目的探讨嗜酸性粒细胞型鼻息肉内镜术中应用全降解鼻窦药物支架对临床疗效的影响。方法入组行鼻内镜手术的嗜酸性粒细胞型鼻息肉患者15例,设计自身对照研究,将双侧鼻腔随机分为支架侧与对照侧。支架侧内镜术中植入全降解鼻窦药物支架;...目的探讨嗜酸性粒细胞型鼻息肉内镜术中应用全降解鼻窦药物支架对临床疗效的影响。方法入组行鼻内镜手术的嗜酸性粒细胞型鼻息肉患者15例,设计自身对照研究,将双侧鼻腔随机分为支架侧与对照侧。支架侧内镜术中植入全降解鼻窦药物支架;对照侧鼻腔未植入全降解鼻窦药物支架。分别于内镜术前,术后2周、1个月、2个月、3个月进行随访评估,主要评估指标为鼻部症状视觉模拟量表评分、Lund-Kennedy鼻内镜评分、黏膜病理嗜酸性粒细胞计数。结果支架侧鼻内镜评分在术后3个月时明显低于对照侧(1.786±1.051 vs 2.643±1.151,t=2.064,P=0.0208);黏膜病理嗜酸性粒细胞计数在术后1个月时显著低于对照侧(61.33±28.50 vs 84.33±27.83,t=3.044,P=0.0088);鼻部症状视觉模拟量表评分双侧无明显差异。结论嗜酸性粒细胞型鼻息肉内镜术中应用全降解鼻窦药物支架可以抑制黏膜炎症,改善鼻内镜评分,促进术腔良性转归。展开更多
慢性鼻窦炎鼻息肉(chronic rhinosinusitis with nasal polyps,CRSwNP)是耳鼻咽喉头颈外科常见难治性疾病,严重影响患者生活质量,发病机制尚未完全明确,其核心是多种细胞参与的炎症反应。糖皮质激素以其强大的抗炎作用在CRSwNP的治疗中...慢性鼻窦炎鼻息肉(chronic rhinosinusitis with nasal polyps,CRSwNP)是耳鼻咽喉头颈外科常见难治性疾病,严重影响患者生活质量,发病机制尚未完全明确,其核心是多种细胞参与的炎症反应。糖皮质激素以其强大的抗炎作用在CRSwNP的治疗中具有重要地位,而激素抵抗是鼻窦炎难治性的重要原因之一。维生素D作为一种经典的固醇类药物,主要与调节人体钙磷代谢有关,近年来逐渐发现其能够发挥抗炎作用。现有研究报道维生素D能够减少CRSwNP的炎症反应水平,调节免疫细胞功能,可能增强机体对激素治疗的敏感性。本文主要就维生素D对CRSwNP的研究现状及可能的免疫学机制做一综述。展开更多
In order to obtain high comprehensive performance hollow ceramic microspheres(HCMs),used Al-Cr2O3 as the main reaction system,HCMs were prepared by Self-reactive flame quenching technology in Ar2 and N2 atmosphere res...In order to obtain high comprehensive performance hollow ceramic microspheres(HCMs),used Al-Cr2O3 as the main reaction system,HCMs were prepared by Self-reactive flame quenching technology in Ar2 and N2 atmosphere respectively.Effects of the two different atmospheres on synthesizing HCMs were studied.Results show that in Ar2 atmosphere,because of incomplete reaction of agglomerate powders,porous particles with hollow structure and smooth-faced HCMs constitute the products.However in N2 atmosphere,because agglomerate powders react completely,all of them become smooth-faced HCMs.Results above show that experiment atmosphere is a important parameter to synthesize HCMs and to a great extent influences reaction process of agglomerate powders in the flame field.展开更多
文摘目的探讨嗜酸性粒细胞型鼻息肉内镜术中应用全降解鼻窦药物支架对临床疗效的影响。方法入组行鼻内镜手术的嗜酸性粒细胞型鼻息肉患者15例,设计自身对照研究,将双侧鼻腔随机分为支架侧与对照侧。支架侧内镜术中植入全降解鼻窦药物支架;对照侧鼻腔未植入全降解鼻窦药物支架。分别于内镜术前,术后2周、1个月、2个月、3个月进行随访评估,主要评估指标为鼻部症状视觉模拟量表评分、Lund-Kennedy鼻内镜评分、黏膜病理嗜酸性粒细胞计数。结果支架侧鼻内镜评分在术后3个月时明显低于对照侧(1.786±1.051 vs 2.643±1.151,t=2.064,P=0.0208);黏膜病理嗜酸性粒细胞计数在术后1个月时显著低于对照侧(61.33±28.50 vs 84.33±27.83,t=3.044,P=0.0088);鼻部症状视觉模拟量表评分双侧无明显差异。结论嗜酸性粒细胞型鼻息肉内镜术中应用全降解鼻窦药物支架可以抑制黏膜炎症,改善鼻内镜评分,促进术腔良性转归。
文摘慢性鼻窦炎鼻息肉(chronic rhinosinusitis with nasal polyps,CRSwNP)是耳鼻咽喉头颈外科常见难治性疾病,严重影响患者生活质量,发病机制尚未完全明确,其核心是多种细胞参与的炎症反应。糖皮质激素以其强大的抗炎作用在CRSwNP的治疗中具有重要地位,而激素抵抗是鼻窦炎难治性的重要原因之一。维生素D作为一种经典的固醇类药物,主要与调节人体钙磷代谢有关,近年来逐渐发现其能够发挥抗炎作用。现有研究报道维生素D能够减少CRSwNP的炎症反应水平,调节免疫细胞功能,可能增强机体对激素治疗的敏感性。本文主要就维生素D对CRSwNP的研究现状及可能的免疫学机制做一综述。
基金National Nature Science Foundation of China(50672130)
文摘In order to obtain high comprehensive performance hollow ceramic microspheres(HCMs),used Al-Cr2O3 as the main reaction system,HCMs were prepared by Self-reactive flame quenching technology in Ar2 and N2 atmosphere respectively.Effects of the two different atmospheres on synthesizing HCMs were studied.Results show that in Ar2 atmosphere,because of incomplete reaction of agglomerate powders,porous particles with hollow structure and smooth-faced HCMs constitute the products.However in N2 atmosphere,because agglomerate powders react completely,all of them become smooth-faced HCMs.Results above show that experiment atmosphere is a important parameter to synthesize HCMs and to a great extent influences reaction process of agglomerate powders in the flame field.
