Insight into the carbon turnover in soil aggregates and density fractions is essential for reducing the uncertainty in estimating carbon pools on the Tibetan Plateau,and how they vary with land use type is unclear.In ...Insight into the carbon turnover in soil aggregates and density fractions is essential for reducing the uncertainty in estimating carbon pools on the Tibetan Plateau,and how they vary with land use type is unclear.In this study,the effect of land use type on carbon storage and fractionation was quantified based on organic carbon and its ^(13)C abundance at the microscale of soil aggregates and density fractions in Tibetan alpine ecosystems.The sequence of soil aggregate destruction in the land use types of plantation(13.1%)<shrubland(32.7%)<grassland(47.9%)<farmland(61.8%)shows that plantations strengthen the soil structure.Plantation land had a greater contribution of light fraction organic carbon(28.3%)but a lower contribution of mineral-associated organic carbon(40.6%)to the carbon stock compared to farmland(13.5 and 70.3%).Interestingly,plantation land enhanced the aggregational differentiation of organic carbon and ^(13)C in each density fraction,whereas no such phenomenon existed in the soil organic carbon.Carbon isotope analyses revealed that carbon transfer in the plantation land occurred from the light fraction in macroaggregates(–24.9‰)to the mineral-associated fraction in microaggregates(–19.9‰).When compared to the other three land use types,the low transferability of carbon in aggregates and density fractions in plantation land provides a stable carbon pool for the Tibetan Plateau.This study shows that plantations can mitigate global climate change by slowing carbon transfer and increasing carbon storage at the microscale of aggregates and density fractions in alpine regions.展开更多
Lysine-targeting reversible covalent inhibitors,particularly salicylaldehyde-based compounds such as the Food and Drug Administration(FDA)-approved drug Voxelotor,exhibit significant therapeutic potential but are limi...Lysine-targeting reversible covalent inhibitors,particularly salicylaldehyde-based compounds such as the Food and Drug Administration(FDA)-approved drug Voxelotor,exhibit significant therapeutic potential but are limited by challenges including instability and off-target effects.To overcome these limitations in kinase inhibitor A5,we devised a pH-responsive prodrug strategy by masking its reactive aldehyde group with an acid-labile hydrazone linkage and enhancing intracellular delivery through conjugation with FK506.The optimized prodrug demonstrated robust antitumor efficacy in K562 tumor-bearing mice.Furthermore,the incorporation of the photosensitizer chlorin e6(Ce6)led to the formation of self-assembled nanoparticles(AKNP),which not only improved physiological stability and prolonged tumor retention but also enabled light-triggered release of A5 in conjunction with photodynamic therapy(PDT).Our study thus presents a promising prodrug self-assembly strategy that combines the on-demand release of a novel lysine-targeting,reversible covalent kinase inhibitor with PDT in clinical cancer therapy.展开更多
The limited redox capability of photocatalysts often leads to harmful NO_(2) byproduct formation during photocatalytic NO oxidation.Herein,Bi_(4)Ti_(3)O_(12) nanosheets modified with plasmonic metallic bismuth and abu...The limited redox capability of photocatalysts often leads to harmful NO_(2) byproduct formation during photocatalytic NO oxidation.Herein,Bi_(4)Ti_(3)O_(12) nanosheets modified with plasmonic metallic bismuth and abundant oxygen vacancies were synthesized via an in-situ reduction method.The optimized catalyst(BTOR2,with a molar ratio of 40%NaBH_(4) to Bi_(4)Ti_(3)O_(12))achieved a maximum NO removal efficiency of 62.3%,significantly higher than pristine Bi_(4)Ti_(3)O_(12)(40.5%) while minimizing NO_(2) production.The results reveal that the synergistic effects of Bi’s plasmonic resonance and oxygen vacancies enhanced visible light absorption and charge separation.The density functional theory(DFT)analysis showed electrons can transfer from Bi_(4)Ti_(3)O_(12)to Bi,promoting O_(2)activation to·O_(2)^(-)radicals.In-situ diffuse reflectance infrared Fourier transform spectroscopy(DRIFTS)confirmed that light-induced H2O adsorption was strengthened,improving·OH radical generation.These radicals promoted the selective conversion of activated NO-to NO_(3)^(-),rather than NO_(2).This work provides valuable insights for advancing research into efficient photocatalysts for air pollution control.展开更多
Moirésuperlattices hosting flat bands and correlated states have become a central focus in condensed matter research.Using first-principles calculations,we investigate three-dimensional flat bands in alternating ...Moirésuperlattices hosting flat bands and correlated states have become a central focus in condensed matter research.Using first-principles calculations,we investigate three-dimensional flat bands in alternating twisted NbSe_(2)moirébulk structures,which exhibit stronger interlayer interactions than twisted bilayer configurations.Our results show that moirébulks undergo spontaneous large-scale structural relaxation,leading to the formation of remarkably flat energy bands at twist angles≤7.31°.The k_(z)-dependent dispersion of these flat bands across different moirébulks highlights their intrinsic three-dimensional character.Moreover,the presence of out-of-plane mirror symmetry in these moirébulk structures indicates potential interlayer triplet superconducting pairing mechanisms,distinct from those in twisted bilayer systems.This work opens new avenues for exploring three-dimensional flat bands in other moirébulk systems.展开更多
基金financially supported by the National Natural Science Foundation of China (42477044,32171648 and U23A2017)the Hubei Provincial Science and Technology Program,China (2025AFD451 and 2022CFB030)。
文摘Insight into the carbon turnover in soil aggregates and density fractions is essential for reducing the uncertainty in estimating carbon pools on the Tibetan Plateau,and how they vary with land use type is unclear.In this study,the effect of land use type on carbon storage and fractionation was quantified based on organic carbon and its ^(13)C abundance at the microscale of soil aggregates and density fractions in Tibetan alpine ecosystems.The sequence of soil aggregate destruction in the land use types of plantation(13.1%)<shrubland(32.7%)<grassland(47.9%)<farmland(61.8%)shows that plantations strengthen the soil structure.Plantation land had a greater contribution of light fraction organic carbon(28.3%)but a lower contribution of mineral-associated organic carbon(40.6%)to the carbon stock compared to farmland(13.5 and 70.3%).Interestingly,plantation land enhanced the aggregational differentiation of organic carbon and ^(13)C in each density fraction,whereas no such phenomenon existed in the soil organic carbon.Carbon isotope analyses revealed that carbon transfer in the plantation land occurred from the light fraction in macroaggregates(–24.9‰)to the mineral-associated fraction in microaggregates(–19.9‰).When compared to the other three land use types,the low transferability of carbon in aggregates and density fractions in plantation land provides a stable carbon pool for the Tibetan Plateau.This study shows that plantations can mitigate global climate change by slowing carbon transfer and increasing carbon storage at the microscale of aggregates and density fractions in alpine regions.
基金supported by the grants from National Key R&D Program of China(No.2022YFA1104800)Shenzhen Science and Technology Program(No.JCYJ20210324124214038)+4 种基金National Natural Science Foundation of China(Nos.52072418,82300016)Natural Science Foundation of Guangdong Province(No.2023A1515140072)Shenzhen Key Laboratory of Neural Cell Reprogramming and Drug Research,Social Development Science and Technology Key Project of Dongguan(No.20231800940512)the National Medical Research Council(NMRC,No.23-0740-A0001)the Ministry of Education(MOE,No.T2EP10222-0002)of Singapore.
文摘Lysine-targeting reversible covalent inhibitors,particularly salicylaldehyde-based compounds such as the Food and Drug Administration(FDA)-approved drug Voxelotor,exhibit significant therapeutic potential but are limited by challenges including instability and off-target effects.To overcome these limitations in kinase inhibitor A5,we devised a pH-responsive prodrug strategy by masking its reactive aldehyde group with an acid-labile hydrazone linkage and enhancing intracellular delivery through conjugation with FK506.The optimized prodrug demonstrated robust antitumor efficacy in K562 tumor-bearing mice.Furthermore,the incorporation of the photosensitizer chlorin e6(Ce6)led to the formation of self-assembled nanoparticles(AKNP),which not only improved physiological stability and prolonged tumor retention but also enabled light-triggered release of A5 in conjunction with photodynamic therapy(PDT).Our study thus presents a promising prodrug self-assembly strategy that combines the on-demand release of a novel lysine-targeting,reversible covalent kinase inhibitor with PDT in clinical cancer therapy.
基金supported by the Natural Science Foundation of Chongqing(Nos.CSTB2024NSCQ-MSX1278,CSTB2023NSCQ-MSX0006)Technology Innovation Project of Shapingba District,Chongqing(No.2024004)+2 种基金Science and Technology Research Program of Chongqing Municipal Education Commission(Nos.KJZD-K202403102,KJQN202103110,KJQN202400512,KJQN202403107)National Natural Science Foundation of China(No.22406014)China Postdoctoral Science Foundation(No.2023MD744137).
文摘The limited redox capability of photocatalysts often leads to harmful NO_(2) byproduct formation during photocatalytic NO oxidation.Herein,Bi_(4)Ti_(3)O_(12) nanosheets modified with plasmonic metallic bismuth and abundant oxygen vacancies were synthesized via an in-situ reduction method.The optimized catalyst(BTOR2,with a molar ratio of 40%NaBH_(4) to Bi_(4)Ti_(3)O_(12))achieved a maximum NO removal efficiency of 62.3%,significantly higher than pristine Bi_(4)Ti_(3)O_(12)(40.5%) while minimizing NO_(2) production.The results reveal that the synergistic effects of Bi’s plasmonic resonance and oxygen vacancies enhanced visible light absorption and charge separation.The density functional theory(DFT)analysis showed electrons can transfer from Bi_(4)Ti_(3)O_(12)to Bi,promoting O_(2)activation to·O_(2)^(-)radicals.In-situ diffuse reflectance infrared Fourier transform spectroscopy(DRIFTS)confirmed that light-induced H2O adsorption was strengthened,improving·OH radical generation.These radicals promoted the selective conversion of activated NO-to NO_(3)^(-),rather than NO_(2).This work provides valuable insights for advancing research into efficient photocatalysts for air pollution control.
基金supported by the National Key Research and Development Program of China(Grant No.2024YFA1410300)the National Natural Science Foundation of China(Grant No.12304217)+1 种基金the Natural Science Foundation of Hunan Province(Grant No.2025JJ60002)the Fundamental Research Funds for the Central Universities of China(Grant No.531119200247)。
文摘Moirésuperlattices hosting flat bands and correlated states have become a central focus in condensed matter research.Using first-principles calculations,we investigate three-dimensional flat bands in alternating twisted NbSe_(2)moirébulk structures,which exhibit stronger interlayer interactions than twisted bilayer configurations.Our results show that moirébulks undergo spontaneous large-scale structural relaxation,leading to the formation of remarkably flat energy bands at twist angles≤7.31°.The k_(z)-dependent dispersion of these flat bands across different moirébulks highlights their intrinsic three-dimensional character.Moreover,the presence of out-of-plane mirror symmetry in these moirébulk structures indicates potential interlayer triplet superconducting pairing mechanisms,distinct from those in twisted bilayer systems.This work opens new avenues for exploring three-dimensional flat bands in other moirébulk systems.
