HighlightsA novel conjugative plasmid pHJ90-cfr carrying the multiresistance gene cfr was characterized in Proteus vulgaris.A new IS5-family member,ISPmi4,was identified for the first time.Both plasmids and ICEs were ...HighlightsA novel conjugative plasmid pHJ90-cfr carrying the multiresistance gene cfr was characterized in Proteus vulgaris.A new IS5-family member,ISPmi4,was identified for the first time.Both plasmids and ICEs were vital mobile genetic elements for horizontal transmission of cfr gene in Proteus species.展开更多
Oxazolidinones are highly effective antimicrobial agents for the treatment of serious infections caused by Gram-positive organisms,including methicillin-resistant Staphylococcus aureus(MRSA),vancomycin-resistant enter...Oxazolidinones are highly effective antimicrobial agents for the treatment of serious infections caused by Gram-positive organisms,including methicillin-resistant Staphylococcus aureus(MRSA),vancomycin-resistant enterococci(VRE),multidrug-resistant(MDR)pneumococci and MDR mycobacteria(Brenciani et al.2022).However,the emergence and prevalence of acquired oxazolidinone resistance genes.展开更多
Road obstacles that unexpectedly appear due to vehicle breakdowns and accidents are major causes of fatal road accidents.Connected Autonomous Vehicles(CAVs)can be used to avoid collisions to ensure road safety through...Road obstacles that unexpectedly appear due to vehicle breakdowns and accidents are major causes of fatal road accidents.Connected Autonomous Vehicles(CAVs)can be used to avoid collisions to ensure road safety through cooperative sensing and driving.However,the collision avoidance performance of CAVs with unexpected obstacles has not been studied in the existing works.In this paper,we first design a platoon-based collision avoidance framework for CAVs.In this framework,we deploy a Digital Twin(DT)system at the head vehicle in a platoon to reduce communication overhead and decision-making delay based on a proposed trajectory planning scheme.In addition,a DT-assistant system is deployed on the assistant vehicle to monitor vehicles out of the sensing range of the head vehicle for the maintenance of the DT system.In this case,the transmission frequency of kinetic states of platoon members can be reduced to ensure low-overhead communication.Moreover,we design a variable resource reservation interval that can ensure DT synchronization between DT and the assistant system with high reliability.To further improve road safety,an urgency level-based trajectory planning algorithm is proposed to avoid unexpected obstacles considering different levels of emergency risks.Simulation results show that our DT system-based scheme can achieve significant performance gains in unexpected obstacle avoidance.Compared to the existing schemes,it can reduce collisions by 95%and is faster by about 10%passing by the unexpected obstacle.展开更多
基金supported by the National Key Research and Development Program of China(2022YFF0710505)the Central Public-interest Scientific Institution Basal Research Fund,China(1610302022001)。
文摘HighlightsA novel conjugative plasmid pHJ90-cfr carrying the multiresistance gene cfr was characterized in Proteus vulgaris.A new IS5-family member,ISPmi4,was identified for the first time.Both plasmids and ICEs were vital mobile genetic elements for horizontal transmission of cfr gene in Proteus species.
基金supported by the National Key Research and Development Program of China(2022YFF0710505)The Central Public-interest Scientific Institution Basal Research Fund,China(1610302022001)the Talents Introduction Projects of Hebei Agricultural University,China(YJ201945)。
文摘Oxazolidinones are highly effective antimicrobial agents for the treatment of serious infections caused by Gram-positive organisms,including methicillin-resistant Staphylococcus aureus(MRSA),vancomycin-resistant enterococci(VRE),multidrug-resistant(MDR)pneumococci and MDR mycobacteria(Brenciani et al.2022).However,the emergence and prevalence of acquired oxazolidinone resistance genes.
基金partly supported by National Key R&D Program of China(No.2018YFE0117500)National Natural Science Foundation of China(No.62171104)+2 种基金EU Horizon2020(824019),EU Horizon2020(101022280)Horizon Europe(101086228)the UK EPSRC(EP/Y027787/1)。
文摘Road obstacles that unexpectedly appear due to vehicle breakdowns and accidents are major causes of fatal road accidents.Connected Autonomous Vehicles(CAVs)can be used to avoid collisions to ensure road safety through cooperative sensing and driving.However,the collision avoidance performance of CAVs with unexpected obstacles has not been studied in the existing works.In this paper,we first design a platoon-based collision avoidance framework for CAVs.In this framework,we deploy a Digital Twin(DT)system at the head vehicle in a platoon to reduce communication overhead and decision-making delay based on a proposed trajectory planning scheme.In addition,a DT-assistant system is deployed on the assistant vehicle to monitor vehicles out of the sensing range of the head vehicle for the maintenance of the DT system.In this case,the transmission frequency of kinetic states of platoon members can be reduced to ensure low-overhead communication.Moreover,we design a variable resource reservation interval that can ensure DT synchronization between DT and the assistant system with high reliability.To further improve road safety,an urgency level-based trajectory planning algorithm is proposed to avoid unexpected obstacles considering different levels of emergency risks.Simulation results show that our DT system-based scheme can achieve significant performance gains in unexpected obstacle avoidance.Compared to the existing schemes,it can reduce collisions by 95%and is faster by about 10%passing by the unexpected obstacle.
