Purpose–The precast concrete slab track(PST)has advantages of fewer maintenance frequencies,better smooth rides and structural stability,which has been widely applied in urban rail transit.Precise positioning of prec...Purpose–The precast concrete slab track(PST)has advantages of fewer maintenance frequencies,better smooth rides and structural stability,which has been widely applied in urban rail transit.Precise positioning of precast concrete slab(PCS)is vital for keeping the initial track regularity.However,the cast-in-place process of the self-compacting concrete(SCC)filling layer generally causes a large deformation of PCS due to the water-hammer effect of flowing SCC,even cracking of PCS.Currently,the buoyancy characteristic and influencing factors of PCS during the SCC casting process have not been thoroughly studied in urban rail transit.Design/methodology/approach–In this work,a Computational Fluid Dynamics(CFD)model is established to calculate the buoyancy of PCS caused by the flowing SCC.The main influencing factors,including the inlet speed and flowability of SCC,have been analyzed and discussed.A new structural optimization scheme has been proposed for PST to reduce the buoyancy caused by the flowing SCC.Findings–The simulation and field test results showed that the buoyancy and deformation of PCS decreased obviously after adopting the new scheme.Originality/value–The findings of this study can provide guidance for the control of the deformation of PCS during the SCC construction process.展开更多
文摘目的评价加味凉血五花汤与强脉冲光结合对玫瑰痤疮(肺胃湿热型)患者疗效影响。方法按照随机数字表法将六安市中医院皮肤科门诊收治的66例红斑毛细血管扩张型和(或)丘疹脓疱型玫瑰痤疮患者(2021年8月-2023年8月)分为对照组、观察组,每组33例。对照组予单纯强脉冲光治疗,每3周一次,共4次。观察组在对照组基础上加用加味凉血五花汤,治疗后均要求保湿防晒;比较两组的临床疗效及治疗前后两组患者皮肤敏感性评分及医师主观评分变化、皮肤红斑指数E值及面部皮肤的经皮水分丢失量(transepidermal water loss,TEWL)、角质层含水量(stratum corneum hydration,SCH)变化,观察两组不良反应发生情况。结果对照组总有效率为67.0%(22/33),观察组为90.0%(28/31)(P<0.05);治疗前两组患者的皮肤敏感性评分及医师主观评分、皮肤红斑指数E值与面部皮肤TEWL、SCH数据比较差异无统计学意义(P>0.05),治疗后,两组患者以上指标均改善,而观察组患者指标改善明显优于对照组(P<0.05);对照组(18.2%,6/33)与观察组患者不良反应率(12.9%,4/31)比较,差异有统计学意义(P<0.05)。结论在强脉冲光治疗基础上,加味凉血五花汤治疗肺胃湿热型玫瑰痤疮的临床疗效显著,安全性高,能有效提高面部角质层含水量水平,且同时降低经皮水分丢失量、改善皮肤敏感、红斑等主要症状。
基金Supported by the Shaanxi Provincial Key Research and Development Plan Project,No.2020ZDLSF01-02.
文摘BACKGROUND At present,the conventional methods for diagnosing cerebral edema in clinical practice are computed tomography(CT)and magnetic resonance imaging(MRI),which can evaluate the location and degree of peripheral cerebral edema,but cannot realize quantification.When patients have symptoms of diffuse cerebral edema or high cranial pressure,CT or MRI often suggests that cerebral edema is lagging and cannot be dynamically monitored in real time.Intracranial pressure monitoring is the gold standard,but it is an invasive operation with high cost and complications.For clinical purposes,the ideal cerebral edema monitoring should be non-invasive,real-time,bedside,and continuous dynamic monitoring.The dis-turbance coefficient(DC)was used in this study to dynamically monitor the occu-rrence,development,and evolution of cerebral edema in patients with cerebral hemorrhage in real time,and review head CT or MRI to evaluate the development of the disease and guide further treatment,so as to improve the prognosis of patients with cerebral hemorrhage.AIM To offer a promising new approach for non-invasive adjuvant therapy in cerebral edema treatment.METHODS A total of 160 patients with hypertensive cerebral hemorrhage admitted to the Department of Neurosurgery,Second Affiliated Hospital of Xi’an Medical University from September 2018 to September 2019 were recruited.The patients were randomly divided into a control group(n=80)and an experimental group(n=80).Patients in the control group received conventional empirical treatment,while those in the experimental group were treated with mannitol dehydration under the guidance of DC.Subsequently,we compared the two groups with regards to the total dosage of mannitol,the total course of treatment,the incidence of complications,and prognosis.RESULTS The mean daily consumption of mannitol,the total course of treatment,and the mean hospitalization days were 362.7±117.7 mL,14.8±5.2 days,and 29.4±7.9 in the control group and 283.1±93.6 mL,11.8±4.2 days,and 23.9±8.3 in the experimental group(P<0.05).In the control group,there were 20 patients with pulmonary infection(25%),30 with electrolyte disturbance(37.5%),20 with renal impairment(25%),and 16 with stress ulcer(20%).In the experimental group,pulmonary infection occurred in 18 patients(22.5%),electrolyte disturbance in 6(7.5%),renal impairment in 2(2.5%),and stress ulcers in 15(18.8%)(P<0.05).According to the Glasgow coma scale score 6 months after discharge,the prognosis of the control group was good in 20 patients(25%),fair in 26(32.5%),and poor in 34(42.5%);the prognosis of the experimental group was good in 32(40%),fair in 36(45%),and poor in 12(15%)(P<0.05).CONCLUSION Using DC for non-invasive dynamic monitoring of cerebral edema demonstrates considerable clinical potential.It reduces mannitol dosage,treatment duration,complication rates,and hospital stays,ultimately lowering hospital-ization costs.Additionally,it improves overall patient prognosis,offering a promising new approach for non-invasive adjuvant therapy in cerebral edema treatment.
文摘Purpose–The precast concrete slab track(PST)has advantages of fewer maintenance frequencies,better smooth rides and structural stability,which has been widely applied in urban rail transit.Precise positioning of precast concrete slab(PCS)is vital for keeping the initial track regularity.However,the cast-in-place process of the self-compacting concrete(SCC)filling layer generally causes a large deformation of PCS due to the water-hammer effect of flowing SCC,even cracking of PCS.Currently,the buoyancy characteristic and influencing factors of PCS during the SCC casting process have not been thoroughly studied in urban rail transit.Design/methodology/approach–In this work,a Computational Fluid Dynamics(CFD)model is established to calculate the buoyancy of PCS caused by the flowing SCC.The main influencing factors,including the inlet speed and flowability of SCC,have been analyzed and discussed.A new structural optimization scheme has been proposed for PST to reduce the buoyancy caused by the flowing SCC.Findings–The simulation and field test results showed that the buoyancy and deformation of PCS decreased obviously after adopting the new scheme.Originality/value–The findings of this study can provide guidance for the control of the deformation of PCS during the SCC construction process.
