In order to address the issues of complex system structure and variable selection difficulty for the current heavy haul railway line status evaluation system, a three-category and three-layer heavy-haul line status ev...In order to address the issues of complex system structure and variable selection difficulty for the current heavy haul railway line status evaluation system, a three-category and three-layer heavy-haul line status evaluation variable set construction and reduction optimization method is proposed. Firstly, the status of heavy haul railway line is analyzed, and an initial set of evaluation variables affecting the line status is constructed. Then, based on the association rule and the principal component analysis method, key variables are extracted from the initial variable set to establish the evaluation system. Finally, this method is verified with actual data of a line. The results show that the service performance of heavy haul railway line can still be evaluated accurately when the evaluation variables are reduced by 60% in the proposed method.展开更多
AIM: To study the effects of low-dose amitriptyline (AMT) on gastrointestinal function and brain-gut peptides in healthy Chinese volunteers. METHODS: This was a double-blind, randomised, placebo-controlled, two-period...AIM: To study the effects of low-dose amitriptyline (AMT) on gastrointestinal function and brain-gut peptides in healthy Chinese volunteers. METHODS: This was a double-blind, randomised, placebo-controlled, two-period cross-over trial. Twentyeight healthy volunteers were randomised and administered 1-wk treatments of AMT (12.5 mg tid) or placebo. Before and during the final two days of treatment, gastric emptying, proximal gastric accommodation and visceral sensitivity were measured by drinkingultrasonography test; the orocecal transit time (OCTT) was measured by lactulose hydrogen breath test, and fasting blood was collected. Plasma levels of ghrelin, motilin and neuropeptide Y (NPY) were measured by enzyme-linked immunosorbent assay kits.RESULTS: AMT slowed the OCTT (109.2 ± 29.68 min vs 96.61 ± 23.9 min, P = 0.004) but did not affect liquid gastric emptying and had no effect on proximal gastric accommodation. AMT resulted in decreases in the visual analogue scale (VAS) for difficulty in drinking 600 and 800 mL of water (3.57 ± 0.94 vs 2.98 ± 0.85, 5.57 ± 0.82 vs 4.57 ± 0.98, P < 0.01 for both), although it had no significant effect on the VAS for difficulty in drinking 200 mL and 400 mL of water. AMT significantly increased the plasma ghrelin level (442.87 ± 176.79 pg/mL vs 526.87 ± 158.44 pg/mL, P = 0.04) and the neuropeptide-Y level (890.15 ± 131.46 pg/mL vs 965.64 ± 165.63 pg/mL, P = 0.03), whereas it had no effect on the MTL level. CONCLUSION: Low-dose AMT could slow OCTT, make the stomach less sensitive and increase the plasma levels of ghrelin and NPY. Thus, we recommend the use of low-dose AMT for functional gastrointestinal disorders.展开更多
Aerogels,renowned as ultra-lightweight solids with exceptional porosity and specific surface area,have emerged as pivotal materials for thermal insulation,catalysis,energy storage,and biomedicine.This review comprehen...Aerogels,renowned as ultra-lightweight solids with exceptional porosity and specific surface area,have emerged as pivotal materials for thermal insulation,catalysis,energy storage,and biomedicine.This review comprehensively evaluates the recent strides in sustainable,high-performance cellulose-based aerogels,emphasizing their fabrication,functionalization,and application prospects.It details the extraction of cellulose fromdiverse sources and its subsequent processing into nanocellulose(e.g.,cellulose nanofibrils and nanocrystals),which serves as the fundamental building block for aerogel synthesis.The critical sol-gel transition,solvent selection,and the pivotal role of drying techniques—freeze-drying,supercritical drying,and ambient pressure drying—in determining final aerogel architecture and properties are systematically analyzed.Special emphasis is placed on the advanced chemical modification of nanocellulose,including esterification,click chemistry,etherification,silanization,and amidation,which tailors surface chemistry to impart hydrophobicity,reactivity,or specific binding sites.The profound influence of cellulose source characteristics(aspect ratio,crystallinity,surface charge)on the pore-forming mechanism and aerogel performance is thoroughly discussed,bridging raw material selection with microstructure design.The review further elucidates the engineering of hybrid and composite aerogels by integrating silica,graphene,polymers,semiconductors,and metal-organic frameworks(MOFs),which synergistically enhance functionalities for targeted applications such as adsorption,photocatalysis,energy storage,sensing,and biomedical engineering.Despite significant progress,challenges remain in scalable green fabrication,balancing ultra-high porosity with mechanical robustness,and deepening the mechanistic understanding in complex applications.This work consolidates the current state-of-the-art,identifies key knowledge gaps,and provides a forward-looking perspective on the development of cellulose aerogels as versatile platforms for next-generation sustainable technologies.展开更多
The valorization of agricultural waste into high-value nanomaterials is crucial for advancing sustainable biorefineries.This study presents an efficient approach for extracting carboxylated cellulose nanocrystals(CNCs...The valorization of agricultural waste into high-value nanomaterials is crucial for advancing sustainable biorefineries.This study presents an efficient approach for extracting carboxylated cellulose nanocrystals(CNCs)from poplar leaf waste(PL),an abundant and underutilized biomass.The process involved alkaline treatment and hydrogen peroxide bleaching to purify cellulose(PL-CEL),followed by sequential periodate-chlorite oxidation to produce dicarboxylic cellulose nanocrystals(PL-CNCs).The resulting nanocrystals were comprehensively characterized using compositional analysis,XRD,FTIR,TEM,TGA,and zeta potential measurements.XRD analysis confirmed a high crystallinity index of 82%for PL-CEL,which decreased to 72.2%after oxidation due to the introduction of carboxyl groups.FTIR spectra revealed a prominent peak at 1720 cm-1,confirming successful carboxylation.TEM images showed rod-like nanocrystalswith an average length of 271.22 nmand width of 14.68 nm,while conductometric titration indicated a carboxyl content of 1.9 mmol/g.The PL-CNCs exhibited good colloidal stability with a zeta potential of-30.2mV at pH7.0.TGA demonstratedmoderate thermal stability with enhanced char formation.This work highlights a green and scalable route for converting poplar leaf waste into functional nanocellulose,suitable for applications in composites,adsorption,and sustainable materials.The novelty of this study lies in the pioneering use of poplar leaf waste combined with a sequential periodate-chlorite oxidation to sustainably produce carboxylated CNCs with enhanced functionality.展开更多
AIM:To compare the efficacy and side effects of lowdose amitriptyline(AMT)with proton pump inhibitor treatment in patients with globus pharyngeus.METHODS:Thirty-four patients who fulfilled the RomeⅢcriteria for funct...AIM:To compare the efficacy and side effects of lowdose amitriptyline(AMT)with proton pump inhibitor treatment in patients with globus pharyngeus.METHODS:Thirty-four patients who fulfilled the RomeⅢcriteria for functional esophageal disorders were included in this study.Patients were randomly assigned to receive either 25 mg AMT before bedtime(AMT group)or 40 mg Pantoprazole once daily for 4 wk(conventional group).The main efficacy endpoint was assessed using the Glasgow Edinburgh Throat Scale(GETS).The secondary efficacy endpoints included the Medical Outcomes Study 36-item short form health survey[social functioning(SF)-36]and the Pittsburgh Sleep Quality Index.Treatment response was defined as a>50%reduction in GETS scores.All patients entering this study recorded side effects at days 1,8,15,22 and 29 using a visual analogue scale.RESULTS:Thirty patients completed the study.After 4 wk of treatment,the AMT group had a greater response than the conventional group(75%vs 35.7%,P=0.004).At day 3,the AMT group showed significantly more improvement than the Conventional group in GETS score(3.69±1.14 vs 5.64±1.28,P=0.000).After 4 wk of treatment,the AMT group showed significantly greater improvement in GETS score and sleep quality than the Conventional group(1.25±1.84 vs 3.79±2.33,4.19±2.07 vs 8.5±4.97;P<0.01 for both).Additionally,the AMT group was more likely than the Conventional group to experience improvement in the SF-36,including general health,vitality,social functioning and mental health(P=0.044,0.024,0.049 and 0.005).Dry mouth,sleepiness,dizziness and constipation were the most common side effects.CONCLUSION:Low-dose AMT is well tolerated and can significantly improve patient symptoms,sleep and quality of life.Thus,low-dose AMT may be an effective treatment for globus pharyngeus.展开更多
Objective： The aim of this study was to study the clinical efficacy and toxicity of combination of the radiotherapy and IP regimen for patients with local advanced esophageal cancer. Methods： Sixty-eight cases of lo...Objective： The aim of this study was to study the clinical efficacy and toxicity of combination of the radiotherapy and IP regimen for patients with local advanced esophageal cancer. Methods： Sixty-eight cases of local advanced esophageal cancer were randomized into two groups, simple irradiation group （control group, n = 33） receiving conventional radiotherepy to a total of 60 Gy, combined group （research group, n = 35） which received the same radiotherapy as simple irradiation group ptus chemotherapy with IP regimen, patients in research group were treated with infusion of Irinotecan 65 mg/m^2 and DDP 30 mg/m^2 on days 1 and 8. Twenty-one days was a cycle and 4 cycles were given. Results： The remission rate, one and two year disease-free survival rate in research group were significant higher than it in control group. But the incidence of nausea, vomiting, myelosuppression and diarrhea was higher in research group. Conclusion： The efficacy of concomitant radiotherapy and IP regimen for local advanced esophageal cancer is obviously and it can improve the survival rate of patients, which worthy of clinical application.展开更多
文摘In order to address the issues of complex system structure and variable selection difficulty for the current heavy haul railway line status evaluation system, a three-category and three-layer heavy-haul line status evaluation variable set construction and reduction optimization method is proposed. Firstly, the status of heavy haul railway line is analyzed, and an initial set of evaluation variables affecting the line status is constructed. Then, based on the association rule and the principal component analysis method, key variables are extracted from the initial variable set to establish the evaluation system. Finally, this method is verified with actual data of a line. The results show that the service performance of heavy haul railway line can still be evaluated accurately when the evaluation variables are reduced by 60% in the proposed method.
文摘AIM: To study the effects of low-dose amitriptyline (AMT) on gastrointestinal function and brain-gut peptides in healthy Chinese volunteers. METHODS: This was a double-blind, randomised, placebo-controlled, two-period cross-over trial. Twentyeight healthy volunteers were randomised and administered 1-wk treatments of AMT (12.5 mg tid) or placebo. Before and during the final two days of treatment, gastric emptying, proximal gastric accommodation and visceral sensitivity were measured by drinkingultrasonography test; the orocecal transit time (OCTT) was measured by lactulose hydrogen breath test, and fasting blood was collected. Plasma levels of ghrelin, motilin and neuropeptide Y (NPY) were measured by enzyme-linked immunosorbent assay kits.RESULTS: AMT slowed the OCTT (109.2 ± 29.68 min vs 96.61 ± 23.9 min, P = 0.004) but did not affect liquid gastric emptying and had no effect on proximal gastric accommodation. AMT resulted in decreases in the visual analogue scale (VAS) for difficulty in drinking 600 and 800 mL of water (3.57 ± 0.94 vs 2.98 ± 0.85, 5.57 ± 0.82 vs 4.57 ± 0.98, P < 0.01 for both), although it had no significant effect on the VAS for difficulty in drinking 200 mL and 400 mL of water. AMT significantly increased the plasma ghrelin level (442.87 ± 176.79 pg/mL vs 526.87 ± 158.44 pg/mL, P = 0.04) and the neuropeptide-Y level (890.15 ± 131.46 pg/mL vs 965.64 ± 165.63 pg/mL, P = 0.03), whereas it had no effect on the MTL level. CONCLUSION: Low-dose AMT could slow OCTT, make the stomach less sensitive and increase the plasma levels of ghrelin and NPY. Thus, we recommend the use of low-dose AMT for functional gastrointestinal disorders.
基金funded by Basic Scientific Research Funds Project of Heilongjiang Universities of Department of Education,Heilongjiang Province,China,grant number 2025-KYYWF-ZR0763.
文摘Aerogels,renowned as ultra-lightweight solids with exceptional porosity and specific surface area,have emerged as pivotal materials for thermal insulation,catalysis,energy storage,and biomedicine.This review comprehensively evaluates the recent strides in sustainable,high-performance cellulose-based aerogels,emphasizing their fabrication,functionalization,and application prospects.It details the extraction of cellulose fromdiverse sources and its subsequent processing into nanocellulose(e.g.,cellulose nanofibrils and nanocrystals),which serves as the fundamental building block for aerogel synthesis.The critical sol-gel transition,solvent selection,and the pivotal role of drying techniques—freeze-drying,supercritical drying,and ambient pressure drying—in determining final aerogel architecture and properties are systematically analyzed.Special emphasis is placed on the advanced chemical modification of nanocellulose,including esterification,click chemistry,etherification,silanization,and amidation,which tailors surface chemistry to impart hydrophobicity,reactivity,or specific binding sites.The profound influence of cellulose source characteristics(aspect ratio,crystallinity,surface charge)on the pore-forming mechanism and aerogel performance is thoroughly discussed,bridging raw material selection with microstructure design.The review further elucidates the engineering of hybrid and composite aerogels by integrating silica,graphene,polymers,semiconductors,and metal-organic frameworks(MOFs),which synergistically enhance functionalities for targeted applications such as adsorption,photocatalysis,energy storage,sensing,and biomedical engineering.Despite significant progress,challenges remain in scalable green fabrication,balancing ultra-high porosity with mechanical robustness,and deepening the mechanistic understanding in complex applications.This work consolidates the current state-of-the-art,identifies key knowledge gaps,and provides a forward-looking perspective on the development of cellulose aerogels as versatile platforms for next-generation sustainable technologies.
基金funded by the basic scientific research Funds project of Heilongjiang Universities,grant number 2023-KYYWF-0570.
文摘The valorization of agricultural waste into high-value nanomaterials is crucial for advancing sustainable biorefineries.This study presents an efficient approach for extracting carboxylated cellulose nanocrystals(CNCs)from poplar leaf waste(PL),an abundant and underutilized biomass.The process involved alkaline treatment and hydrogen peroxide bleaching to purify cellulose(PL-CEL),followed by sequential periodate-chlorite oxidation to produce dicarboxylic cellulose nanocrystals(PL-CNCs).The resulting nanocrystals were comprehensively characterized using compositional analysis,XRD,FTIR,TEM,TGA,and zeta potential measurements.XRD analysis confirmed a high crystallinity index of 82%for PL-CEL,which decreased to 72.2%after oxidation due to the introduction of carboxyl groups.FTIR spectra revealed a prominent peak at 1720 cm-1,confirming successful carboxylation.TEM images showed rod-like nanocrystalswith an average length of 271.22 nmand width of 14.68 nm,while conductometric titration indicated a carboxyl content of 1.9 mmol/g.The PL-CNCs exhibited good colloidal stability with a zeta potential of-30.2mV at pH7.0.TGA demonstratedmoderate thermal stability with enhanced char formation.This work highlights a green and scalable route for converting poplar leaf waste into functional nanocellulose,suitable for applications in composites,adsorption,and sustainable materials.The novelty of this study lies in the pioneering use of poplar leaf waste combined with a sequential periodate-chlorite oxidation to sustainably produce carboxylated CNCs with enhanced functionality.
文摘AIM:To compare the efficacy and side effects of lowdose amitriptyline(AMT)with proton pump inhibitor treatment in patients with globus pharyngeus.METHODS:Thirty-four patients who fulfilled the RomeⅢcriteria for functional esophageal disorders were included in this study.Patients were randomly assigned to receive either 25 mg AMT before bedtime(AMT group)or 40 mg Pantoprazole once daily for 4 wk(conventional group).The main efficacy endpoint was assessed using the Glasgow Edinburgh Throat Scale(GETS).The secondary efficacy endpoints included the Medical Outcomes Study 36-item short form health survey[social functioning(SF)-36]and the Pittsburgh Sleep Quality Index.Treatment response was defined as a>50%reduction in GETS scores.All patients entering this study recorded side effects at days 1,8,15,22 and 29 using a visual analogue scale.RESULTS:Thirty patients completed the study.After 4 wk of treatment,the AMT group had a greater response than the conventional group(75%vs 35.7%,P=0.004).At day 3,the AMT group showed significantly more improvement than the Conventional group in GETS score(3.69±1.14 vs 5.64±1.28,P=0.000).After 4 wk of treatment,the AMT group showed significantly greater improvement in GETS score and sleep quality than the Conventional group(1.25±1.84 vs 3.79±2.33,4.19±2.07 vs 8.5±4.97;P<0.01 for both).Additionally,the AMT group was more likely than the Conventional group to experience improvement in the SF-36,including general health,vitality,social functioning and mental health(P=0.044,0.024,0.049 and 0.005).Dry mouth,sleepiness,dizziness and constipation were the most common side effects.CONCLUSION:Low-dose AMT is well tolerated and can significantly improve patient symptoms,sleep and quality of life.Thus,low-dose AMT may be an effective treatment for globus pharyngeus.
文摘Objective： The aim of this study was to study the clinical efficacy and toxicity of combination of the radiotherapy and IP regimen for patients with local advanced esophageal cancer. Methods： Sixty-eight cases of local advanced esophageal cancer were randomized into two groups, simple irradiation group （control group, n = 33） receiving conventional radiotherepy to a total of 60 Gy, combined group （research group, n = 35） which received the same radiotherapy as simple irradiation group ptus chemotherapy with IP regimen, patients in research group were treated with infusion of Irinotecan 65 mg/m^2 and DDP 30 mg/m^2 on days 1 and 8. Twenty-one days was a cycle and 4 cycles were given. Results： The remission rate, one and two year disease-free survival rate in research group were significant higher than it in control group. But the incidence of nausea, vomiting, myelosuppression and diarrhea was higher in research group. Conclusion： The efficacy of concomitant radiotherapy and IP regimen for local advanced esophageal cancer is obviously and it can improve the survival rate of patients, which worthy of clinical application.
